Incidental Mutation 'R7344:Cyp2c23'
ID 580623
Institutional Source Beutler Lab
Gene Symbol Cyp2c23
Ensembl Gene ENSMUSG00000025197
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms Cyp2c44
MMRRC Submission 045434-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7344 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 43993461-44017647 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 44010176 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026211] [ENSMUST00000211830]
AlphaFold E9Q5K4
Predicted Effect probably null
Transcript: ENSMUST00000026211
SMART Domains Protein: ENSMUSP00000026211
Gene: ENSMUSG00000025197

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 34 491 2.1e-152 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000211830
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (58/58)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele show reduced proliferative and tubulogenic responses in lung endothelial cells, decreased tumor angiogenesis and growth of induced tumors, and high potassium-induced hypertension with decreased urinary sodium excretion and increased plasma sodium levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930438A08Rik A C 11: 58,182,273 (GRCm39) Y216S Het
Anpep G T 7: 79,488,398 (GRCm39) S477R possibly damaging Het
Atp7b T C 8: 22,487,515 (GRCm39) D1293G probably damaging Het
Caprin2 A G 6: 148,774,565 (GRCm39) V249A probably benign Het
Cep41 C T 6: 30,693,655 (GRCm39) R5K probably benign Het
Dazap2 T A 15: 100,514,824 (GRCm39) V15E possibly damaging Het
Ecpas A T 4: 58,824,770 (GRCm39) D1070E probably benign Het
Epha8 T A 4: 136,661,849 (GRCm39) H582L probably benign Het
Fam193a A G 5: 34,643,074 (GRCm39) T1513A possibly damaging Het
Fancd2 T C 6: 113,545,670 (GRCm39) V901A probably benign Het
Fbl T A 7: 27,878,360 (GRCm39) V284E probably damaging Het
Fbln2 A G 6: 91,246,955 (GRCm39) E1065G probably damaging Het
Fbxw16 A G 9: 109,278,103 (GRCm39) V25A probably benign Het
Fcgbpl1 C T 7: 27,852,185 (GRCm39) T1236I possibly damaging Het
Fcgbpl1 T C 7: 27,839,704 (GRCm39) S506P possibly damaging Het
Gm11562 T G 11: 99,511,195 (GRCm39) T2P unknown Het
Gm17728 G T 17: 9,640,955 (GRCm39) G22W probably damaging Het
Gm30083 A G 14: 33,721,537 (GRCm39) Y190H probably benign Het
Gm6793 T A 8: 112,741,561 (GRCm39) D27V probably damaging Het
Gm7324 A G 14: 43,952,134 (GRCm39) D259G probably benign Het
Gtf2a1l G A 17: 89,001,531 (GRCm39) G129D probably damaging Het
Ildr2 T A 1: 166,122,166 (GRCm39) V203E probably damaging Het
Ipo4 C T 14: 55,872,988 (GRCm39) R23Q probably benign Het
Irx5 A G 8: 93,086,183 (GRCm39) T89A probably benign Het
Itga7 A G 10: 128,776,798 (GRCm39) N221S possibly damaging Het
Lpcat2 T C 8: 93,602,195 (GRCm39) W259R probably damaging Het
Lrrc8e C T 8: 4,284,815 (GRCm39) R347C probably damaging Het
Lyst T A 13: 13,881,140 (GRCm39) D2790E probably benign Het
Magi2 G A 5: 20,755,238 (GRCm39) R604Q probably benign Het
Mertk C A 2: 128,613,417 (GRCm39) H478N probably benign Het
Mical3 T A 6: 121,013,505 (GRCm39) K293* probably null Het
Nod2 T C 8: 89,387,210 (GRCm39) L168P probably damaging Het
Npnt T C 3: 132,614,100 (GRCm39) probably null Het
Or1x6 T G 11: 50,939,122 (GRCm39) F63V probably damaging Het
Or5af1 A T 11: 58,722,308 (GRCm39) E109D probably damaging Het
Or8b37 T C 9: 37,959,253 (GRCm39) M245T probably benign Het
Or9g4 A T 2: 85,505,275 (GRCm39) Y73* probably null Het
Plcd4 A T 1: 74,593,811 (GRCm39) D312V probably damaging Het
Prss58 A G 6: 40,872,399 (GRCm39) I208T probably damaging Het
Pus7l A G 15: 94,438,498 (GRCm39) S116P probably benign Het
Rcc1l A T 5: 134,205,276 (GRCm39) I93N probably benign Het
Rftn2 A C 1: 55,265,311 (GRCm39) Y36* probably null Het
Rp1l1 G A 14: 64,267,069 (GRCm39) R885Q probably benign Het
Rpgrip1 A T 14: 52,378,116 (GRCm39) D488V probably damaging Het
Sacs A G 14: 61,444,893 (GRCm39) Y2313C possibly damaging Het
Scrib T C 15: 75,921,107 (GRCm39) Y1332C probably damaging Het
Serpinb10 T C 1: 107,468,672 (GRCm39) V105A probably damaging Het
Slc35d1 A T 4: 103,070,243 (GRCm39) probably null Het
Slfn3 T C 11: 83,103,648 (GRCm39) V173A probably benign Het
Smpd3 C T 8: 106,991,825 (GRCm39) V243M probably damaging Het
Stard9 A T 2: 120,535,167 (GRCm39) D3808V possibly damaging Het
Supt16 A T 14: 52,411,028 (GRCm39) V692D probably damaging Het
Tapt1 A T 5: 44,345,999 (GRCm39) V317E probably damaging Het
Vmn2r101 T C 17: 19,832,059 (GRCm39) I685T probably benign Het
Vmn2r92 A G 17: 18,387,513 (GRCm39) I173V probably benign Het
Vps54 T C 11: 21,224,999 (GRCm39) I165T probably damaging Het
Zswim4 G A 8: 84,950,327 (GRCm39) R628* probably null Het
Zzz3 T C 3: 152,157,736 (GRCm39) S770P probably damaging Het
Other mutations in Cyp2c23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01467:Cyp2c23 APN 19 44,003,512 (GRCm39) missense possibly damaging 0.94
IGL01642:Cyp2c23 APN 19 43,993,995 (GRCm39) missense probably damaging 1.00
IGL01782:Cyp2c23 APN 19 44,017,554 (GRCm39) missense possibly damaging 0.77
IGL01843:Cyp2c23 APN 19 43,994,046 (GRCm39) missense probably benign 0.02
IGL02902:Cyp2c23 APN 19 44,009,997 (GRCm39) splice site probably benign
IGL03382:Cyp2c23 APN 19 44,003,371 (GRCm39) missense probably damaging 0.99
R0196:Cyp2c23 UTSW 19 44,000,795 (GRCm39) missense probably damaging 0.98
R0735:Cyp2c23 UTSW 19 44,005,249 (GRCm39) missense probably damaging 1.00
R1384:Cyp2c23 UTSW 19 44,002,102 (GRCm39) missense probably damaging 1.00
R1495:Cyp2c23 UTSW 19 43,993,947 (GRCm39) missense probably benign 0.07
R1809:Cyp2c23 UTSW 19 44,009,997 (GRCm39) splice site probably benign
R1872:Cyp2c23 UTSW 19 43,993,990 (GRCm39) nonsense probably null
R2866:Cyp2c23 UTSW 19 43,993,885 (GRCm39) missense probably damaging 1.00
R3801:Cyp2c23 UTSW 19 43,995,478 (GRCm39) missense probably benign 0.11
R4234:Cyp2c23 UTSW 19 44,017,604 (GRCm39) missense unknown
R4748:Cyp2c23 UTSW 19 44,005,176 (GRCm39) splice site probably null
R4948:Cyp2c23 UTSW 19 44,010,138 (GRCm39) missense possibly damaging 0.49
R5101:Cyp2c23 UTSW 19 44,017,622 (GRCm39) missense unknown
R5420:Cyp2c23 UTSW 19 44,004,103 (GRCm39) critical splice donor site probably null
R5770:Cyp2c23 UTSW 19 44,010,018 (GRCm39) missense probably damaging 0.99
R5993:Cyp2c23 UTSW 19 44,000,799 (GRCm39) missense probably damaging 1.00
R6254:Cyp2c23 UTSW 19 43,993,902 (GRCm39) missense probably benign 0.03
R6269:Cyp2c23 UTSW 19 44,017,626 (GRCm39) start codon destroyed unknown
R6610:Cyp2c23 UTSW 19 43,995,520 (GRCm39) missense probably damaging 1.00
R7603:Cyp2c23 UTSW 19 44,003,369 (GRCm39) missense probably damaging 1.00
R8054:Cyp2c23 UTSW 19 43,995,555 (GRCm39) missense probably damaging 0.99
R8098:Cyp2c23 UTSW 19 44,004,242 (GRCm39) missense probably benign 0.29
R8157:Cyp2c23 UTSW 19 44,010,066 (GRCm39) missense probably benign 0.00
R8813:Cyp2c23 UTSW 19 44,002,054 (GRCm39) missense probably benign 0.07
R9497:Cyp2c23 UTSW 19 44,010,085 (GRCm39) missense probably damaging 0.99
X0065:Cyp2c23 UTSW 19 44,017,610 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AAGGAAGTTCACCTGCATTTTGG -3'
(R):5'- CAGTCCGGATGCTTAGTGAG -3'

Sequencing Primer
(F):5'- TGGCTTGAAACATACCATGTCC -3'
(R):5'- CGGATGCTTAGTGAGAATTTGCTAAC -3'
Posted On 2019-10-14