Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00559:Cyp2d26'

5821

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2d26

Ensembl Gene

ENSMUSG00000022445

Gene Name

cytochrome P450, family 2, subfamily d, polypeptide 26

Synonyms

1300006E06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

IGL00559

Quality Score

Status

Chromosome

Chromosomal Location

82674302-82678495 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 82675244 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 370 (A370V)

Ref Sequence

ENSEMBL: ENSMUSP00000006094 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006094] [ENSMUST00000229387] [ENSMUST00000229512]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000006094
AA Change: A370V

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000006094
Gene: ENSMUSG00000022445
AA Change: A370V

Domain	Start	End	E-Value	Type
transmembrane domain	10	27	N/A	INTRINSIC
Pfam:p450	37	497	3.5e-141	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000229387

Predicted Effect

probably benign
Transcript: ENSMUST00000229512

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230125

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 16 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cers4	G	A	8: 4,571,216 (GRCm39)	D262N	probably benign	Het
Dnah7c	T	C	1: 46,846,449 (GRCm39)	M4000T	possibly damaging	Het
Enkd1	C	T	8: 106,430,974 (GRCm39)		probably benign	Het
H60b	A	G	10: 22,161,692 (GRCm39)	H60R	probably benign	Het
Hmgb4	T	C	4: 128,154,082 (GRCm39)	N162S	probably benign	Het
Htt	T	C	5: 35,006,448 (GRCm39)		probably benign	Het
Kbtbd6	A	G	14: 79,690,688 (GRCm39)	D461G	probably damaging	Het
Nell2	A	G	15: 95,425,166 (GRCm39)	L62P	possibly damaging	Het
Pi4k2b	T	A	5: 52,908,790 (GRCm39)	F205L	probably damaging	Het
Polr1b	G	T	2: 128,955,651 (GRCm39)	V521F	probably damaging	Het
Prn	G	A	2: 131,795,335 (GRCm39)	V152I	probably benign	Het
Ryr1	T	C	7: 28,711,667 (GRCm39)		probably benign	Het
Sema3c	G	T	5: 17,899,858 (GRCm39)	G450V	probably damaging	Het
Sema3d	G	A	5: 12,613,189 (GRCm39)	R422K	probably benign	Het
Snw1	T	C	12: 87,515,501 (GRCm39)	D16G	probably damaging	Het
Tas2r121	T	C	6: 132,677,484 (GRCm39)	I163V	probably benign	Het

Other mutations in Cyp2d26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00670:Cyp2d26	APN	15	82,675,942 (GRCm39)	missense	probably benign
IGL01646:Cyp2d26	APN	15	82,675,619 (GRCm39)	missense	probably benign	0.00
IGL01915:Cyp2d26	APN	15	82,674,450 (GRCm39)	missense	probably benign	0.06
IGL01940:Cyp2d26	APN	15	82,676,758 (GRCm39)	missense	probably benign	0.00
IGL02127:Cyp2d26	APN	15	82,675,307 (GRCm39)	missense	probably benign	0.09
IGL02452:Cyp2d26	APN	15	82,676,827 (GRCm39)	missense	probably benign	0.00
IGL03216:Cyp2d26	APN	15	82,677,462 (GRCm39)	missense	probably benign
IGL03377:Cyp2d26	APN	15	82,674,755 (GRCm39)	missense	possibly damaging	0.47
R0149:Cyp2d26	UTSW	15	82,676,968 (GRCm39)	missense	probably damaging	1.00
R0848:Cyp2d26	UTSW	15	82,674,434 (GRCm39)	missense	probably benign	0.00
R1165:Cyp2d26	UTSW	15	82,678,242 (GRCm39)	missense	probably damaging	1.00
R1217:Cyp2d26	UTSW	15	82,677,068 (GRCm39)	splice site	probably benign
R1780:Cyp2d26	UTSW	15	82,678,208 (GRCm39)	missense	probably damaging	1.00
R2048:Cyp2d26	UTSW	15	82,676,928 (GRCm39)	utr 3 prime	probably benign
R2152:Cyp2d26	UTSW	15	82,676,907 (GRCm39)	critical splice donor site	probably null
R2397:Cyp2d26	UTSW	15	82,678,236 (GRCm39)	missense	probably damaging	1.00
R4702:Cyp2d26	UTSW	15	82,676,648 (GRCm39)	intron	probably benign
R5157:Cyp2d26	UTSW	15	82,675,190 (GRCm39)	missense	probably benign	0.01
R5444:Cyp2d26	UTSW	15	82,676,739 (GRCm39)	missense	probably benign	0.18
R6017:Cyp2d26	UTSW	15	82,674,774 (GRCm39)	missense	possibly damaging	0.68
R6223:Cyp2d26	UTSW	15	82,675,918 (GRCm39)	missense	probably benign	0.04
R6390:Cyp2d26	UTSW	15	82,676,825 (GRCm39)	missense	possibly damaging	0.68
R6473:Cyp2d26	UTSW	15	82,675,968 (GRCm39)	missense	probably benign	0.02
R6858:Cyp2d26	UTSW	15	82,678,284 (GRCm39)	missense	probably damaging	1.00
R6912:Cyp2d26	UTSW	15	82,675,320 (GRCm39)	missense	probably benign	0.16
R6936:Cyp2d26	UTSW	15	82,676,741 (GRCm39)	missense	probably benign	0.14
R6960:Cyp2d26	UTSW	15	82,674,446 (GRCm39)	missense	probably damaging	0.98
R7053:Cyp2d26	UTSW	15	82,676,801 (GRCm39)	missense	probably benign	0.00
R7113:Cyp2d26	UTSW	15	82,674,403 (GRCm39)	missense	probably benign	0.02
R7126:Cyp2d26	UTSW	15	82,678,209 (GRCm39)	missense	probably benign	0.00
R7272:Cyp2d26	UTSW	15	82,676,764 (GRCm39)	missense	probably benign
R7771:Cyp2d26	UTSW	15	82,675,947 (GRCm39)	missense	probably benign
R8695:Cyp2d26	UTSW	15	82,676,907 (GRCm39)	critical splice donor site	probably benign
R9466:Cyp2d26	UTSW	15	82,674,424 (GRCm39)	missense	probably benign	0.01
R9489:Cyp2d26	UTSW	15	82,674,672 (GRCm39)	missense	probably benign	0.00
R9605:Cyp2d26	UTSW	15	82,674,672 (GRCm39)	missense	probably benign	0.00
R9656:Cyp2d26	UTSW	15	82,677,059 (GRCm39)	missense	probably benign	0.03
X0021:Cyp2d26	UTSW	15	82,674,718 (GRCm39)	missense	probably benign	0.04

Posted On

2012-04-20