Incidental Mutation 'R7508:Wars1'
ID 581910
Institutional Source Beutler Lab
Gene Symbol Wars1
Ensembl Gene ENSMUSG00000021266
Gene Name tryptophanyl-tRNA synthetase1
Synonyms Wars
MMRRC Submission 045581-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7508 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 108825956-108860095 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108848801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 49 (S49P)
Ref Sequence ENSEMBL: ENSMUSP00000124625 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109848] [ENSMUST00000160477] [ENSMUST00000161154] [ENSMUST00000161410] [ENSMUST00000162748]
AlphaFold P32921
Predicted Effect probably benign
Transcript: ENSMUST00000109848
AA Change: S49P

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
AA Change: S49P

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160477
Predicted Effect probably benign
Transcript: ENSMUST00000161154
AA Change: S49P

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
AA Change: S49P

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 446 1.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161410
AA Change: S49P

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
AA Change: S49P

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000162748
SMART Domains Protein: ENSMUSP00000125102
Gene: ENSMUSG00000021266

DomainStartEndE-ValueType
PDB:2QUK|A 4 37 1e-8 PDB
SCOP:d1fyja_ 14 37 8e-7 SMART
Blast:WHEP 16 37 3e-7 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 C T 5: 50,174,209 (GRCm39) A110T probably benign Het
Adra1a A C 14: 66,875,384 (GRCm39) I120L probably damaging Het
Ahnak2 C T 12: 112,740,839 (GRCm39) V1078I possibly damaging Het
Ccser1 A G 6: 61,547,707 (GRCm39) H590R probably benign Het
Cdh12 T G 15: 21,583,851 (GRCm39) L564V probably benign Het
Celsr3 T A 9: 108,713,821 (GRCm39) H1900Q probably benign Het
Clasp1 T A 1: 118,473,164 (GRCm39) M918K probably benign Het
Cmtm6 A G 9: 114,560,308 (GRCm39) E2G probably damaging Het
Ctsg A G 14: 56,337,998 (GRCm39) probably null Het
Cylc2 T A 4: 51,229,256 (GRCm39) probably null Het
Dna2 A G 10: 62,807,772 (GRCm39) probably null Het
Dnai1 G A 4: 41,614,323 (GRCm39) R333H probably benign Het
Egln3 T C 12: 54,227,414 (GRCm39) D239G probably benign Het
Eif1ad12 T C 12: 87,541,612 (GRCm39) M41T possibly damaging Het
Fam13a A T 6: 58,964,269 (GRCm39) D54E probably damaging Het
Fn1 A G 1: 71,636,675 (GRCm39) V2159A probably benign Het
Gcnt2 T A 13: 41,041,157 (GRCm39) F105L probably benign Het
Gpd1 G A 15: 99,619,967 (GRCm39) S255N probably damaging Het
Hacd4 A G 4: 88,355,715 (GRCm39) F57L probably benign Het
Helb T C 10: 119,941,188 (GRCm39) D500G probably benign Het
Ighv1-26 G A 12: 114,752,062 (GRCm39) S94F probably damaging Het
Kirrel1 T C 3: 86,990,746 (GRCm39) D692G possibly damaging Het
Klra7 A T 6: 130,207,054 (GRCm39) probably null Het
Lyl1 T C 8: 85,430,929 (GRCm39) V277A probably benign Het
Mon2 A C 10: 122,859,844 (GRCm39) W811G probably damaging Het
Myo9b T C 8: 71,807,445 (GRCm39) L1627P probably benign Het
Neurl1b C G 17: 26,657,720 (GRCm39) H219Q probably benign Het
Odf4 A T 11: 68,813,249 (GRCm39) C218S possibly damaging Het
Or2b6 T A 13: 21,822,779 (GRCm39) I305F probably benign Het
Or8u3-ps A G 2: 85,952,282 (GRCm39) N5S possibly damaging Het
Pde5a A G 3: 122,611,679 (GRCm39) D571G probably damaging Het
Pgc A G 17: 48,045,111 (GRCm39) E343G probably benign Het
Pik3cd A G 4: 149,739,040 (GRCm39) F667L possibly damaging Het
Prf1 G A 10: 61,135,934 (GRCm39) R70H possibly damaging Het
Ptprb C T 10: 116,189,896 (GRCm39) Q1565* probably null Het
Rapgef4 T A 2: 72,036,077 (GRCm39) N523K probably benign Het
Rbm25 T C 12: 83,719,651 (GRCm39) L557P probably damaging Het
Rhobtb3 C T 13: 76,026,976 (GRCm39) V466I probably benign Het
Rnpep A G 1: 135,206,596 (GRCm39) V166A probably benign Het
Sgo2a A G 1: 58,056,954 (GRCm39) K1046R probably benign Het
Slc12a2 T C 18: 58,037,465 (GRCm39) V525A probably benign Het
Slc1a4 A T 11: 20,256,487 (GRCm39) I448N probably damaging Het
Slc29a4 C T 5: 142,704,261 (GRCm39) P305L probably benign Het
Slc9a5 T A 8: 106,089,885 (GRCm39) probably null Het
Spag16 A T 1: 69,926,679 (GRCm39) N258I possibly damaging Het
Sspo T A 6: 48,443,633 (GRCm39) L2076Q probably damaging Het
Taok1 T A 11: 77,436,152 (GRCm39) H704L probably damaging Het
Tbc1d9b T C 11: 50,035,947 (GRCm39) F148L probably damaging Het
Tm4sf1 A G 3: 57,202,176 (GRCm39) Y12H probably benign Het
Traj6 C T 14: 54,450,171 (GRCm39) T9M Het
Ttll4 A G 1: 74,726,418 (GRCm39) N672S possibly damaging Het
Ube3a T A 7: 58,953,437 (GRCm39) H790Q possibly damaging Het
Usp49 G A 17: 47,983,205 (GRCm39) R70Q probably benign Het
Vmn2r32 C T 7: 7,470,373 (GRCm39) V515M possibly damaging Het
Zbp1 T A 2: 173,049,604 (GRCm39) Q386L possibly damaging Het
Zfp369 T C 13: 65,427,087 (GRCm39) F10S unknown Het
Zfp512 C G 5: 31,630,883 (GRCm39) I408M possibly damaging Het
Zfp952 A G 17: 33,222,756 (GRCm39) I412V probably benign Het
Other mutations in Wars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01961:Wars1 APN 12 108,832,096 (GRCm39) missense probably damaging 1.00
IGL02327:Wars1 APN 12 108,832,227 (GRCm39) critical splice acceptor site probably null
IGL02864:Wars1 APN 12 108,848,791 (GRCm39) missense probably benign
IGL02962:Wars1 APN 12 108,841,706 (GRCm39) missense probably damaging 0.99
R0271:Wars1 UTSW 12 108,841,119 (GRCm39) missense probably benign
R0485:Wars1 UTSW 12 108,841,083 (GRCm39) missense probably damaging 1.00
R0669:Wars1 UTSW 12 108,831,944 (GRCm39) missense probably benign 0.00
R1144:Wars1 UTSW 12 108,854,291 (GRCm39) nonsense probably null
R1581:Wars1 UTSW 12 108,841,635 (GRCm39) nonsense probably null
R1730:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1783:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1990:Wars1 UTSW 12 108,854,359 (GRCm39) missense possibly damaging 0.94
R5382:Wars1 UTSW 12 108,848,706 (GRCm39) missense probably benign
R5703:Wars1 UTSW 12 108,841,047 (GRCm39) missense probably damaging 1.00
R6299:Wars1 UTSW 12 108,827,309 (GRCm39) missense probably benign 0.00
R7186:Wars1 UTSW 12 108,846,982 (GRCm39) missense probably damaging 0.99
R7919:Wars1 UTSW 12 108,847,030 (GRCm39) missense probably benign 0.11
R8530:Wars1 UTSW 12 108,848,818 (GRCm39) missense probably damaging 0.99
R9132:Wars1 UTSW 12 108,827,199 (GRCm39) missense probably benign 0.41
Predicted Primers PCR Primer
(F):5'- TGTCATAGTCGATGCCTTTTGC -3'
(R):5'- TATACCGGAGCCCAGTTTTC -3'

Sequencing Primer
(F):5'- GCACTGCTTGTCCGCAC -3'
(R):5'- GGACGACTCCCTGGCTCTTAAAC -3'
Posted On 2019-10-17