Mutagenetix > Incidental Mutation

Incidental Mutation 'R7504:Zfp760'

581691

Institutional Source

Beutler Lab

Gene Symbol

Zfp760

Ensembl Gene

ENSMUSG00000067928

Gene Name

zinc finger protein 760

Synonyms

MMRRC Submission

045577-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

R7504 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

21707741-21725636 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 21722674 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 277 (S277P)

Ref Sequence

ENSEMBL: ENSMUSP00000073038 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073312]

AlphaFold

E9QAF5

Predicted Effect

probably damaging
Transcript: ENSMUST00000073312
AA Change: S277P

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000073038
Gene: ENSMUSG00000067928
AA Change: S277P

Domain	Start	End	E-Value	Type
KRAB	8	69	3.62e-21	SMART
ZnF_C2H2	183	202	1.78e2	SMART
ZnF_C2H2	208	230	1.69e-3	SMART
ZnF_C2H2	236	258	4.54e-4	SMART
ZnF_C2H2	264	286	2.79e-4	SMART
ZnF_C2H2	292	314	1.1e-2	SMART
ZnF_C2H2	320	342	2.71e-2	SMART
ZnF_C2H2	348	370	7.9e-4	SMART
ZnF_C2H2	376	398	1.72e-4	SMART
ZnF_C2H2	404	426	1.14e0	SMART
ZnF_C2H2	432	454	4.05e-1	SMART
ZnF_C2H2	460	482	5.14e-3	SMART
ZnF_C2H2	488	510	1.18e-2	SMART
ZnF_C2H2	516	538	1.95e-3	SMART
ZnF_C2H2	544	566	1.82e-3	SMART
ZnF_C2H2	572	594	4.17e-3	SMART
ZnF_C2H2	600	622	1.04e-3	SMART
ZnF_C2H2	628	650	1.28e-3	SMART

Meta Mutation Damage Score

0.1482

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (43/43)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600012H06Rik	C	G	17: 14,943,653 (GRCm38)	A14G	probably damaging	Het
Btn1a1	A	T	13: 23,461,716 (GRCm38)	M161K	probably benign	Het
Camkk2	G	A	5: 122,746,308 (GRCm38)	T350I	probably damaging	Het
Cdc42bpg	C	A	19: 6,306,784 (GRCm38)	D23E	possibly damaging	Het
Cdkn1a	T	C	17: 29,098,514 (GRCm38)	L36P	probably damaging	Het
Dek	A	G	13: 47,088,035 (GRCm38)	I351T	probably damaging	Het
Dst	T	C	1: 34,201,017 (GRCm38)	Y1816H	probably damaging	Het
Efl1	T	A	7: 82,683,049 (GRCm38)	N300K	probably damaging	Het
Ephx2	A	G	14: 66,101,617 (GRCm38)	Y294H	probably damaging	Het
Fancd2	T	A	6: 113,545,038 (GRCm38)	I198N	probably damaging	Het
Grid1	G	T	14: 35,562,513 (GRCm38)	A738S	probably damaging	Het
Gsx2	G	A	5: 75,076,399 (GRCm38)		probably null	Het
Hc	G	A	2: 35,061,319 (GRCm38)	T22I	not run	Het
Hps1	T	C	19: 42,766,720 (GRCm38)	D261G	probably benign	Het
Ift80	T	C	3: 68,918,005 (GRCm38)	Y539C	probably damaging	Het
Insc	G	T	7: 114,791,298 (GRCm38)		probably null	Het
Isg15	T	C	4: 156,200,045 (GRCm38)	M9V	probably damaging	Het
Kalrn	A	G	16: 34,256,233 (GRCm38)	L695P	unknown	Het
Nars1	A	C	18: 64,512,022 (GRCm38)	F52V	probably benign	Het
Nmt1	T	G	11: 103,056,459 (GRCm38)	F225V	probably damaging	Het
Or10q12	T	A	19: 13,768,732 (GRCm38)	I130N	probably damaging	Het
Or7a36	A	G	10: 78,984,660 (GRCm38)	Y290C	possibly damaging	Het
Or8c8	A	T	9: 38,254,243 (GRCm38)	K272N	possibly damaging	Het
Pbx3	T	C	2: 34,175,924 (GRCm38)	T385A	probably damaging	Het
Pcdhb11	A	T	18: 37,421,799 (GRCm38)	T61S	probably benign	Het
Pramel40	G	T	5: 94,317,047 (GRCm38)	V431L	probably benign	Het
Rab11fip1	T	C	8: 27,152,953 (GRCm38)	E606G	possibly damaging	Het
Rnf216	A	G	5: 143,075,759 (GRCm38)	Y589H	probably benign	Het
Scara3	A	G	14: 65,931,331 (GRCm38)	I279T	possibly damaging	Het
Sdk2	T	A	11: 113,867,967 (GRCm38)	Y477F	possibly damaging	Het
Secisbp2l	T	C	2: 125,758,171 (GRCm38)	K415E	probably benign	Het
Stag1	C	T	9: 100,888,328 (GRCm38)	T639I	probably benign	Het
Sv2b	A	T	7: 75,136,383 (GRCm38)	F430I	probably benign	Het
Tenm2	C	T	11: 36,139,743 (GRCm38)	C743Y	probably damaging	Het
Tet2	C	A	3: 133,487,339 (GRCm38)	V445L	probably benign	Het
Tmem132c	T	C	5: 127,554,632 (GRCm38)	S652P	probably damaging	Het
Togaram1	A	G	12: 64,992,617 (GRCm38)	D1155G	possibly damaging	Het
Traip	T	C	9: 107,961,544 (GRCm38)	I169T	probably benign	Het
Trmt9b	A	C	8: 36,512,155 (GRCm38)	N304T	probably benign	Het
Usp45	T	G	4: 21,816,892 (GRCm38)	M374R	possibly damaging	Het
Vmn2r81	A	T	10: 79,268,332 (GRCm38)	H263L	probably benign	Het
Wdr95	T	C	5: 149,581,846 (GRCm38)	V364A	probably damaging	Het
Zfp128	G	A	7: 12,890,478 (GRCm38)	D258N	probably damaging	Het
Zfp335	G	A	2: 164,909,418 (GRCm38)	T76I	probably benign	Het
Zfp688	C	A	7: 127,419,311 (GRCm38)	C214F	probably damaging	Het

Other mutations in Zfp760

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00472:Zfp760	APN	17	21,723,476 (GRCm38)	missense	possibly damaging	0.75
IGL00862:Zfp760	APN	17	21,722,284 (GRCm38)	missense	probably benign	0.00
IGL02198:Zfp760	APN	17	21,722,212 (GRCm38)	missense	probably benign	0.00
R0478:Zfp760	UTSW	17	21,722,014 (GRCm38)	nonsense	probably null
R0835:Zfp760	UTSW	17	21,723,578 (GRCm38)	missense	possibly damaging	0.63
R1191:Zfp760	UTSW	17	21,723,305 (GRCm38)	missense	probably damaging	1.00
R1760:Zfp760	UTSW	17	21,722,330 (GRCm38)	missense	probably damaging	1.00
R2698:Zfp760	UTSW	17	21,720,954 (GRCm38)	missense	probably damaging	0.99
R3722:Zfp760	UTSW	17	21,722,162 (GRCm38)	missense	probably damaging	1.00
R4561:Zfp760	UTSW	17	21,723,667 (GRCm38)	missense	probably benign	0.00
R4700:Zfp760	UTSW	17	21,722,407 (GRCm38)	missense	probably benign	0.01
R4859:Zfp760	UTSW	17	21,723,535 (GRCm38)	nonsense	probably null
R4859:Zfp760	UTSW	17	21,723,530 (GRCm38)	missense	probably damaging	0.97
R4897:Zfp760	UTSW	17	21,723,248 (GRCm38)	missense	probably benign	0.02
R6675:Zfp760	UTSW	17	21,723,010 (GRCm38)	missense	possibly damaging	0.92
R7286:Zfp760	UTSW	17	21,722,779 (GRCm38)	missense	probably benign	0.04
R7336:Zfp760	UTSW	17	21,723,833 (GRCm38)	missense	unknown
R7356:Zfp760	UTSW	17	21,722,620 (GRCm38)	missense	probably benign
R7369:Zfp760	UTSW	17	21,723,233 (GRCm38)	missense	probably benign	0.00
R7553:Zfp760	UTSW	17	21,722,891 (GRCm38)	missense	possibly damaging	0.82
R7577:Zfp760	UTSW	17	21,722,261 (GRCm38)	nonsense	probably null
R7579:Zfp760	UTSW	17	21,722,926 (GRCm38)	missense	possibly damaging	0.93
R7608:Zfp760	UTSW	17	21,722,816 (GRCm38)	missense	probably benign	0.00
R7973:Zfp760	UTSW	17	21,722,103 (GRCm38)	missense	probably benign	0.00
R8078:Zfp760	UTSW	17	21,723,455 (GRCm38)	missense	probably benign	0.27
R8332:Zfp760	UTSW	17	21,723,320 (GRCm38)	missense	probably damaging	0.99
R8750:Zfp760	UTSW	17	21,722,375 (GRCm38)	missense	possibly damaging	0.56
R9094:Zfp760	UTSW	17	21,722,951 (GRCm38)	missense	possibly damaging	0.86
R9264:Zfp760	UTSW	17	21,723,682 (GRCm38)	missense	possibly damaging	0.80
R9372:Zfp760	UTSW	17	21,722,054 (GRCm38)	missense	probably benign	0.00
R9520:Zfp760	UTSW	17	21,722,055 (GRCm38)	missense	probably benign	0.00
R9564:Zfp760	UTSW	17	21,723,291 (GRCm38)	missense	possibly damaging	0.94
R9743:Zfp760	UTSW	17	21,723,357 (GRCm38)	missense	probably benign
X0057:Zfp760	UTSW	17	21,723,682 (GRCm38)	missense	possibly damaging	0.80

Predicted Primers

PCR Primer
(F):5'- GTGGCTCTACACACAGACTTGT -3'
(R):5'- TTTTAAGGCCTGACAACCAATGGAA -3'

Sequencing Primer
(F):5'- TAGGAGTTGCTCAAGCCTCAGTAC -3'
(R):5'- GGAAGAACTTACCACATTCTTTGCAC -3'

Posted On

2019-10-17