Incidental Mutation 'R7503:Vmn2r6'
| ID |
581603 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r6
|
| Ensembl Gene |
ENSMUSG00000090581 |
| Gene Name |
vomeronasal 2, receptor 6 |
| Synonyms |
EG667069, EG620718 |
| MMRRC Submission |
045576-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.241)
|
| Stock # |
R7503 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
64444916-64472855 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 64447372 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 565
(Q565*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135148
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165012]
[ENSMUST00000176481]
|
| AlphaFold |
H3BK29 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000165012
AA Change: Q476*
|
| SMART Domains |
Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: Q476*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
416 |
1.4e-72 |
PFAM |
|
Pfam:Peripla_BP_6
|
58 |
244 |
1.2e-10 |
PFAM |
|
Pfam:NCD3G
|
458 |
511 |
1.8e-17 |
PFAM |
|
Pfam:7tm_3
|
542 |
779 |
3.9e-76 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176481
AA Change: Q565*
|
| SMART Domains |
Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: Q565*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
88 |
505 |
9.8e-77 |
PFAM |
|
Pfam:Peripla_BP_6
|
142 |
331 |
3.4e-10 |
PFAM |
|
Pfam:NCD3G
|
547 |
600 |
5.4e-17 |
PFAM |
|
Pfam:7tm_3
|
633 |
867 |
3.9e-47 |
PFAM |
|
| Meta Mutation Damage Score |
0.9756 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
100% (63/63) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A230072I06Rik |
G |
A |
8: 12,329,554 (GRCm39) |
G3D |
unknown |
Het |
| Aif1 |
A |
T |
17: 35,390,549 (GRCm39) |
I67N |
probably damaging |
Het |
| Akap11 |
T |
C |
14: 78,749,441 (GRCm39) |
D982G |
|
Het |
| Anpep |
A |
G |
7: 79,476,385 (GRCm39) |
L827P |
probably damaging |
Het |
| Arhgef5 |
A |
T |
6: 43,250,933 (GRCm39) |
K561N |
probably benign |
Het |
| Arsj |
T |
C |
3: 126,158,493 (GRCm39) |
F24S |
probably benign |
Het |
| Bard1 |
T |
C |
1: 71,069,995 (GRCm39) |
D661G |
probably damaging |
Het |
| Cc2d2b |
A |
G |
19: 40,783,056 (GRCm39) |
I618V |
unknown |
Het |
| Cfap251 |
G |
T |
5: 123,435,521 (GRCm39) |
E994* |
probably null |
Het |
| Cfap54 |
T |
A |
10: 92,723,298 (GRCm39) |
|
probably null |
Het |
| Cfhr2 |
T |
A |
1: 139,758,952 (GRCm39) |
I33F |
probably damaging |
Het |
| Dsc1 |
G |
A |
18: 20,218,922 (GRCm39) |
H827Y |
probably damaging |
Het |
| Eif3i |
C |
T |
4: 129,494,207 (GRCm39) |
D31N |
probably damaging |
Het |
| Eno1b |
A |
T |
18: 48,179,878 (GRCm39) |
T19S |
probably damaging |
Het |
| Eva1a |
G |
A |
6: 82,048,210 (GRCm39) |
W29* |
probably null |
Het |
| Evc |
T |
C |
5: 37,458,111 (GRCm39) |
K803R |
unknown |
Het |
| F5 |
T |
A |
1: 164,019,779 (GRCm39) |
N751K |
probably damaging |
Het |
| Fam120a |
A |
T |
13: 49,102,723 (GRCm39) |
N177K |
probably benign |
Het |
| Farp2 |
T |
G |
1: 93,495,219 (GRCm39) |
I164R |
probably benign |
Het |
| Gm20379 |
C |
T |
13: 92,442,565 (GRCm39) |
P26L |
|
Het |
| Hmgcs2 |
T |
C |
3: 98,209,940 (GRCm39) |
S433P |
probably damaging |
Het |
| Inava |
T |
C |
1: 136,143,675 (GRCm39) |
D587G |
possibly damaging |
Het |
| Ints2 |
T |
C |
11: 86,122,881 (GRCm39) |
T633A |
probably benign |
Het |
| Invs |
C |
T |
4: 48,396,347 (GRCm39) |
T340M |
probably damaging |
Het |
| Mef2c |
A |
C |
13: 83,810,623 (GRCm39) |
D391A |
possibly damaging |
Het |
| Msh4 |
A |
C |
3: 153,573,387 (GRCm39) |
S756A |
probably damaging |
Het |
| Mylk3 |
T |
C |
8: 86,080,218 (GRCm39) |
T490A |
probably benign |
Het |
| Myo1b |
A |
T |
1: 51,815,761 (GRCm39) |
|
probably null |
Het |
| Nsmce1 |
A |
G |
7: 125,071,106 (GRCm39) |
S107P |
probably benign |
Het |
| Or52a24 |
T |
A |
7: 103,381,474 (GRCm39) |
S114T |
probably damaging |
Het |
| Or5d43 |
T |
C |
2: 88,105,039 (GRCm39) |
Y118C |
probably damaging |
Het |
| Pcdhb21 |
G |
A |
18: 37,648,028 (GRCm39) |
D386N |
probably benign |
Het |
| Pcdhb22 |
T |
G |
18: 37,652,155 (GRCm39) |
L208V |
probably benign |
Het |
| Pigu |
C |
T |
2: 155,173,064 (GRCm39) |
|
probably null |
Het |
| Plcz1 |
T |
A |
6: 139,936,474 (GRCm39) |
E585V |
probably damaging |
Het |
| Pnpla7 |
C |
A |
2: 24,873,544 (GRCm39) |
C183* |
probably null |
Het |
| Pomgnt1 |
T |
C |
4: 116,009,949 (GRCm39) |
V133A |
possibly damaging |
Het |
| Prl3d3 |
A |
G |
13: 27,345,096 (GRCm39) |
Y156C |
probably benign |
Het |
| Prpf39 |
A |
G |
12: 65,100,167 (GRCm39) |
D280G |
probably benign |
Het |
| Recql5 |
C |
A |
11: 115,785,881 (GRCm39) |
A631S |
probably benign |
Het |
| Runx3 |
C |
A |
4: 134,882,679 (GRCm39) |
N138K |
probably damaging |
Het |
| Scaper |
T |
C |
9: 55,715,038 (GRCm39) |
D750G |
probably damaging |
Het |
| Slc16a3 |
T |
C |
11: 120,847,853 (GRCm39) |
L347P |
probably damaging |
Het |
| Slc25a1 |
G |
T |
16: 17,744,303 (GRCm39) |
Y209* |
probably null |
Het |
| Smad2 |
A |
G |
18: 76,419,956 (GRCm39) |
S88G |
probably benign |
Het |
| Sorcs1 |
A |
G |
19: 50,141,490 (GRCm39) |
C1125R |
probably benign |
Het |
| Spata21 |
T |
A |
4: 140,822,614 (GRCm39) |
I140N |
probably benign |
Het |
| Speer3 |
A |
T |
5: 13,843,348 (GRCm39) |
D85V |
probably benign |
Het |
| Spopfm1 |
A |
T |
3: 94,173,780 (GRCm39) |
M259L |
probably benign |
Het |
| Stra6 |
A |
G |
9: 58,058,528 (GRCm39) |
N463S |
possibly damaging |
Het |
| Tmem14a |
T |
G |
1: 21,299,623 (GRCm39) |
|
probably null |
Het |
| Tsc1 |
T |
A |
2: 28,577,088 (GRCm39) |
L1130Q |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,611,401 (GRCm39) |
D17377G |
possibly damaging |
Het |
| Utf1 |
A |
G |
7: 139,524,046 (GRCm39) |
D87G |
probably damaging |
Het |
| Vmn2r63 |
A |
T |
7: 42,583,014 (GRCm39) |
M67K |
probably benign |
Het |
| Vmn2r90 |
T |
C |
17: 17,933,510 (GRCm39) |
Y357H |
not run |
Het |
| Vmn2r97 |
A |
G |
17: 19,148,470 (GRCm39) |
T122A |
probably benign |
Het |
| Wdhd1 |
T |
C |
14: 47,488,248 (GRCm39) |
E753G |
probably benign |
Het |
| Wdr11 |
A |
G |
7: 129,204,834 (GRCm39) |
N213S |
probably benign |
Het |
| Xdh |
A |
C |
17: 74,233,205 (GRCm39) |
D207E |
probably damaging |
Het |
| Zfp281 |
T |
A |
1: 136,554,678 (GRCm39) |
I552N |
possibly damaging |
Het |
| Zzef1 |
T |
A |
11: 72,716,893 (GRCm39) |
I361K |
probably damaging |
Het |
|
| Other mutations in Vmn2r6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01547:Vmn2r6
|
APN |
3 |
64,445,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01968:Vmn2r6
|
APN |
3 |
64,463,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02009:Vmn2r6
|
APN |
3 |
64,445,323 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL02039:Vmn2r6
|
APN |
3 |
64,463,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02652:Vmn2r6
|
APN |
3 |
64,463,749 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02737:Vmn2r6
|
APN |
3 |
64,463,911 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02808:Vmn2r6
|
APN |
3 |
64,463,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03066:Vmn2r6
|
APN |
3 |
64,472,574 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03331:Vmn2r6
|
APN |
3 |
64,445,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB010:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
|
BB020:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0010:Vmn2r6
|
UTSW |
3 |
64,466,966 (GRCm39) |
nonsense |
probably null |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
|
R0208:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
|
R0427:Vmn2r6
|
UTSW |
3 |
64,467,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r6
|
UTSW |
3 |
64,463,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1018:Vmn2r6
|
UTSW |
3 |
64,464,261 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1104:Vmn2r6
|
UTSW |
3 |
64,445,487 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1186:Vmn2r6
|
UTSW |
3 |
64,472,488 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1245:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1295:Vmn2r6
|
UTSW |
3 |
64,445,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1473:Vmn2r6
|
UTSW |
3 |
64,445,579 (GRCm39) |
nonsense |
probably null |
|
|
R1498:Vmn2r6
|
UTSW |
3 |
64,463,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1925:Vmn2r6
|
UTSW |
3 |
64,463,698 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2044:Vmn2r6
|
UTSW |
3 |
64,445,262 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2069:Vmn2r6
|
UTSW |
3 |
64,463,519 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2253:Vmn2r6
|
UTSW |
3 |
64,467,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2261:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
|
R2262:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
|
R2350:Vmn2r6
|
UTSW |
3 |
64,463,773 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2680:Vmn2r6
|
UTSW |
3 |
64,445,707 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2846:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2860:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2861:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3766:Vmn2r6
|
UTSW |
3 |
64,463,929 (GRCm39) |
missense |
probably benign |
0.19 |
|
R3870:Vmn2r6
|
UTSW |
3 |
64,464,042 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4018:Vmn2r6
|
UTSW |
3 |
64,463,893 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4024:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4026:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4227:Vmn2r6
|
UTSW |
3 |
64,445,369 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4526:Vmn2r6
|
UTSW |
3 |
64,445,145 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4570:Vmn2r6
|
UTSW |
3 |
64,467,068 (GRCm39) |
missense |
probably benign |
0.31 |
|
R4894:Vmn2r6
|
UTSW |
3 |
64,454,829 (GRCm39) |
missense |
probably benign |
|
|
R4934:Vmn2r6
|
UTSW |
3 |
64,463,766 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5057:Vmn2r6
|
UTSW |
3 |
64,445,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5059:Vmn2r6
|
UTSW |
3 |
64,445,044 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5148:Vmn2r6
|
UTSW |
3 |
64,464,015 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5155:Vmn2r6
|
UTSW |
3 |
64,445,935 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5179:Vmn2r6
|
UTSW |
3 |
64,445,411 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5256:Vmn2r6
|
UTSW |
3 |
64,464,263 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5861:Vmn2r6
|
UTSW |
3 |
64,463,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5950:Vmn2r6
|
UTSW |
3 |
64,472,652 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6081:Vmn2r6
|
UTSW |
3 |
64,463,953 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6173:Vmn2r6
|
UTSW |
3 |
64,467,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r6
|
UTSW |
3 |
64,445,424 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6240:Vmn2r6
|
UTSW |
3 |
64,464,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6433:Vmn2r6
|
UTSW |
3 |
64,454,801 (GRCm39) |
nonsense |
probably null |
|
|
R6645:Vmn2r6
|
UTSW |
3 |
64,464,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6791:Vmn2r6
|
UTSW |
3 |
64,445,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7265:Vmn2r6
|
UTSW |
3 |
64,464,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7562:Vmn2r6
|
UTSW |
3 |
64,463,941 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7584:Vmn2r6
|
UTSW |
3 |
64,472,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7611:Vmn2r6
|
UTSW |
3 |
64,472,563 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7759:Vmn2r6
|
UTSW |
3 |
64,463,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7834:Vmn2r6
|
UTSW |
3 |
64,445,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7933:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7982:Vmn2r6
|
UTSW |
3 |
64,467,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8024:Vmn2r6
|
UTSW |
3 |
64,467,245 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8074:Vmn2r6
|
UTSW |
3 |
64,455,064 (GRCm39) |
intron |
probably benign |
|
|
R8169:Vmn2r6
|
UTSW |
3 |
64,447,310 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8337:Vmn2r6
|
UTSW |
3 |
64,463,526 (GRCm39) |
nonsense |
probably null |
|
|
R8736:Vmn2r6
|
UTSW |
3 |
64,467,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8962:Vmn2r6
|
UTSW |
3 |
64,463,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9139:Vmn2r6
|
UTSW |
3 |
64,464,277 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9206:Vmn2r6
|
UTSW |
3 |
64,467,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9295:Vmn2r6
|
UTSW |
3 |
64,463,484 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9332:Vmn2r6
|
UTSW |
3 |
64,454,671 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9616:Vmn2r6
|
UTSW |
3 |
64,445,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9663:Vmn2r6
|
UTSW |
3 |
64,463,549 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9685:Vmn2r6
|
UTSW |
3 |
64,464,081 (GRCm39) |
missense |
probably benign |
0.19 |
|
X0020:Vmn2r6
|
UTSW |
3 |
64,445,871 (GRCm39) |
missense |
probably benign |
|
|
X0066:Vmn2r6
|
UTSW |
3 |
64,454,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r6
|
UTSW |
3 |
64,463,746 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTGTAAGTCTTTTCCAACTGCAG -3'
(R):5'- CTGCACTTAGTATCCTTTGTAATGG -3'
Sequencing Primer
(F):5'- CTTTTCCAACTGCAGTAAGAAAAAC -3'
(R):5'- CCTTTGTAATGGGAAACATGTCTCC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation