Incidental Mutation 'R7495:Capn10'
ID 581020
Institutional Source Beutler Lab
Gene Symbol Capn10
Ensembl Gene ENSMUSG00000026270
Gene Name calpain 10
Synonyms Capn8
MMRRC Submission 045568-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R7495 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 92862130-92875670 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92871092 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 301 (F301L)
Ref Sequence ENSEMBL: ENSMUSP00000027488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027488] [ENSMUST00000117814] [ENSMUST00000152983]
AlphaFold Q9ESK3
Predicted Effect probably damaging
Transcript: ENSMUST00000027488
AA Change: F301L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027488
Gene: ENSMUSG00000026270
AA Change: F301L

DomainStartEndE-ValueType
CysPc 2 329 1.75e-59 SMART
calpain_III 338 488 2.05e-60 SMART
calpain_III 507 645 1.3e-39 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000117814
SMART Domains Protein: ENSMUSP00000112831
Gene: ENSMUSG00000026270

DomainStartEndE-ValueType
CysPc 2 263 1.29e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000152983
AA Change: F301L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000122158
Gene: ENSMUSG00000026270
AA Change: F301L

DomainStartEndE-ValueType
CysPc 2 329 1.75e-59 SMART
calpain_III 338 488 2.71e-60 SMART
low complexity region 490 499 N/A INTRINSIC
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to ryanodine- and palmitate-induced pancreatic apoptosis. Mice homozygous for a different knock-out allele exhibit increased adiposity, body and organ weights, and leptin serum levels on background containing LG/J. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,915,871 (GRCm39) E1251G probably damaging Het
Apba1 T C 19: 23,913,963 (GRCm39) probably null Het
Arap2 C T 5: 62,833,893 (GRCm39) S858N possibly damaging Het
Catip T C 1: 74,401,851 (GRCm39) W9R probably benign Het
Cfap46 A G 7: 139,183,112 (GRCm39) probably null Het
Cpq C T 15: 33,302,586 (GRCm39) R246C probably damaging Het
Dgkh A G 14: 78,816,239 (GRCm39) S1067P probably benign Het
Dpp3 T C 19: 4,967,941 (GRCm39) E316G probably damaging Het
Dpp9 T C 17: 56,502,044 (GRCm39) Q508R probably benign Het
Frem2 T C 3: 53,424,258 (GRCm39) N3060D probably benign Het
Fstl5 A G 3: 76,615,099 (GRCm39) Y720C possibly damaging Het
Gm28168 T C 1: 117,875,637 (GRCm39) S89P possibly damaging Het
Hk2 C T 6: 82,704,346 (GRCm39) G900E probably damaging Het
Hrh1 A C 6: 114,457,634 (GRCm39) D305A probably benign Het
Htt C T 5: 34,968,821 (GRCm39) S435L probably benign Het
Ice2 G T 9: 69,323,511 (GRCm39) V669L probably benign Het
Klk1b27 G A 7: 43,705,500 (GRCm39) V191I probably benign Het
Med12l A G 3: 59,152,194 (GRCm39) K993R probably damaging Het
Nfe2l1 A G 11: 96,710,622 (GRCm39) Y536H probably damaging Het
Nr4a2 T C 2: 57,002,171 (GRCm39) D94G possibly damaging Het
Oit3 T C 10: 59,259,765 (GRCm39) D546G possibly damaging Het
Paxbp1 T C 16: 90,813,837 (GRCm39) T847A probably damaging Het
Pde12 A T 14: 26,389,994 (GRCm39) N238K probably benign Het
Pfkfb3 A C 2: 11,487,312 (GRCm39) I366S probably damaging Het
Ptma GGAAGAAG GGAAGAAGAAG 1: 86,457,261 (GRCm39) probably benign Het
Ptprb C A 10: 116,177,353 (GRCm39) Q1018K probably benign Het
Rxfp3 C A 15: 11,036,011 (GRCm39) G454C probably damaging Het
Scn5a A G 9: 119,372,200 (GRCm39) V223A probably damaging Het
Sema4c C A 1: 36,589,774 (GRCm39) V527L probably benign Het
Slk C A 19: 47,627,417 (GRCm39) P1182T probably damaging Het
Stt3a A G 9: 36,659,235 (GRCm39) V368A probably benign Het
Trpm3 T C 19: 22,875,160 (GRCm39) F601L probably benign Het
Ttn T C 2: 76,540,299 (GRCm39) D34229G probably benign Het
Vmn2r107 A G 17: 20,595,271 (GRCm39) H608R possibly damaging Het
Vmn2r49 A T 7: 9,710,826 (GRCm39) C635* probably null Het
Zfp473 A T 7: 44,387,368 (GRCm39) F95Y probably benign Het
Zfp984 A C 4: 147,839,287 (GRCm39) S521R possibly damaging Het
Other mutations in Capn10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Capn10 APN 1 92,870,281 (GRCm39) missense probably benign 0.00
IGL01071:Capn10 APN 1 92,872,797 (GRCm39) missense probably damaging 1.00
IGL01682:Capn10 APN 1 92,868,106 (GRCm39) missense probably benign 0.16
IGL01771:Capn10 APN 1 92,868,087 (GRCm39) missense probably damaging 1.00
IGL02952:Capn10 APN 1 92,872,896 (GRCm39) missense probably damaging 0.97
IGL03177:Capn10 APN 1 92,862,704 (GRCm39) missense probably benign 0.02
IGL03224:Capn10 APN 1 92,867,046 (GRCm39) missense probably damaging 1.00
P4717OSA:Capn10 UTSW 1 92,867,116 (GRCm39) missense probably damaging 1.00
R1256:Capn10 UTSW 1 92,874,668 (GRCm39) missense probably damaging 1.00
R1405:Capn10 UTSW 1 92,872,744 (GRCm39) missense probably benign 0.34
R1405:Capn10 UTSW 1 92,872,744 (GRCm39) missense probably benign 0.34
R1653:Capn10 UTSW 1 92,874,620 (GRCm39) missense probably damaging 1.00
R1737:Capn10 UTSW 1 92,862,677 (GRCm39) missense probably benign 0.10
R2127:Capn10 UTSW 1 92,865,756 (GRCm39) nonsense probably null
R2433:Capn10 UTSW 1 92,870,247 (GRCm39) missense probably benign 0.22
R2484:Capn10 UTSW 1 92,872,565 (GRCm39) missense probably damaging 0.97
R4004:Capn10 UTSW 1 92,868,313 (GRCm39) missense probably damaging 0.98
R4005:Capn10 UTSW 1 92,868,313 (GRCm39) missense probably damaging 0.98
R4560:Capn10 UTSW 1 92,867,084 (GRCm39) missense probably damaging 1.00
R4684:Capn10 UTSW 1 92,871,503 (GRCm39) missense probably damaging 1.00
R4766:Capn10 UTSW 1 92,871,141 (GRCm39) missense probably damaging 0.98
R4996:Capn10 UTSW 1 92,872,858 (GRCm39) missense probably damaging 1.00
R5665:Capn10 UTSW 1 92,865,653 (GRCm39) splice site probably null
R5733:Capn10 UTSW 1 92,871,635 (GRCm39) missense probably benign 0.03
R5937:Capn10 UTSW 1 92,867,105 (GRCm39) missense probably damaging 1.00
R6985:Capn10 UTSW 1 92,871,146 (GRCm39) missense probably damaging 1.00
R7140:Capn10 UTSW 1 92,872,993 (GRCm39) missense possibly damaging 0.85
R8170:Capn10 UTSW 1 92,862,686 (GRCm39) missense probably damaging 0.98
R8393:Capn10 UTSW 1 92,871,130 (GRCm39) missense probably benign 0.09
R8943:Capn10 UTSW 1 92,871,454 (GRCm39) missense probably damaging 1.00
R9303:Capn10 UTSW 1 92,871,665 (GRCm39) critical splice donor site probably null
R9305:Capn10 UTSW 1 92,871,665 (GRCm39) critical splice donor site probably null
R9655:Capn10 UTSW 1 92,867,111 (GRCm39) missense probably damaging 1.00
R9776:Capn10 UTSW 1 92,871,586 (GRCm39) missense possibly damaging 0.67
Predicted Primers PCR Primer
(F):5'- AGTTTACAGTGCAGTGTATGGC -3'
(R):5'- AGACCAGTGGCAGTCAACTC -3'

Sequencing Primer
(F):5'- GCAAAAGTTTGAGGCTCTCC -3'
(R):5'- GGCAGTCAACTCACCCTCTG -3'
Posted On 2019-10-17