Incidental Mutation 'R7472:Ugcg'
ID 581272
Institutional Source Beutler Lab
Gene Symbol Ugcg
Ensembl Gene ENSMUSG00000028381
Gene Name UDP-glucose ceramide glucosyltransferase
Synonyms Epcs21, Ugcgl, GlcT-1
MMRRC Submission 045546-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7472 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 59189452-59222833 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59217156 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 227 (I227V)
Ref Sequence ENSEMBL: ENSMUSP00000030074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030074]
AlphaFold O88693
Predicted Effect probably benign
Transcript: ENSMUST00000030074
AA Change: I227V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000030074
Gene: ENSMUSG00000028381
AA Change: I227V

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Pfam:Glyco_tranf_2_3 51 278 1.3e-26 PFAM
Pfam:Glyco_transf_21 106 278 8.4e-61 PFAM
Pfam:Glyco_trans_2_3 139 368 9.6e-13 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 99% (99/100)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]
PHENOTYPE: At embryonic day 7.5, embryos homozygous for a null mutation exhibit decreased size, markedly reduced extraembryonic tissues and a large increase in cells undergoing apoptosis. Mutants die by embryonic day 8.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 99 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921504E06Rik A G 2: 19,545,219 (GRCm39) I78T probably benign Het
4921524J17Rik G A 8: 86,159,438 (GRCm39) probably benign Het
4932438H23Rik T C 16: 90,852,744 (GRCm39) T131A probably benign Het
Acbd6 G T 1: 155,463,213 (GRCm39) E138* probably null Het
Ago3 A G 4: 126,239,310 (GRCm39) V847A probably damaging Het
Akap13 G A 7: 75,380,213 (GRCm39) R462H probably damaging Het
Als2cl C A 9: 110,727,174 (GRCm39) H913Q probably benign Het
Atf6 A C 1: 170,643,060 (GRCm39) S360R possibly damaging Het
Atm G C 9: 53,359,425 (GRCm39) N2789K possibly damaging Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Bpifa6 A T 2: 153,831,249 (GRCm39) I272F possibly damaging Het
Cabin1 G T 10: 75,494,481 (GRCm39) P1633T probably damaging Het
Camsap2 A G 1: 136,209,131 (GRCm39) V119A probably damaging Het
Ccdc40 A G 11: 119,153,974 (GRCm39) E1082G probably benign Het
Cchcr1 C A 17: 35,839,248 (GRCm39) A479D probably damaging Het
Chpt1 C T 10: 88,312,230 (GRCm39) V349I probably benign Het
Cldn13 A T 5: 134,943,975 (GRCm39) I70K probably damaging Het
Col6a6 T A 9: 105,659,622 (GRCm39) D441V probably damaging Het
Cpne5 G T 17: 29,423,714 (GRCm39) T138K probably benign Het
Creb3l3 A T 10: 80,925,301 (GRCm39) probably null Het
Cst5 C T 2: 149,247,496 (GRCm39) L71F probably benign Het
Ctsb T C 14: 63,375,550 (GRCm39) V172A probably benign Het
Cyp19a1 A G 9: 54,074,277 (GRCm39) Y426H possibly damaging Het
Cyth4 T C 15: 78,490,094 (GRCm39) F72S probably damaging Het
D430041D05Rik G T 2: 104,240,484 (GRCm39) Q9K unknown Het
Dnah1 T A 14: 30,983,547 (GRCm39) I4099F probably damaging Het
Dnah1 T A 14: 31,022,748 (GRCm39) I1130F possibly damaging Het
Dnah12 A G 14: 26,578,592 (GRCm39) K3117R probably benign Het
Dpf3 A T 12: 83,319,159 (GRCm39) S275R probably benign Het
Dst A G 1: 34,257,578 (GRCm39) N2450S probably benign Het
Dync1h1 C T 12: 110,632,109 (GRCm39) R4460W probably damaging Het
Ecm1 A C 3: 95,642,632 (GRCm39) C414G possibly damaging Het
Eef2 G A 10: 81,015,384 (GRCm39) D302N probably benign Het
Egf T C 3: 129,479,912 (GRCm39) D1038G possibly damaging Het
Epm2aip1 T C 9: 111,101,467 (GRCm39) S147P probably damaging Het
Esam C A 9: 37,448,863 (GRCm39) P324T possibly damaging Het
Fbxo36 A G 1: 84,874,301 (GRCm39) D99G probably damaging Het
Fhad1 G A 4: 141,691,937 (GRCm39) R400C probably benign Het
Fhip2a A G 19: 57,357,017 (GRCm39) Y36C probably damaging Het
Fndc3b T C 3: 27,515,893 (GRCm39) T638A probably benign Het
Gba2 T C 4: 43,568,967 (GRCm39) T563A probably benign Het
Gm8180 T A 14: 44,021,094 (GRCm39) N38I possibly damaging Het
Hs3st4 A G 7: 123,996,249 (GRCm39) E305G probably damaging Het
Ireb2 T A 9: 54,791,338 (GRCm39) F191I probably benign Het
Irx3 T G 8: 92,526,625 (GRCm39) T360P probably benign Het
Itpr1 T A 6: 108,380,357 (GRCm39) I1375N probably benign Het
Klrh1 A T 6: 129,752,345 (GRCm39) F57I probably benign Het
Lama4 A T 10: 38,963,369 (GRCm39) I1314F possibly damaging Het
Lamb2 C A 9: 108,363,347 (GRCm39) A842D probably benign Het
Ldlrap1 A G 4: 134,486,307 (GRCm39) Y51H possibly damaging Het
Leo1 A G 9: 75,355,623 (GRCm39) D321G probably damaging Het
Lrrc14b A G 13: 74,511,226 (GRCm39) S285P probably damaging Het
Macf1 A G 4: 123,326,860 (GRCm39) V4881A probably benign Het
Mfsd2b A T 12: 4,916,481 (GRCm39) F333I probably damaging Het
Micall1 T C 15: 79,006,760 (GRCm39) S196P unknown Het
Mrps21 T C 3: 95,770,110 (GRCm39) N73S probably benign Het
Msantd5f5 G A 4: 73,542,736 (GRCm39) G79S probably damaging Het
Msln C T 17: 25,969,708 (GRCm39) V341M possibly damaging Het
Mybpc3 A T 2: 90,962,001 (GRCm39) M840L probably damaging Het
Myo7a A C 7: 97,714,000 (GRCm39) F1613V probably damaging Het
Naprt C T 15: 75,763,607 (GRCm39) probably null Het
Nbr1 T C 11: 101,462,765 (GRCm39) V572A probably damaging Het
Nfkbie A T 17: 45,870,233 (GRCm39) T193S probably damaging Het
Nlrp14 T G 7: 106,789,251 (GRCm39) N672K probably benign Het
Or11l3 A T 11: 58,516,260 (GRCm39) I204N probably damaging Het
Or4b1d A G 2: 89,968,668 (GRCm39) Y272H probably damaging Het
Or52ab2 A G 7: 102,969,656 (GRCm39) T13A Het
Or5b101 T C 19: 13,005,439 (GRCm39) T85A probably benign Het
Or6k14 A T 1: 173,927,299 (GRCm39) I92F probably damaging Het
Or8b49 A T 9: 38,506,200 (GRCm39) I228L probably benign Het
Oscar T C 7: 3,614,149 (GRCm39) T197A possibly damaging Het
P3h3 C A 6: 124,827,594 (GRCm39) A481S possibly damaging Het
Pcdh8 T C 14: 80,008,691 (GRCm39) probably null Het
Pcsk9 A T 4: 106,316,094 (GRCm39) H116Q probably benign Het
Ptcd1 A G 5: 145,091,540 (GRCm39) F520L possibly damaging Het
Rapgef2 T C 3: 78,976,580 (GRCm39) T1261A probably benign Het
Ribc2 T A 15: 85,019,446 (GRCm39) M76K probably benign Het
Sin3b A G 8: 73,479,853 (GRCm39) E853G probably damaging Het
Slit2 A G 5: 48,414,180 (GRCm39) D940G probably damaging Het
Smarcb1 T A 10: 75,733,373 (GRCm39) N342Y probably damaging Het
Smurf2 A T 11: 106,726,921 (GRCm39) I469N probably damaging Het
Spata31h1 T C 10: 82,119,421 (GRCm39) I4530V probably benign Het
Spta1 T C 1: 174,074,065 (GRCm39) Y2335H probably damaging Het
Suz12 C T 11: 79,915,801 (GRCm39) R425C probably benign Het
Synpo G A 18: 60,762,895 (GRCm39) A4V probably benign Het
Tet1 A C 10: 62,649,129 (GRCm39) S157A possibly damaging Het
Themis A G 10: 28,637,415 (GRCm39) E173G possibly damaging Het
Timmdc1 A T 16: 38,325,780 (GRCm39) L197* probably null Het
Tmem63c T C 12: 87,115,932 (GRCm39) F191S possibly damaging Het
Tnn G A 1: 159,937,917 (GRCm39) T1200I probably benign Het
Traf6 A G 2: 101,527,537 (GRCm39) H429R probably benign Het
Trem3 T C 17: 48,556,873 (GRCm39) S115P probably benign Het
Trip11 A T 12: 101,851,639 (GRCm39) N808K probably benign Het
Trub2 A T 2: 29,673,385 (GRCm39) V106E probably damaging Het
Vat1l G A 8: 114,963,539 (GRCm39) probably null Het
Vmn1r184 T C 7: 25,966,824 (GRCm39) M190T possibly damaging Het
Vmn2r3 T C 3: 64,182,953 (GRCm39) T249A probably benign Het
Zfp729b A C 13: 67,742,002 (GRCm39) S88A probably benign Het
Zfp995 T C 17: 22,099,181 (GRCm39) Y351C probably damaging Het
Other mutations in Ugcg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Ugcg APN 4 59,213,865 (GRCm39) missense possibly damaging 0.94
IGL01768:Ugcg APN 4 59,217,216 (GRCm39) critical splice donor site probably null
IGL02636:Ugcg APN 4 59,207,763 (GRCm39) missense possibly damaging 0.73
IGL02672:Ugcg APN 4 59,218,587 (GRCm39) splice site probably benign
IGL02798:Ugcg APN 4 59,220,346 (GRCm39) missense probably damaging 1.00
congee UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
cream_o_wheat UTSW 4 59,220,387 (GRCm39) missense possibly damaging 0.91
gruel UTSW 4 59,189,690 (GRCm39) missense probably benign
Porridge UTSW 4 59,219,530 (GRCm39) missense possibly damaging 0.86
slop UTSW 4 59,211,883 (GRCm39) missense probably benign 0.16
wheatina UTSW 4 59,220,272 (GRCm39) missense probably damaging 0.96
PIT4382001:Ugcg UTSW 4 59,213,246 (GRCm39) missense possibly damaging 0.68
R0013:Ugcg UTSW 4 59,213,931 (GRCm39) missense possibly damaging 0.82
R0013:Ugcg UTSW 4 59,213,931 (GRCm39) missense possibly damaging 0.82
R0068:Ugcg UTSW 4 59,217,130 (GRCm39) missense probably benign 0.16
R0068:Ugcg UTSW 4 59,217,130 (GRCm39) missense probably benign 0.16
R0119:Ugcg UTSW 4 59,217,036 (GRCm39) missense possibly damaging 0.85
R0230:Ugcg UTSW 4 59,189,739 (GRCm39) nonsense probably null
R0299:Ugcg UTSW 4 59,217,036 (GRCm39) missense possibly damaging 0.85
R0384:Ugcg UTSW 4 59,220,387 (GRCm39) missense possibly damaging 0.91
R0499:Ugcg UTSW 4 59,217,036 (GRCm39) missense possibly damaging 0.85
R0645:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0688:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0726:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0802:Ugcg UTSW 4 59,189,685 (GRCm39) missense probably benign 0.00
R0803:Ugcg UTSW 4 59,189,685 (GRCm39) missense probably benign 0.00
R0811:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0812:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0828:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0831:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0944:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0945:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R0947:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1104:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1209:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1210:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1252:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1253:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1255:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1488:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1490:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1548:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1698:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1771:Ugcg UTSW 4 59,207,775 (GRCm39) missense probably benign 0.05
R1776:Ugcg UTSW 4 59,207,775 (GRCm39) missense probably benign 0.05
R1781:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1794:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R1840:Ugcg UTSW 4 59,219,517 (GRCm39) missense probably damaging 1.00
R1942:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2228:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2229:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2237:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2239:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2314:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2337:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2338:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2340:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2422:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2426:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R2433:Ugcg UTSW 4 59,207,876 (GRCm39) missense possibly damaging 0.89
R2680:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3076:Ugcg UTSW 4 59,213,922 (GRCm39) missense probably damaging 1.00
R3078:Ugcg UTSW 4 59,213,922 (GRCm39) missense probably damaging 1.00
R3689:Ugcg UTSW 4 59,211,883 (GRCm39) missense probably benign 0.16
R3732:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3732:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3733:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3766:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3767:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3768:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3769:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3771:Ugcg UTSW 4 59,189,690 (GRCm39) missense probably benign
R3847:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3848:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3916:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3917:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3958:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R3959:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R4023:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R4024:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R4025:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R4065:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R4066:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
R4427:Ugcg UTSW 4 59,219,555 (GRCm39) missense probably benign 0.02
R5842:Ugcg UTSW 4 59,219,545 (GRCm39) missense possibly damaging 0.93
R6012:Ugcg UTSW 4 59,220,272 (GRCm39) missense probably damaging 0.96
R6080:Ugcg UTSW 4 59,218,524 (GRCm39) missense possibly damaging 0.70
R6762:Ugcg UTSW 4 59,219,530 (GRCm39) missense possibly damaging 0.86
R7194:Ugcg UTSW 4 59,213,210 (GRCm39) missense probably damaging 0.99
R7286:Ugcg UTSW 4 59,217,111 (GRCm39) missense possibly damaging 0.95
R7362:Ugcg UTSW 4 59,217,109 (GRCm39) missense probably damaging 1.00
R7638:Ugcg UTSW 4 59,220,299 (GRCm39) missense probably benign 0.26
R7866:Ugcg UTSW 4 59,211,927 (GRCm39) missense possibly damaging 0.71
R8170:Ugcg UTSW 4 59,211,974 (GRCm39) missense possibly damaging 0.71
R8488:Ugcg UTSW 4 59,213,896 (GRCm39) missense probably benign 0.00
R8793:Ugcg UTSW 4 59,207,794 (GRCm39) missense probably benign 0.22
R9441:Ugcg UTSW 4 59,207,843 (GRCm39) missense probably damaging 1.00
Y4336:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
Y4337:Ugcg UTSW 4 59,207,798 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- TTTAGGGAAAGTTGGCAGGC -3'
(R):5'- ATATTGAATGCGAATGCTCTGC -3'

Sequencing Primer
(F):5'- GGCAGGCCTCATAGTTTTAACAC -3'
(R):5'- TGCGAATGCTCTGCCAAAATTAC -3'
Posted On 2019-10-17