Mutagenetix > Incidental Mutation

Incidental Mutation 'R7537:Or1e26'

583673

Institutional Source

Beutler Lab

Gene Symbol

Or1e26

Ensembl Gene

ENSMUSG00000095095

Gene Name

olfactory receptor family 1 subfamily E member 26

Synonyms

Olfr385, GA_x6K02T2P1NL-3760313-3759375, MOR135-3

MMRRC Submission

045609-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.150) question?

Stock #

R7537 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

73479624-73480562 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 73480094 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 157 (T157S)

Ref Sequence

ENSEMBL: ENSMUSP00000149293 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071553] [ENSMUST00000215689]

AlphaFold

Q8VGT1

Predicted Effect

probably benign
Transcript: ENSMUST00000071553
AA Change: T157S

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000071484
Gene: ENSMUSG00000095095
AA Change: T157S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	6.1e-55	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.7e-6	PFAM
Pfam:7tm_1	41	290	2.2e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215689
AA Change: T157S

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.9%

Validation Efficiency

100% (63/63)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	C	3: 121,967,637 (GRCm39)	L2229P	possibly damaging	Het
Acaca	T	A	11: 84,151,460 (GRCm39)	M786K	probably damaging	Het
Acta2	G	A	19: 34,229,931 (GRCm39)	T8I	probably benign	Het
Adap1	T	G	5: 139,278,928 (GRCm39)	E117D	possibly damaging	Het
Ap5z1	T	C	5: 142,463,053 (GRCm39)	S746P	probably benign	Het
Appl2	A	G	10: 83,453,292 (GRCm39)	I208T	possibly damaging	Het
Astn1	A	G	1: 158,332,956 (GRCm39)	E346G	possibly damaging	Het
Astn1	G	A	1: 158,495,208 (GRCm39)		probably null	Het
Atp23	T	A	10: 126,704,594 (GRCm39)	I180L	unknown	Het
Bean1	CT	C	8: 104,908,664 (GRCm39)		probably null	Het
Cdh23	A	T	10: 60,220,724 (GRCm39)	I1340N	probably benign	Het
Cdh8	G	A	8: 99,825,517 (GRCm39)	Q493*	probably null	Het
Ces1g	T	C	8: 94,046,455 (GRCm39)	I357V	probably benign	Het
Ddx46	A	G	13: 55,798,291 (GRCm39)	D226G	probably damaging	Het
Eea1	C	T	10: 95,830,767 (GRCm39)	Q143*	probably null	Het
Erlin2	G	T	8: 27,521,800 (GRCm39)		probably null	Het
Fat3	T	A	9: 15,849,615 (GRCm39)	D3929V	probably damaging	Het
Flt3	T	C	5: 147,271,247 (GRCm39)	D898G	probably damaging	Het
Gm16519	A	G	17: 71,236,351 (GRCm39)	N100S	probably benign	Het
Gnl1	A	G	17: 36,299,428 (GRCm39)	H533R	probably damaging	Het
Gphn	A	G	12: 78,551,454 (GRCm39)	T301A	possibly damaging	Het
Herc2	C	T	7: 55,869,527 (GRCm39)	R4295*	probably null	Het
Insm2	T	C	12: 55,646,303 (GRCm39)	S16P	possibly damaging	Het
Jak2	C	T	19: 29,276,037 (GRCm39)	T778I	probably benign	Het
Lrriq3	A	G	3: 154,806,734 (GRCm39)	T128A	probably damaging	Het
Lst1	A	G	17: 35,405,920 (GRCm39)		probably null	Het
Magi1	G	T	6: 93,685,091 (GRCm39)	Y762*	probably null	Het
Man2b1	T	A	8: 85,817,594 (GRCm39)	C358*	probably null	Het
Mga	T	C	2: 119,766,032 (GRCm39)	V1432A	probably damaging	Het
Mmp1a	TG	TGG	9: 7,465,083 (GRCm38)		probably null	Het
Morc2a	C	T	11: 3,633,566 (GRCm39)	Q587*	probably null	Het
Mrc2	T	C	11: 105,183,623 (GRCm39)	I4T	probably benign	Het
Muc16	C	A	9: 18,549,431 (GRCm39)	V5621F	probably benign	Het
Myl10	G	C	5: 136,726,825 (GRCm39)	V70L	probably benign	Het
Myo3b	A	G	2: 70,047,513 (GRCm39)	R340G	probably benign	Het
Nipal3	T	C	4: 135,218,248 (GRCm39)	Y34C	probably damaging	Het
Nktr	T	A	9: 121,578,345 (GRCm39)	D804E	unknown	Het
Nlrp4b	A	G	7: 10,448,816 (GRCm39)	M340V	probably benign	Het
Or2ag2b	G	A	7: 106,417,581 (GRCm39)	C97Y	probably damaging	Het
Or56a41	A	T	7: 104,741,978 (GRCm39)	M16K	probably benign	Het
Or5al5	A	G	2: 85,961,608 (GRCm39)	V133A	probably benign	Het
Pard3	T	A	8: 128,337,063 (GRCm39)	N1271K	probably damaging	Het
Pcdhb11	A	T	18: 37,554,672 (GRCm39)	M1L	possibly damaging	Het
Pclo	T	C	5: 14,732,118 (GRCm39)	V3540A	unknown	Het
Pemt	A	G	11: 59,867,670 (GRCm39)	F154S	probably damaging	Het
Ptpn18	G	A	1: 34,512,445 (GRCm39)	D417N	possibly damaging	Het
Rnpc3	G	T	3: 113,407,481 (GRCm39)	T376K	probably benign	Het
Rpe65	A	G	3: 159,310,246 (GRCm39)	Y143C	probably damaging	Het
Sbk2	T	C	7: 4,966,148 (GRCm39)	E12G	probably benign	Het
Slc2a5	T	C	4: 150,213,526 (GRCm39)	I106T	possibly damaging	Het
Snx13	A	G	12: 35,135,981 (GRCm39)	D92G	probably damaging	Het
Sorl1	C	T	9: 41,891,984 (GRCm39)	V1889I	probably benign	Het
Spag17	A	T	3: 99,846,563 (GRCm39)	N29I	possibly damaging	Het
Speg	T	C	1: 75,378,108 (GRCm39)	V878A	probably damaging	Het
Timp4	A	G	6: 115,227,421 (GRCm39)	S53P	probably damaging	Het
Tssk1	G	T	16: 17,712,948 (GRCm39)	E244D	probably benign	Het
Usp29	A	C	7: 6,964,219 (GRCm39)	T21P	possibly damaging	Het
Vmn2r85	A	T	10: 130,258,735 (GRCm39)	V440E	probably benign	Het
Wdr59	T	C	8: 112,217,001 (GRCm39)	D270G		Het
Zbbx	G	A	3: 74,992,826 (GRCm39)	P223S	probably damaging	Het
Zfp936	T	A	7: 42,839,239 (GRCm39)	C235*	probably null	Het
Zranb3	A	T	1: 127,960,584 (GRCm39)		probably null	Het

Other mutations in Or1e26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01570:Or1e26	APN	11	73,480,209 (GRCm39)	missense	probably benign	0.34
IGL02045:Or1e26	APN	11	73,480,058 (GRCm39)	missense	probably damaging	1.00
IGL02324:Or1e26	APN	11	73,480,081 (GRCm39)	missense	probably benign	0.02
IGL02328:Or1e26	APN	11	73,480,081 (GRCm39)	missense	probably benign	0.02
IGL02562:Or1e26	APN	11	73,480,237 (GRCm39)	missense	probably benign
IGL02715:Or1e26	APN	11	73,479,947 (GRCm39)	missense	probably benign	0.00
IGL03182:Or1e26	APN	11	73,480,268 (GRCm39)	missense	probably benign	0.04
IGL03048:Or1e26	UTSW	11	73,479,831 (GRCm39)	missense	possibly damaging	0.56
R0346:Or1e26	UTSW	11	73,480,283 (GRCm39)	missense	probably damaging	1.00
R0675:Or1e26	UTSW	11	73,480,078 (GRCm39)	missense	probably damaging	1.00
R0751:Or1e26	UTSW	11	73,479,970 (GRCm39)	missense	probably benign	0.02
R1220:Or1e26	UTSW	11	73,480,203 (GRCm39)	nonsense	probably null
R1389:Or1e26	UTSW	11	73,480,369 (GRCm39)	missense	possibly damaging	0.88
R1484:Or1e26	UTSW	11	73,480,187 (GRCm39)	missense	possibly damaging	0.91
R1619:Or1e26	UTSW	11	73,480,118 (GRCm39)	missense	probably damaging	1.00
R2290:Or1e26	UTSW	11	73,479,745 (GRCm39)	missense	probably benign	0.37
R3713:Or1e26	UTSW	11	73,479,731 (GRCm39)	missense	probably damaging	1.00
R3781:Or1e26	UTSW	11	73,480,194 (GRCm39)	nonsense	probably null
R3781:Or1e26	UTSW	11	73,479,839 (GRCm39)	missense	probably damaging	1.00
R3782:Or1e26	UTSW	11	73,480,194 (GRCm39)	nonsense	probably null
R3782:Or1e26	UTSW	11	73,479,839 (GRCm39)	missense	probably damaging	1.00
R4402:Or1e26	UTSW	11	73,480,081 (GRCm39)	missense	probably benign	0.02
R4721:Or1e26	UTSW	11	73,480,273 (GRCm39)	missense	probably damaging	1.00
R5157:Or1e26	UTSW	11	73,480,549 (GRCm39)	missense	probably damaging	1.00
R5995:Or1e26	UTSW	11	73,480,076 (GRCm39)	missense	probably benign
R6373:Or1e26	UTSW	11	73,479,724 (GRCm39)	missense	probably benign	0.42
R6658:Or1e26	UTSW	11	73,479,874 (GRCm39)	missense	probably damaging	0.99
R7046:Or1e26	UTSW	11	73,480,558 (GRCm39)	missense	probably benign
R7096:Or1e26	UTSW	11	73,480,463 (GRCm39)	missense	probably benign	0.03
R7238:Or1e26	UTSW	11	73,480,561 (GRCm39)	start codon destroyed	probably null	0.99
R7548:Or1e26	UTSW	11	73,479,802 (GRCm39)	missense	possibly damaging	0.56
R7888:Or1e26	UTSW	11	73,480,354 (GRCm39)	missense	probably damaging	0.99
R7968:Or1e26	UTSW	11	73,480,154 (GRCm39)	missense	probably benign	0.05
R8923:Or1e26	UTSW	11	73,480,076 (GRCm39)	missense	probably benign
R9006:Or1e26	UTSW	11	73,480,036 (GRCm39)	missense	probably benign	0.40
R9281:Or1e26	UTSW	11	73,480,133 (GRCm39)	missense	probably benign
R9689:Or1e26	UTSW	11	73,479,686 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCTATTCCCCGTGTAGATG -3'
(R):5'- CCAAGTTGCTGCAGAACATG -3'

Sequencing Primer
(F):5'- GGCTATTCCCCGTGTAGATGAAAAC -3'
(R):5'- GACACAACCATCTCCTATGTAGGTTG -3'

Posted On

2019-10-17