Incidental Mutation 'R7512:Vmn2r102'
| ID |
582181 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r102
|
| Ensembl Gene |
ENSMUSG00000095961 |
| Gene Name |
vomeronasal 2, receptor 102 |
| Synonyms |
EG224572 |
| MMRRC Submission |
045585-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7512 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19880661-19915010 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 19914363 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 643
(P643S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
| AlphaFold |
L7N279 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171741
AA Change: P643S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: P643S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (59/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
C |
T |
11: 109,829,275 (GRCm39) |
A1395T |
probably benign |
Het |
| Ank3 |
A |
G |
10: 69,826,691 (GRCm39) |
K1787E |
|
Het |
| Atg2a |
C |
T |
19: 6,310,106 (GRCm39) |
A1763V |
probably damaging |
Het |
| Bdp1 |
T |
C |
13: 100,187,457 (GRCm39) |
I1637V |
probably benign |
Het |
| C1ra |
G |
A |
6: 124,494,684 (GRCm39) |
E316K |
probably benign |
Het |
| Camsap3 |
A |
G |
8: 3,648,740 (GRCm39) |
T20A |
probably benign |
Het |
| Ccnt2 |
T |
A |
1: 127,730,031 (GRCm39) |
S303T |
possibly damaging |
Het |
| Cdh3 |
C |
T |
8: 107,265,640 (GRCm39) |
Q228* |
probably null |
Het |
| Col19a1 |
C |
T |
1: 24,356,788 (GRCm39) |
G632R |
probably damaging |
Het |
| Dock2 |
A |
C |
11: 34,262,542 (GRCm39) |
C938G |
possibly damaging |
Het |
| Dync1i1 |
G |
T |
6: 5,969,410 (GRCm39) |
V412L |
possibly damaging |
Het |
| Eif1ad6 |
G |
T |
12: 87,668,751 (GRCm39) |
E128* |
probably null |
Het |
| Entrep2 |
C |
T |
7: 64,805,918 (GRCm39) |
A52T |
probably benign |
Het |
| Fam185a |
G |
A |
5: 21,652,356 (GRCm39) |
|
probably null |
Het |
| Fcho1 |
A |
G |
8: 72,169,507 (GRCm39) |
L133P |
possibly damaging |
Het |
| Galnt12 |
G |
A |
4: 47,108,406 (GRCm39) |
R181H |
possibly damaging |
Het |
| Gen1 |
A |
G |
12: 11,310,977 (GRCm39) |
V85A |
possibly damaging |
Het |
| Gm12185 |
A |
T |
11: 48,806,717 (GRCm39) |
I158K |
probably benign |
Het |
| Gm5624 |
T |
C |
14: 44,799,312 (GRCm39) |
R82G |
|
Het |
| Grap2 |
A |
C |
15: 80,532,754 (GRCm39) |
N307T |
probably benign |
Het |
| H6pd |
A |
G |
4: 150,080,405 (GRCm39) |
F147L |
probably benign |
Het |
| Haspin |
A |
T |
11: 73,027,418 (GRCm39) |
I557N |
probably damaging |
Het |
| Hectd4 |
A |
T |
5: 121,435,172 (GRCm39) |
K961N |
possibly damaging |
Het |
| Helz2 |
A |
G |
2: 180,872,647 (GRCm39) |
M2495T |
probably benign |
Het |
| Helz2 |
A |
T |
2: 180,877,393 (GRCm39) |
|
probably null |
Het |
| Impdh1 |
T |
C |
6: 29,207,168 (GRCm39) |
I59V |
probably benign |
Het |
| Kcnn1 |
A |
T |
8: 71,307,293 (GRCm39) |
L200Q |
possibly damaging |
Het |
| Kif5c |
T |
A |
2: 49,590,977 (GRCm39) |
H276Q |
probably damaging |
Het |
| Kntc1 |
T |
C |
5: 123,929,001 (GRCm39) |
L1259P |
probably damaging |
Het |
| Krtap4-1 |
A |
T |
11: 99,518,859 (GRCm39) |
C50* |
probably null |
Het |
| Lat2 |
T |
A |
5: 134,634,798 (GRCm39) |
D114V |
probably damaging |
Het |
| Lrrc41 |
A |
G |
4: 115,950,191 (GRCm39) |
T535A |
possibly damaging |
Het |
| Ly75 |
A |
T |
2: 60,164,907 (GRCm39) |
V757D |
probably damaging |
Het |
| Masp1 |
C |
A |
16: 23,288,874 (GRCm39) |
R642L |
probably damaging |
Het |
| Morn3 |
A |
G |
5: 123,175,343 (GRCm39) |
|
probably null |
Het |
| Mpl |
A |
T |
4: 118,306,089 (GRCm39) |
I384N |
|
Het |
| Mtmr14 |
C |
T |
6: 113,245,652 (GRCm39) |
Q409* |
probably null |
Het |
| Nek1 |
T |
A |
8: 61,583,179 (GRCm39) |
D1272E |
probably benign |
Het |
| Oit3 |
T |
C |
10: 59,274,716 (GRCm39) |
Y28C |
probably damaging |
Het |
| Or2z8 |
T |
A |
8: 72,812,367 (GRCm39) |
I281N |
probably damaging |
Het |
| Or4x12-ps1 |
A |
G |
2: 89,916,040 (GRCm39) |
I255T |
possibly damaging |
Het |
| Or5ac22 |
T |
A |
16: 59,135,390 (GRCm39) |
N127Y |
probably damaging |
Het |
| Pcdh15 |
T |
C |
10: 74,477,214 (GRCm39) |
Y186H |
possibly damaging |
Het |
| Pcdhgb1 |
T |
A |
18: 37,815,418 (GRCm39) |
D636E |
probably damaging |
Het |
| Pdgfra |
A |
T |
5: 75,355,675 (GRCm39) |
R1062* |
probably null |
Het |
| Pds5b |
T |
C |
5: 150,711,807 (GRCm39) |
F922L |
probably damaging |
Het |
| Pip5k1c |
G |
A |
10: 81,150,953 (GRCm39) |
|
probably null |
Het |
| Ppp2r3d |
T |
C |
9: 101,052,532 (GRCm39) |
T226A |
possibly damaging |
Het |
| Ptprh |
G |
A |
7: 4,574,780 (GRCm39) |
T413I |
possibly damaging |
Het |
| Rora |
C |
A |
9: 69,281,367 (GRCm39) |
D382E |
probably benign |
Het |
| Sacs |
T |
A |
14: 61,441,879 (GRCm39) |
N1308K |
probably benign |
Het |
| Sgce |
C |
T |
6: 4,707,192 (GRCm39) |
D218N |
possibly damaging |
Het |
| Slc34a3 |
A |
T |
2: 25,122,253 (GRCm39) |
|
probably null |
Het |
| Slit1 |
T |
C |
19: 41,589,074 (GRCm39) |
Y1471C |
probably damaging |
Het |
| Smarca2 |
G |
T |
19: 26,661,209 (GRCm39) |
V935L |
possibly damaging |
Het |
| Smchd1 |
T |
C |
17: 71,688,364 (GRCm39) |
N1298S |
possibly damaging |
Het |
| Sort1 |
T |
A |
3: 108,233,323 (GRCm39) |
|
probably null |
Het |
| Spata13 |
T |
C |
14: 60,989,226 (GRCm39) |
L964P |
probably damaging |
Het |
| Spata31h1 |
G |
A |
10: 82,128,469 (GRCm39) |
L1514F |
probably benign |
Het |
| Trav7-6 |
C |
A |
14: 53,954,552 (GRCm39) |
D47E |
probably benign |
Het |
| Ubap2l |
A |
G |
3: 89,917,803 (GRCm39) |
F864L |
unknown |
Het |
| Zfp112 |
T |
A |
7: 23,824,604 (GRCm39) |
C195S |
possibly damaging |
Het |
| Zfp764l1 |
C |
T |
7: 126,992,496 (GRCm39) |
C38Y |
probably null |
Het |
|
| Other mutations in Vmn2r102 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Vmn2r102
|
APN |
17 |
19,899,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Vmn2r102
|
APN |
17 |
19,897,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00978:Vmn2r102
|
APN |
17 |
19,899,185 (GRCm39) |
splice site |
probably null |
|
|
IGL01589:Vmn2r102
|
APN |
17 |
19,899,066 (GRCm39) |
missense |
probably benign |
|
|
IGL01738:Vmn2r102
|
APN |
17 |
19,898,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01994:Vmn2r102
|
APN |
17 |
19,880,731 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r102
|
APN |
17 |
19,914,191 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02525:Vmn2r102
|
APN |
17 |
19,901,447 (GRCm39) |
missense |
probably benign |
|
|
IGL02589:Vmn2r102
|
APN |
17 |
19,901,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Vmn2r102
|
APN |
17 |
19,898,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Vmn2r102
|
APN |
17 |
19,914,328 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03162:Vmn2r102
|
APN |
17 |
19,914,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,896,958 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0042:Vmn2r102
|
UTSW |
17 |
19,880,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0132:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0268:Vmn2r102
|
UTSW |
17 |
19,898,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0441:Vmn2r102
|
UTSW |
17 |
19,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0583:Vmn2r102
|
UTSW |
17 |
19,897,043 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Vmn2r102
|
UTSW |
17 |
19,898,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Vmn2r102
|
UTSW |
17 |
19,899,106 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0709:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0879:Vmn2r102
|
UTSW |
17 |
19,914,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r102
|
UTSW |
17 |
19,880,887 (GRCm39) |
splice site |
probably benign |
|
|
R1473:Vmn2r102
|
UTSW |
17 |
19,914,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1630:Vmn2r102
|
UTSW |
17 |
19,899,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1727:Vmn2r102
|
UTSW |
17 |
19,897,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1759:Vmn2r102
|
UTSW |
17 |
19,914,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2013:Vmn2r102
|
UTSW |
17 |
19,897,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2086:Vmn2r102
|
UTSW |
17 |
19,896,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2241:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Vmn2r102
|
UTSW |
17 |
19,914,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3814:Vmn2r102
|
UTSW |
17 |
19,899,093 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3827:Vmn2r102
|
UTSW |
17 |
19,914,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4159:Vmn2r102
|
UTSW |
17 |
19,898,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Vmn2r102
|
UTSW |
17 |
19,880,845 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4517:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4535:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4662:Vmn2r102
|
UTSW |
17 |
19,901,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r102
|
UTSW |
17 |
19,914,576 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r102
|
UTSW |
17 |
19,897,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Vmn2r102
|
UTSW |
17 |
19,898,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4927:Vmn2r102
|
UTSW |
17 |
19,880,661 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R5077:Vmn2r102
|
UTSW |
17 |
19,897,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5181:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5277:Vmn2r102
|
UTSW |
17 |
19,914,393 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5418:Vmn2r102
|
UTSW |
17 |
19,914,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Vmn2r102
|
UTSW |
17 |
19,897,804 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5864:Vmn2r102
|
UTSW |
17 |
19,914,943 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6168:Vmn2r102
|
UTSW |
17 |
19,914,402 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6266:Vmn2r102
|
UTSW |
17 |
19,899,007 (GRCm39) |
missense |
probably benign |
|
|
R6432:Vmn2r102
|
UTSW |
17 |
19,901,483 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6487:Vmn2r102
|
UTSW |
17 |
19,898,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Vmn2r102
|
UTSW |
17 |
19,914,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6797:Vmn2r102
|
UTSW |
17 |
19,880,694 (GRCm39) |
nonsense |
probably null |
|
|
R7009:Vmn2r102
|
UTSW |
17 |
19,914,456 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7098:Vmn2r102
|
UTSW |
17 |
19,914,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Vmn2r102
|
UTSW |
17 |
19,897,749 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7463:Vmn2r102
|
UTSW |
17 |
19,896,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7511:Vmn2r102
|
UTSW |
17 |
19,901,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r102
|
UTSW |
17 |
19,898,093 (GRCm39) |
missense |
probably benign |
|
|
R8126:Vmn2r102
|
UTSW |
17 |
19,880,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8385:Vmn2r102
|
UTSW |
17 |
19,914,088 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8410:Vmn2r102
|
UTSW |
17 |
19,898,196 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9045:Vmn2r102
|
UTSW |
17 |
19,880,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Vmn2r102
|
UTSW |
17 |
19,896,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Vmn2r102
|
UTSW |
17 |
19,897,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9363:Vmn2r102
|
UTSW |
17 |
19,897,614 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9524:Vmn2r102
|
UTSW |
17 |
19,897,564 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9747:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r102
|
UTSW |
17 |
19,914,305 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCCTATGAAGACCCCTTGG -3'
(R):5'- TCCACAGATGAGAAGTTGGATC -3'
Sequencing Primer
(F):5'- CCTTGGGGATGGCTCTAGC -3'
(R):5'- TGAGAAGTTGGATCAGGGTGC -3'
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| Posted On |
2019-10-17 |
Incidental Mutation