Incidental Mutation 'R7514:Hivep3'
| ID |
582291 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hivep3
|
| Ensembl Gene |
ENSMUSG00000028634 |
| Gene Name |
human immunodeficiency virus type I enhancer binding protein 3 |
| Synonyms |
Krc, E030045D18Rik, Schnurri-3, Shn3, 2900056N03Rik |
| MMRRC Submission |
045587-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7514 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
119590982-119992608 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 119954052 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 789
(F789L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101914
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106307]
[ENSMUST00000166542]
[ENSMUST00000226560]
|
| AlphaFold |
A2A884 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106307
AA Change: F789L
PolyPhen 2
Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000101914
Gene: ENSMUSG00000028634
AA Change: F789L
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
185 |
207 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
213 |
235 |
8.34e-3 |
SMART |
|
low complexity region
|
257 |
285 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
323 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
438 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
527 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
612 |
N/A |
INTRINSIC |
|
low complexity region
|
622 |
633 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
636 |
656 |
2.06e1 |
SMART |
|
low complexity region
|
736 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
806 |
817 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
894 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
1010 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1136 |
N/A |
INTRINSIC |
|
low complexity region
|
1143 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1183 |
N/A |
INTRINSIC |
|
low complexity region
|
1259 |
1284 |
N/A |
INTRINSIC |
|
low complexity region
|
1376 |
1390 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1547 |
N/A |
INTRINSIC |
|
low complexity region
|
1673 |
1684 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1720 |
1742 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
1748 |
1772 |
1.69e-3 |
SMART |
|
low complexity region
|
1778 |
1791 |
N/A |
INTRINSIC |
|
low complexity region
|
1814 |
1843 |
N/A |
INTRINSIC |
|
low complexity region
|
2203 |
2216 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166542
AA Change: F789L
PolyPhen 2
Score 0.483 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000130249
Gene: ENSMUSG00000028634
AA Change: F789L
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
185 |
207 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
213 |
235 |
8.34e-3 |
SMART |
|
low complexity region
|
257 |
285 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
323 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
438 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
527 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
612 |
N/A |
INTRINSIC |
|
low complexity region
|
622 |
633 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
636 |
656 |
2.06e1 |
SMART |
|
low complexity region
|
736 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
806 |
817 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
894 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
1010 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1136 |
N/A |
INTRINSIC |
|
low complexity region
|
1143 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1183 |
N/A |
INTRINSIC |
|
low complexity region
|
1259 |
1284 |
N/A |
INTRINSIC |
|
low complexity region
|
1376 |
1390 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1547 |
N/A |
INTRINSIC |
|
low complexity region
|
1673 |
1684 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1720 |
1742 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
1748 |
1772 |
1.69e-3 |
SMART |
|
low complexity region
|
1778 |
1791 |
N/A |
INTRINSIC |
|
low complexity region
|
1814 |
1843 |
N/A |
INTRINSIC |
|
low complexity region
|
2203 |
2216 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226560
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]
PHENOTYPE: Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933427D14Rik |
A |
G |
11: 72,086,628 (GRCm39) |
L261P |
probably damaging |
Het |
| A4gnt |
A |
G |
9: 99,502,598 (GRCm39) |
I253V |
probably benign |
Het |
| AAdacl4fm3 |
A |
T |
4: 144,429,798 (GRCm39) |
V397D |
possibly damaging |
Het |
| Acap2 |
A |
T |
16: 30,973,385 (GRCm39) |
|
probably null |
Het |
| Adora2b |
G |
T |
11: 62,156,146 (GRCm39) |
M198I |
probably damaging |
Het |
| Akap5 |
C |
A |
12: 76,375,303 (GRCm39) |
T245K |
probably benign |
Het |
| Aldh1a2 |
T |
C |
9: 71,192,245 (GRCm39) |
I399T |
probably damaging |
Het |
| Ank2 |
G |
A |
3: 126,819,252 (GRCm39) |
S473L |
probably benign |
Het |
| Anln |
A |
T |
9: 22,272,153 (GRCm39) |
D655E |
probably damaging |
Het |
| Arhgef10 |
T |
C |
8: 15,025,956 (GRCm39) |
V820A |
probably benign |
Het |
| Arid1b |
A |
G |
17: 5,391,989 (GRCm39) |
K1787E |
probably benign |
Het |
| Art4 |
T |
C |
6: 136,831,739 (GRCm39) |
H134R |
probably benign |
Het |
| Borcs6 |
G |
A |
11: 68,951,410 (GRCm39) |
V263M |
probably damaging |
Het |
| C8a |
A |
T |
4: 104,703,247 (GRCm39) |
M314K |
possibly damaging |
Het |
| Cbfa2t3 |
T |
G |
8: 123,361,865 (GRCm39) |
M386L |
probably damaging |
Het |
| Ccdc170 |
T |
A |
10: 4,496,839 (GRCm39) |
V459E |
probably benign |
Het |
| Cdh4 |
T |
A |
2: 179,532,636 (GRCm39) |
N699K |
possibly damaging |
Het |
| Cdk12 |
T |
C |
11: 98,113,484 (GRCm39) |
L756P |
unknown |
Het |
| Chsy1 |
A |
G |
7: 65,821,868 (GRCm39) |
D701G |
probably damaging |
Het |
| Cnot9 |
A |
G |
1: 74,567,921 (GRCm39) |
T270A |
probably benign |
Het |
| Crat |
C |
T |
2: 30,294,577 (GRCm39) |
R497Q |
probably benign |
Het |
| Csnk2a1-ps3 |
A |
G |
1: 156,352,324 (GRCm39) |
D175G |
probably benign |
Het |
| Cyb5r1 |
A |
G |
1: 134,338,268 (GRCm39) |
E228G |
probably damaging |
Het |
| D630003M21Rik |
A |
G |
2: 158,059,273 (GRCm39) |
L209P |
probably damaging |
Het |
| Dennd2c |
T |
A |
3: 103,070,378 (GRCm39) |
D791E |
probably benign |
Het |
| Dnah14 |
T |
C |
1: 181,455,632 (GRCm39) |
I919T |
probably damaging |
Het |
| Dpp8 |
T |
C |
9: 64,986,036 (GRCm39) |
L842S |
probably damaging |
Het |
| Ern1 |
A |
G |
11: 106,300,719 (GRCm39) |
|
probably null |
Het |
| Exo1 |
T |
C |
1: 175,734,232 (GRCm39) |
|
probably null |
Het |
| Fam161b |
T |
G |
12: 84,404,512 (GRCm39) |
E56A |
possibly damaging |
Het |
| Fbrsl1 |
T |
C |
5: 110,580,799 (GRCm39) |
T153A |
probably benign |
Het |
| Fcgr3 |
T |
G |
1: 170,886,912 (GRCm39) |
D4A |
probably benign |
Het |
| Gltp |
C |
T |
5: 114,808,521 (GRCm39) |
A193T |
probably benign |
Het |
| Gm3159 |
A |
T |
14: 4,399,690 (GRCm38) |
S142C |
probably damaging |
Het |
| Gphn |
T |
C |
12: 78,672,939 (GRCm39) |
V485A |
probably damaging |
Het |
| Grik2 |
A |
T |
10: 49,399,904 (GRCm39) |
N275K |
probably damaging |
Het |
| Gstt3 |
G |
T |
10: 75,612,625 (GRCm39) |
Q102K |
probably damaging |
Het |
| Ing5 |
A |
G |
1: 93,744,164 (GRCm39) |
N157D |
possibly damaging |
Het |
| Itga3 |
C |
T |
11: 94,956,722 (GRCm39) |
W177* |
probably null |
Het |
| Jag2 |
T |
C |
12: 112,892,672 (GRCm39) |
T83A |
probably benign |
Het |
| Krt90 |
G |
A |
15: 101,461,605 (GRCm39) |
T532I |
unknown |
Het |
| Lcn2 |
A |
G |
2: 32,277,861 (GRCm39) |
|
probably null |
Het |
| Lrig2 |
A |
G |
3: 104,373,076 (GRCm39) |
S602P |
probably damaging |
Het |
| Lsm1 |
A |
C |
8: 26,282,237 (GRCm39) |
R33S |
probably damaging |
Het |
| Mast4 |
A |
T |
13: 102,923,934 (GRCm39) |
Y492* |
probably null |
Het |
| Mcm3 |
A |
T |
1: 20,876,120 (GRCm39) |
L658Q |
probably benign |
Het |
| Myh4 |
G |
A |
11: 67,134,148 (GRCm39) |
|
probably null |
Het |
| Nck2 |
T |
C |
1: 43,608,381 (GRCm39) |
V341A |
probably benign |
Het |
| Nucb1 |
T |
C |
7: 45,151,142 (GRCm39) |
|
probably null |
Het |
| Nup210l |
G |
C |
3: 90,117,766 (GRCm39) |
|
probably null |
Het |
| Or1j1 |
A |
G |
2: 36,702,651 (GRCm39) |
I151T |
probably benign |
Het |
| Or5al5 |
A |
T |
2: 85,961,972 (GRCm39) |
F12I |
probably damaging |
Het |
| Or7g22 |
A |
T |
9: 19,049,161 (GRCm39) |
S291C |
possibly damaging |
Het |
| Or8b48 |
T |
A |
9: 38,493,347 (GRCm39) |
M258K |
probably damaging |
Het |
| Or8b54 |
G |
A |
9: 38,686,974 (GRCm39) |
C141Y |
probably damaging |
Het |
| Pla2g4a |
G |
A |
1: 149,727,113 (GRCm39) |
P556S |
probably damaging |
Het |
| Plat |
T |
C |
8: 23,265,658 (GRCm39) |
C234R |
probably damaging |
Het |
| Ppfia1 |
T |
C |
7: 144,071,450 (GRCm39) |
I321V |
probably benign |
Het |
| Prrc1 |
T |
A |
18: 57,496,325 (GRCm39) |
V92E |
probably benign |
Het |
| Prss3 |
A |
G |
6: 41,350,848 (GRCm39) |
V214A |
probably damaging |
Het |
| Ptprg |
G |
T |
14: 12,179,342 (GRCm38) |
K786N |
possibly damaging |
Het |
| Rabgap1 |
G |
T |
2: 37,427,354 (GRCm39) |
G645V |
probably damaging |
Het |
| Rfx4 |
T |
C |
10: 84,716,090 (GRCm39) |
S470P |
probably damaging |
Het |
| Rin3 |
C |
T |
12: 102,335,909 (GRCm39) |
Q607* |
probably null |
Het |
| Sema3a |
A |
G |
5: 13,573,093 (GRCm39) |
H207R |
probably benign |
Het |
| Serpinb12 |
G |
A |
1: 106,878,534 (GRCm39) |
E181K |
probably damaging |
Het |
| Serpinb6c |
G |
A |
13: 34,081,386 (GRCm39) |
Q88* |
probably null |
Het |
| Shmt1 |
A |
C |
11: 60,692,812 (GRCm39) |
C90W |
probably damaging |
Het |
| Slc16a13 |
C |
T |
11: 70,109,710 (GRCm39) |
V264M |
probably damaging |
Het |
| Slc17a8 |
G |
T |
10: 89,427,969 (GRCm39) |
P286Q |
probably damaging |
Het |
| Slc27a6 |
C |
T |
18: 58,745,293 (GRCm39) |
Q576* |
probably null |
Het |
| Slc30a9 |
T |
C |
5: 67,505,421 (GRCm39) |
S470P |
possibly damaging |
Het |
| Slc44a2 |
G |
T |
9: 21,253,768 (GRCm39) |
K136N |
possibly damaging |
Het |
| Smarca5 |
A |
T |
8: 81,444,163 (GRCm39) |
H534Q |
probably damaging |
Het |
| Son |
T |
G |
16: 91,451,748 (GRCm39) |
L165R |
probably damaging |
Het |
| Sox10 |
G |
A |
15: 79,040,421 (GRCm39) |
P373L |
probably benign |
Het |
| Sp100 |
C |
T |
1: 85,608,860 (GRCm39) |
R330* |
probably null |
Het |
| Srrm4 |
A |
G |
5: 116,584,570 (GRCm39) |
L500P |
probably damaging |
Het |
| Tap1 |
T |
C |
17: 34,415,639 (GRCm39) |
L689P |
probably damaging |
Het |
| Tfg |
A |
G |
16: 56,525,972 (GRCm39) |
|
probably null |
Het |
| Tjp2 |
C |
T |
19: 24,088,886 (GRCm39) |
V677I |
probably benign |
Het |
| Tmprss11g |
T |
G |
5: 86,645,176 (GRCm39) |
D85A |
probably damaging |
Het |
| Tnfsf9 |
T |
C |
17: 57,414,238 (GRCm39) |
S222P |
probably damaging |
Het |
| Trank1 |
A |
G |
9: 111,193,824 (GRCm39) |
N616S |
probably damaging |
Het |
| Tubgcp6 |
C |
A |
15: 89,004,728 (GRCm39) |
W297L |
probably damaging |
Het |
| Twist1 |
T |
C |
12: 34,008,355 (GRCm39) |
S127P |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,179,966 (GRCm39) |
I247T |
unknown |
Het |
| Ubr5 |
G |
A |
15: 37,988,481 (GRCm39) |
T2153M |
|
Het |
| Utrn |
A |
G |
10: 12,573,833 (GRCm39) |
V1079A |
probably benign |
Het |
| Vcan |
T |
C |
13: 89,852,237 (GRCm39) |
T908A |
probably damaging |
Het |
| Vmn2r104 |
A |
G |
17: 20,249,791 (GRCm39) |
F827L |
probably damaging |
Het |
| Vmn2r111 |
T |
A |
17: 22,767,380 (GRCm39) |
T706S |
probably benign |
Het |
| Vmn2r114 |
T |
C |
17: 23,527,035 (GRCm39) |
D499G |
probably null |
Het |
| Vmn2r92 |
T |
C |
17: 18,391,533 (GRCm39) |
S512P |
probably damaging |
Het |
| Vps4b |
A |
T |
1: 106,708,232 (GRCm39) |
|
probably null |
Het |
| Vwa8 |
A |
C |
14: 79,219,674 (GRCm39) |
|
probably null |
Het |
| Wnt10b |
T |
C |
15: 98,672,045 (GRCm39) |
Q224R |
probably benign |
Het |
| Ylpm1 |
C |
T |
12: 85,077,268 (GRCm39) |
P1331L |
possibly damaging |
Het |
| Zfhx4 |
G |
A |
3: 5,307,267 (GRCm39) |
M164I |
possibly damaging |
Het |
| Zfp51 |
A |
G |
17: 21,683,762 (GRCm39) |
T126A |
probably benign |
Het |
| Zfp609 |
A |
G |
9: 65,613,418 (GRCm39) |
V339A |
probably benign |
Het |
| Zfp687 |
C |
T |
3: 94,914,841 (GRCm39) |
R1220H |
probably damaging |
Het |
| Zfyve21 |
C |
T |
12: 111,790,249 (GRCm39) |
L84F |
probably damaging |
Het |
|
| Other mutations in Hivep3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00953:Hivep3
|
APN |
4 |
119,955,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01017:Hivep3
|
APN |
4 |
119,956,443 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01837:Hivep3
|
APN |
4 |
119,951,759 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01878:Hivep3
|
APN |
4 |
119,952,424 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02134:Hivep3
|
APN |
4 |
119,990,771 (GRCm39) |
splice site |
probably benign |
|
|
IGL02183:Hivep3
|
APN |
4 |
119,989,221 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02350:Hivep3
|
APN |
4 |
119,980,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02451:Hivep3
|
APN |
4 |
119,991,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02567:Hivep3
|
APN |
4 |
119,991,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02617:Hivep3
|
APN |
4 |
119,952,641 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02725:Hivep3
|
APN |
4 |
119,953,019 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02828:Hivep3
|
APN |
4 |
119,954,929 (GRCm39) |
nonsense |
probably null |
|
|
IGL02954:Hivep3
|
APN |
4 |
119,990,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02966:Hivep3
|
APN |
4 |
119,989,383 (GRCm39) |
missense |
probably benign |
0.04 |
|
Branchial
|
UTSW |
4 |
119,953,772 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Deceit
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
Mandible
|
UTSW |
4 |
119,954,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Sclerotic
|
UTSW |
4 |
119,952,296 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Stealth
|
UTSW |
4 |
119,980,073 (GRCm39) |
nonsense |
probably null |
|
|
Yellowjacket
|
UTSW |
4 |
119,989,554 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4260001:Hivep3
|
UTSW |
4 |
119,956,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0321:Hivep3
|
UTSW |
4 |
119,952,788 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0336:Hivep3
|
UTSW |
4 |
119,961,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0558:Hivep3
|
UTSW |
4 |
119,953,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0562:Hivep3
|
UTSW |
4 |
119,953,751 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0637:Hivep3
|
UTSW |
4 |
119,989,738 (GRCm39) |
nonsense |
probably null |
|
|
R0645:Hivep3
|
UTSW |
4 |
119,954,531 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1186:Hivep3
|
UTSW |
4 |
119,671,920 (GRCm39) |
start gained |
probably benign |
|
|
R1254:Hivep3
|
UTSW |
4 |
119,956,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1428:Hivep3
|
UTSW |
4 |
119,953,772 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1623:Hivep3
|
UTSW |
4 |
119,952,901 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1739:Hivep3
|
UTSW |
4 |
119,952,371 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1766:Hivep3
|
UTSW |
4 |
119,953,868 (GRCm39) |
missense |
probably benign |
|
|
R1769:Hivep3
|
UTSW |
4 |
119,954,768 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1773:Hivep3
|
UTSW |
4 |
119,956,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1968:Hivep3
|
UTSW |
4 |
119,953,435 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2220:Hivep3
|
UTSW |
4 |
119,591,235 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2428:Hivep3
|
UTSW |
4 |
119,955,705 (GRCm39) |
nonsense |
probably null |
|
|
R3789:Hivep3
|
UTSW |
4 |
119,955,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3917:Hivep3
|
UTSW |
4 |
119,956,624 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4366:Hivep3
|
UTSW |
4 |
119,953,286 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4436:Hivep3
|
UTSW |
4 |
119,953,120 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4504:Hivep3
|
UTSW |
4 |
119,590,990 (GRCm39) |
unclassified |
probably benign |
|
|
R4705:Hivep3
|
UTSW |
4 |
119,729,247 (GRCm39) |
intron |
probably benign |
|
|
R4713:Hivep3
|
UTSW |
4 |
119,989,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4756:Hivep3
|
UTSW |
4 |
119,955,020 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4887:Hivep3
|
UTSW |
4 |
119,980,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4888:Hivep3
|
UTSW |
4 |
119,980,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5008:Hivep3
|
UTSW |
4 |
119,956,114 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5204:Hivep3
|
UTSW |
4 |
119,961,053 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5594:Hivep3
|
UTSW |
4 |
119,980,245 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5697:Hivep3
|
UTSW |
4 |
119,954,152 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5715:Hivep3
|
UTSW |
4 |
119,953,570 (GRCm39) |
missense |
probably benign |
|
|
R5740:Hivep3
|
UTSW |
4 |
119,953,220 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5760:Hivep3
|
UTSW |
4 |
119,952,208 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5923:Hivep3
|
UTSW |
4 |
119,953,490 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5927:Hivep3
|
UTSW |
4 |
119,954,305 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6042:Hivep3
|
UTSW |
4 |
119,955,061 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6074:Hivep3
|
UTSW |
4 |
119,954,891 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6150:Hivep3
|
UTSW |
4 |
119,591,274 (GRCm39) |
nonsense |
probably null |
|
|
R6211:Hivep3
|
UTSW |
4 |
119,955,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6251:Hivep3
|
UTSW |
4 |
119,952,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6451:Hivep3
|
UTSW |
4 |
119,956,105 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6531:Hivep3
|
UTSW |
4 |
119,980,073 (GRCm39) |
nonsense |
probably null |
|
|
R6651:Hivep3
|
UTSW |
4 |
119,980,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6701:Hivep3
|
UTSW |
4 |
119,951,737 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6721:Hivep3
|
UTSW |
4 |
119,952,296 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6796:Hivep3
|
UTSW |
4 |
119,953,558 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6864:Hivep3
|
UTSW |
4 |
119,952,085 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6902:Hivep3
|
UTSW |
4 |
119,953,192 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7111:Hivep3
|
UTSW |
4 |
119,952,431 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7113:Hivep3
|
UTSW |
4 |
119,955,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7140:Hivep3
|
UTSW |
4 |
119,954,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7189:Hivep3
|
UTSW |
4 |
119,989,416 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7218:Hivep3
|
UTSW |
4 |
119,952,649 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7366:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7368:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7491:Hivep3
|
UTSW |
4 |
119,956,027 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7496:Hivep3
|
UTSW |
4 |
119,989,599 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7604:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7605:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7607:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7610:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7611:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7613:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7626:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7707:Hivep3
|
UTSW |
4 |
119,591,156 (GRCm39) |
missense |
|
|
|
R7736:Hivep3
|
UTSW |
4 |
119,952,740 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7915:Hivep3
|
UTSW |
4 |
119,954,962 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7943:Hivep3
|
UTSW |
4 |
119,989,554 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7972:Hivep3
|
UTSW |
4 |
119,954,711 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8093:Hivep3
|
UTSW |
4 |
119,952,632 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8111:Hivep3
|
UTSW |
4 |
119,955,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8215:Hivep3
|
UTSW |
4 |
119,980,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Hivep3
|
UTSW |
4 |
119,956,639 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8467:Hivep3
|
UTSW |
4 |
119,952,238 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8768:Hivep3
|
UTSW |
4 |
119,989,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8890:Hivep3
|
UTSW |
4 |
119,953,657 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8902:Hivep3
|
UTSW |
4 |
119,953,937 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9022:Hivep3
|
UTSW |
4 |
119,955,304 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9336:Hivep3
|
UTSW |
4 |
119,952,400 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9606:Hivep3
|
UTSW |
4 |
119,989,786 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF019:Hivep3
|
UTSW |
4 |
119,955,467 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0062:Hivep3
|
UTSW |
4 |
119,955,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0067:Hivep3
|
UTSW |
4 |
119,988,984 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Hivep3
|
UTSW |
4 |
119,990,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Hivep3
|
UTSW |
4 |
119,988,975 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Hivep3
|
UTSW |
4 |
119,953,143 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCCCTTCAGAAACAGCTC -3'
(R):5'- GGGCCACTGGAATTCTTCTGTC -3'
Sequencing Primer
(F):5'- AGCTCATAACCGTCCCCTGG -3'
(R):5'- TCAGGCTCTGTGTCAGGC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation