Incidental Mutation 'R7535:Slc22a29'
ID 583558
Institutional Source Beutler Lab
Gene Symbol Slc22a29
Ensembl Gene ENSMUSG00000075044
Gene Name solute carrier family 22. member 29
Synonyms D630002G06Rik
MMRRC Submission 045607-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7535 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 8160165-8218900 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 8169978 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 340 (F340S)
Ref Sequence ENSEMBL: ENSMUSP00000108923 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113298] [ENSMUST00000222533]
AlphaFold Q8BWG6
Predicted Effect probably damaging
Transcript: ENSMUST00000113298
AA Change: F340S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108923
Gene: ENSMUSG00000075044
AA Change: F340S

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:Sugar_tr 99 528 1.3e-25 PFAM
Pfam:MFS_1 140 372 7.7e-14 PFAM
Pfam:MFS_1 348 549 6.5e-11 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000222533
AA Change: F340S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (82/82)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T A 10: 80,001,629 (GRCm38) L449Q probably benign Het
Agtpbp1 T C 13: 59,504,253 (GRCm38) T415A probably benign Het
Akt3 A T 1: 177,097,034 (GRCm38) V165D probably damaging Het
Cbr2 T A 11: 120,729,802 (GRCm38) I219F probably damaging Het
Cdh20 T A 1: 104,975,043 (GRCm38) D486E probably damaging Het
Cenpe A G 3: 135,243,762 (GRCm38) S103G possibly damaging Het
Chd4 T A 6: 125,128,873 (GRCm38) S1818T probably benign Het
Chst5 T C 8: 111,890,163 (GRCm38) D275G probably damaging Het
Clca1 A G 3: 145,018,567 (GRCm38) I244T probably damaging Het
Cyp2c54 A G 19: 40,070,272 (GRCm38) Y239H probably benign Het
Czib T G 4: 107,894,900 (GRCm38) S159A probably benign Het
Ddx25 A G 9: 35,543,655 (GRCm38) F446L possibly damaging Het
Dgkb T C 12: 38,136,647 (GRCm38) L265P probably damaging Het
Dis3 A G 14: 99,089,979 (GRCm38) S363P probably benign Het
Disp3 T C 4: 148,242,866 (GRCm38) E1187G probably damaging Het
Dop1b G A 16: 93,806,361 (GRCm38) G2061R probably damaging Het
Dsp T C 13: 38,192,789 (GRCm38) S1517P probably benign Het
Epg5 T A 18: 78,032,926 (GRCm38) V2513E probably benign Het
Fryl T A 5: 73,098,196 (GRCm38) T831S probably benign Het
Gm6309 A T 5: 146,168,290 (GRCm38) V271D probably damaging Het
H2-M2 G T 17: 37,482,637 (GRCm38) S159R probably benign Het
Helq A G 5: 100,790,133 (GRCm38) probably null Het
Herc1 G C 9: 66,474,853 (GRCm38) D3621H probably damaging Het
Hsd11b2 A T 8: 105,519,123 (GRCm38) I87F probably damaging Het
Ice2 A G 9: 69,432,078 (GRCm38) N959S probably damaging Het
Ifi47 T A 11: 49,096,625 (GRCm38) D406E probably damaging Het
Ifit3 T G 19: 34,587,880 (GRCm38) S275R probably damaging Het
Insl5 C A 4: 103,018,198 (GRCm38) K118N probably damaging Het
Irf7 A T 7: 141,264,637 (GRCm38) F158I probably benign Het
Kat2b T C 17: 53,624,403 (GRCm38) L143P probably damaging Het
Klk1b1 A T 7: 43,970,322 (GRCm38) N102Y probably damaging Het
Krt13 C T 11: 100,117,998 (GRCm38) G410S unknown Het
Larp6 A T 9: 60,724,154 (GRCm38) T70S probably benign Het
Lrrc37a T C 11: 103,501,857 (GRCm38) E914G possibly damaging Het
Mindy4 T C 6: 55,297,753 (GRCm38) probably null Het
Myl10 G C 5: 136,697,971 (GRCm38) V70L probably benign Het
Myom2 A G 8: 15,117,679 (GRCm38) Y1088C probably damaging Het
Mysm1 T C 4: 94,952,215 (GRCm38) N655D probably benign Het
Nbas T A 12: 13,279,389 (GRCm38) S112T probably damaging Het
Neb A G 2: 52,165,103 (GRCm38) probably null Het
Noxred1 G A 12: 87,233,432 (GRCm38) A42V probably benign Het
Olfm5 G A 7: 104,154,237 (GRCm38) P340S possibly damaging Het
Or11h4 G A 14: 50,736,665 (GRCm38) P166S probably benign Het
Or2l5 T C 16: 19,514,794 (GRCm38) T281A probably damaging Het
Or5al5 A G 2: 86,131,264 (GRCm38) V133A probably benign Het
Or5m8 T A 2: 85,991,901 (GRCm38) V28E probably benign Het
Or9i1b A G 19: 13,919,085 (GRCm38) K22E probably benign Het
Pccb A T 9: 100,994,562 (GRCm38) probably null Het
Pnn T A 12: 59,072,137 (GRCm38) V502E probably benign Het
Pole2 A T 12: 69,222,429 (GRCm38) I98K probably benign Het
Ptpn18 G A 1: 34,473,364 (GRCm38) D417N possibly damaging Het
Rasgrp4 A G 7: 29,139,059 (GRCm38) K111E probably benign Het
Rbbp6 G A 7: 122,990,143 (GRCm38) M351I probably benign Het
Rgs19 T G 2: 181,691,308 (GRCm38) H53P probably damaging Het
Rin1 A T 19: 5,052,536 (GRCm38) T369S probably benign Het
Rnaset2b G A 17: 6,991,739 (GRCm38) E135K possibly damaging Het
Rprd2 G A 3: 95,776,587 (GRCm38) P379S probably damaging Het
Sbno1 A G 5: 124,413,279 (GRCm38) L47P possibly damaging Het
Slamf6 T A 1: 171,919,758 (GRCm38) L29Q unknown Het
Slc16a14 T C 1: 84,913,122 (GRCm38) Y154C probably damaging Het
Slc6a4 T G 11: 77,015,150 (GRCm38) I259S possibly damaging Het
Smarca4 G A 9: 21,647,625 (GRCm38) V651I possibly damaging Het
Susd5 C T 9: 114,064,040 (GRCm38) A62V possibly damaging Het
Syt1 T A 10: 108,627,422 (GRCm38) probably null Het
Taf10 T C 7: 105,740,910 (GRCm38) I218T probably benign Het
Tas1r1 C A 4: 152,028,362 (GRCm38) V745F probably benign Het
Tas2r125 C A 6: 132,910,324 (GRCm38) T225K probably damaging Het
Tcp11l2 G T 10: 84,594,659 (GRCm38) R216L possibly damaging Het
Tnks1bp1 C T 2: 85,063,280 (GRCm38) Q1184* probably null Het
Treml2 T A 17: 48,302,819 (GRCm38) V93D probably damaging Het
Trim11 G A 11: 58,982,065 (GRCm38) E192K probably damaging Het
Trim43a A G 9: 88,588,148 (GRCm38) K336E probably damaging Het
Tspan33 T A 6: 29,717,589 (GRCm38) I268N possibly damaging Het
Tstd2 C T 4: 46,116,960 (GRCm38) C458Y probably damaging Het
Ttc6 A G 12: 57,576,519 (GRCm38) S235G probably benign Het
Usp29 A C 7: 6,961,220 (GRCm38) T21P possibly damaging Het
Usp36 A T 11: 118,262,046 (GRCm38) S1084T possibly damaging Het
Vps39 T A 2: 120,324,695 (GRCm38) N550I probably damaging Het
Wdr47 A G 3: 108,629,711 (GRCm38) I572V probably benign Het
Zfp112 A T 7: 24,126,710 (GRCm38) Y705F probably damaging Het
Zfp282 A G 6: 47,904,944 (GRCm38) T522A probably benign Het
Zfp292 T C 4: 34,811,487 (GRCm38) D524G probably benign Het
Zfp90 A T 8: 106,424,268 (GRCm38) K204N possibly damaging Het
Zmym2 T C 14: 56,957,079 (GRCm38) S1265P probably damaging Het
Other mutations in Slc22a29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00230:Slc22a29 APN 19 8,217,813 (GRCm38) missense probably benign 0.44
IGL00562:Slc22a29 APN 19 8,161,629 (GRCm38) missense probably benign 0.03
IGL00563:Slc22a29 APN 19 8,161,629 (GRCm38) missense probably benign 0.03
IGL00952:Slc22a29 APN 19 8,217,857 (GRCm38) missense probably damaging 1.00
IGL01526:Slc22a29 APN 19 8,207,178 (GRCm38) splice site probably benign
IGL01792:Slc22a29 APN 19 8,218,529 (GRCm38) missense probably damaging 1.00
IGL02191:Slc22a29 APN 19 8,218,681 (GRCm38) unclassified probably benign
IGL02391:Slc22a29 APN 19 8,169,353 (GRCm38) missense probably benign 0.13
IGL02408:Slc22a29 APN 19 8,207,285 (GRCm38) missense probably benign 0.00
IGL02957:Slc22a29 APN 19 8,169,990 (GRCm38) missense probably benign 0.01
IGL03059:Slc22a29 APN 19 8,169,990 (GRCm38) missense probably benign 0.01
IGL03299:Slc22a29 APN 19 8,162,648 (GRCm38) critical splice donor site probably null
IGL03368:Slc22a29 APN 19 8,207,262 (GRCm38) critical splice donor site probably null
R0017:Slc22a29 UTSW 19 8,218,266 (GRCm38) splice site probably benign
R0105:Slc22a29 UTSW 19 8,160,627 (GRCm38) unclassified probably benign
R0157:Slc22a29 UTSW 19 8,162,742 (GRCm38) missense possibly damaging 0.61
R0265:Slc22a29 UTSW 19 8,169,970 (GRCm38) missense probably benign 0.18
R1758:Slc22a29 UTSW 19 8,217,762 (GRCm38) critical splice donor site probably null
R1918:Slc22a29 UTSW 19 8,217,759 (GRCm38) splice site probably null
R1927:Slc22a29 UTSW 19 8,207,066 (GRCm38) missense probably benign 0.01
R1959:Slc22a29 UTSW 19 8,169,193 (GRCm38) missense probably benign 0.05
R1960:Slc22a29 UTSW 19 8,169,193 (GRCm38) missense probably benign 0.05
R1961:Slc22a29 UTSW 19 8,169,193 (GRCm38) missense probably benign 0.05
R1966:Slc22a29 UTSW 19 8,218,408 (GRCm38) missense probably damaging 1.00
R1968:Slc22a29 UTSW 19 8,218,343 (GRCm38) missense probably benign 0.27
R1997:Slc22a29 UTSW 19 8,217,798 (GRCm38) missense probably benign 0.00
R3105:Slc22a29 UTSW 19 8,169,973 (GRCm38) missense probably benign 0.25
R3725:Slc22a29 UTSW 19 8,218,609 (GRCm38) missense possibly damaging 0.78
R4118:Slc22a29 UTSW 19 8,160,529 (GRCm38) unclassified probably benign
R4465:Slc22a29 UTSW 19 8,162,724 (GRCm38) nonsense probably null
R4584:Slc22a29 UTSW 19 8,169,291 (GRCm38) missense probably benign 0.02
R4656:Slc22a29 UTSW 19 8,218,300 (GRCm38) missense possibly damaging 0.90
R4679:Slc22a29 UTSW 19 8,161,584 (GRCm38) missense possibly damaging 0.65
R4899:Slc22a29 UTSW 19 8,161,569 (GRCm38) missense probably benign 0.00
R4913:Slc22a29 UTSW 19 8,218,358 (GRCm38) missense probably benign 0.17
R5119:Slc22a29 UTSW 19 8,217,830 (GRCm38) missense probably damaging 0.99
R5470:Slc22a29 UTSW 19 8,161,516 (GRCm38) missense probably benign 0.01
R5474:Slc22a29 UTSW 19 8,217,857 (GRCm38) missense probably damaging 1.00
R6794:Slc22a29 UTSW 19 8,161,523 (GRCm38) missense probably benign 0.06
R6798:Slc22a29 UTSW 19 8,160,604 (GRCm38) missense probably benign 0.16
R7025:Slc22a29 UTSW 19 8,160,580 (GRCm38) missense probably benign
R7240:Slc22a29 UTSW 19 8,161,511 (GRCm38) missense probably damaging 0.98
R7846:Slc22a29 UTSW 19 8,193,487 (GRCm38) missense probably benign 0.39
R8169:Slc22a29 UTSW 19 8,207,332 (GRCm38) missense probably damaging 1.00
R8275:Slc22a29 UTSW 19 8,169,317 (GRCm38) missense probably benign 0.00
R8403:Slc22a29 UTSW 19 8,161,640 (GRCm38) missense possibly damaging 0.95
R8872:Slc22a29 UTSW 19 8,160,567 (GRCm38) missense probably damaging 0.99
R9129:Slc22a29 UTSW 19 8,169,305 (GRCm38) missense probably benign 0.03
R9381:Slc22a29 UTSW 19 8,218,477 (GRCm38) missense probably benign 0.03
R9550:Slc22a29 UTSW 19 8,217,860 (GRCm38) nonsense probably null
R9645:Slc22a29 UTSW 19 8,207,124 (GRCm38) missense probably benign 0.04
R9673:Slc22a29 UTSW 19 8,162,740 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCTCACTGCACAGTAAGTTCC -3'
(R):5'- CTGTAGAAATCCCCTGAGTGTC -3'

Sequencing Primer
(F):5'- TCACTGCACAGTAAGTTCCATATAC -3'
(R):5'- AGAAATCCCCTGAGTGTCTTTTTG -3'
Posted On 2019-10-17