Incidental Mutation 'R7472:Trip11'
| ID |
581323 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
045546-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7472 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 101851639 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 808
(N808K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021605
AA Change: N808K
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: N808K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177183
AA Change: N523K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: N523K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921504E06Rik |
A |
G |
2: 19,545,219 (GRCm39) |
I78T |
probably benign |
Het |
| 4921524J17Rik |
G |
A |
8: 86,159,438 (GRCm39) |
|
probably benign |
Het |
| 4932438H23Rik |
T |
C |
16: 90,852,744 (GRCm39) |
T131A |
probably benign |
Het |
| Acbd6 |
G |
T |
1: 155,463,213 (GRCm39) |
E138* |
probably null |
Het |
| Ago3 |
A |
G |
4: 126,239,310 (GRCm39) |
V847A |
probably damaging |
Het |
| Akap13 |
G |
A |
7: 75,380,213 (GRCm39) |
R462H |
probably damaging |
Het |
| Als2cl |
C |
A |
9: 110,727,174 (GRCm39) |
H913Q |
probably benign |
Het |
| Atf6 |
A |
C |
1: 170,643,060 (GRCm39) |
S360R |
possibly damaging |
Het |
| Atm |
G |
C |
9: 53,359,425 (GRCm39) |
N2789K |
possibly damaging |
Het |
| Bhlhe40 |
TG |
TGG |
6: 108,641,818 (GRCm39) |
254 |
probably null |
Het |
| Bpifa6 |
A |
T |
2: 153,831,249 (GRCm39) |
I272F |
possibly damaging |
Het |
| Cabin1 |
G |
T |
10: 75,494,481 (GRCm39) |
P1633T |
probably damaging |
Het |
| Camsap2 |
A |
G |
1: 136,209,131 (GRCm39) |
V119A |
probably damaging |
Het |
| Ccdc40 |
A |
G |
11: 119,153,974 (GRCm39) |
E1082G |
probably benign |
Het |
| Cchcr1 |
C |
A |
17: 35,839,248 (GRCm39) |
A479D |
probably damaging |
Het |
| Chpt1 |
C |
T |
10: 88,312,230 (GRCm39) |
V349I |
probably benign |
Het |
| Cldn13 |
A |
T |
5: 134,943,975 (GRCm39) |
I70K |
probably damaging |
Het |
| Col6a6 |
T |
A |
9: 105,659,622 (GRCm39) |
D441V |
probably damaging |
Het |
| Cpne5 |
G |
T |
17: 29,423,714 (GRCm39) |
T138K |
probably benign |
Het |
| Creb3l3 |
A |
T |
10: 80,925,301 (GRCm39) |
|
probably null |
Het |
| Cst5 |
C |
T |
2: 149,247,496 (GRCm39) |
L71F |
probably benign |
Het |
| Ctsb |
T |
C |
14: 63,375,550 (GRCm39) |
V172A |
probably benign |
Het |
| Cyp19a1 |
A |
G |
9: 54,074,277 (GRCm39) |
Y426H |
possibly damaging |
Het |
| Cyth4 |
T |
C |
15: 78,490,094 (GRCm39) |
F72S |
probably damaging |
Het |
| D430041D05Rik |
G |
T |
2: 104,240,484 (GRCm39) |
Q9K |
unknown |
Het |
| Dnah1 |
T |
A |
14: 30,983,547 (GRCm39) |
I4099F |
probably damaging |
Het |
| Dnah1 |
T |
A |
14: 31,022,748 (GRCm39) |
I1130F |
possibly damaging |
Het |
| Dnah12 |
A |
G |
14: 26,578,592 (GRCm39) |
K3117R |
probably benign |
Het |
| Dpf3 |
A |
T |
12: 83,319,159 (GRCm39) |
S275R |
probably benign |
Het |
| Dst |
A |
G |
1: 34,257,578 (GRCm39) |
N2450S |
probably benign |
Het |
| Dync1h1 |
C |
T |
12: 110,632,109 (GRCm39) |
R4460W |
probably damaging |
Het |
| Ecm1 |
A |
C |
3: 95,642,632 (GRCm39) |
C414G |
possibly damaging |
Het |
| Eef2 |
G |
A |
10: 81,015,384 (GRCm39) |
D302N |
probably benign |
Het |
| Egf |
T |
C |
3: 129,479,912 (GRCm39) |
D1038G |
possibly damaging |
Het |
| Epm2aip1 |
T |
C |
9: 111,101,467 (GRCm39) |
S147P |
probably damaging |
Het |
| Esam |
C |
A |
9: 37,448,863 (GRCm39) |
P324T |
possibly damaging |
Het |
| Fbxo36 |
A |
G |
1: 84,874,301 (GRCm39) |
D99G |
probably damaging |
Het |
| Fhad1 |
G |
A |
4: 141,691,937 (GRCm39) |
R400C |
probably benign |
Het |
| Fhip2a |
A |
G |
19: 57,357,017 (GRCm39) |
Y36C |
probably damaging |
Het |
| Fndc3b |
T |
C |
3: 27,515,893 (GRCm39) |
T638A |
probably benign |
Het |
| Gba2 |
T |
C |
4: 43,568,967 (GRCm39) |
T563A |
probably benign |
Het |
| Gm8180 |
T |
A |
14: 44,021,094 (GRCm39) |
N38I |
possibly damaging |
Het |
| Hs3st4 |
A |
G |
7: 123,996,249 (GRCm39) |
E305G |
probably damaging |
Het |
| Ireb2 |
T |
A |
9: 54,791,338 (GRCm39) |
F191I |
probably benign |
Het |
| Irx3 |
T |
G |
8: 92,526,625 (GRCm39) |
T360P |
probably benign |
Het |
| Itpr1 |
T |
A |
6: 108,380,357 (GRCm39) |
I1375N |
probably benign |
Het |
| Klrh1 |
A |
T |
6: 129,752,345 (GRCm39) |
F57I |
probably benign |
Het |
| Lama4 |
A |
T |
10: 38,963,369 (GRCm39) |
I1314F |
possibly damaging |
Het |
| Lamb2 |
C |
A |
9: 108,363,347 (GRCm39) |
A842D |
probably benign |
Het |
| Ldlrap1 |
A |
G |
4: 134,486,307 (GRCm39) |
Y51H |
possibly damaging |
Het |
| Leo1 |
A |
G |
9: 75,355,623 (GRCm39) |
D321G |
probably damaging |
Het |
| Lrrc14b |
A |
G |
13: 74,511,226 (GRCm39) |
S285P |
probably damaging |
Het |
| Macf1 |
A |
G |
4: 123,326,860 (GRCm39) |
V4881A |
probably benign |
Het |
| Mfsd2b |
A |
T |
12: 4,916,481 (GRCm39) |
F333I |
probably damaging |
Het |
| Micall1 |
T |
C |
15: 79,006,760 (GRCm39) |
S196P |
unknown |
Het |
| Mrps21 |
T |
C |
3: 95,770,110 (GRCm39) |
N73S |
probably benign |
Het |
| Msantd5f5 |
G |
A |
4: 73,542,736 (GRCm39) |
G79S |
probably damaging |
Het |
| Msln |
C |
T |
17: 25,969,708 (GRCm39) |
V341M |
possibly damaging |
Het |
| Mybpc3 |
A |
T |
2: 90,962,001 (GRCm39) |
M840L |
probably damaging |
Het |
| Myo7a |
A |
C |
7: 97,714,000 (GRCm39) |
F1613V |
probably damaging |
Het |
| Naprt |
C |
T |
15: 75,763,607 (GRCm39) |
|
probably null |
Het |
| Nbr1 |
T |
C |
11: 101,462,765 (GRCm39) |
V572A |
probably damaging |
Het |
| Nfkbie |
A |
T |
17: 45,870,233 (GRCm39) |
T193S |
probably damaging |
Het |
| Nlrp14 |
T |
G |
7: 106,789,251 (GRCm39) |
N672K |
probably benign |
Het |
| Or11l3 |
A |
T |
11: 58,516,260 (GRCm39) |
I204N |
probably damaging |
Het |
| Or4b1d |
A |
G |
2: 89,968,668 (GRCm39) |
Y272H |
probably damaging |
Het |
| Or52ab2 |
A |
G |
7: 102,969,656 (GRCm39) |
T13A |
|
Het |
| Or5b101 |
T |
C |
19: 13,005,439 (GRCm39) |
T85A |
probably benign |
Het |
| Or6k14 |
A |
T |
1: 173,927,299 (GRCm39) |
I92F |
probably damaging |
Het |
| Or8b49 |
A |
T |
9: 38,506,200 (GRCm39) |
I228L |
probably benign |
Het |
| Oscar |
T |
C |
7: 3,614,149 (GRCm39) |
T197A |
possibly damaging |
Het |
| P3h3 |
C |
A |
6: 124,827,594 (GRCm39) |
A481S |
possibly damaging |
Het |
| Pcdh8 |
T |
C |
14: 80,008,691 (GRCm39) |
|
probably null |
Het |
| Pcsk9 |
A |
T |
4: 106,316,094 (GRCm39) |
H116Q |
probably benign |
Het |
| Ptcd1 |
A |
G |
5: 145,091,540 (GRCm39) |
F520L |
possibly damaging |
Het |
| Rapgef2 |
T |
C |
3: 78,976,580 (GRCm39) |
T1261A |
probably benign |
Het |
| Ribc2 |
T |
A |
15: 85,019,446 (GRCm39) |
M76K |
probably benign |
Het |
| Sin3b |
A |
G |
8: 73,479,853 (GRCm39) |
E853G |
probably damaging |
Het |
| Slit2 |
A |
G |
5: 48,414,180 (GRCm39) |
D940G |
probably damaging |
Het |
| Smarcb1 |
T |
A |
10: 75,733,373 (GRCm39) |
N342Y |
probably damaging |
Het |
| Smurf2 |
A |
T |
11: 106,726,921 (GRCm39) |
I469N |
probably damaging |
Het |
| Spata31h1 |
T |
C |
10: 82,119,421 (GRCm39) |
I4530V |
probably benign |
Het |
| Spta1 |
T |
C |
1: 174,074,065 (GRCm39) |
Y2335H |
probably damaging |
Het |
| Suz12 |
C |
T |
11: 79,915,801 (GRCm39) |
R425C |
probably benign |
Het |
| Synpo |
G |
A |
18: 60,762,895 (GRCm39) |
A4V |
probably benign |
Het |
| Tet1 |
A |
C |
10: 62,649,129 (GRCm39) |
S157A |
possibly damaging |
Het |
| Themis |
A |
G |
10: 28,637,415 (GRCm39) |
E173G |
possibly damaging |
Het |
| Timmdc1 |
A |
T |
16: 38,325,780 (GRCm39) |
L197* |
probably null |
Het |
| Tmem63c |
T |
C |
12: 87,115,932 (GRCm39) |
F191S |
possibly damaging |
Het |
| Tnn |
G |
A |
1: 159,937,917 (GRCm39) |
T1200I |
probably benign |
Het |
| Traf6 |
A |
G |
2: 101,527,537 (GRCm39) |
H429R |
probably benign |
Het |
| Trem3 |
T |
C |
17: 48,556,873 (GRCm39) |
S115P |
probably benign |
Het |
| Trub2 |
A |
T |
2: 29,673,385 (GRCm39) |
V106E |
probably damaging |
Het |
| Ugcg |
A |
G |
4: 59,217,156 (GRCm39) |
I227V |
probably benign |
Het |
| Vat1l |
G |
A |
8: 114,963,539 (GRCm39) |
|
probably null |
Het |
| Vmn1r184 |
T |
C |
7: 25,966,824 (GRCm39) |
M190T |
possibly damaging |
Het |
| Vmn2r3 |
T |
C |
3: 64,182,953 (GRCm39) |
T249A |
probably benign |
Het |
| Zfp729b |
A |
C |
13: 67,742,002 (GRCm39) |
S88A |
probably benign |
Het |
| Zfp995 |
T |
C |
17: 22,099,181 (GRCm39) |
Y351C |
probably damaging |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCAGCTCCTCTTGCAAGTGATTG -3'
(R):5'- CGGAAGTACGAGCAAACTGTC -3'
Sequencing Primer
(F):5'- GTTCTCTTCTTTCATGGATCCAAGAC -3'
(R):5'- GTACGAGCAAACTGTCCAGGAAC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation