Incidental Mutation 'R7506:Vmn2r63'
ID 581791
Institutional Source Beutler Lab
Gene Symbol Vmn2r63
Ensembl Gene ENSMUSG00000090751
Gene Name vomeronasal 2, receptor 63
Synonyms EG435975
MMRRC Submission 045579-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R7506 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 42552675-42583213 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 42576391 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 474 (F474Y)
Ref Sequence ENSEMBL: ENSMUSP00000129089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163803]
AlphaFold E9Q0K5
Predicted Effect probably damaging
Transcript: ENSMUST00000163803
AA Change: F474Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: F474Y

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 3.5e-43 PFAM
Pfam:NCD3G 514 567 5.1e-23 PFAM
Pfam:7tm_3 600 835 3.5e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (58/59)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406C07Rik C T 9: 15,209,202 (GRCm39) V31I probably benign Het
4933430I17Rik T C 4: 62,450,498 (GRCm39) V24A possibly damaging Het
Adamtsl3 A T 7: 82,164,186 (GRCm39) R334W probably damaging Het
Aox1 G A 1: 58,088,562 (GRCm39) C116Y probably damaging Het
B3gntl1 A T 11: 121,561,740 (GRCm39) I74N probably damaging Het
Bicra C T 7: 15,722,138 (GRCm39) V460M possibly damaging Het
Ccdc18 G A 5: 108,311,605 (GRCm39) C437Y possibly damaging Het
Cdh6 A G 15: 13,034,396 (GRCm39) S755P probably damaging Het
Crtc2 G T 3: 90,166,519 (GRCm39) A165S probably damaging Het
Cwf19l2 C T 9: 3,456,775 (GRCm39) H703Y probably damaging Het
Cyc1 C A 15: 76,227,885 (GRCm39) T41K probably benign Het
Defb28 A T 2: 152,360,221 (GRCm39) H12L possibly damaging Het
Dsg3 T A 18: 20,666,521 (GRCm39) C577S probably benign Het
Ggt6 G T 11: 72,328,724 (GRCm39) C408F possibly damaging Het
Gm3278 T A 14: 16,080,479 (GRCm39) Y97N probably damaging Het
Gpr155 A G 2: 73,198,683 (GRCm39) L412P probably damaging Het
Gucd1 T C 10: 75,347,019 (GRCm39) H77R probably benign Het
H2bc8 G A 13: 23,755,658 (GRCm39) A18T unknown Het
Hat1 T A 2: 71,250,691 (GRCm39) I158N probably damaging Het
Hhla1 C T 15: 65,808,231 (GRCm39) W271* probably null Het
Igsf10 T A 3: 59,226,775 (GRCm39) L2299F probably damaging Het
Iqsec1 A G 6: 90,644,891 (GRCm39) S914P probably damaging Het
Iqsec1 G T 6: 90,639,788 (GRCm39) H983Q possibly damaging Het
Irx2 G T 13: 72,777,328 (GRCm39) G50C probably damaging Het
Kif26b T C 1: 178,357,064 (GRCm39) probably benign Het
Lmo7 A G 14: 102,157,045 (GRCm39) E1405G unknown Het
Mdm2 T C 10: 117,526,596 (GRCm39) D330G possibly damaging Het
Mgat5 A C 1: 127,294,192 (GRCm39) D178A probably benign Het
Mier2 C A 10: 79,386,176 (GRCm39) R25L probably benign Het
Mlip T C 9: 77,072,085 (GRCm39) K257E probably damaging Het
Mtfr2 T C 10: 20,229,131 (GRCm39) S80P probably benign Het
Ndst2 A G 14: 20,780,153 (GRCm39) V29A probably benign Het
Negr1 T G 3: 156,774,870 (GRCm39) Y195* probably null Het
Nptn T C 9: 58,526,156 (GRCm39) L101P probably damaging Het
Nrip1 G A 16: 76,091,347 (GRCm39) T70I probably damaging Het
Nrtn C T 17: 57,058,633 (GRCm39) V123M probably damaging Het
Onecut1 T A 9: 74,770,522 (GRCm39) F315Y possibly damaging Het
Or1p1 A T 11: 74,179,949 (GRCm39) H159L possibly damaging Het
P4htm A G 9: 108,460,878 (GRCm39) L198S probably damaging Het
Pappa A C 4: 65,149,419 (GRCm39) I920L probably benign Het
Pcdhgb5 A C 18: 37,865,525 (GRCm39) D440A probably damaging Het
Ppard A T 17: 28,517,735 (GRCm39) N268Y possibly damaging Het
Rapgef6 T A 11: 54,526,997 (GRCm39) S563T probably benign Het
Rtn3 T A 19: 7,407,118 (GRCm39) E949D probably benign Het
Sf3a1 T C 11: 4,127,561 (GRCm39) M629T probably benign Het
Slc39a8 T C 3: 135,590,067 (GRCm39) I319T probably benign Het
Sorcs1 C T 19: 50,171,112 (GRCm39) W925* probably null Het
Spag9 G A 11: 93,999,290 (GRCm39) D1069N probably damaging Het
Taar7a A G 10: 23,868,892 (GRCm39) V163A possibly damaging Het
Tmem150a G A 6: 72,333,753 (GRCm39) probably null Het
Tnxb G A 17: 34,934,665 (GRCm39) V2425I possibly damaging Het
Tppp2 A G 14: 52,158,058 (GRCm39) K168E possibly damaging Het
Ttn T A 2: 76,719,812 (GRCm39) D7099V unknown Het
Vmn1r41 A T 6: 89,724,159 (GRCm39) R50* probably null Het
Vmn1r60 T C 7: 5,547,861 (GRCm39) K80E Het
Vmn2r18 A G 5: 151,508,485 (GRCm39) F213S possibly damaging Het
Vmn2r26 G A 6: 124,016,700 (GRCm39) S388N probably benign Het
Zc3hav1 G A 6: 38,309,875 (GRCm39) R316* probably null Het
Zfp654 A T 16: 64,612,211 (GRCm39) I225N probably damaging Het
Zfp97 A G 17: 17,365,542 (GRCm39) E347G probably damaging Het
Other mutations in Vmn2r63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01399:Vmn2r63 APN 7 42,553,543 (GRCm39) missense probably damaging 0.99
IGL01765:Vmn2r63 APN 7 42,552,788 (GRCm39) missense probably benign
IGL02203:Vmn2r63 APN 7 42,553,432 (GRCm39) missense probably benign 0.01
IGL02825:Vmn2r63 APN 7 42,576,274 (GRCm39) critical splice donor site probably null
IGL03155:Vmn2r63 APN 7 42,552,878 (GRCm39) missense probably damaging 1.00
IGL03260:Vmn2r63 APN 7 42,578,616 (GRCm39) missense probably damaging 1.00
IGL03411:Vmn2r63 APN 7 42,577,368 (GRCm39) missense probably benign 0.42
PIT4280001:Vmn2r63 UTSW 7 42,553,409 (GRCm39) missense probably damaging 1.00
R0066:Vmn2r63 UTSW 7 42,576,514 (GRCm39) splice site probably benign
R0328:Vmn2r63 UTSW 7 42,552,699 (GRCm39) missense probably benign 0.09
R0344:Vmn2r63 UTSW 7 42,553,042 (GRCm39) missense probably damaging 0.98
R0554:Vmn2r63 UTSW 7 42,583,129 (GRCm39) nonsense probably null
R0555:Vmn2r63 UTSW 7 42,577,952 (GRCm39) nonsense probably null
R0685:Vmn2r63 UTSW 7 42,577,434 (GRCm39) missense probably benign 0.13
R0751:Vmn2r63 UTSW 7 42,577,459 (GRCm39) missense probably damaging 1.00
R1349:Vmn2r63 UTSW 7 42,578,642 (GRCm39) missense possibly damaging 0.95
R1372:Vmn2r63 UTSW 7 42,578,642 (GRCm39) missense possibly damaging 0.95
R1416:Vmn2r63 UTSW 7 42,577,339 (GRCm39) missense probably benign 0.00
R1502:Vmn2r63 UTSW 7 42,578,015 (GRCm39) missense possibly damaging 0.62
R1563:Vmn2r63 UTSW 7 42,553,550 (GRCm39) missense probably benign 0.00
R1652:Vmn2r63 UTSW 7 42,577,635 (GRCm39) missense probably benign 0.32
R1693:Vmn2r63 UTSW 7 42,577,743 (GRCm39) missense probably benign
R1698:Vmn2r63 UTSW 7 42,583,038 (GRCm39) missense probably benign
R1753:Vmn2r63 UTSW 7 42,577,669 (GRCm39) nonsense probably null
R2136:Vmn2r63 UTSW 7 42,576,297 (GRCm39) missense probably damaging 0.99
R2175:Vmn2r63 UTSW 7 42,583,004 (GRCm39) critical splice donor site probably null
R2261:Vmn2r63 UTSW 7 42,578,031 (GRCm39) missense probably benign 0.02
R2262:Vmn2r63 UTSW 7 42,578,031 (GRCm39) missense probably benign 0.02
R2263:Vmn2r63 UTSW 7 42,578,031 (GRCm39) missense probably benign 0.02
R3413:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R3426:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R3427:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R3802:Vmn2r63 UTSW 7 42,552,829 (GRCm39) missense probably damaging 0.99
R4319:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R4321:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R4323:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense probably benign 0.04
R4346:Vmn2r63 UTSW 7 42,577,537 (GRCm39) missense possibly damaging 0.67
R4568:Vmn2r63 UTSW 7 42,583,250 (GRCm39) splice site probably null
R4649:Vmn2r63 UTSW 7 42,553,114 (GRCm39) missense possibly damaging 0.79
R4653:Vmn2r63 UTSW 7 42,553,114 (GRCm39) missense possibly damaging 0.79
R4679:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4734:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4741:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4748:Vmn2r63 UTSW 7 42,577,544 (GRCm39) missense probably benign 0.00
R4806:Vmn2r63 UTSW 7 42,576,314 (GRCm39) missense probably benign 0.34
R4933:Vmn2r63 UTSW 7 42,553,402 (GRCm39) missense probably damaging 1.00
R5198:Vmn2r63 UTSW 7 42,553,169 (GRCm39) missense probably benign 0.01
R5399:Vmn2r63 UTSW 7 42,577,701 (GRCm39) missense probably benign
R5400:Vmn2r63 UTSW 7 42,577,635 (GRCm39) missense probably benign 0.32
R6158:Vmn2r63 UTSW 7 42,583,104 (GRCm39) missense probably damaging 1.00
R6185:Vmn2r63 UTSW 7 42,578,435 (GRCm39) missense probably damaging 0.98
R6267:Vmn2r63 UTSW 7 42,578,059 (GRCm39) splice site probably null
R6362:Vmn2r63 UTSW 7 42,552,721 (GRCm39) missense probably benign
R6706:Vmn2r63 UTSW 7 42,578,001 (GRCm39) missense probably damaging 1.00
R6764:Vmn2r63 UTSW 7 42,552,695 (GRCm39) missense probably damaging 0.97
R7104:Vmn2r63 UTSW 7 42,577,959 (GRCm39) missense possibly damaging 0.67
R7503:Vmn2r63 UTSW 7 42,583,014 (GRCm39) missense probably benign 0.02
R7525:Vmn2r63 UTSW 7 42,576,406 (GRCm39) missense possibly damaging 0.52
R7658:Vmn2r63 UTSW 7 42,574,693 (GRCm39) missense probably damaging 1.00
R7663:Vmn2r63 UTSW 7 42,576,466 (GRCm39) missense probably benign 0.00
R7702:Vmn2r63 UTSW 7 42,577,553 (GRCm39) missense possibly damaging 0.46
R7918:Vmn2r63 UTSW 7 42,552,955 (GRCm39) missense probably damaging 1.00
R8826:Vmn2r63 UTSW 7 42,576,441 (GRCm39) missense probably benign 0.38
R8973:Vmn2r63 UTSW 7 42,577,919 (GRCm39) missense probably benign 0.19
R9024:Vmn2r63 UTSW 7 42,577,874 (GRCm39) missense probably benign 0.14
R9154:Vmn2r63 UTSW 7 42,576,413 (GRCm39) missense probably damaging 0.96
R9731:Vmn2r63 UTSW 7 42,553,361 (GRCm39) missense probably benign 0.32
Z1088:Vmn2r63 UTSW 7 42,577,983 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- GAGTGTCCAATTAACACCATATCC -3'
(R):5'- TTCATCATGAGGGGATAAAAGACAC -3'

Sequencing Primer
(F):5'- CTGTGTCGGCCATTGTAT -3'
(R):5'- GGGATAAAAGACACTGAGATTGTTTG -3'
Posted On 2019-10-17