Incidental Mutation 'R7501:Vmn2r83'
ID 581487
Institutional Source Beutler Lab
Gene Symbol Vmn2r83
Ensembl Gene ENSMUSG00000091381
Gene Name vomeronasal 2, receptor 83
Synonyms EG625029
MMRRC Submission 045574-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.141) question?
Stock # R7501 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 79304792-79327988 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 79327771 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 793 (C793Y)
Ref Sequence ENSEMBL: ENSMUSP00000131426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167976]
AlphaFold E9Q0G7
Predicted Effect probably damaging
Transcript: ENSMUST00000167976
AA Change: C793Y

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131426
Gene: ENSMUSG00000091381
AA Change: C793Y

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 79 473 1.5e-33 PFAM
Pfam:NCD3G 516 569 6.2e-22 PFAM
Pfam:7tm_3 602 837 8.1e-52 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad9 A G 3: 36,142,974 (GRCm39) N503S probably benign Het
Adam1a C T 5: 121,657,011 (GRCm39) A761T possibly damaging Het
Amn1 C T 6: 149,086,529 (GRCm39) M44I probably benign Het
Ankrd44 T C 1: 54,688,522 (GRCm39) E238G Het
Ap3b2 A T 7: 81,123,194 (GRCm39) I440K probably damaging Het
Atp2a1 G A 7: 126,049,344 (GRCm39) T566I probably benign Het
B3galnt1 T C 3: 69,482,632 (GRCm39) I210V probably benign Het
Bag5 T C 12: 111,676,722 (GRCm39) K367R probably benign Het
Cdc25b T C 2: 131,036,080 (GRCm39) Y410H probably damaging Het
Cgref1 G T 5: 31,102,800 (GRCm39) P7Q probably damaging Het
Cnot6 T C 11: 49,576,159 (GRCm39) I136V probably benign Het
Comp A G 8: 70,832,059 (GRCm39) D500G possibly damaging Het
Dnah7b T C 1: 46,395,714 (GRCm39) L3872P probably damaging Het
Dync2h1 A T 9: 7,175,336 (GRCm39) L91Q possibly damaging Het
Fancd2 T C 6: 113,525,364 (GRCm39) V280A possibly damaging Het
Fat4 T A 3: 39,012,597 (GRCm39) Y2297* probably null Het
Fem1c A T 18: 46,638,868 (GRCm39) M378K probably damaging Het
Gata6 A G 18: 11,054,082 (GRCm39) T4A probably damaging Het
Gatb G C 3: 85,544,297 (GRCm39) V422L probably damaging Het
Gfpt1 T A 6: 87,059,508 (GRCm39) D510E probably benign Het
Gria4 A T 9: 4,502,436 (GRCm39) Y366N probably benign Het
Gucy1b1 T C 3: 81,942,666 (GRCm39) H492R probably damaging Het
H2bc6 A G 13: 23,769,776 (GRCm39) I55T possibly damaging Het
Hecw2 T C 1: 53,953,031 (GRCm39) probably null Het
Hnrnph1 A C 11: 50,270,383 (GRCm39) E62D probably benign Het
Itga2 A G 13: 115,012,095 (GRCm39) V274A probably damaging Het
Kdm5d T A Y: 941,488 (GRCm39) W1230R probably damaging Het
Lctl A T 9: 64,038,861 (GRCm39) M317L probably benign Het
Lrp6 T C 6: 134,463,471 (GRCm39) D570G probably damaging Het
Lrrc9 G T 12: 72,496,490 (GRCm39) M39I probably damaging Het
Ltbp2 A T 12: 84,877,419 (GRCm39) I402N probably damaging Het
Mst1 G A 9: 107,959,748 (GRCm39) G297D probably damaging Het
Muc6 G C 7: 141,217,659 (GRCm39) P2338R probably damaging Het
Nbr1 G A 11: 101,457,026 (GRCm39) R163Q probably damaging Het
Nlrp4f A G 13: 65,342,143 (GRCm39) F501L probably damaging Het
Nup133 A C 8: 124,649,153 (GRCm39) I563S probably benign Het
Oacyl T G 18: 65,858,369 (GRCm39) probably null Het
Oog4 CAA CA 4: 143,164,022 (GRCm39) probably null Het
Plxna2 C T 1: 194,326,203 (GRCm39) R46C possibly damaging Het
Ppp1r26 T A 2: 28,340,749 (GRCm39) D126E probably damaging Het
Prl6a1 A T 13: 27,500,282 (GRCm39) R84S possibly damaging Het
Ptprz1 C T 6: 23,001,746 (GRCm39) Q1279* probably null Het
Ptx4 C T 17: 25,344,166 (GRCm39) T472I possibly damaging Het
Rabgap1l A G 1: 160,528,358 (GRCm39) V416A probably damaging Het
Rbfox2 A T 15: 76,989,834 (GRCm39) D231E probably benign Het
Reln A T 5: 22,432,636 (GRCm39) F121L possibly damaging Het
Rfx7 G A 9: 72,524,054 (GRCm39) V415I probably benign Het
Scaf4 A T 16: 90,026,964 (GRCm39) M951K unknown Het
Sdf4 T C 4: 156,080,977 (GRCm39) probably null Het
Sec16a T C 2: 26,331,863 (GRCm39) T51A probably damaging Het
Sema3a A G 5: 13,607,008 (GRCm39) N281S probably damaging Het
Snai2 G A 16: 14,524,754 (GRCm39) V87I possibly damaging Het
Spata31f1e T C 4: 42,791,357 (GRCm39) E925G probably damaging Het
Synj2 T A 17: 6,040,514 (GRCm39) S197T possibly damaging Het
Syt6 A T 3: 103,495,018 (GRCm39) M328L probably benign Het
Tdrd12 A G 7: 35,177,516 (GRCm39) V946A unknown Het
Trat1 A T 16: 48,574,657 (GRCm39) probably null Het
Vmn1r75 T A 7: 11,614,997 (GRCm39) I243K possibly damaging Het
Wnt9a G A 11: 59,219,583 (GRCm39) G203D probably damaging Het
Xrn2 T C 2: 146,871,676 (GRCm39) I366T probably damaging Het
Zfp280d A G 9: 72,269,224 (GRCm39) D787G possibly damaging Het
Zfp706 T C 15: 37,002,169 (GRCm39) T53A probably damaging Het
Other mutations in Vmn2r83
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Vmn2r83 APN 10 79,314,805 (GRCm39) missense probably damaging 1.00
IGL01096:Vmn2r83 APN 10 79,313,662 (GRCm39) missense probably damaging 1.00
IGL01542:Vmn2r83 APN 10 79,314,846 (GRCm39) missense probably benign 0.30
IGL01803:Vmn2r83 APN 10 79,304,894 (GRCm39) missense probably benign 0.01
IGL02110:Vmn2r83 APN 10 79,327,534 (GRCm39) missense possibly damaging 0.82
IGL02347:Vmn2r83 APN 10 79,316,067 (GRCm39) missense possibly damaging 0.75
IGL02417:Vmn2r83 APN 10 79,314,881 (GRCm39) missense probably benign 0.00
IGL02544:Vmn2r83 APN 10 79,317,293 (GRCm39) splice site probably benign
IGL02683:Vmn2r83 APN 10 79,327,115 (GRCm39) missense probably benign
IGL02976:Vmn2r83 APN 10 79,304,832 (GRCm39) missense probably benign 0.00
PIT4378001:Vmn2r83 UTSW 10 79,304,849 (GRCm39) missense probably benign 0.00
PIT4468001:Vmn2r83 UTSW 10 79,313,884 (GRCm39) missense probably damaging 1.00
R0092:Vmn2r83 UTSW 10 79,327,798 (GRCm39) missense probably damaging 1.00
R1391:Vmn2r83 UTSW 10 79,314,931 (GRCm39) missense probably damaging 0.96
R1539:Vmn2r83 UTSW 10 79,327,759 (GRCm39) missense probably damaging 1.00
R1575:Vmn2r83 UTSW 10 79,314,956 (GRCm39) missense probably damaging 0.98
R2033:Vmn2r83 UTSW 10 79,327,653 (GRCm39) missense probably benign 0.03
R3916:Vmn2r83 UTSW 10 79,314,744 (GRCm39) missense probably benign 0.01
R3967:Vmn2r83 UTSW 10 79,327,154 (GRCm39) missense probably benign 0.00
R4840:Vmn2r83 UTSW 10 79,313,682 (GRCm39) missense possibly damaging 0.73
R5063:Vmn2r83 UTSW 10 79,314,921 (GRCm39) missense probably benign 0.04
R5630:Vmn2r83 UTSW 10 79,327,785 (GRCm39) missense possibly damaging 0.94
R5707:Vmn2r83 UTSW 10 79,327,183 (GRCm39) missense possibly damaging 0.53
R5980:Vmn2r83 UTSW 10 79,314,626 (GRCm39) missense probably benign 0.04
R6294:Vmn2r83 UTSW 10 79,313,688 (GRCm39) missense probably damaging 0.99
R6302:Vmn2r83 UTSW 10 79,304,837 (GRCm39) missense possibly damaging 0.95
R6769:Vmn2r83 UTSW 10 79,313,856 (GRCm39) missense probably damaging 1.00
R6986:Vmn2r83 UTSW 10 79,316,093 (GRCm39) missense probably benign
R7221:Vmn2r83 UTSW 10 79,316,001 (GRCm39) missense probably benign 0.02
R7376:Vmn2r83 UTSW 10 79,314,790 (GRCm39) missense probably benign 0.00
R7431:Vmn2r83 UTSW 10 79,327,306 (GRCm39) missense probably damaging 0.99
R7526:Vmn2r83 UTSW 10 79,327,392 (GRCm39) missense probably damaging 1.00
R7663:Vmn2r83 UTSW 10 79,314,956 (GRCm39) missense probably damaging 0.98
R7881:Vmn2r83 UTSW 10 79,314,261 (GRCm39) missense probably benign 0.01
R7939:Vmn2r83 UTSW 10 79,314,651 (GRCm39) missense probably damaging 1.00
R8314:Vmn2r83 UTSW 10 79,317,313 (GRCm39) missense possibly damaging 0.76
R8364:Vmn2r83 UTSW 10 79,316,037 (GRCm39) missense probably benign 0.12
R8802:Vmn2r83 UTSW 10 79,314,261 (GRCm39) missense probably benign 0.01
R8947:Vmn2r83 UTSW 10 79,304,873 (GRCm39) missense probably benign 0.00
R8969:Vmn2r83 UTSW 10 79,313,853 (GRCm39) missense probably benign 0.15
R8983:Vmn2r83 UTSW 10 79,327,360 (GRCm39) missense probably damaging 1.00
R9018:Vmn2r83 UTSW 10 79,316,020 (GRCm39) missense probably damaging 1.00
R9082:Vmn2r83 UTSW 10 79,304,894 (GRCm39) missense probably benign 0.00
R9390:Vmn2r83 UTSW 10 79,317,322 (GRCm39) nonsense probably null
X0026:Vmn2r83 UTSW 10 79,314,486 (GRCm39) missense probably benign
X0026:Vmn2r83 UTSW 10 79,304,849 (GRCm39) missense probably benign 0.00
Z1176:Vmn2r83 UTSW 10 79,314,756 (GRCm39) missense possibly damaging 0.74
Predicted Primers PCR Primer
(F):5'- TCTGGAATATGGCTGGGAACG -3'
(R):5'- AATGTGATGGACTGTGTTCCTC -3'

Sequencing Primer
(F):5'- GGATGCTCACTCTGAATATGGACAC -3'
(R):5'- TCCTCTCTGGCCTAAACAAAATAATG -3'
Posted On 2019-10-17