Incidental Mutation 'R7502:Jmjd1c'
| ID |
581566 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Jmjd1c
|
| Ensembl Gene |
ENSMUSG00000037876 |
| Gene Name |
jumonji domain containing 1C |
| Synonyms |
D630035I23Rik, TRIP8, 5430433L24Rik |
| MMRRC Submission |
045575-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.662)
|
| Stock # |
R7502 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
66932189-67092105 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 67067794 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Alanine
at position 1585
(S1585A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133700
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051446]
[ENSMUST00000173689]
[ENSMUST00000174408]
|
| AlphaFold |
Q69ZK6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000051446
AA Change: S1765A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000056227
Gene: ENSMUSG00000037876
AA Change: S1765A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2236 |
N/A |
BLAST |
|
JmjC
|
2264 |
2488 |
3.29e-53 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173689
AA Change: S1585A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000133700
Gene: ENSMUSG00000037876
AA Change: S1585A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
1 |
2056 |
N/A |
BLAST |
|
JmjC
|
2084 |
2308 |
3.29e-53 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000174408
AA Change: S1766A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000134551
Gene: ENSMUSG00000037876
AA Change: S1766A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:JmjC
|
143 |
2237 |
N/A |
BLAST |
|
JmjC
|
2265 |
2489 |
3.29e-53 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit an age-dependent male infertility phenotype, characterized by early loss of undifferentiated spermatogonia, and a progressive reduction in testis size/weight and male germ cells, partly due to increased male germ cell apoptosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acan |
A |
G |
7: 78,743,951 (GRCm39) |
T661A |
probably damaging |
Het |
| Actrt2 |
T |
C |
4: 154,751,383 (GRCm39) |
Y251C |
probably benign |
Het |
| Adat3 |
T |
A |
10: 80,442,255 (GRCm39) |
V31D |
probably damaging |
Het |
| Adgrf4 |
T |
C |
17: 42,980,548 (GRCm39) |
H179R |
possibly damaging |
Het |
| Ahcyl1 |
A |
T |
3: 107,578,513 (GRCm39) |
Y241* |
probably null |
Het |
| Anks1 |
C |
A |
17: 28,227,114 (GRCm39) |
T589K |
possibly damaging |
Het |
| Arhgap15 |
A |
G |
2: 43,670,630 (GRCm39) |
T5A |
probably benign |
Het |
| Cacna1e |
A |
T |
1: 154,344,734 (GRCm39) |
M1130K |
probably null |
Het |
| Ccdc121rt1 |
G |
A |
1: 181,338,443 (GRCm39) |
Q170* |
probably null |
Het |
| Ceacam18 |
A |
T |
7: 43,286,298 (GRCm39) |
D57V |
probably damaging |
Het |
| Celf1 |
C |
T |
2: 90,835,100 (GRCm39) |
Q194* |
probably null |
Het |
| Celsr2 |
T |
A |
3: 108,306,218 (GRCm39) |
T2029S |
probably benign |
Het |
| Cep170 |
T |
C |
1: 176,583,595 (GRCm39) |
D163G |
probably damaging |
Het |
| Cfap210 |
A |
T |
2: 69,606,488 (GRCm39) |
D309E |
probably benign |
Het |
| Cftr |
T |
C |
6: 18,214,295 (GRCm39) |
F157S |
probably damaging |
Het |
| Chchd3 |
T |
C |
6: 32,945,164 (GRCm39) |
E114G |
probably damaging |
Het |
| Cntnap2 |
T |
A |
6: 46,460,963 (GRCm39) |
S666R |
possibly damaging |
Het |
| Col6a5 |
C |
T |
9: 105,753,075 (GRCm39) |
V2266I |
probably benign |
Het |
| Ctr9 |
A |
G |
7: 110,633,133 (GRCm39) |
D127G |
probably benign |
Het |
| Ctsl |
A |
T |
13: 64,514,882 (GRCm39) |
F141I |
probably damaging |
Het |
| Dcpp1 |
T |
A |
17: 24,101,615 (GRCm39) |
Y121* |
probably null |
Het |
| Ddx42 |
T |
C |
11: 106,138,565 (GRCm39) |
V788A |
probably benign |
Het |
| Ehd4 |
T |
C |
2: 119,921,874 (GRCm39) |
I461V |
probably benign |
Het |
| Elp6 |
C |
A |
9: 110,134,376 (GRCm39) |
L5I |
possibly damaging |
Het |
| Faap20 |
T |
C |
4: 155,334,793 (GRCm39) |
S2P |
|
Het |
| Fam98b |
A |
C |
2: 117,094,344 (GRCm39) |
Y218S |
probably damaging |
Het |
| Fbxl4 |
T |
A |
4: 22,376,655 (GRCm39) |
D30E |
probably benign |
Het |
| Fcrlb |
T |
C |
1: 170,736,210 (GRCm39) |
T189A |
probably damaging |
Het |
| Gfpt1 |
A |
G |
6: 87,043,671 (GRCm39) |
D302G |
probably benign |
Het |
| Gzmg |
T |
G |
14: 56,394,284 (GRCm39) |
E203D |
not run |
Het |
| Hsph1 |
A |
C |
5: 149,553,838 (GRCm39) |
V210G |
probably damaging |
Het |
| Il20rb |
A |
T |
9: 100,350,479 (GRCm39) |
M138K |
probably damaging |
Het |
| Itpr1 |
A |
T |
6: 108,360,639 (GRCm39) |
E688D |
probably benign |
Het |
| Kcnk3 |
A |
T |
5: 30,780,062 (GRCm39) |
T371S |
possibly damaging |
Het |
| Kif11 |
T |
A |
19: 37,398,255 (GRCm39) |
S694T |
possibly damaging |
Het |
| Kpna7 |
T |
A |
5: 144,942,731 (GRCm39) |
H85L |
probably benign |
Het |
| Lipf |
A |
T |
19: 33,954,006 (GRCm39) |
I366F |
probably damaging |
Het |
| Lrrc27 |
A |
G |
7: 138,794,748 (GRCm39) |
H37R |
probably benign |
Het |
| Mki67 |
T |
C |
7: 135,302,512 (GRCm39) |
T841A |
possibly damaging |
Het |
| Mtss1 |
A |
G |
15: 58,820,210 (GRCm39) |
S120P |
probably damaging |
Het |
| Nav1 |
A |
G |
1: 135,397,404 (GRCm39) |
W922R |
probably damaging |
Het |
| Nwd1 |
A |
G |
8: 73,434,021 (GRCm39) |
E1206G |
probably damaging |
Het |
| Obscn |
T |
C |
11: 58,885,635 (GRCm39) |
S7933G |
unknown |
Het |
| Or13j1 |
T |
C |
4: 43,706,316 (GRCm39) |
H84R |
probably damaging |
Het |
| Or1p4-ps1 |
T |
C |
11: 74,208,010 (GRCm39) |
V53A |
probably benign |
Het |
| Or2g25 |
T |
A |
17: 37,971,122 (GRCm39) |
Y34F |
probably damaging |
Het |
| Or2k2 |
T |
C |
4: 58,785,648 (GRCm39) |
I25V |
probably benign |
Het |
| Or4c52 |
T |
C |
2: 89,845,355 (GRCm39) |
L27S |
probably benign |
Het |
| Otog |
A |
T |
7: 45,948,039 (GRCm39) |
I162F |
probably damaging |
Het |
| Paf1 |
G |
A |
7: 28,095,293 (GRCm39) |
V153I |
possibly damaging |
Het |
| Pcdhga11 |
T |
A |
18: 37,889,554 (GRCm39) |
D187E |
probably benign |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Pitrm1 |
G |
T |
13: 6,610,658 (GRCm39) |
R424L |
probably damaging |
Het |
| Pla2g4e |
T |
A |
2: 120,004,819 (GRCm39) |
|
probably null |
Het |
| Plaat1 |
T |
C |
16: 29,046,919 (GRCm39) |
V146A |
probably benign |
Het |
| Prorp |
T |
C |
12: 55,351,206 (GRCm39) |
Y172H |
probably damaging |
Het |
| Prrc2a |
T |
C |
17: 35,381,286 (GRCm39) |
N61S |
unknown |
Het |
| Ror1 |
T |
A |
4: 100,190,827 (GRCm39) |
D61E |
probably benign |
Het |
| Ryr3 |
G |
A |
2: 112,542,706 (GRCm39) |
P3168S |
probably benign |
Het |
| Serinc4 |
T |
A |
2: 121,284,250 (GRCm39) |
I289F |
probably damaging |
Het |
| Sez6l |
A |
T |
5: 112,623,347 (GRCm39) |
L68H |
possibly damaging |
Het |
| Sez6l2 |
A |
G |
7: 126,560,915 (GRCm39) |
E460G |
probably benign |
Het |
| Sh3tc1 |
C |
T |
5: 35,863,406 (GRCm39) |
G927D |
probably damaging |
Het |
| Slc22a27 |
G |
C |
19: 7,903,747 (GRCm39) |
T130S |
probably damaging |
Het |
| Slc38a8 |
C |
A |
8: 120,227,820 (GRCm39) |
A37S |
possibly damaging |
Het |
| Slc40a1 |
T |
C |
1: 45,958,134 (GRCm39) |
N100D |
probably damaging |
Het |
| Slc49a3 |
G |
A |
5: 108,591,646 (GRCm39) |
|
probably null |
Het |
| Snx30 |
T |
C |
4: 59,894,567 (GRCm39) |
F382L |
possibly damaging |
Het |
| Sox1 |
A |
G |
8: 12,446,913 (GRCm39) |
N185D |
possibly damaging |
Het |
| Spsb1 |
C |
T |
4: 149,991,385 (GRCm39) |
R61H |
possibly damaging |
Het |
| Sptbn2 |
T |
C |
19: 4,798,110 (GRCm39) |
V1945A |
probably benign |
Het |
| St18 |
T |
A |
1: 6,898,194 (GRCm39) |
N665K |
probably benign |
Het |
| Syne1 |
A |
G |
10: 5,283,446 (GRCm39) |
S1540P |
probably damaging |
Het |
| Syne2 |
G |
A |
12: 76,141,100 (GRCm39) |
V1331M |
probably damaging |
Het |
| Tfap2c |
T |
C |
2: 172,393,639 (GRCm39) |
S185P |
probably benign |
Het |
| Tnfsf8 |
T |
A |
4: 63,769,398 (GRCm39) |
D71V |
probably damaging |
Het |
| Tnn |
T |
C |
1: 159,937,929 (GRCm39) |
D1196G |
probably benign |
Het |
| Ttll8 |
A |
G |
15: 88,817,639 (GRCm39) |
|
probably null |
Het |
| Tubgcp3 |
A |
G |
8: 12,691,207 (GRCm39) |
F444L |
probably damaging |
Het |
| Txndc11 |
G |
A |
16: 10,905,742 (GRCm39) |
P596L |
probably benign |
Het |
| Ubr4 |
C |
T |
4: 139,139,983 (GRCm39) |
P1189S |
possibly damaging |
Het |
| Usp32 |
T |
C |
11: 84,913,724 (GRCm39) |
D869G |
possibly damaging |
Het |
| Vmn1r202 |
G |
T |
13: 22,686,188 (GRCm39) |
N76K |
probably damaging |
Het |
| Wfdc6a |
C |
T |
2: 164,421,761 (GRCm39) |
M132I |
probably benign |
Het |
| Wnk2 |
A |
T |
13: 49,300,720 (GRCm39) |
|
probably null |
Het |
| Xbp1 |
A |
G |
11: 5,474,683 (GRCm39) |
|
probably null |
Het |
| Zfp551 |
A |
T |
7: 12,149,725 (GRCm39) |
Y561* |
probably null |
Het |
|
| Other mutations in Jmjd1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01062:Jmjd1c
|
APN |
10 |
67,062,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01604:Jmjd1c
|
APN |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Jmjd1c
|
APN |
10 |
67,067,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02081:Jmjd1c
|
APN |
10 |
67,055,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02128:Jmjd1c
|
APN |
10 |
67,079,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02134:Jmjd1c
|
APN |
10 |
67,056,171 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02215:Jmjd1c
|
APN |
10 |
67,056,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Jmjd1c
|
APN |
10 |
67,062,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02502:Jmjd1c
|
APN |
10 |
67,061,640 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02546:Jmjd1c
|
APN |
10 |
67,061,115 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02943:Jmjd1c
|
APN |
10 |
67,055,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03171:Jmjd1c
|
APN |
10 |
67,061,277 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03261:Jmjd1c
|
APN |
10 |
67,067,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Accordion
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Jmjd1c
|
UTSW |
10 |
67,065,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Jmjd1c
|
UTSW |
10 |
67,055,105 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0133:Jmjd1c
|
UTSW |
10 |
67,076,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0201:Jmjd1c
|
UTSW |
10 |
67,054,888 (GRCm39) |
missense |
unknown |
|
|
R0396:Jmjd1c
|
UTSW |
10 |
67,055,302 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0401:Jmjd1c
|
UTSW |
10 |
67,056,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Jmjd1c
|
UTSW |
10 |
67,091,261 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0488:Jmjd1c
|
UTSW |
10 |
67,076,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0504:Jmjd1c
|
UTSW |
10 |
67,061,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Jmjd1c
|
UTSW |
10 |
67,061,568 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0673:Jmjd1c
|
UTSW |
10 |
67,062,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Jmjd1c
|
UTSW |
10 |
67,054,725 (GRCm39) |
splice site |
probably null |
|
|
R0755:Jmjd1c
|
UTSW |
10 |
66,932,378 (GRCm39) |
intron |
probably benign |
|
|
R1142:Jmjd1c
|
UTSW |
10 |
67,061,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Jmjd1c
|
UTSW |
10 |
67,075,015 (GRCm39) |
splice site |
probably benign |
|
|
R1413:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1619:Jmjd1c
|
UTSW |
10 |
67,055,654 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1676:Jmjd1c
|
UTSW |
10 |
67,060,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1751:Jmjd1c
|
UTSW |
10 |
67,061,469 (GRCm39) |
missense |
probably benign |
|
|
R1950:Jmjd1c
|
UTSW |
10 |
67,075,701 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1968:Jmjd1c
|
UTSW |
10 |
67,061,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Jmjd1c
|
UTSW |
10 |
66,993,777 (GRCm39) |
nonsense |
probably null |
|
|
R2061:Jmjd1c
|
UTSW |
10 |
67,054,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2203:Jmjd1c
|
UTSW |
10 |
67,075,242 (GRCm39) |
splice site |
probably null |
|
|
R2256:Jmjd1c
|
UTSW |
10 |
67,061,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Jmjd1c
|
UTSW |
10 |
67,074,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2349:Jmjd1c
|
UTSW |
10 |
67,091,279 (GRCm39) |
missense |
probably benign |
|
|
R2392:Jmjd1c
|
UTSW |
10 |
67,065,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Jmjd1c
|
UTSW |
10 |
66,993,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Jmjd1c
|
UTSW |
10 |
67,075,863 (GRCm39) |
splice site |
probably benign |
|
|
R4043:Jmjd1c
|
UTSW |
10 |
67,055,245 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4097:Jmjd1c
|
UTSW |
10 |
67,054,787 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4118:Jmjd1c
|
UTSW |
10 |
67,055,532 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4193:Jmjd1c
|
UTSW |
10 |
66,932,460 (GRCm39) |
intron |
probably benign |
|
|
R4352:Jmjd1c
|
UTSW |
10 |
67,080,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4577:Jmjd1c
|
UTSW |
10 |
67,085,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Jmjd1c
|
UTSW |
10 |
66,993,753 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Jmjd1c
|
UTSW |
10 |
66,993,830 (GRCm39) |
nonsense |
probably null |
|
|
R4741:Jmjd1c
|
UTSW |
10 |
67,060,718 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4774:Jmjd1c
|
UTSW |
10 |
67,060,571 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R4836:Jmjd1c
|
UTSW |
10 |
67,069,225 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4914:Jmjd1c
|
UTSW |
10 |
67,054,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Jmjd1c
|
UTSW |
10 |
67,081,916 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5211:Jmjd1c
|
UTSW |
10 |
67,067,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Jmjd1c
|
UTSW |
10 |
67,076,480 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5514:Jmjd1c
|
UTSW |
10 |
67,053,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5530:Jmjd1c
|
UTSW |
10 |
67,085,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Jmjd1c
|
UTSW |
10 |
67,069,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5640:Jmjd1c
|
UTSW |
10 |
67,061,857 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5654:Jmjd1c
|
UTSW |
10 |
67,065,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5742:Jmjd1c
|
UTSW |
10 |
67,056,112 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5764:Jmjd1c
|
UTSW |
10 |
67,062,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Jmjd1c
|
UTSW |
10 |
67,075,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Jmjd1c
|
UTSW |
10 |
67,083,827 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6256:Jmjd1c
|
UTSW |
10 |
67,056,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Jmjd1c
|
UTSW |
10 |
67,085,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6358:Jmjd1c
|
UTSW |
10 |
67,061,718 (GRCm39) |
missense |
probably benign |
|
|
R6430:Jmjd1c
|
UTSW |
10 |
67,059,939 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6455:Jmjd1c
|
UTSW |
10 |
67,061,795 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6887:Jmjd1c
|
UTSW |
10 |
67,025,599 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6895:Jmjd1c
|
UTSW |
10 |
67,052,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Jmjd1c
|
UTSW |
10 |
67,056,388 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7095:Jmjd1c
|
UTSW |
10 |
67,055,411 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7113:Jmjd1c
|
UTSW |
10 |
66,993,780 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7225:Jmjd1c
|
UTSW |
10 |
67,061,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Jmjd1c
|
UTSW |
10 |
67,025,596 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7361:Jmjd1c
|
UTSW |
10 |
67,054,143 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7383:Jmjd1c
|
UTSW |
10 |
67,025,537 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7460:Jmjd1c
|
UTSW |
10 |
67,052,815 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7475:Jmjd1c
|
UTSW |
10 |
67,061,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7699:Jmjd1c
|
UTSW |
10 |
67,054,195 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7745:Jmjd1c
|
UTSW |
10 |
67,052,824 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7897:Jmjd1c
|
UTSW |
10 |
67,075,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Jmjd1c
|
UTSW |
10 |
67,061,621 (GRCm39) |
missense |
probably benign |
|
|
R7911:Jmjd1c
|
UTSW |
10 |
67,067,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Jmjd1c
|
UTSW |
10 |
67,085,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Jmjd1c
|
UTSW |
10 |
67,090,274 (GRCm39) |
missense |
not run |
|
|
R8224:Jmjd1c
|
UTSW |
10 |
67,080,628 (GRCm39) |
missense |
noncoding transcript |
|
|
R8251:Jmjd1c
|
UTSW |
10 |
67,075,068 (GRCm39) |
missense |
noncoding transcript |
|
|
R8797:Jmjd1c
|
UTSW |
10 |
67,060,616 (GRCm39) |
missense |
probably benign |
|
|
R8833:Jmjd1c
|
UTSW |
10 |
67,054,162 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9262:Jmjd1c
|
UTSW |
10 |
67,083,793 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9354:Jmjd1c
|
UTSW |
10 |
67,059,875 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Jmjd1c
|
UTSW |
10 |
66,932,495 (GRCm39) |
intron |
probably benign |
|
|
R9477:Jmjd1c
|
UTSW |
10 |
66,993,734 (GRCm39) |
nonsense |
probably null |
|
|
R9519:Jmjd1c
|
UTSW |
10 |
66,993,798 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9701:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9802:Jmjd1c
|
UTSW |
10 |
67,060,745 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
RF011:Jmjd1c
|
UTSW |
10 |
67,055,978 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1088:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,081,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Jmjd1c
|
UTSW |
10 |
67,073,953 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGCTTTAGATCCCCAACCC -3'
(R):5'- TTTTCACCCAGGACAACGC -3'
Sequencing Primer
(F):5'- CACTGTCACTATATAATGCCTGAGAC -3'
(R):5'- AGGACAACGCTGTTTTCTCAGAC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation