Mutagenetix > Incidental Mutations

Incidental Mutation 'R7508:Vmn2r32'

581893

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r32

Ensembl Gene

ENSMUSG00000096743

Gene Name

vomeronasal 2, receptor 32

Synonyms

V2r5

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.215) question?

Stock #

R7508 (G1)

Quality Score

121.008

Status

Not validated

Chromosome

Chromosomal Location

7463015-7479973 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 7467374 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 515 (V515M)

Ref Sequence

ENSEMBL: ENSMUSP00000092462 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094866]

AlphaFold

K7N686

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094866
AA Change: V515M

PolyPhen 2 Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: V515M

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	470	3.6e-33	PFAM
Pfam:NCD3G	512	565	8.1e-21	PFAM
Pfam:7tm_3	598	833	9.5e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (56/56)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra3	C	T	5: 50,016,867	A110T	probably benign	Het
Adra1a	A	C	14: 66,637,935	I120L	probably damaging	Het
Ahnak2	C	T	12: 112,774,405	V1078I	possibly damaging	Het
Ccser1	A	G	6: 61,570,723	H590R	probably benign	Het
Cdh12	T	G	15: 21,583,765	L564V	probably benign	Het
Celsr3	T	A	9: 108,836,622	H1900Q	probably benign	Het
Clasp1	T	A	1: 118,545,434	M918K	probably benign	Het
Cmtm6	A	G	9: 114,731,240	E2G	probably damaging	Het
Ctsg	A	G	14: 56,100,541		probably null	Het
Cylc2	T	A	4: 51,229,256		probably null	Het
Dna2	A	G	10: 62,971,993		probably null	Het
Dnaic1	G	A	4: 41,614,323	R333H	probably benign	Het
Egln3	T	C	12: 54,180,628	D239G	probably benign	Het
Fam13a	A	T	6: 58,987,284	D54E	probably damaging	Het
Fn1	A	G	1: 71,597,516	V2159A	probably benign	Het
Gcnt2	T	A	13: 40,887,681	F105L	probably benign	Het
Gm5788	T	C	12: 87,494,842	M41T	possibly damaging	Het
Gpd1	G	A	15: 99,722,086	S255N	probably damaging	Het
Hacd4	A	G	4: 88,437,478	F57L	probably benign	Het
Helb	T	C	10: 120,105,283	D500G	probably benign	Het
Ighv1-26	G	A	12: 114,788,442	S94F	probably damaging	Het
Kirrel	T	C	3: 87,083,439	D692G	possibly damaging	Het
Klra7	A	T	6: 130,230,091		probably null	Het
Lyl1	T	C	8: 84,704,300	V277A	probably benign	Het
Mon2	A	C	10: 123,023,939	W811G	probably damaging	Het
Myo9b	T	C	8: 71,354,801	L1627P	probably benign	Het
Neurl1b	C	G	17: 26,438,746	H219Q	probably benign	Het
Odf4	A	T	11: 68,922,423	C218S	possibly damaging	Het
Olfr1038-ps	A	G	2: 86,121,938	N5S	possibly damaging	Het
Olfr11	T	A	13: 21,638,609	I305F	probably benign	Het
Pde5a	A	G	3: 122,818,030	D571G	probably damaging	Het
Pgc	A	G	17: 47,734,186	E343G	probably benign	Het
Pik3cd	A	G	4: 149,654,583	F667L	possibly damaging	Het
Prf1	G	A	10: 61,300,155	R70H	possibly damaging	Het
Ptprb	C	T	10: 116,353,991	Q1565*	probably null	Het
Rapgef4	T	A	2: 72,205,733	N523K	probably benign	Het
Rbm25	T	C	12: 83,672,877	L557P	probably damaging	Het
Rhobtb3	C	T	13: 75,878,857	V466I	probably benign	Het
Rnpep	A	G	1: 135,278,858	V166A	probably benign	Het
Sgo2a	A	G	1: 58,017,795	K1046R	probably benign	Het
Slc12a2	T	C	18: 57,904,393	V525A	probably benign	Het
Slc1a4	A	T	11: 20,306,487	I448N	probably damaging	Het
Slc29a4	C	T	5: 142,718,506	P305L	probably benign	Het
Slc9a5	T	A	8: 105,363,253		probably null	Het
Spag16	A	T	1: 69,887,520	N258I	possibly damaging	Het
Sspo	T	A	6: 48,466,699	L2076Q	probably damaging	Het
Taok1	T	A	11: 77,545,326	H704L	probably damaging	Het
Tbc1d9b	T	C	11: 50,145,120	F148L	probably damaging	Het
Tm4sf1	A	G	3: 57,294,755	Y12H	probably benign	Het
Traj6	C	T	14: 54,212,714	T9M		Het
Ttll4	A	G	1: 74,687,259	N672S	possibly damaging	Het
Ube3a	T	A	7: 59,303,689	H790Q	possibly damaging	Het
Usp49	G	A	17: 47,672,280	R70Q	probably benign	Het
Wars	A	G	12: 108,882,875	S49P	probably benign	Het
Zbp1	T	A	2: 173,207,811	Q386L	possibly damaging	Het
Zfp369	T	C	13: 65,279,273	F10S	unknown	Het
Zfp512	C	G	5: 31,473,539	I408M	possibly damaging	Het
Zfp952	A	G	17: 33,003,782	I412V	probably benign	Het

Other mutations in Vmn2r32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02140:Vmn2r32	APN	7	7476697	missense	probably damaging	0.97
IGL02333:Vmn2r32	APN	7	7464144	missense	probably damaging	1.00
IGL02406:Vmn2r32	APN	7	7476710	missense	probably benign
IGL02428:Vmn2r32	APN	7	7474284	missense	probably benign	0.02
IGL02484:Vmn2r32	APN	7	7464117	missense	probably damaging	1.00
IGL03277:Vmn2r32	APN	7	7474252	missense	probably benign	0.23
IGL03366:Vmn2r32	APN	7	7464030	missense	probably damaging	0.99
R1055:Vmn2r32	UTSW	7	7474327	nonsense	probably null
R1695:Vmn2r32	UTSW	7	7463992	missense	probably benign	0.01
R2172:Vmn2r32	UTSW	7	7474615	missense	probably damaging	0.99
R2262:Vmn2r32	UTSW	7	7474619	missense	probably benign
R3150:Vmn2r32	UTSW	7	7472555	missense	probably benign
R4362:Vmn2r32	UTSW	7	7479858	nonsense	probably null
R4432:Vmn2r32	UTSW	7	7479919	missense	probably damaging	0.98
R4851:Vmn2r32	UTSW	7	7479954	missense	possibly damaging	0.59
R4949:Vmn2r32	UTSW	7	7464084	missense	probably benign	0.22
R5990:Vmn2r32	UTSW	7	7479810	missense	probably damaging	0.97
R6083:Vmn2r32	UTSW	7	7464210	missense	probably benign	0.15
R6084:Vmn2r32	UTSW	7	7464210	missense	probably benign	0.15
R6116:Vmn2r32	UTSW	7	7464093	missense	probably damaging	1.00
R6263:Vmn2r32	UTSW	7	7476692	missense	possibly damaging	0.90
R6889:Vmn2r32	UTSW	7	7472574	missense	possibly damaging	0.82
R7286:Vmn2r32	UTSW	7	7479808	missense	probably benign	0.21
R7390:Vmn2r32	UTSW	7	7479852	missense	probably benign	0.00
R7412:Vmn2r32	UTSW	7	7474213	missense	possibly damaging	0.53
R8812:Vmn2r32	UTSW	7	7474670	missense	probably damaging	1.00
R8968:Vmn2r32	UTSW	7	7474205	missense	probably benign	0.00
R9331:Vmn2r32	UTSW	7	7464403	nonsense	probably null
R9358:Vmn2r32	UTSW	7	7474198	missense	probably damaging	1.00
Z1177:Vmn2r32	UTSW	7	7474161	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- TGACTTCATTATTCCAGGGTGATG -3'
(R):5'- ACCAGGTTGCAACTTCTGTAG -3'

Sequencing Primer
(F):5'- TGGAAGAGAAATACATATCTTCGGG -3'
(R):5'- TAATCCCAGCACTTTGGAGG -3'

Posted On

2019-10-17