|Institutional Source||Beutler Lab|
|Gene Name||cAMP responsive element binding protein 3-like 2|
|Is this an essential gene?||Possibly essential (E-score: 0.526)|
|Stock #||R0634 (G1)|
|Chromosomal Location||37327255-37442146 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 37334348 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000040208 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041093]|
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||98% (62/63)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severe chondrodysplasia and die shortly after first birth from suffocation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Creb3l2||
(F):5'- ATACTGACTGAGGCGGCTCACATC -3'
(R):5'- ATCTATGAGGAACACGCTCCCCTG -3'
(F):5'- TTGGGATCATCACTGCCAGC -3'
(R):5'- AAGAGTCGTCGAGCCCAG -3'