Incidental Mutation 'R7653:Vmn2r120'
ID |
580516 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r120
|
Ensembl Gene |
ENSMUSG00000090655 |
Gene Name |
vomeronasal 2, receptor 120 |
Synonyms |
EG224916 |
MMRRC Submission |
045730-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R7653 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
57815783-57852314 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 57816258 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Aspartic acid
at position 699
(V699D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129296
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165781]
|
AlphaFold |
A0A3Q4EG79 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165781
AA Change: V699D
PolyPhen 2
Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000129296 Gene: ENSMUSG00000090655 AA Change: V699D
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
80 |
474 |
5.9e-42 |
PFAM |
Pfam:NCD3G
|
517 |
570 |
7.5e-22 |
PFAM |
Pfam:7tm_3
|
598 |
836 |
1.3e-54 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 71 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A730049H05Rik |
A |
T |
6: 92,805,050 (GRCm39) |
Q70L |
unknown |
Het |
Adamts12 |
T |
A |
15: 11,257,115 (GRCm39) |
N489K |
probably benign |
Het |
Alms1 |
A |
G |
6: 85,597,577 (GRCm39) |
D801G |
possibly damaging |
Het |
Apex1 |
T |
G |
14: 51,163,995 (GRCm39) |
N173K |
probably damaging |
Het |
Arhgap32 |
A |
T |
9: 32,168,441 (GRCm39) |
N808I |
probably benign |
Het |
Arhgef28 |
T |
C |
13: 98,105,821 (GRCm39) |
Y706C |
probably benign |
Het |
Atg2b |
A |
T |
12: 105,602,731 (GRCm39) |
F1604Y |
possibly damaging |
Het |
Atm |
A |
T |
9: 53,401,602 (GRCm39) |
Y1422* |
probably null |
Het |
Bace2 |
T |
A |
16: 97,237,852 (GRCm39) |
V38E |
|
Het |
Birc6 |
C |
A |
17: 74,954,729 (GRCm39) |
L3442I |
possibly damaging |
Het |
C6 |
T |
A |
15: 4,844,244 (GRCm39) |
S889T |
|
Het |
Calcrl |
A |
T |
2: 84,175,529 (GRCm39) |
L275* |
probably null |
Het |
Casp6 |
T |
C |
3: 129,705,872 (GRCm39) |
Y180H |
probably benign |
Het |
Cd5 |
T |
C |
19: 10,703,910 (GRCm39) |
M51V |
probably benign |
Het |
Cdhr1 |
G |
T |
14: 36,804,158 (GRCm39) |
P500Q |
probably benign |
Het |
Celsr3 |
G |
A |
9: 108,712,269 (GRCm39) |
W1732* |
probably null |
Het |
Ces2g |
T |
C |
8: 105,689,285 (GRCm39) |
V87A |
probably damaging |
Het |
Chil6 |
T |
C |
3: 106,301,641 (GRCm39) |
N153S |
possibly damaging |
Het |
Chrna5 |
A |
T |
9: 54,909,718 (GRCm39) |
D113V |
probably benign |
Het |
Cimip2b |
T |
G |
4: 43,427,273 (GRCm39) |
|
probably null |
Het |
Cox20 |
A |
G |
1: 178,150,164 (GRCm39) |
T113A |
probably benign |
Het |
Cryl1 |
T |
C |
14: 57,541,148 (GRCm39) |
I179V |
probably benign |
Het |
Dennd3 |
A |
G |
15: 73,434,275 (GRCm39) |
T982A |
probably damaging |
Het |
Drosha |
G |
A |
15: 12,859,522 (GRCm39) |
V577I |
probably benign |
Het |
Dync2h1 |
A |
G |
9: 7,117,570 (GRCm39) |
S2240P |
probably benign |
Het |
Eif1ad14 |
T |
A |
12: 87,886,248 (GRCm39) |
D127V |
unknown |
Het |
Fbxl5 |
C |
T |
5: 43,916,116 (GRCm39) |
S432N |
probably benign |
Het |
Fez1 |
T |
A |
9: 36,772,146 (GRCm39) |
S150R |
probably benign |
Het |
Gabrb2 |
T |
G |
11: 42,378,039 (GRCm39) |
M85R |
probably damaging |
Het |
Lhx4 |
A |
G |
1: 155,580,617 (GRCm39) |
V203A |
probably damaging |
Het |
Med23 |
G |
A |
10: 24,780,282 (GRCm39) |
D977N |
probably damaging |
Het |
Mplkip |
T |
C |
13: 17,870,367 (GRCm39) |
F100L |
probably damaging |
Het |
Ncoa7 |
C |
T |
10: 30,570,239 (GRCm39) |
G240E |
probably damaging |
Het |
Nedd4 |
A |
G |
9: 72,650,910 (GRCm39) |
E827G |
probably damaging |
Het |
Nfatc2 |
A |
G |
2: 168,413,065 (GRCm39) |
F207L |
probably benign |
Het |
Nr2f1 |
A |
T |
13: 78,343,716 (GRCm39) |
S183T |
probably benign |
Het |
Ocel1 |
A |
G |
8: 71,824,560 (GRCm39) |
E81G |
probably benign |
Het |
Or10aa3 |
T |
C |
1: 173,878,488 (GRCm39) |
V183A |
probably benign |
Het |
Or10g3b |
C |
A |
14: 52,586,889 (GRCm39) |
G205* |
probably null |
Het |
Or4n4b |
C |
T |
14: 50,536,604 (GRCm39) |
G54E |
possibly damaging |
Het |
Pcdh8 |
G |
A |
14: 80,005,086 (GRCm39) |
P980S |
probably benign |
Het |
Pex26 |
A |
T |
6: 121,170,510 (GRCm39) |
Q285L |
possibly damaging |
Het |
Pgap6 |
T |
A |
17: 26,339,423 (GRCm39) |
M579K |
probably damaging |
Het |
Plce1 |
A |
T |
19: 38,737,763 (GRCm39) |
N1603I |
probably benign |
Het |
Poli |
A |
T |
18: 70,642,698 (GRCm39) |
C501S |
probably benign |
Het |
Ppp4r4 |
C |
T |
12: 103,550,404 (GRCm39) |
T276I |
probably damaging |
Het |
Rbpj |
T |
A |
5: 53,747,693 (GRCm39) |
M1K |
probably null |
Het |
Recql4 |
T |
A |
15: 76,587,982 (GRCm39) |
M1204L |
probably benign |
Het |
Ribc2 |
T |
C |
15: 85,025,876 (GRCm39) |
I284T |
probably benign |
Het |
Rreb1 |
C |
A |
13: 38,114,362 (GRCm39) |
Q574K |
probably benign |
Het |
Scn9a |
A |
T |
2: 66,357,424 (GRCm39) |
L959Q |
probably damaging |
Het |
Shank1 |
C |
A |
7: 43,969,093 (GRCm39) |
H329Q |
unknown |
Het |
Soat2 |
A |
T |
15: 102,071,013 (GRCm39) |
D469V |
probably damaging |
Het |
Spag7 |
T |
A |
11: 70,555,691 (GRCm39) |
H82L |
probably damaging |
Het |
Sptb |
T |
C |
12: 76,675,271 (GRCm39) |
I248V |
probably benign |
Het |
Tacr3 |
A |
G |
3: 134,566,843 (GRCm39) |
I239V |
probably benign |
Het |
Tbc1d1 |
T |
C |
5: 64,414,133 (GRCm39) |
F165L |
probably benign |
Het |
Tchhl1 |
A |
G |
3: 93,378,451 (GRCm39) |
E385G |
probably benign |
Het |
Tecta |
C |
T |
9: 42,248,532 (GRCm39) |
D1957N |
probably damaging |
Het |
Tenm2 |
T |
C |
11: 35,938,174 (GRCm39) |
I1501V |
probably benign |
Het |
Tet2 |
G |
T |
3: 133,192,146 (GRCm39) |
Q763K |
probably benign |
Het |
Timd6 |
A |
C |
11: 46,475,200 (GRCm39) |
S132R |
probably benign |
Het |
Tox3 |
G |
A |
8: 90,975,617 (GRCm39) |
T338I |
probably damaging |
Het |
Usp30 |
G |
A |
5: 114,259,730 (GRCm39) |
D479N |
probably damaging |
Het |
Vmn1r27 |
T |
C |
6: 58,192,785 (GRCm39) |
D73G |
possibly damaging |
Het |
Vmn1r27 |
A |
T |
6: 58,192,879 (GRCm39) |
S42T |
probably benign |
Het |
Vwa2 |
A |
T |
19: 56,897,767 (GRCm39) |
T691S |
probably benign |
Het |
Wdr31 |
T |
A |
4: 62,381,666 (GRCm39) |
Q55L |
probably benign |
Het |
Xdh |
A |
G |
17: 74,204,040 (GRCm39) |
F1107L |
probably benign |
Het |
Zfp184 |
A |
G |
13: 22,143,887 (GRCm39) |
H531R |
probably damaging |
Het |
Zfp366 |
T |
C |
13: 99,365,709 (GRCm39) |
L290P |
probably damaging |
Het |
|
Other mutations in Vmn2r120 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01335:Vmn2r120
|
APN |
17 |
57,832,732 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL01346:Vmn2r120
|
APN |
17 |
57,852,232 (GRCm39) |
missense |
probably benign |
0.11 |
IGL01996:Vmn2r120
|
APN |
17 |
57,832,222 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02503:Vmn2r120
|
APN |
17 |
57,816,385 (GRCm39) |
missense |
probably benign |
0.40 |
IGL02582:Vmn2r120
|
APN |
17 |
57,831,724 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02747:Vmn2r120
|
APN |
17 |
57,831,719 (GRCm39) |
missense |
probably benign |
0.19 |
IGL02896:Vmn2r120
|
APN |
17 |
57,816,008 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03139:Vmn2r120
|
APN |
17 |
57,831,742 (GRCm39) |
missense |
probably benign |
0.39 |
IGL03342:Vmn2r120
|
APN |
17 |
57,816,372 (GRCm39) |
missense |
probably benign |
0.03 |
A4554:Vmn2r120
|
UTSW |
17 |
57,832,715 (GRCm39) |
missense |
probably benign |
0.01 |
R0207:Vmn2r120
|
UTSW |
17 |
57,832,052 (GRCm39) |
missense |
probably benign |
0.17 |
R0472:Vmn2r120
|
UTSW |
17 |
57,831,518 (GRCm39) |
missense |
probably benign |
0.03 |
R0517:Vmn2r120
|
UTSW |
17 |
57,815,949 (GRCm39) |
missense |
probably damaging |
1.00 |
R1109:Vmn2r120
|
UTSW |
17 |
57,832,829 (GRCm39) |
missense |
probably benign |
0.09 |
R1316:Vmn2r120
|
UTSW |
17 |
57,832,939 (GRCm39) |
missense |
probably benign |
0.28 |
R1543:Vmn2r120
|
UTSW |
17 |
57,829,374 (GRCm39) |
missense |
probably benign |
0.09 |
R1795:Vmn2r120
|
UTSW |
17 |
57,832,038 (GRCm39) |
missense |
probably benign |
0.35 |
R1850:Vmn2r120
|
UTSW |
17 |
57,832,826 (GRCm39) |
missense |
probably benign |
0.19 |
R1920:Vmn2r120
|
UTSW |
17 |
57,831,839 (GRCm39) |
missense |
probably benign |
0.01 |
R1921:Vmn2r120
|
UTSW |
17 |
57,831,839 (GRCm39) |
missense |
probably benign |
0.01 |
R1922:Vmn2r120
|
UTSW |
17 |
57,831,839 (GRCm39) |
missense |
probably benign |
0.01 |
R2063:Vmn2r120
|
UTSW |
17 |
57,831,553 (GRCm39) |
missense |
possibly damaging |
0.88 |
R2064:Vmn2r120
|
UTSW |
17 |
57,831,553 (GRCm39) |
missense |
possibly damaging |
0.88 |
R2065:Vmn2r120
|
UTSW |
17 |
57,831,553 (GRCm39) |
missense |
possibly damaging |
0.88 |
R2067:Vmn2r120
|
UTSW |
17 |
57,831,553 (GRCm39) |
missense |
possibly damaging |
0.88 |
R2286:Vmn2r120
|
UTSW |
17 |
57,815,958 (GRCm39) |
missense |
probably damaging |
1.00 |
R2291:Vmn2r120
|
UTSW |
17 |
57,816,479 (GRCm39) |
missense |
probably damaging |
1.00 |
R3416:Vmn2r120
|
UTSW |
17 |
57,816,241 (GRCm39) |
missense |
possibly damaging |
0.89 |
R3874:Vmn2r120
|
UTSW |
17 |
57,831,954 (GRCm39) |
missense |
probably benign |
0.40 |
R4023:Vmn2r120
|
UTSW |
17 |
57,843,718 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4024:Vmn2r120
|
UTSW |
17 |
57,843,718 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4348:Vmn2r120
|
UTSW |
17 |
57,829,466 (GRCm39) |
missense |
possibly damaging |
0.47 |
R4409:Vmn2r120
|
UTSW |
17 |
57,816,477 (GRCm39) |
missense |
probably damaging |
1.00 |
R4610:Vmn2r120
|
UTSW |
17 |
57,816,120 (GRCm39) |
missense |
probably damaging |
1.00 |
R4771:Vmn2r120
|
UTSW |
17 |
57,831,887 (GRCm39) |
missense |
probably damaging |
1.00 |
R4786:Vmn2r120
|
UTSW |
17 |
57,829,048 (GRCm39) |
missense |
probably benign |
0.14 |
R4927:Vmn2r120
|
UTSW |
17 |
57,816,125 (GRCm39) |
missense |
probably damaging |
1.00 |
R5285:Vmn2r120
|
UTSW |
17 |
57,843,703 (GRCm39) |
missense |
probably damaging |
1.00 |
R5566:Vmn2r120
|
UTSW |
17 |
57,852,290 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5578:Vmn2r120
|
UTSW |
17 |
57,829,514 (GRCm39) |
missense |
probably benign |
0.01 |
R5643:Vmn2r120
|
UTSW |
17 |
57,831,977 (GRCm39) |
missense |
probably benign |
0.01 |
R5644:Vmn2r120
|
UTSW |
17 |
57,831,977 (GRCm39) |
missense |
probably benign |
0.01 |
R5781:Vmn2r120
|
UTSW |
17 |
57,831,938 (GRCm39) |
missense |
probably benign |
0.00 |
R6084:Vmn2r120
|
UTSW |
17 |
57,832,721 (GRCm39) |
missense |
probably benign |
0.15 |
R6120:Vmn2r120
|
UTSW |
17 |
57,832,973 (GRCm39) |
missense |
probably benign |
0.02 |
R6160:Vmn2r120
|
UTSW |
17 |
57,816,418 (GRCm39) |
missense |
probably benign |
0.03 |
R6248:Vmn2r120
|
UTSW |
17 |
57,852,287 (GRCm39) |
missense |
probably benign |
0.03 |
R6256:Vmn2r120
|
UTSW |
17 |
57,831,700 (GRCm39) |
nonsense |
probably null |
|
R6730:Vmn2r120
|
UTSW |
17 |
57,832,012 (GRCm39) |
missense |
probably benign |
0.03 |
R6821:Vmn2r120
|
UTSW |
17 |
57,843,659 (GRCm39) |
missense |
probably benign |
0.00 |
R6868:Vmn2r120
|
UTSW |
17 |
57,852,218 (GRCm39) |
missense |
probably benign |
0.00 |
R6880:Vmn2r120
|
UTSW |
17 |
57,816,187 (GRCm39) |
missense |
probably damaging |
1.00 |
R6986:Vmn2r120
|
UTSW |
17 |
57,816,340 (GRCm39) |
missense |
probably damaging |
1.00 |
R7276:Vmn2r120
|
UTSW |
17 |
57,831,881 (GRCm39) |
missense |
probably benign |
0.11 |
R7373:Vmn2r120
|
UTSW |
17 |
57,816,406 (GRCm39) |
missense |
probably benign |
0.35 |
R7667:Vmn2r120
|
UTSW |
17 |
57,843,657 (GRCm39) |
missense |
probably benign |
0.04 |
R7775:Vmn2r120
|
UTSW |
17 |
57,832,942 (GRCm39) |
missense |
probably damaging |
1.00 |
R7778:Vmn2r120
|
UTSW |
17 |
57,832,942 (GRCm39) |
missense |
probably damaging |
1.00 |
R7797:Vmn2r120
|
UTSW |
17 |
57,815,874 (GRCm39) |
missense |
probably damaging |
1.00 |
R7824:Vmn2r120
|
UTSW |
17 |
57,832,942 (GRCm39) |
missense |
probably damaging |
1.00 |
R7902:Vmn2r120
|
UTSW |
17 |
57,816,244 (GRCm39) |
missense |
possibly damaging |
0.87 |
R7922:Vmn2r120
|
UTSW |
17 |
57,831,683 (GRCm39) |
missense |
probably damaging |
0.99 |
R8508:Vmn2r120
|
UTSW |
17 |
57,832,843 (GRCm39) |
missense |
probably benign |
0.03 |
R8847:Vmn2r120
|
UTSW |
17 |
57,816,217 (GRCm39) |
missense |
probably benign |
0.01 |
R8882:Vmn2r120
|
UTSW |
17 |
57,852,229 (GRCm39) |
missense |
probably benign |
0.01 |
R9134:Vmn2r120
|
UTSW |
17 |
57,832,093 (GRCm39) |
missense |
probably damaging |
1.00 |
R9161:Vmn2r120
|
UTSW |
17 |
57,831,864 (GRCm39) |
missense |
|
|
R9336:Vmn2r120
|
UTSW |
17 |
57,832,201 (GRCm39) |
missense |
possibly damaging |
0.91 |
RF005:Vmn2r120
|
UTSW |
17 |
57,828,991 (GRCm39) |
missense |
possibly damaging |
0.65 |
Z1177:Vmn2r120
|
UTSW |
17 |
57,816,245 (GRCm39) |
missense |
probably benign |
0.00 |
Z1188:Vmn2r120
|
UTSW |
17 |
57,829,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGCCTAGGTATCCCAGCAC -3'
(R):5'- ATTGTGAAAGCCAATAACCGC -3'
Sequencing Primer
(F):5'- TAGGTATCCCAGCACACAGTAAAAGG -3'
(R):5'- GCACTCTCAGCTACATCCTG -3'
|
Posted On |
2019-10-07 |