Mutagenetix > Incidental Mutations

Incidental Mutation 'R7482:Vmn1r234'

579877

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r234

Ensembl Gene

ENSMUSG00000057203

Gene Name

vomeronasal 1 receptor 234

Synonyms

V1rf1

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R7482 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

21228826-21229815 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 21229375 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 184 (N184D)

Ref Sequence

ENSEMBL: ENSMUSP00000078579 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079633]

Predicted Effect

probably benign
Transcript: ENSMUST00000079633
AA Change: N184D

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000078579
Gene: ENSMUSG00000057203
AA Change: N184D

Domain	Start	End	E-Value	Type
Pfam:TAS2R	25	315	2.8e-14	PFAM
Pfam:V1R	57	318	2.3e-26	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (37/37)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actbl2	G	A	13: 111,256,139	R336H	probably damaging	Het
Akap9	C	G	5: 3,968,745	H1109D	probably benign	Het
Ap2a2	C	T	7: 141,602,297	P180S	possibly damaging	Het
Arfgef2	T	C	2: 166,851,279		probably null	Het
Arhgef25	A	T	10: 127,185,671	M226K	probably damaging	Het
Brd7	T	C	8: 88,361,626	D45G	probably damaging	Het
Bsn	C	A	9: 108,113,529	V1675F	probably damaging	Het
Chtf18	C	A	17: 25,719,989	R820L	possibly damaging	Het
Cldn7	A	G	11: 69,966,039	D38G	possibly damaging	Het
Clpb	T	C	7: 101,786,719	V615A	possibly damaging	Het
Cntnap4	T	C	8: 112,733,562		probably null	Het
Dchs2	T	A	3: 83,248,725	S798T	possibly damaging	Het
Ect2l	A	T	10: 18,168,454	M311K	probably benign	Het
Gm6205	T	C	5: 94,682,880	I79T	possibly damaging	Het
Hectd4	T	A	5: 121,363,878	C4225S	possibly damaging	Het
Hecw2	T	C	1: 54,040,470	H8R	probably damaging	Het
Hif3a	G	A	7: 17,042,635	T462I	possibly damaging	Het
Itgb2l	T	C	16: 96,426,833	E490G	probably benign	Het
Jakmip3	T	A	7: 139,025,499	C411S	possibly damaging	Het
Klhl24	A	G	16: 20,114,655	T339A	possibly damaging	Het
Mctp1	A	T	13: 76,741,460		probably null	Het
Mlf1	T	A	3: 67,392,894	H81Q	probably benign	Het
Muc4	T	A	16: 32,766,950	Y652N		Het
Myo9b	A	G	8: 71,342,798	S804G	probably benign	Het
Olfr906	T	G	9: 38,488,451	C141G	probably damaging	Het
Rab11fip5	T	C	6: 85,340,778	E1043G	probably benign	Het
Radil	A	G	5: 142,486,763	V941A	probably benign	Het
Senp8	A	G	9: 59,737,660	V71A	probably damaging	Het
Sh2d4a	G	A	8: 68,296,676	A121T	probably benign	Het
Stx17	A	G	4: 48,181,722	D297G	possibly damaging	Het
Tas2r105	A	T	6: 131,687,009	M152K	probably benign	Het
Tlr11	G	T	14: 50,362,999	C814F	probably damaging	Het
Tsc22d1	T	C	14: 76,418,487	V802A	probably benign	Het
Vmn2r114	T	C	17: 23,291,494	K671E	probably damaging	Het
Vmn2r27	A	G	6: 124,224,261	F246L	probably damaging	Het
Xpo1	T	G	11: 23,282,544	L355V	probably benign	Het

Other mutations in Vmn1r234

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Vmn1r234	APN	17	21229598	missense	possibly damaging	0.95
IGL01485:Vmn1r234	APN	17	21228909	missense	possibly damaging	0.53
IGL02149:Vmn1r234	APN	17	21229007	missense	probably benign	0.00
IGL02291:Vmn1r234	APN	17	21228931	missense	probably benign	0.28
IGL02993:Vmn1r234	APN	17	21229703	missense	probably damaging	0.99
IGL03223:Vmn1r234	APN	17	21229391	missense	probably damaging	0.98
R0626:Vmn1r234	UTSW	17	21229745	missense	probably benign	0.17
R1274:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1275:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1288:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1289:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1319:Vmn1r234	UTSW	17	21228910	missense	probably benign	0.01
R1412:Vmn1r234	UTSW	17	21229250	missense	probably benign	0.01
R2323:Vmn1r234	UTSW	17	21229703	missense	probably benign	0.10
R3755:Vmn1r234	UTSW	17	21229009	missense	probably damaging	0.98
R4299:Vmn1r234	UTSW	17	21229021	missense	probably benign	0.03
R5301:Vmn1r234	UTSW	17	21229327	missense	probably benign	0.11
R5741:Vmn1r234	UTSW	17	21229469	missense	probably benign	0.21
R6197:Vmn1r234	UTSW	17	21229327	missense	probably benign	0.04
R6218:Vmn1r234	UTSW	17	21229721	missense	possibly damaging	0.71
R6486:Vmn1r234	UTSW	17	21229342	missense	probably benign	0.11
R7635:Vmn1r234	UTSW	17	21229217	missense	probably damaging	1.00
R8295:Vmn1r234	UTSW	17	21228839	missense	probably benign	0.01
X0028:Vmn1r234	UTSW	17	21228890	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- CAGTGCATGCTTATTGAGTGTC -3'
(R):5'- TGGACTCATGGCTGGATCTAG -3'

Sequencing Primer
(F):5'- GAGTGTCTTCCAGGTCATCAC -3'
(R):5'- GCTGGATCTAGGGAAAATATTGCTCC -3'

Posted On

2019-10-07