Incidental Mutation 'R7516:Or4g7'
ID 582436
Institutional Source Beutler Lab
Gene Symbol Or4g7
Ensembl Gene ENSMUSG00000044039
Gene Name olfactory receptor family 4 subfamily G member 7
Synonyms Olfr1288, GA_x6K02T2Q125-72530279-72531217, MOR245-9
MMRRC Submission 045589-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R7516 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111309131-111310069 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 111309282 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 51 (V51D)
Ref Sequence ENSEMBL: ENSMUSP00000150331 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104889] [ENSMUST00000120021] [ENSMUST00000207494] [ENSMUST00000214816]
AlphaFold Q7TQY0
Predicted Effect probably benign
Transcript: ENSMUST00000104889
AA Change: V51D

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000100485
Gene: ENSMUSG00000044039
AA Change: V51D

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 1.3e-43 PFAM
Pfam:7tm_1 41 287 2.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120021
Predicted Effect probably benign
Transcript: ENSMUST00000207494
Predicted Effect probably benign
Transcript: ENSMUST00000214816
AA Change: V51D

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam28 T A 14: 68,868,125 (GRCm39) I407F probably damaging Het
Agbl1 A G 7: 76,075,669 (GRCm39) Y437C probably damaging Het
Alkbh5 T C 11: 60,429,979 (GRCm39) V244A probably damaging Het
Arap1 T C 7: 101,058,538 (GRCm39) F1390L probably benign Het
Asph T C 4: 9,630,940 (GRCm39) D136G possibly damaging Het
Atp8a2 A T 14: 60,094,516 (GRCm39) Y841N probably damaging Het
Cald1 A T 6: 34,686,492 (GRCm39) probably benign Het
Capn11 A G 17: 45,949,766 (GRCm39) I400T possibly damaging Het
Cdh18 T A 15: 23,259,684 (GRCm39) probably null Het
Ces2h T A 8: 105,743,458 (GRCm39) L204Q probably damaging Het
Chrna3 G A 9: 54,922,653 (GRCm39) A385V probably benign Het
Clca4a A T 3: 144,672,009 (GRCm39) L311Q probably damaging Het
Clip1 A G 5: 123,721,448 (GRCm39) V1149A probably benign Het
Clip3 T A 7: 29,998,268 (GRCm39) V238D possibly damaging Het
Col12a1 A G 9: 79,520,192 (GRCm39) probably null Het
Coro2a A G 4: 46,562,992 (GRCm39) V54A probably benign Het
Crem T C 18: 3,299,141 (GRCm39) probably null Het
Dennd5b T C 6: 148,969,878 (GRCm39) I192V probably benign Het
Dst A G 1: 34,209,560 (GRCm39) N1209S probably benign Het
Ero1a T A 14: 45,525,480 (GRCm39) M385L probably benign Het
Fam13a A T 6: 58,932,248 (GRCm39) V375D probably damaging Het
Fgfbp3 T A 19: 36,896,324 (GRCm39) Y98F possibly damaging Het
Frem3 T C 8: 81,338,712 (GRCm39) V335A probably damaging Het
Gm19410 T A 8: 36,263,433 (GRCm39) D951E probably benign Het
Gpatch1 T C 7: 35,007,625 (GRCm39) D145G probably benign Het
H60c G T 10: 3,209,746 (GRCm39) C180* probably null Het
Hmcn1 T C 1: 150,498,718 (GRCm39) T4054A probably benign Het
Hrg A G 16: 22,780,048 (GRCm39) Y442C unknown Het
Hspg2 C T 4: 137,269,931 (GRCm39) R2327C possibly damaging Het
Klhl31 G T 9: 77,558,429 (GRCm39) A382S probably damaging Het
Knl1 T C 2: 118,901,179 (GRCm39) V960A probably damaging Het
Lztr1 C T 16: 17,327,525 (GRCm39) A76V possibly damaging Het
Me3 G T 7: 89,497,183 (GRCm39) E395* probably null Het
Morc2b G A 17: 33,356,435 (GRCm39) H446Y probably benign Het
Mroh7 A T 4: 106,548,316 (GRCm39) M1054K probably benign Het
Ms4a6b T C 19: 11,506,907 (GRCm39) V232A probably benign Het
Nmt2 C A 2: 3,313,767 (GRCm39) D224E probably damaging Het
Nox4 C A 7: 86,970,905 (GRCm39) R261S probably benign Het
Obscn T A 11: 59,015,416 (GRCm39) K1019* probably null Het
Or4a15 T A 2: 89,193,719 (GRCm39) N18I probably benign Het
Or5p67 G A 7: 107,922,223 (GRCm39) S220F probably damaging Het
Or8k24 C T 2: 86,216,328 (GRCm39) V145I probably benign Het
Pcdha11 A T 18: 37,144,671 (GRCm39) N254I probably damaging Het
Pck2 T A 14: 55,779,913 (GRCm39) I54N probably benign Het
Pkd1l3 T A 8: 110,361,861 (GRCm39) W978R probably damaging Het
Plxna4 T C 6: 32,214,703 (GRCm39) T593A probably benign Het
Podn G A 4: 107,879,321 (GRCm39) R266W probably damaging Het
Ptpn22 A G 3: 103,792,854 (GRCm39) D335G probably benign Het
Pxn A G 5: 115,644,922 (GRCm39) D3G unknown Het
Rapgefl1 T G 11: 98,736,960 (GRCm39) V320G probably benign Het
Rel A G 11: 23,692,785 (GRCm39) I416T probably benign Het
Sema5b A G 16: 35,471,540 (GRCm39) N378D probably benign Het
Sh3bp4 C A 1: 89,073,368 (GRCm39) L739M probably damaging Het
Skint2 A T 4: 112,483,168 (GRCm39) D191V probably damaging Het
Slc3a1 T C 17: 85,371,190 (GRCm39) Y581H probably damaging Het
Smcr8 G T 11: 60,670,814 (GRCm39) C654F probably benign Het
Spta1 A C 1: 174,025,349 (GRCm39) Q738P probably damaging Het
Sptlc3 C A 2: 139,431,438 (GRCm39) A320D probably benign Het
Thnsl2 T A 6: 71,108,990 (GRCm39) K274* probably null Het
Tmed2 T A 5: 124,685,055 (GRCm39) I68K possibly damaging Het
Tmtc4 G A 14: 123,180,735 (GRCm39) A326V possibly damaging Het
Tnks2 T A 19: 36,849,064 (GRCm39) S179T possibly damaging Het
Trim34b G T 7: 103,978,918 (GRCm39) C55F probably damaging Het
Trpm4 T A 7: 44,954,444 (GRCm39) E1129V probably damaging Het
Tvp23b T C 11: 62,782,867 (GRCm39) S188P possibly damaging Het
Usp1 A G 4: 98,822,356 (GRCm39) T557A probably damaging Het
Vmn2r66 C T 7: 84,661,176 (GRCm39) C18Y possibly damaging Het
Vmn2r85 T A 10: 130,254,852 (GRCm39) T611S probably damaging Het
Vps13c T C 9: 67,862,289 (GRCm39) S2969P possibly damaging Het
Wdr74 T A 19: 8,713,554 (GRCm39) C62* probably null Het
Wfikkn1 A T 17: 26,097,020 (GRCm39) C435S probably damaging Het
Zbtb45 A T 7: 12,740,269 (GRCm39) F449I probably damaging Het
Other mutations in Or4g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01800:Or4g7 APN 2 111,309,209 (GRCm39) missense probably benign
IGL02021:Or4g7 APN 2 111,309,825 (GRCm39) missense probably benign 0.03
IGL02061:Or4g7 APN 2 111,309,614 (GRCm39) missense possibly damaging 0.94
R2016:Or4g7 UTSW 2 111,309,532 (GRCm39) missense probably benign 0.00
R2017:Or4g7 UTSW 2 111,309,532 (GRCm39) missense probably benign 0.00
R2848:Or4g7 UTSW 2 111,309,699 (GRCm39) missense probably benign 0.00
R2849:Or4g7 UTSW 2 111,309,699 (GRCm39) missense probably benign 0.00
R3421:Or4g7 UTSW 2 111,309,297 (GRCm39) missense probably benign 0.12
R4223:Or4g7 UTSW 2 111,309,489 (GRCm39) missense probably benign 0.00
R4432:Or4g7 UTSW 2 111,309,757 (GRCm39) nonsense probably null
R4433:Or4g7 UTSW 2 111,309,757 (GRCm39) nonsense probably null
R4476:Or4g7 UTSW 2 111,310,009 (GRCm39) missense possibly damaging 0.58
R4631:Or4g7 UTSW 2 111,309,908 (GRCm39) missense probably damaging 1.00
R6029:Or4g7 UTSW 2 111,309,310 (GRCm39) nonsense probably null
R6036:Or4g7 UTSW 2 111,309,333 (GRCm39) missense probably damaging 1.00
R6036:Or4g7 UTSW 2 111,309,333 (GRCm39) missense probably damaging 1.00
R6084:Or4g7 UTSW 2 111,309,734 (GRCm39) missense probably damaging 1.00
R6329:Or4g7 UTSW 2 111,309,573 (GRCm39) missense possibly damaging 0.90
R7307:Or4g7 UTSW 2 111,309,105 (GRCm39) start gained probably benign
R7577:Or4g7 UTSW 2 111,309,477 (GRCm39) missense probably damaging 0.98
R8108:Or4g7 UTSW 2 111,309,579 (GRCm39) missense possibly damaging 0.90
R8210:Or4g7 UTSW 2 111,309,753 (GRCm39) missense possibly damaging 0.89
R8465:Or4g7 UTSW 2 111,309,425 (GRCm39) missense probably benign 0.01
R8717:Or4g7 UTSW 2 111,309,992 (GRCm39) missense probably damaging 1.00
R8730:Or4g7 UTSW 2 111,309,934 (GRCm39) missense probably damaging 1.00
R9360:Or4g7 UTSW 2 111,309,684 (GRCm39) missense probably benign 0.10
Z1177:Or4g7 UTSW 2 111,309,552 (GRCm39) missense probably damaging 1.00
Z1177:Or4g7 UTSW 2 111,309,159 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TCCCAACTTTCTGATCCAATGG -3'
(R):5'- AGAGGCTTGCAGATTGCTATATATCTG -3'

Sequencing Primer
(F):5'- GGACCAAGTTAATGCTTCTGC -3'
(R):5'- TCATATGCCATGGCTATGAGC -3'
Posted On 2019-10-17