Incidental Mutation 'R7537:Zfp936'
ID 583650
Institutional Source Beutler Lab
Gene Symbol Zfp936
Ensembl Gene ENSMUSG00000064194
Gene Name zinc finger protein 936
Synonyms EG435970, Gm9272, I1C0022H11Rik
MMRRC Submission 045609-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.686) question?
Stock # R7537 (G1)
Quality Score 153.008
Status Validated
Chromosome 7
Chromosomal Location 42763653-42841533 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 42839239 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 235 (C235*)
Ref Sequence ENSEMBL: ENSMUSP00000143800 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072829] [ENSMUST00000200973] [ENSMUST00000202535] [ENSMUST00000205912]
AlphaFold Q3ULA8
Predicted Effect probably null
Transcript: ENSMUST00000072829
AA Change: C234*
SMART Domains Protein: ENSMUSP00000072608
Gene: ENSMUSG00000064194
AA Change: C234*

DomainStartEndE-ValueType
KRAB 3 65 5.32e-19 SMART
ZnF_C2H2 148 170 5.9e-3 SMART
ZnF_C2H2 176 198 5.9e-3 SMART
ZnF_C2H2 204 226 1.4e-4 SMART
ZnF_C2H2 232 254 1.2e-3 SMART
ZnF_C2H2 260 282 7.37e-4 SMART
ZnF_C2H2 288 310 2.27e-4 SMART
ZnF_C2H2 316 338 2.09e-3 SMART
ZnF_C2H2 344 366 1.45e-2 SMART
ZnF_C2H2 372 394 1.82e-3 SMART
ZnF_C2H2 400 422 2.53e-2 SMART
ZnF_C2H2 428 450 4.54e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000200973
SMART Domains Protein: ENSMUSP00000144191
Gene: ENSMUSG00000064194

DomainStartEndE-ValueType
KRAB 4 66 1.4e-21 SMART
Predicted Effect probably null
Transcript: ENSMUST00000202535
AA Change: C235*
SMART Domains Protein: ENSMUSP00000143800
Gene: ENSMUSG00000064194
AA Change: C235*

DomainStartEndE-ValueType
KRAB 4 66 2.3e-21 SMART
ZnF_C2H2 149 171 2.6e-5 SMART
ZnF_C2H2 177 199 2.5e-5 SMART
ZnF_C2H2 205 227 5.9e-7 SMART
ZnF_C2H2 233 255 5.1e-6 SMART
ZnF_C2H2 261 283 3.1e-6 SMART
ZnF_C2H2 289 311 9.4e-7 SMART
ZnF_C2H2 317 339 8.7e-6 SMART
ZnF_C2H2 345 367 6.3e-5 SMART
ZnF_C2H2 373 395 7.7e-6 SMART
ZnF_C2H2 401 423 1.1e-4 SMART
ZnF_C2H2 429 451 2e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205912
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,967,637 (GRCm39) L2229P possibly damaging Het
Acaca T A 11: 84,151,460 (GRCm39) M786K probably damaging Het
Acta2 G A 19: 34,229,931 (GRCm39) T8I probably benign Het
Adap1 T G 5: 139,278,928 (GRCm39) E117D possibly damaging Het
Ap5z1 T C 5: 142,463,053 (GRCm39) S746P probably benign Het
Appl2 A G 10: 83,453,292 (GRCm39) I208T possibly damaging Het
Astn1 A G 1: 158,332,956 (GRCm39) E346G possibly damaging Het
Astn1 G A 1: 158,495,208 (GRCm39) probably null Het
Atp23 T A 10: 126,704,594 (GRCm39) I180L unknown Het
Bean1 CT C 8: 104,908,664 (GRCm39) probably null Het
Cdh23 A T 10: 60,220,724 (GRCm39) I1340N probably benign Het
Cdh8 G A 8: 99,825,517 (GRCm39) Q493* probably null Het
Ces1g T C 8: 94,046,455 (GRCm39) I357V probably benign Het
Ddx46 A G 13: 55,798,291 (GRCm39) D226G probably damaging Het
Eea1 C T 10: 95,830,767 (GRCm39) Q143* probably null Het
Erlin2 G T 8: 27,521,800 (GRCm39) probably null Het
Fat3 T A 9: 15,849,615 (GRCm39) D3929V probably damaging Het
Flt3 T C 5: 147,271,247 (GRCm39) D898G probably damaging Het
Gm16519 A G 17: 71,236,351 (GRCm39) N100S probably benign Het
Gnl1 A G 17: 36,299,428 (GRCm39) H533R probably damaging Het
Gphn A G 12: 78,551,454 (GRCm39) T301A possibly damaging Het
Herc2 C T 7: 55,869,527 (GRCm39) R4295* probably null Het
Insm2 T C 12: 55,646,303 (GRCm39) S16P possibly damaging Het
Jak2 C T 19: 29,276,037 (GRCm39) T778I probably benign Het
Lrriq3 A G 3: 154,806,734 (GRCm39) T128A probably damaging Het
Lst1 A G 17: 35,405,920 (GRCm39) probably null Het
Magi1 G T 6: 93,685,091 (GRCm39) Y762* probably null Het
Man2b1 T A 8: 85,817,594 (GRCm39) C358* probably null Het
Mga T C 2: 119,766,032 (GRCm39) V1432A probably damaging Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Morc2a C T 11: 3,633,566 (GRCm39) Q587* probably null Het
Mrc2 T C 11: 105,183,623 (GRCm39) I4T probably benign Het
Muc16 C A 9: 18,549,431 (GRCm39) V5621F probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Myo3b A G 2: 70,047,513 (GRCm39) R340G probably benign Het
Nipal3 T C 4: 135,218,248 (GRCm39) Y34C probably damaging Het
Nktr T A 9: 121,578,345 (GRCm39) D804E unknown Het
Nlrp4b A G 7: 10,448,816 (GRCm39) M340V probably benign Het
Or1e26 T A 11: 73,480,094 (GRCm39) T157S probably benign Het
Or2ag2b G A 7: 106,417,581 (GRCm39) C97Y probably damaging Het
Or56a41 A T 7: 104,741,978 (GRCm39) M16K probably benign Het
Or5al5 A G 2: 85,961,608 (GRCm39) V133A probably benign Het
Pard3 T A 8: 128,337,063 (GRCm39) N1271K probably damaging Het
Pcdhb11 A T 18: 37,554,672 (GRCm39) M1L possibly damaging Het
Pclo T C 5: 14,732,118 (GRCm39) V3540A unknown Het
Pemt A G 11: 59,867,670 (GRCm39) F154S probably damaging Het
Ptpn18 G A 1: 34,512,445 (GRCm39) D417N possibly damaging Het
Rnpc3 G T 3: 113,407,481 (GRCm39) T376K probably benign Het
Rpe65 A G 3: 159,310,246 (GRCm39) Y143C probably damaging Het
Sbk2 T C 7: 4,966,148 (GRCm39) E12G probably benign Het
Slc2a5 T C 4: 150,213,526 (GRCm39) I106T possibly damaging Het
Snx13 A G 12: 35,135,981 (GRCm39) D92G probably damaging Het
Sorl1 C T 9: 41,891,984 (GRCm39) V1889I probably benign Het
Spag17 A T 3: 99,846,563 (GRCm39) N29I possibly damaging Het
Speg T C 1: 75,378,108 (GRCm39) V878A probably damaging Het
Timp4 A G 6: 115,227,421 (GRCm39) S53P probably damaging Het
Tssk1 G T 16: 17,712,948 (GRCm39) E244D probably benign Het
Usp29 A C 7: 6,964,219 (GRCm39) T21P possibly damaging Het
Vmn2r85 A T 10: 130,258,735 (GRCm39) V440E probably benign Het
Wdr59 T C 8: 112,217,001 (GRCm39) D270G Het
Zbbx G A 3: 74,992,826 (GRCm39) P223S probably damaging Het
Zranb3 A T 1: 127,960,584 (GRCm39) probably null Het
Other mutations in Zfp936
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02231:Zfp936 APN 7 42,836,909 (GRCm39) splice site probably null
IGL02245:Zfp936 APN 7 42,836,722 (GRCm39) critical splice donor site probably null
IGL02335:Zfp936 APN 7 42,836,691 (GRCm39) missense probably damaging 1.00
FR4340:Zfp936 UTSW 7 42,838,913 (GRCm39) missense possibly damaging 0.63
R0437:Zfp936 UTSW 7 42,838,734 (GRCm39) missense probably benign 0.00
R3899:Zfp936 UTSW 7 42,839,158 (GRCm39) missense possibly damaging 0.93
R4120:Zfp936 UTSW 7 42,839,630 (GRCm39) missense probably benign 0.10
R4406:Zfp936 UTSW 7 42,839,748 (GRCm39) missense possibly damaging 0.82
R4959:Zfp936 UTSW 7 42,839,034 (GRCm39) missense probably damaging 1.00
R5023:Zfp936 UTSW 7 42,836,681 (GRCm39) missense probably damaging 1.00
R5163:Zfp936 UTSW 7 42,839,664 (GRCm39) missense probably damaging 1.00
R5182:Zfp936 UTSW 7 42,839,331 (GRCm39) missense probably damaging 1.00
R5292:Zfp936 UTSW 7 42,838,759 (GRCm39) nonsense probably null
R5668:Zfp936 UTSW 7 42,839,858 (GRCm39) missense possibly damaging 0.93
R6057:Zfp936 UTSW 7 42,839,787 (GRCm39) missense probably benign 0.00
R6901:Zfp936 UTSW 7 42,839,467 (GRCm39) missense probably damaging 1.00
R7139:Zfp936 UTSW 7 42,839,715 (GRCm39) missense possibly damaging 0.54
R7258:Zfp936 UTSW 7 42,839,803 (GRCm39) missense probably damaging 1.00
R7440:Zfp936 UTSW 7 42,836,685 (GRCm39) missense probably damaging 1.00
R7561:Zfp936 UTSW 7 42,839,339 (GRCm39) missense probably damaging 0.98
R7662:Zfp936 UTSW 7 42,839,336 (GRCm39) nonsense probably null
R7775:Zfp936 UTSW 7 42,839,720 (GRCm39) missense possibly damaging 0.70
R7778:Zfp936 UTSW 7 42,839,720 (GRCm39) missense possibly damaging 0.70
R8016:Zfp936 UTSW 7 42,838,848 (GRCm39) missense possibly damaging 0.61
R8121:Zfp936 UTSW 7 42,839,547 (GRCm39) missense possibly damaging 0.55
R9012:Zfp936 UTSW 7 42,839,416 (GRCm39) nonsense probably null
R9058:Zfp936 UTSW 7 42,839,196 (GRCm39) missense probably benign 0.32
R9188:Zfp936 UTSW 7 42,839,768 (GRCm39) missense probably benign 0.00
R9236:Zfp936 UTSW 7 42,836,922 (GRCm39) missense probably benign 0.00
R9596:Zfp936 UTSW 7 42,839,834 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTGCTTGCATGTCAAAGTACTC -3'
(R):5'- GGTGTGAAAAGGCTTTATCACAC -3'

Sequencing Primer
(F):5'- CCAGCTATCTTCGAATGCATGAAAG -3'
(R):5'- TGAAAAGGCTTTATCACACTGATTAC -3'
Posted On 2019-10-17