Incidental Mutation 'R7504:Wdr95'
ID 581666
Institutional Source Beutler Lab
Gene Symbol Wdr95
Ensembl Gene ENSMUSG00000029658
Gene Name WD40 repeat domain 95
Synonyms 4930434E21Rik
MMRRC Submission 045577-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R7504 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 149452144-149535359 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 149505311 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 364 (V364A)
Ref Sequence ENSEMBL: ENSMUSP00000144385 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110502] [ENSMUST00000201525] [ENSMUST00000202902]
AlphaFold D3Z7A8
Predicted Effect probably damaging
Transcript: ENSMUST00000110502
AA Change: V222A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000106128
Gene: ENSMUSG00000029658
AA Change: V222A

DomainStartEndE-ValueType
Pfam:WD40 4 28 3.3e-3 PFAM
WD40 32 71 4.38e-5 SMART
WD40 120 159 3.27e-4 SMART
WD40 162 203 1.71e-7 SMART
WD40 206 249 3.57e0 SMART
WD40 263 301 1.7e-2 SMART
Blast:WD40 315 363 3e-14 BLAST
Blast:WD40 367 408 4e-13 BLAST
WD40 421 460 2.01e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000201525
SMART Domains Protein: ENSMUSP00000144234
Gene: ENSMUSG00000029658

DomainStartEndE-ValueType
WD40 104 143 2e-6 SMART
WD40 146 187 1.1e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000202902
AA Change: V364A

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000144385
Gene: ENSMUSG00000029658
AA Change: V364A

DomainStartEndE-ValueType
Blast:WD40 44 83 9e-11 BLAST
WD40 132 170 1.61e-3 SMART
WD40 174 213 4.38e-5 SMART
WD40 262 301 3.27e-4 SMART
WD40 304 345 1.71e-7 SMART
WD40 348 391 3.57e0 SMART
WD40 405 443 1.7e-2 SMART
Blast:WD40 457 505 3e-14 BLAST
Blast:WD40 509 550 4e-13 BLAST
WD40 563 602 2.01e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600012H06Rik C G 17: 15,163,915 (GRCm39) A14G probably damaging Het
Btn1a1 A T 13: 23,645,886 (GRCm39) M161K probably benign Het
Camkk2 G A 5: 122,884,371 (GRCm39) T350I probably damaging Het
Cdc42bpg C A 19: 6,356,814 (GRCm39) D23E possibly damaging Het
Cdkn1a T C 17: 29,317,488 (GRCm39) L36P probably damaging Het
Dek A G 13: 47,241,511 (GRCm39) I351T probably damaging Het
Dst T C 1: 34,240,098 (GRCm39) Y1816H probably damaging Het
Efl1 T A 7: 82,332,257 (GRCm39) N300K probably damaging Het
Ephx2 A G 14: 66,339,066 (GRCm39) Y294H probably damaging Het
Fancd2 T A 6: 113,521,999 (GRCm39) I198N probably damaging Het
Grid1 G T 14: 35,284,470 (GRCm39) A738S probably damaging Het
Gsx2 G A 5: 75,237,060 (GRCm39) probably null Het
Hc G A 2: 34,951,331 (GRCm39) T22I not run Het
Hps1 T C 19: 42,755,159 (GRCm39) D261G probably benign Het
Ift80 T C 3: 68,825,338 (GRCm39) Y539C probably damaging Het
Insc G T 7: 114,390,533 (GRCm39) probably null Het
Isg15 T C 4: 156,284,502 (GRCm39) M9V probably damaging Het
Kalrn A G 16: 34,076,603 (GRCm39) L695P unknown Het
Nars1 A C 18: 64,645,093 (GRCm39) F52V probably benign Het
Nmt1 T G 11: 102,947,285 (GRCm39) F225V probably damaging Het
Or10q12 T A 19: 13,746,096 (GRCm39) I130N probably damaging Het
Or7a36 A G 10: 78,820,494 (GRCm39) Y290C possibly damaging Het
Or8c8 A T 9: 38,165,539 (GRCm39) K272N possibly damaging Het
Pbx3 T C 2: 34,065,936 (GRCm39) T385A probably damaging Het
Pcdhb11 A T 18: 37,554,852 (GRCm39) T61S probably benign Het
Pramel40 G T 5: 94,464,906 (GRCm39) V431L probably benign Het
Rab11fip1 T C 8: 27,642,981 (GRCm39) E606G possibly damaging Het
Rnf216 A G 5: 143,061,514 (GRCm39) Y589H probably benign Het
Scara3 A G 14: 66,168,780 (GRCm39) I279T possibly damaging Het
Sdk2 T A 11: 113,758,793 (GRCm39) Y477F possibly damaging Het
Secisbp2l T C 2: 125,600,091 (GRCm39) K415E probably benign Het
Stag1 C T 9: 100,770,381 (GRCm39) T639I probably benign Het
Sv2b A T 7: 74,786,131 (GRCm39) F430I probably benign Het
Tenm2 C T 11: 36,030,570 (GRCm39) C743Y probably damaging Het
Tet2 C A 3: 133,193,100 (GRCm39) V445L probably benign Het
Tmem132c T C 5: 127,631,696 (GRCm39) S652P probably damaging Het
Togaram1 A G 12: 65,039,391 (GRCm39) D1155G possibly damaging Het
Traip T C 9: 107,838,743 (GRCm39) I169T probably benign Het
Trmt9b A C 8: 36,979,309 (GRCm39) N304T probably benign Het
Usp45 T G 4: 21,816,892 (GRCm39) M374R possibly damaging Het
Vmn2r81 A T 10: 79,104,166 (GRCm39) H263L probably benign Het
Zfp128 G A 7: 12,624,405 (GRCm39) D258N probably damaging Het
Zfp335 G A 2: 164,751,338 (GRCm39) T76I probably benign Het
Zfp688 C A 7: 127,018,483 (GRCm39) C214F probably damaging Het
Zfp760 T C 17: 21,941,655 (GRCm39) S277P probably damaging Het
Other mutations in Wdr95
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Wdr95 APN 5 149,518,709 (GRCm39) critical splice acceptor site probably benign 0.00
IGL02352:Wdr95 APN 5 149,504,084 (GRCm39) missense probably damaging 0.99
IGL02359:Wdr95 APN 5 149,504,084 (GRCm39) missense probably damaging 0.99
IGL02478:Wdr95 APN 5 149,519,786 (GRCm39) missense probably benign 0.02
IGL03078:Wdr95 APN 5 149,535,062 (GRCm39) missense possibly damaging 0.63
IGL03201:Wdr95 APN 5 149,505,352 (GRCm39) splice site probably null
P0037:Wdr95 UTSW 5 149,511,536 (GRCm39) missense probably benign 0.27
R0115:Wdr95 UTSW 5 149,487,855 (GRCm39) missense probably damaging 1.00
R0538:Wdr95 UTSW 5 149,504,271 (GRCm39) missense probably damaging 1.00
R0606:Wdr95 UTSW 5 149,511,595 (GRCm39) missense probably damaging 1.00
R0723:Wdr95 UTSW 5 149,497,513 (GRCm39) missense probably damaging 1.00
R1104:Wdr95 UTSW 5 149,529,802 (GRCm39) missense probably benign 0.00
R1233:Wdr95 UTSW 5 149,518,829 (GRCm39) missense probably benign 0.00
R1233:Wdr95 UTSW 5 149,505,323 (GRCm39) missense possibly damaging 0.61
R1344:Wdr95 UTSW 5 149,511,563 (GRCm39) missense probably damaging 1.00
R1513:Wdr95 UTSW 5 149,522,759 (GRCm39) missense probably benign 0.00
R1623:Wdr95 UTSW 5 149,497,581 (GRCm39) missense probably damaging 1.00
R1633:Wdr95 UTSW 5 149,516,637 (GRCm39) missense probably damaging 0.98
R1664:Wdr95 UTSW 5 149,518,752 (GRCm39) missense probably damaging 0.98
R1686:Wdr95 UTSW 5 149,516,566 (GRCm39) missense probably damaging 1.00
R1741:Wdr95 UTSW 5 149,518,861 (GRCm39) splice site probably null
R1750:Wdr95 UTSW 5 149,505,351 (GRCm39) splice site probably null
R1774:Wdr95 UTSW 5 149,487,857 (GRCm39) nonsense probably null
R1831:Wdr95 UTSW 5 149,475,891 (GRCm39) missense probably damaging 1.00
R1838:Wdr95 UTSW 5 149,522,831 (GRCm39) missense probably benign 0.00
R1907:Wdr95 UTSW 5 149,475,891 (GRCm39) missense probably damaging 1.00
R2019:Wdr95 UTSW 5 149,497,613 (GRCm39) splice site probably benign
R2063:Wdr95 UTSW 5 149,502,627 (GRCm39) splice site probably null
R2392:Wdr95 UTSW 5 149,504,135 (GRCm39) missense probably benign 0.03
R2863:Wdr95 UTSW 5 149,505,321 (GRCm39) nonsense probably null
R4116:Wdr95 UTSW 5 149,521,040 (GRCm39) missense probably benign 0.02
R4237:Wdr95 UTSW 5 149,486,802 (GRCm39) nonsense probably null
R4420:Wdr95 UTSW 5 149,456,131 (GRCm39) missense probably damaging 0.99
R4639:Wdr95 UTSW 5 149,505,279 (GRCm39) splice site probably benign
R4824:Wdr95 UTSW 5 149,518,797 (GRCm39) missense probably damaging 1.00
R4911:Wdr95 UTSW 5 149,535,157 (GRCm39) nonsense probably null
R5016:Wdr95 UTSW 5 149,468,266 (GRCm39) missense probably benign 0.00
R5458:Wdr95 UTSW 5 149,487,879 (GRCm39) missense probably damaging 1.00
R5486:Wdr95 UTSW 5 149,519,795 (GRCm39) nonsense probably null
R5613:Wdr95 UTSW 5 149,507,935 (GRCm39) missense probably damaging 1.00
R5906:Wdr95 UTSW 5 149,487,692 (GRCm39) missense possibly damaging 0.50
R5956:Wdr95 UTSW 5 149,517,947 (GRCm39) missense probably benign 0.00
R6309:Wdr95 UTSW 5 149,504,268 (GRCm39) critical splice acceptor site probably null
R6867:Wdr95 UTSW 5 149,504,388 (GRCm39) splice site probably null
R6964:Wdr95 UTSW 5 149,505,315 (GRCm39) missense probably damaging 1.00
R7008:Wdr95 UTSW 5 149,535,005 (GRCm39) missense probably benign 0.00
R7208:Wdr95 UTSW 5 149,518,836 (GRCm39) missense probably benign 0.02
R7309:Wdr95 UTSW 5 149,529,758 (GRCm39) missense probably benign 0.01
R7660:Wdr95 UTSW 5 149,517,945 (GRCm39) missense possibly damaging 0.86
R7997:Wdr95 UTSW 5 149,502,622 (GRCm39) critical splice donor site probably null
R8084:Wdr95 UTSW 5 149,511,598 (GRCm39) missense probably damaging 1.00
R8356:Wdr95 UTSW 5 149,502,572 (GRCm39) missense probably damaging 1.00
R8456:Wdr95 UTSW 5 149,502,572 (GRCm39) missense probably damaging 1.00
R8523:Wdr95 UTSW 5 149,497,461 (GRCm39) missense probably damaging 1.00
R8682:Wdr95 UTSW 5 149,518,752 (GRCm39) missense possibly damaging 0.94
R9451:Wdr95 UTSW 5 149,504,165 (GRCm39) missense probably benign 0.01
R9453:Wdr95 UTSW 5 149,475,917 (GRCm39) missense probably damaging 0.99
R9779:Wdr95 UTSW 5 149,505,293 (GRCm39) missense probably benign 0.01
X0024:Wdr95 UTSW 5 149,511,632 (GRCm39) missense possibly damaging 0.81
Z1176:Wdr95 UTSW 5 149,489,901 (GRCm39) missense probably benign 0.34
Z1177:Wdr95 UTSW 5 149,468,241 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGGCCACAAAGGAATGGTGC -3'
(R):5'- AAAGCTGTGTCCAGTCCTTG -3'

Sequencing Primer
(F):5'- GCTTTAATGGCCCAGGCTACTAG -3'
(R):5'- CATGATATCTCCTGCCTTGCCAG -3'
Posted On 2019-10-17