Incidental Mutation 'R7528:Vmn2r60'
| ID |
583125 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r60
|
| Ensembl Gene |
ENSMUSG00000090619 |
| Gene Name |
vomeronasal 2, receptor 60 |
| Synonyms |
Casr-rs3, EG637898, Gprc2a-rs3 |
| MMRRC Submission |
045600-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.100)
|
| Stock # |
R7528 (G1)
|
| Quality Score |
217.468 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41765895-41845200 bp(+) (GRCm39) |
| Type of Mutation |
frame shift |
| DNA Base Change (assembly) |
AG to A
at 41845158 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128493
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166447]
|
| AlphaFold |
A0A3B2WBC8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000166447
|
| SMART Domains |
Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
471 |
1.2e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
1.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (57/57) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 58 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc4 |
T |
C |
14: 118,767,317 (GRCm39) |
E920G |
probably damaging |
Het |
| Acss2 |
A |
C |
2: 155,399,066 (GRCm39) |
N443H |
probably damaging |
Het |
| Adam3 |
C |
A |
8: 25,167,279 (GRCm39) |
A71S |
unknown |
Het |
| Agpat3 |
A |
G |
10: 78,123,746 (GRCm39) |
L38P |
probably damaging |
Het |
| Akap9 |
C |
G |
5: 4,018,745 (GRCm39) |
H1109D |
probably benign |
Het |
| Amtn |
C |
A |
5: 88,526,711 (GRCm39) |
|
probably null |
Het |
| App |
T |
G |
16: 84,775,146 (GRCm39) |
Y497S |
possibly damaging |
Het |
| Bphl |
T |
A |
13: 34,244,473 (GRCm39) |
Y197N |
probably damaging |
Het |
| Btrc |
T |
A |
19: 45,491,525 (GRCm39) |
M160K |
possibly damaging |
Het |
| Ccdc181 |
A |
C |
1: 164,107,527 (GRCm39) |
N70T |
probably benign |
Het |
| Cd55b |
T |
C |
1: 130,347,473 (GRCm39) |
N113D |
possibly damaging |
Het |
| Ctrb1 |
T |
A |
8: 112,413,783 (GRCm39) |
I194F |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,391,622 (GRCm39) |
H691R |
probably damaging |
Het |
| Dnajc13 |
A |
G |
9: 104,056,164 (GRCm39) |
V1579A |
possibly damaging |
Het |
| Dst |
T |
A |
1: 34,333,603 (GRCm39) |
F5030I |
probably damaging |
Het |
| Eppk1 |
G |
A |
15: 76,004,308 (GRCm39) |
|
probably benign |
Het |
| Fbxw4 |
T |
C |
19: 45,648,449 (GRCm39) |
E7G |
unknown |
Het |
| Fos |
T |
A |
12: 85,522,432 (GRCm39) |
C154S |
probably damaging |
Het |
| Foxh1 |
A |
G |
15: 76,553,511 (GRCm39) |
V97A |
probably benign |
Het |
| Gmeb1 |
G |
A |
4: 131,959,361 (GRCm39) |
T231I |
possibly damaging |
Het |
| Golga3 |
T |
A |
5: 110,360,098 (GRCm39) |
V1112E |
probably damaging |
Het |
| Gprin3 |
T |
C |
6: 59,331,017 (GRCm39) |
D430G |
possibly damaging |
Het |
| Hpse2 |
T |
C |
19: 42,801,463 (GRCm39) |
D441G |
probably damaging |
Het |
| Hydin |
G |
A |
8: 111,107,204 (GRCm39) |
W460* |
probably null |
Het |
| Ifi204 |
T |
C |
1: 173,579,406 (GRCm39) |
I480V |
probably benign |
Het |
| Impg2 |
T |
C |
16: 56,080,743 (GRCm39) |
V849A |
possibly damaging |
Het |
| Kars1 |
T |
C |
8: 112,737,866 (GRCm39) |
D12G |
probably benign |
Het |
| Klhdc7a |
A |
T |
4: 139,694,828 (GRCm39) |
Y40N |
probably damaging |
Het |
| Krtap5-3 |
T |
C |
7: 141,755,219 (GRCm39) |
C19R |
unknown |
Het |
| Macf1 |
G |
A |
4: 123,325,852 (GRCm39) |
A5217V |
possibly damaging |
Het |
| Mlc1 |
A |
T |
15: 88,858,710 (GRCm39) |
I146N |
possibly damaging |
Het |
| Myo3a |
A |
T |
2: 22,270,925 (GRCm39) |
R129* |
probably null |
Het |
| Nsun4 |
G |
T |
4: 115,891,391 (GRCm39) |
Y329* |
probably null |
Het |
| Or4k1 |
A |
G |
14: 50,377,277 (GRCm39) |
V273A |
possibly damaging |
Het |
| Or56a3b |
T |
C |
7: 104,771,071 (GRCm39) |
Y136H |
probably damaging |
Het |
| Pard3 |
G |
A |
8: 128,329,646 (GRCm39) |
R1214H |
probably damaging |
Het |
| Phf20 |
T |
A |
2: 156,144,928 (GRCm39) |
Y845* |
probably null |
Het |
| Pik3c2a |
A |
G |
7: 115,993,474 (GRCm39) |
I431T |
probably damaging |
Het |
| Plxna2 |
A |
G |
1: 194,494,464 (GRCm39) |
S1894G |
probably damaging |
Het |
| Ppp1r7 |
C |
T |
1: 93,282,123 (GRCm39) |
Q225* |
probably null |
Het |
| Ppp4r1 |
C |
A |
17: 66,120,493 (GRCm39) |
T209K |
probably damaging |
Het |
| Prc1 |
T |
C |
7: 79,950,183 (GRCm39) |
|
probably null |
Het |
| Prex2 |
T |
G |
1: 11,274,316 (GRCm39) |
D1329E |
probably damaging |
Het |
| Ptch1 |
C |
T |
13: 63,659,528 (GRCm39) |
R1375H |
probably benign |
Het |
| Rab24 |
A |
T |
13: 55,468,921 (GRCm39) |
C87S |
probably damaging |
Het |
| Rnf43 |
A |
T |
11: 87,622,954 (GRCm39) |
Y558F |
probably benign |
Het |
| Serpinb6e |
T |
C |
13: 34,016,474 (GRCm39) |
I420V |
possibly damaging |
Het |
| Slain2 |
C |
A |
5: 73,072,143 (GRCm39) |
S59* |
probably null |
Het |
| Slfn3 |
A |
G |
11: 83,105,731 (GRCm39) |
D576G |
probably benign |
Het |
| Sptbn4 |
A |
G |
7: 27,141,960 (GRCm39) |
M11T |
probably benign |
Het |
| Tdh |
T |
C |
14: 63,731,460 (GRCm39) |
D238G |
probably damaging |
Het |
| Top2b |
T |
A |
14: 16,395,427 (GRCm38) |
Y337* |
probably null |
Het |
| Trav15-2-dv6-2 |
A |
C |
14: 53,887,308 (GRCm39) |
Y76S |
probably benign |
Het |
| Vmn1r172 |
G |
T |
7: 23,359,189 (GRCm39) |
G25C |
probably damaging |
Het |
| Vps13d |
T |
C |
4: 144,818,492 (GRCm39) |
E3125G |
|
Het |
| Xkr6 |
G |
T |
14: 64,056,610 (GRCm39) |
V430F |
probably benign |
Het |
| Zfp142 |
T |
C |
1: 74,610,061 (GRCm39) |
T1245A |
probably benign |
Het |
| Zfp960 |
C |
T |
17: 17,307,825 (GRCm39) |
H180Y |
possibly damaging |
Het |
|
| Other mutations in Vmn2r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01622:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01623:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02363:Vmn2r60
|
APN |
7 |
41,844,578 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02485:Vmn2r60
|
APN |
7 |
41,844,890 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02651:Vmn2r60
|
APN |
7 |
41,845,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02660:Vmn2r60
|
APN |
7 |
41,791,720 (GRCm39) |
nonsense |
probably null |
|
|
IGL03135:Vmn2r60
|
APN |
7 |
41,786,018 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03307:Vmn2r60
|
APN |
7 |
41,765,971 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0310:Vmn2r60
|
UTSW |
7 |
41,844,564 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R0314:Vmn2r60
|
UTSW |
7 |
41,784,985 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r60
|
UTSW |
7 |
41,791,744 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Vmn2r60
|
UTSW |
7 |
41,785,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0755:Vmn2r60
|
UTSW |
7 |
41,844,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1119:Vmn2r60
|
UTSW |
7 |
41,844,365 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1162:Vmn2r60
|
UTSW |
7 |
41,845,195 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1241:Vmn2r60
|
UTSW |
7 |
41,786,476 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1488:Vmn2r60
|
UTSW |
7 |
41,786,137 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1623:Vmn2r60
|
UTSW |
7 |
41,785,279 (GRCm39) |
nonsense |
probably null |
|
|
R1628:Vmn2r60
|
UTSW |
7 |
41,785,830 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1884:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Vmn2r60
|
UTSW |
7 |
41,844,931 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2275:Vmn2r60
|
UTSW |
7 |
41,786,251 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Vmn2r60
|
UTSW |
7 |
41,785,857 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2885:Vmn2r60
|
UTSW |
7 |
41,790,403 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2894:Vmn2r60
|
UTSW |
7 |
41,785,220 (GRCm39) |
missense |
probably benign |
|
|
R2921:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2922:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3772:Vmn2r60
|
UTSW |
7 |
41,765,980 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3820:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3822:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3872:Vmn2r60
|
UTSW |
7 |
41,785,878 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4222:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4223:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4224:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4526:Vmn2r60
|
UTSW |
7 |
41,844,667 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4547:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R4840:Vmn2r60
|
UTSW |
7 |
41,785,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5173:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5231:Vmn2r60
|
UTSW |
7 |
41,786,448 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5480:Vmn2r60
|
UTSW |
7 |
41,785,154 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5521:Vmn2r60
|
UTSW |
7 |
41,845,049 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5834:Vmn2r60
|
UTSW |
7 |
41,765,932 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6112:Vmn2r60
|
UTSW |
7 |
41,844,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6149:Vmn2r60
|
UTSW |
7 |
41,786,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6170:Vmn2r60
|
UTSW |
7 |
41,785,045 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6383:Vmn2r60
|
UTSW |
7 |
41,765,895 (GRCm39) |
start codon destroyed |
probably null |
0.04 |
|
R6811:Vmn2r60
|
UTSW |
7 |
41,844,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6876:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R6997:Vmn2r60
|
UTSW |
7 |
41,791,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7040:Vmn2r60
|
UTSW |
7 |
41,791,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7116:Vmn2r60
|
UTSW |
7 |
41,786,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Vmn2r60
|
UTSW |
7 |
41,844,536 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7232:Vmn2r60
|
UTSW |
7 |
41,786,166 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7296:Vmn2r60
|
UTSW |
7 |
41,785,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7376:Vmn2r60
|
UTSW |
7 |
41,844,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7526:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7527:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7764:Vmn2r60
|
UTSW |
7 |
41,844,535 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7843:Vmn2r60
|
UTSW |
7 |
41,844,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8080:Vmn2r60
|
UTSW |
7 |
41,790,521 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8290:Vmn2r60
|
UTSW |
7 |
41,791,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8342:Vmn2r60
|
UTSW |
7 |
41,790,494 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8362:Vmn2r60
|
UTSW |
7 |
41,844,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8418:Vmn2r60
|
UTSW |
7 |
41,844,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8848:Vmn2r60
|
UTSW |
7 |
41,786,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Vmn2r60
|
UTSW |
7 |
41,791,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8882:Vmn2r60
|
UTSW |
7 |
41,790,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8913:Vmn2r60
|
UTSW |
7 |
41,785,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9190:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9229:Vmn2r60
|
UTSW |
7 |
41,791,723 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9295:Vmn2r60
|
UTSW |
7 |
41,785,955 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9335:Vmn2r60
|
UTSW |
7 |
41,844,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9796:Vmn2r60
|
UTSW |
7 |
41,785,172 (GRCm39) |
missense |
probably benign |
|
|
RF024:Vmn2r60
|
UTSW |
7 |
41,790,363 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Vmn2r60
|
UTSW |
7 |
41,790,538 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGTCATTCAGCATGCAG -3'
(R):5'- CTGTAGGCTAACAAGGGCACAG -3'
Sequencing Primer
(F):5'- CAGCATGCAGATATTCTTCTGTG -3'
(R):5'- TAACAAGGGCACAGAGTAAAACTATG -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation