Incidental Mutation 'R7354:Or4c122'
ID 580622
Institutional Source Beutler Lab
Gene Symbol Or4c122
Ensembl Gene ENSMUSG00000099486
Gene Name olfactory receptor family 4 subfamily C member 122
Synonyms GA_x6K02T2Q125-50696209-50695274, Olfr1228, MOR233-1
MMRRC Submission 045440-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R7354 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 89079065-89080036 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 89079031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139920 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000190757] [ENSMUST00000215447] [ENSMUST00000216392]
AlphaFold Q8VGM9
Predicted Effect probably null
Transcript: ENSMUST00000190757
SMART Domains Protein: ENSMUSP00000139920
Gene: ENSMUSG00000099486

DomainStartEndE-ValueType
Pfam:7tm_1 51 298 2.6e-27 PFAM
Pfam:7tm_4 150 292 2.9e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215447
Predicted Effect probably benign
Transcript: ENSMUST00000216392
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (82/82)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago3 T A 4: 126,311,099 (GRCm39) Q38L possibly damaging Het
Apon T A 10: 128,090,607 (GRCm39) I95N probably benign Het
Arid1a G T 4: 133,421,258 (GRCm39) P464Q unknown Het
Arid4b A G 13: 14,339,455 (GRCm39) D503G probably benign Het
Asxl2 T C 12: 3,505,637 (GRCm39) probably benign Het
Atp2a1 A T 7: 126,048,028 (GRCm39) V594D probably damaging Het
Begain A G 12: 108,999,215 (GRCm39) F519L possibly damaging Het
Bora A G 14: 99,284,794 (GRCm39) T15A probably damaging Het
Btbd7 A T 12: 102,804,464 (GRCm39) M192K probably benign Het
Ccdc125 T G 13: 100,814,382 (GRCm39) probably null Het
Cdcp3 G A 7: 130,858,458 (GRCm39) C1042Y possibly damaging Het
Cdcp3 G T 7: 130,873,762 (GRCm39) C1696F unknown Het
Cfap74 G T 4: 155,549,804 (GRCm39) V146L unknown Het
Crisp1 G A 17: 40,630,071 (GRCm39) probably benign Het
Ctbp1 A T 5: 33,407,732 (GRCm39) H292Q possibly damaging Het
Defb5 T A 8: 19,300,750 (GRCm39) M34K probably benign Het
Dnajc27 A G 12: 4,146,249 (GRCm39) I93V probably benign Het
Dqx1 T A 6: 83,037,957 (GRCm39) Y448* probably null Het
Dynap A T 18: 70,374,371 (GRCm39) C52S possibly damaging Het
Ehd4 C A 2: 119,932,613 (GRCm39) R271L probably damaging Het
Ercc2 T G 7: 19,127,579 (GRCm39) I619S possibly damaging Het
Etf1 A G 18: 35,039,040 (GRCm39) I409T probably damaging Het
Fam117a A G 11: 95,271,529 (GRCm39) D367G probably damaging Het
Fancd2 A G 6: 113,572,907 (GRCm39) D1447G unknown Het
Fbxw9 T C 8: 85,788,825 (GRCm39) S192P probably damaging Het
Frzb A T 2: 80,277,153 (GRCm39) L11Q probably damaging Het
Gm14496 T C 2: 181,642,479 (GRCm39) S717P probably damaging Het
Gm3250 A G 10: 77,618,367 (GRCm39) probably benign Het
Gm4353 C T 7: 115,683,146 (GRCm39) R145Q probably benign Het
Gpr12 A T 5: 146,520,772 (GRCm39) V50D probably damaging Het
Hes1 T C 16: 29,884,746 (GRCm39) probably null Het
Hmcn1 A T 1: 150,682,196 (GRCm39) C451* probably null Het
Iars1 T C 13: 49,857,796 (GRCm39) V347A probably benign Het
Igfn1 A G 1: 135,903,770 (GRCm39) S323P possibly damaging Het
Itga6 G A 2: 71,650,574 (GRCm39) A207T probably damaging Het
Lgi4 T A 7: 30,760,047 (GRCm39) L81H probably damaging Het
Lrp1 T C 10: 127,407,277 (GRCm39) E1888G probably damaging Het
Man2a1 C T 17: 65,059,539 (GRCm39) T1142M probably damaging Het
Mdfic2 T A 6: 98,215,242 (GRCm39) D127V probably damaging Het
Mgam A T 6: 40,721,732 (GRCm39) Y350F probably damaging Het
Miga1 T C 3: 151,996,137 (GRCm39) D351G probably damaging Het
Mro A G 18: 74,006,385 (GRCm39) T111A probably benign Het
Mtrr A T 13: 68,714,326 (GRCm39) V471E probably damaging Het
Myh3 C A 11: 66,987,708 (GRCm39) L1394I probably damaging Het
Myocd A G 11: 65,078,319 (GRCm39) V492A probably benign Het
Nbeal2 A G 9: 110,458,247 (GRCm39) F2115S probably damaging Het
Nlrp1b A T 11: 71,072,376 (GRCm39) M489K possibly damaging Het
Or12j5 A C 7: 140,084,099 (GRCm39) I91R probably damaging Het
Or14j7 A G 17: 38,235,284 (GRCm39) I276V probably benign Het
Or1e1c A T 11: 73,266,201 (GRCm39) I212F probably benign Het
Or4k44 C T 2: 111,367,909 (GRCm39) A242T possibly damaging Het
Orc2 A G 1: 58,508,906 (GRCm39) S462P possibly damaging Het
Pcdh9 T C 14: 94,125,706 (GRCm39) T155A probably benign Het
Pcdhb16 G A 18: 37,611,177 (GRCm39) V46I possibly damaging Het
Pcdhb22 A G 18: 37,653,311 (GRCm39) D336G probably damaging Het
Pde4dip T A 3: 97,626,646 (GRCm39) R1297S probably damaging Het
Plin4 A G 17: 56,411,427 (GRCm39) M868T probably benign Het
Plxnb2 A G 15: 89,049,928 (GRCm39) M531T possibly damaging Het
Poc5 T C 13: 96,531,033 (GRCm39) V77A probably benign Het
Recql5 G A 11: 115,819,027 (GRCm39) R180C probably damaging Het
Rho C A 6: 115,912,464 (GRCm39) Y268* probably null Het
Riok1 A T 13: 38,231,288 (GRCm39) H182L probably benign Het
Rnf207 T C 4: 152,398,548 (GRCm39) D273G probably damaging Het
Serpinb11 A G 1: 107,305,263 (GRCm39) Y213C probably benign Het
Slc16a10 T C 10: 39,952,951 (GRCm39) Y181C probably damaging Het
Slc22a15 G A 3: 101,771,897 (GRCm39) H401Y probably benign Het
Slc5a5 C A 8: 71,342,247 (GRCm39) R268L probably damaging Het
Slc9a8 T C 2: 167,316,051 (GRCm39) F576S possibly damaging Het
Slx4 T C 16: 3,804,963 (GRCm39) E617G probably benign Het
Spata31d1e A T 13: 59,889,648 (GRCm39) L724* probably null Het
Top1 T C 2: 160,546,878 (GRCm39) I386T probably damaging Het
Tor1aip1 G T 1: 155,911,859 (GRCm39) D41E probably damaging Het
Tsc22d4 G A 5: 137,766,371 (GRCm39) R479Q probably benign Het
Unc79 C T 12: 103,108,961 (GRCm39) T2191I possibly damaging Het
Vmn2r109 A T 17: 20,761,043 (GRCm39) D771E probably damaging Het
Vmn2r82 A C 10: 79,192,464 (GRCm39) M14L probably benign Het
Zc3h7a C T 16: 10,966,378 (GRCm39) S583N probably damaging Het
Zfp518b G A 5: 38,840,122 (GRCm39) probably benign Het
Zswim4 A G 8: 84,955,478 (GRCm39) W314R probably damaging Het
Other mutations in Or4c122
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01804:Or4c122 APN 2 89,079,566 (GRCm39) missense probably benign 0.00
IGL02588:Or4c122 APN 2 89,080,042 (GRCm39) splice site probably benign
R0384:Or4c122 UTSW 2 89,079,414 (GRCm39) missense possibly damaging 0.82
R0600:Or4c122 UTSW 2 89,079,742 (GRCm39) nonsense probably null
R0613:Or4c122 UTSW 2 89,079,469 (GRCm39) missense probably damaging 1.00
R1564:Or4c122 UTSW 2 89,080,016 (GRCm39) missense probably benign 0.00
R2115:Or4c122 UTSW 2 89,079,874 (GRCm39) missense probably damaging 1.00
R2313:Or4c122 UTSW 2 89,079,285 (GRCm39) missense probably damaging 1.00
R3083:Or4c122 UTSW 2 89,079,345 (GRCm39) missense probably damaging 0.96
R3790:Or4c122 UTSW 2 89,079,337 (GRCm39) missense probably benign 0.02
R3948:Or4c122 UTSW 2 89,079,336 (GRCm39) missense possibly damaging 0.95
R4373:Or4c122 UTSW 2 89,079,589 (GRCm39) missense possibly damaging 0.90
R4376:Or4c122 UTSW 2 89,079,589 (GRCm39) missense possibly damaging 0.90
R4825:Or4c122 UTSW 2 89,079,034 (GRCm39) splice site probably null
R5022:Or4c122 UTSW 2 89,079,761 (GRCm39) missense probably benign 0.00
R5141:Or4c122 UTSW 2 89,079,473 (GRCm39) nonsense probably null
R5313:Or4c122 UTSW 2 89,079,721 (GRCm39) missense probably benign 0.05
R6010:Or4c122 UTSW 2 89,079,087 (GRCm39) missense probably benign 0.00
R7548:Or4c122 UTSW 2 89,079,430 (GRCm39) missense probably benign 0.09
R8014:Or4c122 UTSW 2 89,079,343 (GRCm39) missense probably damaging 0.98
R8098:Or4c122 UTSW 2 89,079,652 (GRCm39) missense possibly damaging 0.95
R8280:Or4c122 UTSW 2 89,079,234 (GRCm39) missense probably damaging 0.98
R8554:Or4c122 UTSW 2 89,079,595 (GRCm39) missense possibly damaging 0.48
R8678:Or4c122 UTSW 2 89,079,351 (GRCm39) missense probably damaging 1.00
R8725:Or4c122 UTSW 2 89,079,658 (GRCm39) missense probably benign 0.00
R9039:Or4c122 UTSW 2 89,079,545 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGGGGAGGTATCATAGCATATTTAG -3'
(R):5'- ATATATGCACGACCTCCTTCTG -3'

Sequencing Primer
(F):5'- AGCAGATTGCCCTGTATCAG -3'
(R):5'- TATATGCACGACCTCCTTCTGCTTTC -3'
Posted On 2019-10-14