Incidental Mutation 'R7515:Vmn2r53'
ID 582391
Institutional Source Beutler Lab
Gene Symbol Vmn2r53
Ensembl Gene ENSMUSG00000096002
Gene Name vomeronasal 2, receptor 53
Synonyms EG637908
MMRRC Submission 045588-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R7515 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 12315397-12342583 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 12315846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 658 (M658L)
Ref Sequence ENSEMBL: ENSMUSP00000126979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170412]
AlphaFold A0A3B2W4A7
Predicted Effect probably benign
Transcript: ENSMUST00000170412
AA Change: M658L

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: M658L

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 397 3.6e-58 PFAM
Pfam:NCD3G 442 495 2.2e-19 PFAM
Pfam:7tm_3 526 763 3.1e-53 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd36 A T 11: 5,578,905 (GRCm39) E56D possibly damaging Het
Ankrd44 T C 1: 54,805,514 (GRCm39) Y182C probably damaging Het
Anxa3 A T 5: 96,986,179 (GRCm39) N273Y probably damaging Het
Apobec2 T C 17: 48,730,015 (GRCm39) E217G probably damaging Het
Arhgap24 A G 5: 102,993,882 (GRCm39) probably benign Het
Asap2 A G 12: 21,279,240 (GRCm39) H374R possibly damaging Het
Camsap2 T C 1: 136,273,108 (GRCm39) D23G probably damaging Het
Ccr2 T C 9: 123,906,197 (GRCm39) V159A probably damaging Het
Cfap61 T A 2: 145,884,645 (GRCm39) D614E unknown Het
Crb2 G A 2: 37,673,412 (GRCm39) G103R probably damaging Het
Cyp2b9 A G 7: 25,898,596 (GRCm39) Y317C probably damaging Het
Dhx36 A G 3: 62,379,508 (GRCm39) V860A probably benign Het
Dnah3 T C 7: 119,672,815 (GRCm39) D553G probably benign Het
Dnah7c T C 1: 46,496,450 (GRCm39) S112P probably benign Het
Dnah9 A G 11: 65,732,240 (GRCm39) F4222S probably benign Het
Ei24 T C 9: 36,701,211 (GRCm39) D36G probably damaging Het
Etv3 G T 3: 87,435,363 (GRCm39) R78L possibly damaging Het
Fbxo34 T C 14: 47,767,798 (GRCm39) L437P possibly damaging Het
Foxn1 T C 11: 78,261,970 (GRCm39) D133G possibly damaging Het
Gabra1 T A 11: 42,045,660 (GRCm39) D150V possibly damaging Het
Gpr158 T C 2: 21,373,092 (GRCm39) L9P probably damaging Het
H2-M10.3 G A 17: 36,677,435 (GRCm39) T281I probably damaging Het
Il18r1 T C 1: 40,537,830 (GRCm39) S532P not run Het
Itpr2 T C 6: 146,228,608 (GRCm39) D1329G probably damaging Het
Jakmip2 A T 18: 43,704,191 (GRCm39) N384K probably benign Het
Kdsr A G 1: 106,662,290 (GRCm39) V255A possibly damaging Het
Kifc1 A G 17: 34,103,777 (GRCm39) L182P probably damaging Het
Lgals8 G A 13: 12,463,343 (GRCm39) R198* probably null Het
Lrrk1 A T 7: 65,912,310 (GRCm39) M1750K probably benign Het
Lrsam1 A G 2: 32,830,251 (GRCm39) probably null Het
Lztr1 C T 16: 17,327,525 (GRCm39) A76V possibly damaging Het
Mcc G T 18: 44,626,499 (GRCm39) H366N probably benign Het
Mif4gd A G 11: 115,499,222 (GRCm39) V220A possibly damaging Het
Mtmr12 T A 15: 12,270,037 (GRCm39) F708L probably damaging Het
Muc16 A T 9: 18,550,958 (GRCm39) W5112R probably benign Het
Ndrg2 A G 14: 52,146,380 (GRCm39) I140T probably benign Het
Nid2 C A 14: 19,841,635 (GRCm39) Q887K probably benign Het
Nop16 A T 13: 54,737,550 (GRCm39) S48T possibly damaging Het
Nrap G A 19: 56,354,859 (GRCm39) T489I possibly damaging Het
Oas1e C T 5: 120,929,951 (GRCm39) G189D probably damaging Het
Or4a39 A G 2: 89,237,250 (GRCm39) Y58H possibly damaging Het
Or7g34 A T 9: 19,477,949 (GRCm39) C244S probably damaging Het
Pcdha5 A T 18: 37,095,171 (GRCm39) D560V probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Phldb2 C T 16: 45,594,603 (GRCm39) D901N possibly damaging Het
Piezo1 T C 8: 123,212,035 (GRCm39) H2058R Het
Ptgis T A 2: 167,048,758 (GRCm39) K419N possibly damaging Het
Ptprz1 T C 6: 23,022,266 (GRCm39) F1714L probably damaging Het
Rasa2 T C 9: 96,434,353 (GRCm39) probably null Het
Recql C T 6: 142,320,611 (GRCm39) D146N probably damaging Het
Rnf6 T G 5: 146,148,602 (GRCm39) S139R probably damaging Het
Rock1 A G 18: 10,067,631 (GRCm39) S1301P probably damaging Het
Safb2 A G 17: 56,889,982 (GRCm39) probably null Het
Setd5 T A 6: 113,087,850 (GRCm39) I137N probably damaging Het
Sf3b6 G A 12: 4,870,619 (GRCm39) R19Q probably damaging Het
Slc15a5 T A 6: 138,020,496 (GRCm39) H279L possibly damaging Het
Slc26a9 A G 1: 131,681,711 (GRCm39) T175A probably damaging Het
Sspo A T 6: 48,470,820 (GRCm39) N36I probably damaging Het
Supv3l1 A C 10: 62,268,090 (GRCm39) F585C probably damaging Het
Tnrc6c G T 11: 117,632,507 (GRCm39) V1070L probably benign Het
Zc3h13 A G 14: 75,546,349 (GRCm39) D150G unknown Het
Zfp607b T C 7: 27,402,921 (GRCm39) V459A probably benign Het
Zfp653 T C 9: 21,982,427 (GRCm39) R71G probably damaging Het
Other mutations in Vmn2r53
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Vmn2r53 APN 7 12,334,835 (GRCm39) missense possibly damaging 0.70
IGL01997:Vmn2r53 APN 7 12,316,373 (GRCm39) missense possibly damaging 0.54
IGL02442:Vmn2r53 APN 7 12,315,656 (GRCm39) missense probably damaging 1.00
IGL02449:Vmn2r53 APN 7 12,316,288 (GRCm39) missense probably damaging 1.00
IGL02589:Vmn2r53 APN 7 12,315,872 (GRCm39) missense possibly damaging 0.93
IGL02986:Vmn2r53 APN 7 12,315,393 (GRCm39) unclassified probably benign
IGL03064:Vmn2r53 APN 7 12,334,937 (GRCm39) missense possibly damaging 0.89
IGL03093:Vmn2r53 APN 7 12,334,791 (GRCm39) missense probably benign 0.03
IGL03244:Vmn2r53 APN 7 12,340,435 (GRCm39) missense probably damaging 1.00
IGL03252:Vmn2r53 APN 7 12,340,318 (GRCm39) missense probably damaging 1.00
IGL03264:Vmn2r53 APN 7 12,315,819 (GRCm39) missense possibly damaging 0.95
IGL03293:Vmn2r53 APN 7 12,332,349 (GRCm39) missense probably benign 0.34
R0109:Vmn2r53 UTSW 7 12,315,993 (GRCm39) missense probably damaging 1.00
R0453:Vmn2r53 UTSW 7 12,316,338 (GRCm39) missense probably damaging 1.00
R0735:Vmn2r53 UTSW 7 12,315,707 (GRCm39) missense probably benign
R0881:Vmn2r53 UTSW 7 12,334,859 (GRCm39) missense probably benign 0.01
R0894:Vmn2r53 UTSW 7 12,335,141 (GRCm39) missense probably benign 0.00
R0973:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0973:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0974:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0990:Vmn2r53 UTSW 7 12,315,429 (GRCm39) missense probably benign
R1102:Vmn2r53 UTSW 7 12,332,410 (GRCm39) missense possibly damaging 0.94
R1141:Vmn2r53 UTSW 7 12,334,673 (GRCm39) missense possibly damaging 0.54
R1263:Vmn2r53 UTSW 7 12,315,533 (GRCm39) missense probably benign 0.41
R1343:Vmn2r53 UTSW 7 12,318,701 (GRCm39) missense probably benign 0.08
R1750:Vmn2r53 UTSW 7 12,315,632 (GRCm39) missense probably damaging 1.00
R1836:Vmn2r53 UTSW 7 12,334,812 (GRCm39) missense probably damaging 1.00
R2035:Vmn2r53 UTSW 7 12,332,438 (GRCm39) missense possibly damaging 0.76
R2202:Vmn2r53 UTSW 7 12,335,366 (GRCm39) missense probably damaging 1.00
R3707:Vmn2r53 UTSW 7 12,315,981 (GRCm39) missense possibly damaging 0.95
R4372:Vmn2r53 UTSW 7 12,315,656 (GRCm39) missense probably damaging 0.98
R4615:Vmn2r53 UTSW 7 12,316,229 (GRCm39) missense probably damaging 1.00
R4655:Vmn2r53 UTSW 7 12,315,932 (GRCm39) missense possibly damaging 0.83
R4663:Vmn2r53 UTSW 7 12,334,901 (GRCm39) missense probably benign 0.21
R4708:Vmn2r53 UTSW 7 12,335,129 (GRCm39) missense probably benign
R4710:Vmn2r53 UTSW 7 12,335,129 (GRCm39) missense probably benign
R4774:Vmn2r53 UTSW 7 12,334,692 (GRCm39) nonsense probably null
R4859:Vmn2r53 UTSW 7 12,335,330 (GRCm39) missense probably damaging 1.00
R5061:Vmn2r53 UTSW 7 12,315,741 (GRCm39) missense probably benign 0.01
R5561:Vmn2r53 UTSW 7 12,335,347 (GRCm39) missense probably damaging 1.00
R5729:Vmn2r53 UTSW 7 12,334,733 (GRCm39) missense probably damaging 1.00
R6004:Vmn2r53 UTSW 7 12,316,328 (GRCm39) missense probably benign 0.12
R6083:Vmn2r53 UTSW 7 12,315,808 (GRCm39) missense probably benign
R6312:Vmn2r53 UTSW 7 12,332,566 (GRCm39) critical splice acceptor site probably null
R6700:Vmn2r53 UTSW 7 12,315,633 (GRCm39) missense probably damaging 0.96
R6783:Vmn2r53 UTSW 7 12,335,360 (GRCm39) missense probably damaging 1.00
R6852:Vmn2r53 UTSW 7 12,340,441 (GRCm39) missense probably damaging 0.99
R6889:Vmn2r53 UTSW 7 12,335,069 (GRCm39) missense probably benign 0.10
R6940:Vmn2r53 UTSW 7 12,316,343 (GRCm39) missense probably benign 0.19
R7100:Vmn2r53 UTSW 7 12,315,513 (GRCm39) nonsense probably null
R7174:Vmn2r53 UTSW 7 12,315,628 (GRCm39) missense probably benign 0.01
R7213:Vmn2r53 UTSW 7 12,334,983 (GRCm39) missense probably benign 0.17
R7276:Vmn2r53 UTSW 7 12,340,359 (GRCm39) missense probably damaging 0.99
R7678:Vmn2r53 UTSW 7 12,332,425 (GRCm39) missense probably benign 0.04
R7714:Vmn2r53 UTSW 7 12,340,418 (GRCm39) missense probably damaging 1.00
R7843:Vmn2r53 UTSW 7 12,316,026 (GRCm39) missense probably damaging 1.00
R8208:Vmn2r53 UTSW 7 12,335,322 (GRCm39) missense probably damaging 1.00
R8211:Vmn2r53 UTSW 7 12,315,843 (GRCm39) missense probably benign 0.01
R8478:Vmn2r53 UTSW 7 12,340,281 (GRCm39) missense probably benign 0.01
R8853:Vmn2r53 UTSW 7 12,315,737 (GRCm39) missense probably damaging 1.00
R8924:Vmn2r53 UTSW 7 12,334,752 (GRCm39) missense probably benign 0.17
R8963:Vmn2r53 UTSW 7 12,315,926 (GRCm39) missense probably damaging 1.00
R9042:Vmn2r53 UTSW 7 12,315,435 (GRCm39) missense probably benign
R9076:Vmn2r53 UTSW 7 12,340,231 (GRCm39) missense probably damaging 1.00
R9407:Vmn2r53 UTSW 7 12,335,124 (GRCm39) missense probably damaging 0.99
R9690:Vmn2r53 UTSW 7 12,315,912 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r53 UTSW 7 12,335,231 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGTCCAGACACTGCAGAAG -3'
(R):5'- GTATTCACAGTGGCTGTCTCC -3'

Sequencing Primer
(F):5'- TGCAGAAGAGCAGCATGC -3'
(R):5'- CTCCGTTCTGGCTAAGACTCTAACAG -3'
Posted On 2019-10-17