Mutagenetix > Incidental Mutation

Incidental Mutation 'R7496:Vmn1r61'

581070

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r61

Ensembl Gene

ENSMUSG00000094313

Gene Name

vomeronasal 1 receptor 61

Synonyms

Gm7186

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R7496 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

5610251-5612068 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 5610431 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 295 (S295P)

Ref Sequence

ENSEMBL: ENSMUSP00000128012 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164880]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000164880
AA Change: S295P

PolyPhen 2 Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000128012
Gene: ENSMUSG00000094313
AA Change: S295P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	294	5.3e-12	PFAM
Pfam:7tm_1	20	279	5e-9	PFAM
Pfam:V1R	31	299	9.5e-21	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (50/50)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg7	T	C	16: 56,732,857	I626V	probably benign	Het
Adgrv1	A	T	13: 81,440,225	V4414E	possibly damaging	Het
Ago1	C	T	4: 126,461,752	R88H	probably benign	Het
Ankrd6	C	T	4: 32,810,299	D461N	probably damaging	Het
Bcl2l14	A	G	6: 134,427,454	N202D	probably benign	Het
Bnip2	A	G	9: 70,003,404	I245V	probably damaging	Het
Cdhr3	T	C	12: 33,060,265	D340G	probably damaging	Het
Dchs1	T	C	7: 105,761,859	E1653G	probably damaging	Het
Dhdds	C	A	4: 133,971,254	Q256H	possibly damaging	Het
Dsc2	A	T	18: 20,035,394	C669*	probably null	Het
Dync2h1	T	C	9: 7,135,015		probably null	Het
Dysf	T	C	6: 84,067,478	S276P	probably benign	Het
Galc	A	T	12: 98,259,238	L31*	probably null	Het
Gm527	C	T	12: 64,922,410	R204C	possibly damaging	Het
Hivep3	G	A	4: 120,132,402	D2017N	probably benign	Het
Inf2	C	T	12: 112,600,318	R106C	probably damaging	Het
Itgb1	A	G	8: 128,720,305	K434E	probably benign	Het
Lamb1	A	C	12: 31,300,021	N700T	probably benign	Het
Macc1	T	G	12: 119,446,999	F501V	possibly damaging	Het
Man2a2	G	A	7: 80,352,997	H1079Y	probably damaging	Het
Nedd4l	G	A	18: 65,080,018	V82I	possibly damaging	Het
Nr2f1	T	C	13: 78,195,242	E301G	probably damaging	Het
Olfr1129	A	G	2: 87,575,371	R96G	probably damaging	Het
Olfr1246	T	C	2: 89,590,696	I140V	probably benign	Het
Olfr695	A	G	7: 106,714,228	L151P	probably benign	Het
Pdgfrb	G	A	18: 61,078,932	V844I	possibly damaging	Het
Pkd1l2	T	C	8: 117,060,594	E570G	possibly damaging	Het
R3hdm4	A	T	10: 79,916,874	L4Q	probably damaging	Het
Rb1cc1	A	G	1: 6,248,191	K639R	probably null	Het
Robo3	A	T	9: 37,427,825	C257S	probably damaging	Het
Rprd2	A	T	3: 95,765,775	L772Q	probably damaging	Het
Sall2	T	C	14: 52,315,561	D59G	possibly damaging	Het
Sall3	T	C	18: 80,973,364	T450A	probably benign	Het
Sdhd	T	C	9: 50,597,085	*160W	probably null	Het
Sgca	T	C	11: 94,971,244	E194G	possibly damaging	Het
Shtn1	G	A	19: 59,028,184	R228C	probably damaging	Het
Skor1	A	T	9: 63,146,850	S22T	probably benign	Het
Slc26a8	C	A	17: 28,644,850	G645V	probably benign	Het
Smtn	T	C	11: 3,529,988	E411G	probably damaging	Het
Sox17	A	G	1: 4,492,327	Y217H	probably damaging	Het
Syk	A	G	13: 52,612,416	Q179R	probably benign	Het
Tpp2	A	G	1: 43,983,517	I959M	probably benign	Het
Trim65	T	A	11: 116,126,316	N440I	probably damaging	Het
Ubr2	C	T	17: 46,990,991		probably null	Het
Ush2a	T	C	1: 188,351,087	S276P	possibly damaging	Het
Wdhd1	T	C	14: 47,274,024	Q77R	probably benign	Het
Xylb	T	A	9: 119,391,816	*552R	probably null	Het
Zfp932	C	T	5: 110,008,828	P131S	probably damaging	Het

Other mutations in Vmn1r61

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01700:Vmn1r61	APN	7	5611203	missense	possibly damaging	0.82
IGL02859:Vmn1r61	APN	7	5611289	missense	probably benign	0.37
IGL03344:Vmn1r61	APN	7	5610494	missense	possibly damaging	0.95
R0189:Vmn1r61	UTSW	7	5610700	missense	probably benign	0.03
R0336:Vmn1r61	UTSW	7	5611067	missense	probably benign
R0616:Vmn1r61	UTSW	7	5610999	missense	possibly damaging	0.65
R1490:Vmn1r61	UTSW	7	5611243	missense	probably benign	0.00
R1737:Vmn1r61	UTSW	7	5611061	missense	probably benign	0.01
R1755:Vmn1r61	UTSW	7	5611303	nonsense	probably null
R1795:Vmn1r61	UTSW	7	5611325	utr 5 prime	probably benign
R3929:Vmn1r61	UTSW	7	5611177	missense	probably benign	0.01
R4487:Vmn1r61	UTSW	7	5610925	missense	possibly damaging	0.76
R4629:Vmn1r61	UTSW	7	5611250	missense	probably benign	0.08
R4785:Vmn1r61	UTSW	7	5611125	nonsense	probably null
R4785:Vmn1r61	UTSW	7	5611127	missense	probably benign
R5108:Vmn1r61	UTSW	7	5610520	missense	probably benign
R5305:Vmn1r61	UTSW	7	5610815	missense	probably damaging	1.00
R5914:Vmn1r61	UTSW	7	5610530	missense	probably damaging	1.00
R6150:Vmn1r61	UTSW	7	5610679	missense	probably benign	0.00
R6232:Vmn1r61	UTSW	7	5610851	missense	probably damaging	1.00
R6722:Vmn1r61	UTSW	7	5610688	missense	possibly damaging	0.55
R7488:Vmn1r61	UTSW	7	5610768	missense	possibly damaging	0.56
R8353:Vmn1r61	UTSW	7	5610887	missense	probably benign	0.11
R8453:Vmn1r61	UTSW	7	5610887	missense	probably benign	0.11
R8847:Vmn1r61	UTSW	7	5610818	missense	probably damaging	1.00
R9549:Vmn1r61	UTSW	7	5611186	missense	probably damaging	1.00
R9559:Vmn1r61	UTSW	7	5610499	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCACTAGACTACATGGCTATCACAG -3'
(R):5'- ACACCATCCTGATGCTGGTG -3'

Sequencing Primer
(F):5'- CTACATGGCTATCACAGGGTGG -3'
(R):5'- CATCCTGATGCTGGTGGTCAC -3'

Posted On

2019-10-17