Incidental Mutation 'R7520:Or8g19'
ID 582632
Institutional Source Beutler Lab
Gene Symbol Or8g19
Ensembl Gene ENSMUSG00000049708
Gene Name olfactory receptor family 8 subfamily G member 19
Synonyms MOR171-6, GA_x6K02T2PVTD-32841223-32842158, Olfr27, MTPCR56, Olfr242, GA_x6K02T2KYVW-1037-120
MMRRC Submission 045592-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R7520 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39039463-39056368 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 39055414 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 6 (R6L)
Ref Sequence ENSEMBL: ENSMUSP00000151012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214052] [ENSMUST00000216405]
AlphaFold Q9EQ90
Predicted Effect probably benign
Transcript: ENSMUST00000214052
AA Change: R6L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216405
AA Change: R6L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 T C 4: 144,281,859 (GRCm39) Y311C probably damaging Het
Abca1 A T 4: 53,078,114 (GRCm39) I886N probably benign Het
Adamts6 A G 13: 104,433,694 (GRCm39) H41R probably benign Het
Adck1 T C 12: 88,425,975 (GRCm39) probably null Het
Atat1 G T 17: 36,208,706 (GRCm39) T398K probably benign Het
Bahcc1 A G 11: 120,167,031 (GRCm39) E1144G possibly damaging Het
Cand2 G T 6: 115,762,212 (GRCm39) E213* probably null Het
Cep350 A G 1: 155,791,375 (GRCm39) S1250P probably benign Het
Cln3 A G 7: 126,180,852 (GRCm39) L63P probably damaging Het
Col4a4 A T 1: 82,484,808 (GRCm39) C486* probably null Het
Ctnnal1 A T 4: 56,837,838 (GRCm39) M264K probably damaging Het
Ddr2 T A 1: 169,812,008 (GRCm39) D738V probably damaging Het
Dnah6 T C 6: 73,104,887 (GRCm39) M1901V probably benign Het
Dnhd1 A G 7: 105,345,255 (GRCm39) T2200A probably benign Het
Dolk A G 2: 30,174,555 (GRCm39) Y497H probably benign Het
Drd5 T C 5: 38,478,195 (GRCm39) V396A probably benign Het
Epsti1 A T 14: 78,200,883 (GRCm39) probably null Het
Erich3 A G 3: 154,468,763 (GRCm39) T1072A unknown Het
Ero1a A T 14: 45,544,032 (GRCm39) N57K probably damaging Het
Exph5 T C 9: 53,278,514 (GRCm39) probably null Het
Frmd5 C T 2: 121,384,745 (GRCm39) probably null Het
H2-Q7 A G 17: 35,661,686 (GRCm39) T310A probably benign Het
Hecw2 G T 1: 53,965,215 (GRCm39) A537E probably benign Het
Itga4 A T 2: 79,131,333 (GRCm39) D567V probably damaging Het
Kcnu1 A T 8: 26,375,368 (GRCm39) N361Y probably damaging Het
Keap1 A G 9: 21,144,787 (GRCm39) S408P probably benign Het
Mamdc4 T A 2: 25,455,360 (GRCm39) I928F possibly damaging Het
Mboat4 T C 8: 34,591,028 (GRCm39) F155S probably benign Het
Mtbp A G 15: 55,440,742 (GRCm39) probably benign Het
Nmi T G 2: 51,842,492 (GRCm39) K200T probably benign Het
Or2n1e G A 17: 38,586,331 (GRCm39) C223Y probably benign Het
Pcdha7 G A 18: 37,108,366 (GRCm39) V464M probably damaging Het
Peg10 T A 6: 4,756,796 (GRCm39) N457K unknown Het
Plekha7 A T 7: 115,736,519 (GRCm39) I944N possibly damaging Het
Plpp1 T A 13: 112,937,781 (GRCm39) D13E possibly damaging Het
Pnpla6 G T 8: 3,587,508 (GRCm39) V1070F probably damaging Het
Riox1 T A 12: 83,998,545 (GRCm39) Y360* probably null Het
Sdhb A G 4: 140,693,882 (GRCm39) D50G possibly damaging Het
Slc35f2 T A 9: 53,708,385 (GRCm39) V126D possibly damaging Het
Slmap A G 14: 26,148,575 (GRCm39) V612A probably benign Het
Snap91 T A 9: 86,721,702 (GRCm39) I46F probably damaging Het
Sp110 G A 1: 85,506,813 (GRCm39) R417C probably benign Het
Taar7b T C 10: 23,876,381 (GRCm39) L182P probably damaging Het
Tmc1 T A 19: 20,776,542 (GRCm39) M606L probably damaging Het
Trpm8 T A 1: 88,271,043 (GRCm39) D444E probably benign Het
Tsen54 A G 11: 115,711,797 (GRCm39) T405A probably damaging Het
Ttll5 T C 12: 85,946,245 (GRCm39) W492R probably damaging Het
Ttn T A 2: 76,728,123 (GRCm39) T5566S unknown Het
Utp20 A T 10: 88,654,457 (GRCm39) M210K probably damaging Het
Zfand1 A G 3: 10,411,009 (GRCm39) V115A probably damaging Het
Other mutations in Or8g19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Or8g19 APN 9 39,056,053 (GRCm39) missense possibly damaging 0.94
IGL00905:Or8g19 APN 9 39,056,326 (GRCm39) missense probably damaging 1.00
IGL02346:Or8g19 APN 9 39,055,939 (GRCm39) missense probably damaging 1.00
R0117:Or8g19 UTSW 9 39,056,146 (GRCm39) missense probably damaging 1.00
R0118:Or8g19 UTSW 9 39,055,399 (GRCm39) start codon destroyed probably null 0.97
R0590:Or8g19 UTSW 9 39,056,017 (GRCm39) missense probably benign 0.01
R2915:Or8g19 UTSW 9 39,055,762 (GRCm39) missense possibly damaging 0.94
R4299:Or8g19 UTSW 9 39,056,295 (GRCm39) missense probably benign 0.11
R4367:Or8g19 UTSW 9 39,055,725 (GRCm39) missense probably damaging 0.98
R4663:Or8g19 UTSW 9 39,056,145 (GRCm39) missense probably damaging 0.97
R5276:Or8g19 UTSW 9 39,055,611 (GRCm39) missense probably damaging 1.00
R5503:Or8g19 UTSW 9 39,055,780 (GRCm39) missense probably benign 0.02
R5742:Or8g19 UTSW 9 39,055,974 (GRCm39) missense probably benign 0.07
R5986:Or8g19 UTSW 9 39,056,278 (GRCm39) missense probably null 1.00
R6801:Or8g19 UTSW 9 39,055,506 (GRCm39) missense probably benign 0.01
R7247:Or8g19 UTSW 9 39,056,153 (GRCm39) nonsense probably null
R7787:Or8g19 UTSW 9 39,055,548 (GRCm39) missense probably benign 0.22
R8360:Or8g19 UTSW 9 39,055,761 (GRCm39) nonsense probably null
R8721:Or8g19 UTSW 9 39,055,386 (GRCm39) start gained probably benign
R8880:Or8g19 UTSW 9 39,055,899 (GRCm39) missense probably damaging 1.00
R8883:Or8g19 UTSW 9 39,056,083 (GRCm39) missense probably benign 0.00
R9143:Or8g19 UTSW 9 39,055,722 (GRCm39) missense possibly damaging 0.94
R9445:Or8g19 UTSW 9 39,055,766 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GACACAGTAGGATATCTTTGCACAC -3'
(R):5'- GAAATAGTACATGGGTGTGTGC -3'

Sequencing Primer
(F):5'- TGAGGCATAGTTTTGAACACATG -3'
(R):5'- TGCAGGTGGGAACTGAGCC -3'
Posted On 2019-10-17