Mutagenetix > Incidental Mutations

Incidental Mutation 'R7523:Fam96b'

582787

Institutional Source

Beutler Lab

Gene Symbol

Fam96b

Ensembl Gene

ENSMUSG00000031879

Gene Name

family with sequence similarity 96, member B

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.945) question?

Stock #

R7523 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

104639838-104641965 bp(-) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

G to A at 104641772 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132725 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093234] [ENSMUST00000163140] [ENSMUST00000164884]

Predicted Effect

probably benign
Transcript: ENSMUST00000093234

SMART Domains

Protein: ENSMUSP00000090921
Gene: ENSMUSG00000031879

Domain	Start	End	E-Value	Type
low complexity region	3	10	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163140

Predicted Effect

probably benign
Transcript: ENSMUST00000164884

SMART Domains

Protein: ENSMUSP00000132725
Gene: ENSMUSG00000031879

Domain	Start	End	E-Value	Type
low complexity region	3	10	N/A	INTRINSIC
Pfam:DUF59	43	121	8.8e-20	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (46/46)

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	T	A	2: 68,662,480	H40Q	unknown	Het
4932414N04Rik	A	T	2: 68,739,329	Q463L	probably benign	Het
Ano4	C	A	10: 88,971,395	E775*	probably null	Het
Atp12a	T	C	14: 56,365,968	V10A	possibly damaging	Het
Camkmt	A	G	17: 85,391,628	I144M	probably benign	Het
Cyth1	TGGGCAA	T	11: 118,183,923		probably null	Het
Dazl	G	A	17: 50,287,541	T162I	probably damaging	Het
Dnah10	A	G	5: 124,747,739	K653R	probably damaging	Het
Exosc10	A	T	4: 148,563,842		probably null	Het
Fbn2	T	C	18: 58,066,080	D1372G	probably benign	Het
Fxr1	T	C	3: 34,039,543	V23A	probably benign	Het
Gmps	T	C	3: 64,011,666	I557T	possibly damaging	Het
Ifnab	A	T	4: 88,690,792	Y146N	probably damaging	Het
Krt78	T	C	15: 101,946,601	Y925C	not run	Het
Lrp1b	C	T	2: 41,511,461	V394M		Het
Ltbp2	T	C	12: 84,791,034	T1211A	probably benign	Het
Man2a2	G	C	7: 80,368,865	A82G	probably benign	Het
Mdn1	A	T	4: 32,667,270		probably null	Het
Myo15b	A	T	11: 115,890,858	I2798F	unknown	Het
Nat3	T	C	8: 67,547,574	I35T	probably damaging	Het
Nectin2	A	G	7: 19,730,112	V314A	probably benign	Het
Nexn	T	C	3: 152,247,178	R316G	probably benign	Het
Nfx1	A	G	4: 41,016,119	I894V	probably benign	Het
Olfr1045	T	C	2: 86,198,045	K236E	probably damaging	Het
Olfr15	T	C	16: 3,839,699	V242A	probably benign	Het
Pdcd4	G	T	19: 53,910,948	V123F	probably damaging	Het
Pik3c3	C	T	18: 30,293,655	R275W	probably damaging	Het
Ppt2	A	G	17: 34,626,803		probably null	Het
Prss35	T	A	9: 86,755,374	C66S	probably damaging	Het
Ptbp3	A	G	4: 59,546,159	V11A	probably benign	Het
Ptpn22	A	G	3: 103,912,015	N795S	probably damaging	Het
Ptprg	T	G	14: 12,237,130	I1383S	probably damaging	Het
Rtel1	G	A	2: 181,322,315	V36M	probably damaging	Het
Sf3b3	A	G	8: 110,813,720	I1023T	probably benign	Het
Slc44a2	A	G	9: 21,345,992	E411G	probably null	Het
Stard9	T	C	2: 120,699,597	Y2112H	probably benign	Het
Tada2b	T	C	5: 36,476,767	I156V	probably benign	Het
Tenm2	A	T	11: 36,078,581		probably null	Het
Tle1	A	T	4: 72,145,418	S199R	possibly damaging	Het
Tubgcp2	A	G	7: 140,006,870	I399T	probably benign	Het
Ubr5	T	C	15: 38,004,055	N1344S		Het
Vmn2r114	A	G	17: 23,310,637	F164L	probably benign	Het
Vps13a	G	T	19: 16,703,789	T1041K	probably benign	Het
Zbtb20	T	C	16: 43,610,512	V389A	probably benign	Het
Zfp811	A	T	17: 32,797,752	I438N	probably benign	Het
Zfp90	A	G	8: 106,423,913	D86G	probably benign	Het

Other mutations in Fam96b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0362:Fam96b	UTSW	8	104641590	missense	probably null	0.95
R1635:Fam96b	UTSW	8	104640988	missense	possibly damaging	0.73
R1699:Fam96b	UTSW	8	104640086	missense	probably damaging	1.00
R3080:Fam96b	UTSW	8	104641627	missense	possibly damaging	0.66
R5358:Fam96b	UTSW	8	104641650	missense	probably damaging	1.00
R7998:Fam96b	UTSW	8	104641036	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCAGCGACGGATATCGAAG -3'
(R):5'- TTAGTGCCCTTGTCAGACGG -3'

Sequencing Primer
(F):5'- GATGCTGTCCGGCACTTC -3'
(R):5'- GTTGGCTTCCTGCGATCCAG -3'

Posted On

2019-10-17