Incidental Mutation 'R7495:Ptma'
ID 581019
Institutional Source Beutler Lab
Gene Symbol Ptma
Ensembl Gene ENSMUSG00000026238
Gene Name prothymosin alpha
Synonyms Thym
MMRRC Submission 045568-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.637) question?
Stock # R7495 (G1)
Quality Score 217.468
Status Not validated
Chromosome 1
Chromosomal Location 86454448-86458434 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GGAAGAAG to GGAAGAAGAAG at 86457261 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140270 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045897] [ENSMUST00000186255] [ENSMUST00000188533] [ENSMUST00000188699]
AlphaFold P26350
Predicted Effect probably benign
Transcript: ENSMUST00000045897
SMART Domains Protein: ENSMUSP00000044188
Gene: ENSMUSG00000026238

DomainStartEndE-ValueType
Pfam:Prothymosin 2 110 5.4e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186255
SMART Domains Protein: ENSMUSP00000139690
Gene: ENSMUSG00000026238

DomainStartEndE-ValueType
Pfam:Prothymosin 2 47 2.1e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000188533
SMART Domains Protein: ENSMUSP00000139849
Gene: ENSMUSG00000026238

DomainStartEndE-ValueType
Pfam:Prothymosin 2 98 4.3e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000188699
SMART Domains Protein: ENSMUSP00000140270
Gene: ENSMUSG00000026238

DomainStartEndE-ValueType
Pfam:Prothymosin 88 145 1.9e-13 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,915,871 (GRCm39) E1251G probably damaging Het
Apba1 T C 19: 23,913,963 (GRCm39) probably null Het
Arap2 C T 5: 62,833,893 (GRCm39) S858N possibly damaging Het
Capn10 T C 1: 92,871,092 (GRCm39) F301L probably damaging Het
Catip T C 1: 74,401,851 (GRCm39) W9R probably benign Het
Cfap46 A G 7: 139,183,112 (GRCm39) probably null Het
Cpq C T 15: 33,302,586 (GRCm39) R246C probably damaging Het
Dgkh A G 14: 78,816,239 (GRCm39) S1067P probably benign Het
Dpp3 T C 19: 4,967,941 (GRCm39) E316G probably damaging Het
Dpp9 T C 17: 56,502,044 (GRCm39) Q508R probably benign Het
Frem2 T C 3: 53,424,258 (GRCm39) N3060D probably benign Het
Fstl5 A G 3: 76,615,099 (GRCm39) Y720C possibly damaging Het
Gm28168 T C 1: 117,875,637 (GRCm39) S89P possibly damaging Het
Hk2 C T 6: 82,704,346 (GRCm39) G900E probably damaging Het
Hrh1 A C 6: 114,457,634 (GRCm39) D305A probably benign Het
Htt C T 5: 34,968,821 (GRCm39) S435L probably benign Het
Ice2 G T 9: 69,323,511 (GRCm39) V669L probably benign Het
Klk1b27 G A 7: 43,705,500 (GRCm39) V191I probably benign Het
Med12l A G 3: 59,152,194 (GRCm39) K993R probably damaging Het
Nfe2l1 A G 11: 96,710,622 (GRCm39) Y536H probably damaging Het
Nr4a2 T C 2: 57,002,171 (GRCm39) D94G possibly damaging Het
Oit3 T C 10: 59,259,765 (GRCm39) D546G possibly damaging Het
Paxbp1 T C 16: 90,813,837 (GRCm39) T847A probably damaging Het
Pde12 A T 14: 26,389,994 (GRCm39) N238K probably benign Het
Pfkfb3 A C 2: 11,487,312 (GRCm39) I366S probably damaging Het
Ptprb C A 10: 116,177,353 (GRCm39) Q1018K probably benign Het
Rxfp3 C A 15: 11,036,011 (GRCm39) G454C probably damaging Het
Scn5a A G 9: 119,372,200 (GRCm39) V223A probably damaging Het
Sema4c C A 1: 36,589,774 (GRCm39) V527L probably benign Het
Slk C A 19: 47,627,417 (GRCm39) P1182T probably damaging Het
Stt3a A G 9: 36,659,235 (GRCm39) V368A probably benign Het
Trpm3 T C 19: 22,875,160 (GRCm39) F601L probably benign Het
Ttn T C 2: 76,540,299 (GRCm39) D34229G probably benign Het
Vmn2r107 A G 17: 20,595,271 (GRCm39) H608R possibly damaging Het
Vmn2r49 A T 7: 9,710,826 (GRCm39) C635* probably null Het
Zfp473 A T 7: 44,387,368 (GRCm39) F95Y probably benign Het
Zfp984 A C 4: 147,839,287 (GRCm39) S521R possibly damaging Het
Other mutations in Ptma
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0013:Ptma UTSW 1 86,457,498 (GRCm39) unclassified probably benign
R0013:Ptma UTSW 1 86,457,498 (GRCm39) unclassified probably benign
R5554:Ptma UTSW 1 86,454,649 (GRCm39) missense probably damaging 0.99
R6521:Ptma UTSW 1 86,455,569 (GRCm39) critical splice acceptor site probably null
R7371:Ptma UTSW 1 86,457,261 (GRCm39) unclassified probably benign
R7493:Ptma UTSW 1 86,457,261 (GRCm39) unclassified probably benign
R7494:Ptma UTSW 1 86,457,261 (GRCm39) unclassified probably benign
R9416:Ptma UTSW 1 86,455,694 (GRCm39) missense unknown
R9572:Ptma UTSW 1 86,457,697 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCAGGATGTTGGACCAGACAA -3'
(R):5'- GGAGAATCAATCAAGGCCCA -3'

Sequencing Primer
(F):5'- TGTTGGACCAGACAAGGGAAC -3'
(R):5'- ACATAAACCACTATCCTCCCAGCTG -3'
Posted On 2019-10-17