Incidental Mutation 'R7486:Or12j4'
ID 580167
Institutional Source Beutler Lab
Gene Symbol Or12j4
Ensembl Gene ENSMUSG00000056883
Gene Name olfactory receptor family 12 subfamily J member 4
Synonyms MOR252-3P, Olfr533, GA_x6K02T2PBJ9-42615403-42616365
MMRRC Submission 045560-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.130) question?
Stock # R7486 (G1)
Quality Score 112.008
Status Not validated
Chromosome 7
Chromosomal Location 140046116-140047078 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) C to T at 140045947 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150653 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071755] [ENSMUST00000211093] [ENSMUST00000215308] [ENSMUST00000216258] [ENSMUST00000217179]
AlphaFold Q7TRT7
Predicted Effect probably benign
Transcript: ENSMUST00000071755
SMART Domains Protein: ENSMUSP00000071667
Gene: ENSMUSG00000056883

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 7.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 304 3e-6 PFAM
Pfam:7tm_1 41 289 5.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211093
Predicted Effect probably benign
Transcript: ENSMUST00000215308
Predicted Effect probably benign
Transcript: ENSMUST00000216258
Predicted Effect probably benign
Transcript: ENSMUST00000217179
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam21 T C 12: 81,605,657 (GRCm39) I702V probably benign Het
Adgre5 T C 8: 84,450,515 (GRCm39) E815G probably damaging Het
Adgrl2 A G 3: 148,523,330 (GRCm39) V298A Het
Akp3 A G 1: 87,053,201 (GRCm39) D91G probably damaging Het
Ano8 A G 8: 71,937,642 (GRCm39) probably null Het
Blvra T C 2: 126,929,243 (GRCm39) S136P unknown Het
Cacul1 T A 19: 60,568,868 (GRCm39) M97L probably benign Het
Ccdc80 T C 16: 44,946,542 (GRCm39) V827A probably damaging Het
Cep68 T C 11: 20,192,166 (GRCm39) E11G probably benign Het
Cfap221 A T 1: 119,851,322 (GRCm39) V813E possibly damaging Het
Chd6 A G 2: 160,791,923 (GRCm39) V2478A probably damaging Het
Chmp6 T C 11: 119,807,783 (GRCm39) F148S probably benign Het
Clca3a2 T A 3: 144,503,362 (GRCm39) I863F probably damaging Het
Cnnm2 T C 19: 46,750,513 (GRCm39) V101A possibly damaging Het
Cpne8 A T 15: 90,400,109 (GRCm39) probably null Het
Dmbt1 T G 7: 130,668,192 (GRCm39) C483G unknown Het
Dnah7b G A 1: 46,329,894 (GRCm39) G3246D probably damaging Het
Dnajc3 C A 14: 119,209,816 (GRCm39) T297K probably benign Het
Dpm3 A G 3: 89,174,034 (GRCm39) probably null Het
Eef2k A G 7: 120,457,793 (GRCm39) N51D probably benign Het
Erc1 G A 6: 119,571,907 (GRCm39) Q1022* probably null Het
Ercc5 T A 1: 44,187,224 (GRCm39) M1K probably null Het
Fam114a2 C T 11: 57,404,515 (GRCm39) G83D probably damaging Het
Fat4 C A 3: 39,011,576 (GRCm39) Y2225* probably null Het
Frk G A 10: 34,423,292 (GRCm39) W123* probably null Het
Gm11568 T A 11: 99,749,292 (GRCm39) C166S unknown Het
Gpr153 A G 4: 152,366,858 (GRCm39) D337G probably benign Het
Gpt2 T C 8: 86,252,235 (GRCm39) F517L probably damaging Het
Gsg1 C T 6: 135,214,427 (GRCm39) E361K probably benign Het
Hsfy2 G A 1: 56,676,130 (GRCm39) R136* probably null Het
Insm1 G A 2: 146,065,738 (GRCm39) R518H probably damaging Het
Kank1 G A 19: 25,388,193 (GRCm39) C622Y probably damaging Het
Katnb1 T A 8: 95,825,357 (GRCm39) S640R probably damaging Het
Kcnmb4 A G 10: 116,254,180 (GRCm39) V199A probably benign Het
Lamb1 T G 12: 31,337,441 (GRCm39) S391A probably benign Het
Larp7-ps A T 4: 92,079,506 (GRCm39) V105E probably benign Het
Macf1 T G 4: 123,303,374 (GRCm39) D376A probably benign Het
Map7d1 C A 4: 126,128,179 (GRCm39) R614L unknown Het
Mcm8 C T 2: 132,681,440 (GRCm39) R667W probably damaging Het
Med13l C T 5: 118,866,539 (GRCm39) T531I probably benign Het
Mstn G T 1: 53,103,128 (GRCm39) A155S probably damaging Het
Mycbp2 C T 14: 103,434,690 (GRCm39) R2251K probably damaging Het
Myo19 T C 11: 84,796,463 (GRCm39) S692P probably benign Het
Nipbl A T 15: 8,325,120 (GRCm39) N2514K probably benign Het
Nkd2 T A 13: 73,995,561 (GRCm39) probably benign Het
Nox3 T A 17: 3,720,219 (GRCm39) Y322F probably damaging Het
Nt5dc1 A G 10: 34,275,805 (GRCm39) Y135H probably benign Het
Oog3 T A 4: 143,884,742 (GRCm39) H398L probably benign Het
Or10g9 T A 9: 39,912,181 (GRCm39) Y114F probably benign Het
Or1e29 T C 11: 73,667,847 (GRCm39) Y102C probably damaging Het
Otogl A G 10: 107,657,849 (GRCm39) L1027P probably damaging Het
Pcdh20 T A 14: 88,706,050 (GRCm39) I417F possibly damaging Het
Pcdha12 T A 18: 37,154,610 (GRCm39) V443E probably damaging Het
Pcdhga2 A G 18: 37,803,461 (GRCm39) D435G probably benign Het
Pcnt G T 10: 76,254,270 (GRCm39) T853K probably benign Het
Pcnt T C 10: 76,254,271 (GRCm39) T853A probably benign Het
Pgghg T A 7: 140,522,393 (GRCm39) S57R probably benign Het
Ppm1m T C 9: 106,073,810 (GRCm39) D301G probably damaging Het
Ppp6r1 A G 7: 4,642,899 (GRCm39) V519A probably benign Het
Prss41 ACAGCAGCAGCAGCAGCAGCA ACAGCAGCAGCAGCAGCA 17: 24,063,072 (GRCm39) probably benign Het
Rasa3 C T 8: 13,640,201 (GRCm39) probably null Het
Robo4 T C 9: 37,316,870 (GRCm39) V395A probably damaging Het
Scrib A G 15: 75,929,499 (GRCm39) S1123P probably damaging Het
Setd1b A G 5: 123,301,655 (GRCm39) K45E probably benign Het
Slc14a1 T C 18: 78,154,739 (GRCm39) S216G probably benign Het
Slc25a45 A G 19: 5,934,997 (GRCm39) Y282C probably damaging Het
Slc6a5 T C 7: 49,567,078 (GRCm39) S255P possibly damaging Het
Smc2 A T 4: 52,462,861 (GRCm39) Q617L possibly damaging Het
Spo11 G A 2: 172,825,870 (GRCm39) D103N probably benign Het
Tcf20 A T 15: 82,737,935 (GRCm39) M1172K possibly damaging Het
Tesc T A 5: 118,184,382 (GRCm39) S21T probably benign Het
Tie1 C A 4: 118,337,101 (GRCm39) probably null Het
Trim24 T G 6: 37,934,774 (GRCm39) probably null Het
Trpm7 A G 2: 126,673,115 (GRCm39) probably null Het
Unc13d T C 11: 115,965,259 (GRCm39) D193G possibly damaging Het
Upk3a A T 15: 84,902,225 (GRCm39) probably null Het
Vmn2r25 T C 6: 123,800,101 (GRCm39) N747S probably damaging Het
Wipf1 GCCTCCTCCTCCTCCTCCTCCTCC GCCTCCTCCTCCTCCTCCTCC 2: 73,270,418 (GRCm39) probably benign Het
Zbtb2 G A 10: 4,319,025 (GRCm39) Q334* probably null Het
Zfp653 T C 9: 21,967,824 (GRCm39) N494D probably damaging Het
Zfp865 A G 7: 5,034,259 (GRCm39) D748G possibly damaging Het
Zzef1 T C 11: 72,755,612 (GRCm39) S1014P possibly damaging Het
Other mutations in Or12j4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Or12j4 APN 7 140,046,292 (GRCm39) missense probably damaging 0.99
IGL02582:Or12j4 APN 7 140,046,560 (GRCm39) missense probably benign
IGL02954:Or12j4 APN 7 140,046,353 (GRCm39) nonsense probably null
R0790:Or12j4 UTSW 7 140,046,962 (GRCm39) missense possibly damaging 0.79
R1754:Or12j4 UTSW 7 140,046,773 (GRCm39) missense probably damaging 1.00
R1965:Or12j4 UTSW 7 140,046,574 (GRCm39) missense probably benign
R2155:Or12j4 UTSW 7 140,046,504 (GRCm39) missense probably benign 0.13
R4613:Or12j4 UTSW 7 140,046,981 (GRCm39) missense probably damaging 1.00
R4836:Or12j4 UTSW 7 140,046,989 (GRCm39) missense probably damaging 1.00
R5493:Or12j4 UTSW 7 140,046,720 (GRCm39) missense probably damaging 1.00
R5694:Or12j4 UTSW 7 140,046,644 (GRCm39) missense probably benign 0.28
R6101:Or12j4 UTSW 7 140,046,432 (GRCm39) missense probably benign 0.31
R6156:Or12j4 UTSW 7 140,046,758 (GRCm39) missense probably benign
R6519:Or12j4 UTSW 7 140,046,458 (GRCm39) missense probably benign 0.01
R6672:Or12j4 UTSW 7 140,046,648 (GRCm39) missense probably damaging 1.00
R6736:Or12j4 UTSW 7 140,046,834 (GRCm39) missense probably damaging 1.00
R6736:Or12j4 UTSW 7 140,046,800 (GRCm39) missense probably damaging 1.00
R7086:Or12j4 UTSW 7 140,046,341 (GRCm39) missense possibly damaging 0.89
R7174:Or12j4 UTSW 7 140,047,076 (GRCm39) makesense probably null
R7465:Or12j4 UTSW 7 140,046,711 (GRCm39) missense probably damaging 0.99
R7872:Or12j4 UTSW 7 140,046,696 (GRCm39) missense probably damaging 1.00
R9013:Or12j4 UTSW 7 140,046,179 (GRCm39) missense probably benign
R9014:Or12j4 UTSW 7 140,045,883 (GRCm39) start gained probably benign
R9255:Or12j4 UTSW 7 140,046,423 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CATGTTTCCCCATGATCCACAAG -3'
(R):5'- GAACATGGTCACAACTGACTGG -3'

Sequencing Primer
(F):5'- GACAGTCTCCAATAACTATGCCCTGG -3'
(R):5'- CACAACTGACTGGTTTACTGGAGC -3'
Posted On 2019-10-07