Incidental Mutation 'R7538:Kmt2a'
ID 583730
Institutional Source Beutler Lab
Gene Symbol Kmt2a
Ensembl Gene ENSMUSG00000002028
Gene Name lysine (K)-specific methyltransferase 2A
Synonyms Mll, ALL-1, Mll1, Cxxc7, All1, HTRX1, trithorax Drosophila
MMRRC Submission 045610-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7538 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 44714652-44792594 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 44759041 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 936 (L936P)
Ref Sequence ENSEMBL: ENSMUSP00000110337 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002095] [ENSMUST00000114689] [ENSMUST00000128768] [ENSMUST00000215489]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000002095
AA Change: L936P

PolyPhen 2 Score 0.286 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000002095
Gene: ENSMUSG00000002028
AA Change: L936P

DomainStartEndE-ValueType
low complexity region 14 29 N/A INTRINSIC
low complexity region 41 102 N/A INTRINSIC
PDB:3U88|N 103 151 6e-15 PDB
AT_hook 171 183 2.12e2 SMART
AT_hook 217 229 4.68e1 SMART
AT_hook 298 310 2.8e0 SMART
coiled coil region 366 394 N/A INTRINSIC
low complexity region 450 489 N/A INTRINSIC
low complexity region 524 535 N/A INTRINSIC
low complexity region 544 574 N/A INTRINSIC
low complexity region 589 601 N/A INTRINSIC
low complexity region 660 674 N/A INTRINSIC
low complexity region 717 732 N/A INTRINSIC
low complexity region 760 790 N/A INTRINSIC
low complexity region 866 892 N/A INTRINSIC
low complexity region 989 1005 N/A INTRINSIC
Pfam:zf-CXXC 1144 1191 1.1e-15 PFAM
low complexity region 1204 1233 N/A INTRINSIC
low complexity region 1236 1283 N/A INTRINSIC
low complexity region 1295 1316 N/A INTRINSIC
low complexity region 1323 1345 N/A INTRINSIC
low complexity region 1353 1366 N/A INTRINSIC
PHD 1432 1479 5.57e-3 SMART
PHD 1480 1530 1.17e-10 SMART
PHD 1567 1624 7.94e-8 SMART
BROMO 1632 1766 2.24e-10 SMART
low complexity region 1816 1850 N/A INTRINSIC
PHD 1931 1977 1.74e-4 SMART
low complexity region 1990 2001 N/A INTRINSIC
FYRN 2029 2072 2.33e-20 SMART
low complexity region 2180 2194 N/A INTRINSIC
low complexity region 2215 2227 N/A INTRINSIC
low complexity region 2607 2618 N/A INTRINSIC
low complexity region 2789 2800 N/A INTRINSIC
low complexity region 2824 2833 N/A INTRINSIC
low complexity region 2856 2878 N/A INTRINSIC
low complexity region 2902 2909 N/A INTRINSIC
low complexity region 3115 3141 N/A INTRINSIC
low complexity region 3164 3175 N/A INTRINSIC
low complexity region 3228 3239 N/A INTRINSIC
low complexity region 3299 3312 N/A INTRINSIC
low complexity region 3342 3351 N/A INTRINSIC
low complexity region 3405 3419 N/A INTRINSIC
low complexity region 3498 3526 N/A INTRINSIC
low complexity region 3620 3633 N/A INTRINSIC
FYRC 3662 3747 8.54e-37 SMART
SET 3823 3945 6.09e-45 SMART
PostSET 3947 3963 1.65e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000114689
AA Change: L936P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000110337
Gene: ENSMUSG00000002028
AA Change: L936P

DomainStartEndE-ValueType
low complexity region 14 29 N/A INTRINSIC
low complexity region 41 102 N/A INTRINSIC
PDB:3U88|N 103 151 6e-15 PDB
AT_hook 171 183 2.12e2 SMART
AT_hook 217 229 4.68e1 SMART
AT_hook 298 310 2.8e0 SMART
coiled coil region 366 394 N/A INTRINSIC
low complexity region 450 489 N/A INTRINSIC
low complexity region 524 535 N/A INTRINSIC
low complexity region 544 574 N/A INTRINSIC
low complexity region 589 601 N/A INTRINSIC
low complexity region 660 674 N/A INTRINSIC
low complexity region 717 732 N/A INTRINSIC
low complexity region 760 790 N/A INTRINSIC
low complexity region 866 892 N/A INTRINSIC
low complexity region 989 1005 N/A INTRINSIC
Pfam:zf-CXXC 1144 1191 1.1e-15 PFAM
low complexity region 1204 1233 N/A INTRINSIC
low complexity region 1236 1283 N/A INTRINSIC
low complexity region 1295 1316 N/A INTRINSIC
low complexity region 1323 1345 N/A INTRINSIC
low complexity region 1353 1366 N/A INTRINSIC
PHD 1432 1479 5.57e-3 SMART
PHD 1480 1530 1.17e-10 SMART
PHD 1567 1627 9.12e-8 SMART
BROMO 1635 1769 2.24e-10 SMART
low complexity region 1819 1853 N/A INTRINSIC
PHD 1934 1980 1.74e-4 SMART
low complexity region 1993 2004 N/A INTRINSIC
FYRN 2032 2075 2.33e-20 SMART
low complexity region 2183 2197 N/A INTRINSIC
low complexity region 2218 2230 N/A INTRINSIC
low complexity region 2610 2621 N/A INTRINSIC
low complexity region 2792 2803 N/A INTRINSIC
low complexity region 2827 2836 N/A INTRINSIC
low complexity region 2859 2881 N/A INTRINSIC
low complexity region 2905 2912 N/A INTRINSIC
low complexity region 3118 3144 N/A INTRINSIC
low complexity region 3167 3178 N/A INTRINSIC
low complexity region 3231 3242 N/A INTRINSIC
low complexity region 3302 3315 N/A INTRINSIC
low complexity region 3345 3354 N/A INTRINSIC
low complexity region 3408 3422 N/A INTRINSIC
low complexity region 3501 3529 N/A INTRINSIC
low complexity region 3623 3636 N/A INTRINSIC
FYRC 3665 3750 8.54e-37 SMART
SET 3826 3948 6.09e-45 SMART
PostSET 3950 3966 1.65e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000128768
AA Change: L969P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000122541
Gene: ENSMUSG00000002028
AA Change: L969P

DomainStartEndE-ValueType
low complexity region 14 29 N/A INTRINSIC
SCOP:d1gkub1 59 105 6e-3 SMART
PDB:3U88|N 103 131 2e-10 PDB
low complexity region 132 142 N/A INTRINSIC
AT_hook 204 216 2.12e2 SMART
AT_hook 250 262 4.68e1 SMART
AT_hook 331 343 2.8e0 SMART
coiled coil region 399 427 N/A INTRINSIC
low complexity region 483 522 N/A INTRINSIC
low complexity region 557 568 N/A INTRINSIC
low complexity region 577 607 N/A INTRINSIC
low complexity region 622 634 N/A INTRINSIC
low complexity region 693 707 N/A INTRINSIC
low complexity region 750 765 N/A INTRINSIC
low complexity region 793 823 N/A INTRINSIC
low complexity region 899 925 N/A INTRINSIC
low complexity region 1022 1038 N/A INTRINSIC
Pfam:zf-CXXC 1177 1224 2.4e-16 PFAM
low complexity region 1237 1266 N/A INTRINSIC
low complexity region 1269 1316 N/A INTRINSIC
Blast:BROMO 1317 1438 3e-14 BLAST
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000215489
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (77/79)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
PHENOTYPE: Homozygotes for targeted null mutations die at embryonic day 11.5-14.5 with edematous bodies, petechiae, and hematopoietic insufficiency. Heterozygotes show reduced growth, hematopoietic abnormalities, and homeotic transformations of the axial skeleton. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts8 C A 9: 30,864,766 (GRCm39) P419H probably damaging Het
Adgra3 C T 5: 50,118,792 (GRCm39) V919I probably benign Het
Akap12 G A 10: 4,303,213 (GRCm39) V113I probably damaging Het
Akr1d1 T A 6: 37,513,043 (GRCm39) I113K probably benign Het
Alx3 A T 3: 107,511,680 (GRCm39) I230F probably damaging Het
Apob A T 12: 8,052,219 (GRCm39) D1220V probably damaging Het
Ascc3 T C 10: 50,721,796 (GRCm39) L2083P probably damaging Het
Atp10b A G 11: 43,116,373 (GRCm39) I907V probably benign Het
B4galnt3 G T 6: 120,271,384 (GRCm39) S46* probably null Het
Bfsp1 A C 2: 143,673,755 (GRCm39) probably null Het
Cant1 G A 11: 118,302,291 (GRCm39) R9W possibly damaging Het
Ccdc88a A T 11: 29,413,370 (GRCm39) H636L probably benign Het
Cfi G A 3: 129,652,464 (GRCm39) R297H probably benign Het
Cherp T A 8: 73,216,263 (GRCm39) Q749L Het
Clec10a A G 11: 70,060,604 (GRCm39) D153G probably benign Het
Cnga1 T C 5: 72,769,723 (GRCm39) K99E probably benign Het
Cyp2r1 A T 7: 114,162,002 (GRCm39) V64D probably damaging Het
Dact3 T A 7: 16,609,443 (GRCm39) W32R probably damaging Het
Dennd4c T C 4: 86,692,753 (GRCm39) C88R probably damaging Het
Dock8 A T 19: 25,135,782 (GRCm39) D1200V probably damaging Het
Drosha C G 15: 12,926,329 (GRCm39) S1262W probably damaging Het
Dtnb T C 12: 3,823,611 (GRCm39) M592T possibly damaging Het
Eef2k T A 7: 120,491,215 (GRCm39) V567E probably benign Het
Fem1b A G 9: 62,718,449 (GRCm39) S47P probably damaging Het
Fryl T C 5: 73,180,019 (GRCm39) E2864G probably benign Het
Fscn2 A G 11: 120,258,152 (GRCm39) N358S possibly damaging Het
Fsip2 T C 2: 82,818,894 (GRCm39) S4876P possibly damaging Het
Ggh C G 4: 20,049,833 (GRCm39) S88C probably damaging Het
Grhl2 T C 15: 37,328,603 (GRCm39) Y410H probably damaging Het
Gucy2c C T 6: 136,686,742 (GRCm39) G831D probably damaging Het
Hars1 A T 18: 36,904,194 (GRCm39) D228E probably benign Het
Hdhd5 T C 6: 120,498,257 (GRCm39) D114G possibly damaging Het
Kcna2 A G 3: 107,011,884 (GRCm39) Y155C probably benign Het
Klc1 A G 12: 111,751,879 (GRCm39) K441R probably benign Het
Map3k6 T C 4: 132,979,238 (GRCm39) V1197A probably benign Het
Mthfsd C T 8: 121,825,525 (GRCm39) A349T probably benign Het
Mtmr7 G A 8: 41,050,427 (GRCm39) R123W probably damaging Het
Muc16 T A 9: 18,553,427 (GRCm39) I4289F probably benign Het
Muc16 G A 9: 18,566,747 (GRCm39) T1924I unknown Het
Mybpc3 A C 2: 90,950,832 (GRCm39) D220A probably damaging Het
Neb A T 2: 52,146,587 (GRCm39) probably null Het
Nectin2 A G 7: 19,464,544 (GRCm39) W287R probably damaging Het
Nipsnap1 A T 11: 4,834,089 (GRCm39) T114S probably damaging Het
Nol9 T C 4: 152,124,115 (GRCm39) S102P probably benign Het
Olfml2b A T 1: 170,477,402 (GRCm39) K179I possibly damaging Het
Or4a80 G T 2: 89,582,665 (GRCm39) P169H probably damaging Het
Pcnt T C 10: 76,235,773 (GRCm39) M1403V probably benign Het
Phf7 T C 14: 30,960,386 (GRCm39) D284G probably benign Het
Pias3 A G 3: 96,609,534 (GRCm39) T319A possibly damaging Het
Pik3ip1 A T 11: 3,283,558 (GRCm39) I189F probably damaging Het
Pik3r1 T A 13: 101,825,914 (GRCm39) T371S probably damaging Het
Prmt7 A G 8: 106,964,018 (GRCm39) D304G probably benign Het
Prpf6 T C 2: 181,294,248 (GRCm39) V818A probably benign Het
Pstpip2 A G 18: 77,959,305 (GRCm39) E185G probably damaging Het
Ptprz1 T G 6: 22,999,895 (GRCm39) F662V possibly damaging Het
Rasgrp3 T C 17: 75,803,411 (GRCm39) F70L probably benign Het
Rcor1 A T 12: 111,034,271 (GRCm39) probably null Het
Rnasel A G 1: 153,630,306 (GRCm39) K274R probably benign Het
Rsbn1l G A 5: 21,101,455 (GRCm39) T695I probably benign Het
Rsf1 GGCG GGCGACGGCCGCG 7: 97,229,113 (GRCm39) probably benign Het
Sema3a T C 5: 13,611,787 (GRCm39) V351A probably benign Het
Serpina12 A G 12: 104,004,587 (GRCm39) L15P unknown Het
Siah1a G A 8: 87,451,840 (GRCm39) R215C probably benign Het
Sin3a T A 9: 57,011,210 (GRCm39) V489D possibly damaging Het
Slc22a17 A G 14: 55,149,575 (GRCm39) I208T probably benign Het
Slc36a4 G A 9: 15,645,511 (GRCm39) V313M possibly damaging Het
Sod1 T A 16: 90,023,114 (GRCm39) L145* probably null Het
Svep1 T C 4: 58,053,260 (GRCm39) N3362D possibly damaging Het
Taf4b T C 18: 14,946,602 (GRCm39) L475P probably damaging Het
Telo2 G T 17: 25,329,795 (GRCm39) T239K probably benign Het
Trmt11 T G 10: 30,436,870 (GRCm39) D290A probably damaging Het
Trpc4 A T 3: 54,225,516 (GRCm39) D955V possibly damaging Het
Trpv6 T C 6: 41,603,101 (GRCm39) N257S probably benign Het
Usp12 T C 5: 146,731,430 (GRCm39) T15A probably benign Het
Vars2 G T 17: 35,971,672 (GRCm39) Q526K probably damaging Het
Vipas39 A G 12: 87,310,677 (GRCm39) probably null Het
Zfp689 A T 7: 127,044,010 (GRCm39) C207S probably damaging Het
Zfpl1 C A 19: 6,134,432 (GRCm39) E18* probably null Het
Other mutations in Kmt2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Kmt2a APN 9 44,719,231 (GRCm39) unclassified probably benign
IGL00667:Kmt2a APN 9 44,735,683 (GRCm39) utr 3 prime probably benign
IGL00828:Kmt2a APN 9 44,732,073 (GRCm39) unclassified probably benign
IGL01080:Kmt2a APN 9 44,720,389 (GRCm39) missense unknown
IGL01131:Kmt2a APN 9 44,732,467 (GRCm39) unclassified probably benign
IGL01294:Kmt2a APN 9 44,731,594 (GRCm39) unclassified probably benign
IGL01432:Kmt2a APN 9 44,720,393 (GRCm39) missense unknown
IGL01646:Kmt2a APN 9 44,736,781 (GRCm39) utr 3 prime probably benign
IGL01777:Kmt2a APN 9 44,760,302 (GRCm39) missense probably damaging 0.99
IGL01944:Kmt2a APN 9 44,761,064 (GRCm39) missense probably damaging 1.00
IGL02125:Kmt2a APN 9 44,759,983 (GRCm39) missense probably damaging 1.00
IGL02207:Kmt2a APN 9 44,758,979 (GRCm39) missense probably damaging 0.98
IGL02424:Kmt2a APN 9 44,735,932 (GRCm39) utr 3 prime probably benign
IGL02499:Kmt2a APN 9 44,741,806 (GRCm39) splice site probably benign
IGL02574:Kmt2a APN 9 44,741,810 (GRCm39) splice site probably benign
IGL02711:Kmt2a APN 9 44,735,820 (GRCm39) splice site probably benign
IGL02828:Kmt2a APN 9 44,733,244 (GRCm39) unclassified probably benign
IGL03012:Kmt2a APN 9 44,722,263 (GRCm39) unclassified probably benign
IGL03242:Kmt2a APN 9 44,759,689 (GRCm39) missense probably damaging 0.99
IGL03294:Kmt2a APN 9 44,731,862 (GRCm39) unclassified probably benign
IGL03326:Kmt2a APN 9 44,730,044 (GRCm39) nonsense probably null
Chromas UTSW 9 44,731,639 (GRCm39) unclassified probably benign
Heteros UTSW 9 44,740,108 (GRCm39) nonsense probably null
Polonium UTSW 9 44,725,938 (GRCm39) nonsense probably null
Pyknos UTSW 9 44,738,125 (GRCm39) utr 3 prime probably benign
Skies UTSW 9 44,740,558 (GRCm39) utr 3 prime probably benign
spacious UTSW 9 44,758,942 (GRCm39) missense probably benign 0.03
ukrainium UTSW 9 44,753,997 (GRCm39) unclassified probably benign
Uranium UTSW 9 44,761,154 (GRCm39) nonsense probably null
PIT4402001:Kmt2a UTSW 9 44,752,359 (GRCm39) missense unknown
R0076:Kmt2a UTSW 9 44,741,356 (GRCm39) utr 3 prime probably benign
R0076:Kmt2a UTSW 9 44,741,356 (GRCm39) utr 3 prime probably benign
R0180:Kmt2a UTSW 9 44,738,148 (GRCm39) utr 3 prime probably benign
R0363:Kmt2a UTSW 9 44,721,010 (GRCm39) critical splice donor site probably null
R0411:Kmt2a UTSW 9 44,731,261 (GRCm39) unclassified probably benign
R0555:Kmt2a UTSW 9 44,758,868 (GRCm39) missense probably damaging 1.00
R0587:Kmt2a UTSW 9 44,758,831 (GRCm39) missense probably damaging 0.99
R0865:Kmt2a UTSW 9 44,730,067 (GRCm39) unclassified probably benign
R0988:Kmt2a UTSW 9 44,759,846 (GRCm39) missense probably benign 0.03
R1006:Kmt2a UTSW 9 44,758,993 (GRCm39) missense probably damaging 0.99
R1108:Kmt2a UTSW 9 44,760,359 (GRCm39) missense probably damaging 1.00
R1292:Kmt2a UTSW 9 44,725,991 (GRCm39) utr 3 prime probably benign
R1322:Kmt2a UTSW 9 44,732,418 (GRCm39) unclassified probably benign
R1476:Kmt2a UTSW 9 44,735,932 (GRCm39) utr 3 prime probably benign
R1485:Kmt2a UTSW 9 44,738,225 (GRCm39) utr 3 prime probably benign
R1487:Kmt2a UTSW 9 44,745,287 (GRCm39) utr 3 prime probably benign
R1493:Kmt2a UTSW 9 44,758,202 (GRCm39) missense probably damaging 1.00
R1499:Kmt2a UTSW 9 44,759,563 (GRCm39) missense probably benign 0.36
R1507:Kmt2a UTSW 9 44,729,700 (GRCm39) unclassified probably benign
R1603:Kmt2a UTSW 9 44,752,858 (GRCm39) splice site probably null
R1635:Kmt2a UTSW 9 44,735,666 (GRCm39) utr 3 prime probably benign
R1662:Kmt2a UTSW 9 44,747,967 (GRCm39) utr 3 prime probably benign
R1711:Kmt2a UTSW 9 44,752,918 (GRCm39) missense unknown
R1785:Kmt2a UTSW 9 44,730,972 (GRCm39) unclassified probably benign
R1786:Kmt2a UTSW 9 44,730,972 (GRCm39) unclassified probably benign
R1919:Kmt2a UTSW 9 44,731,642 (GRCm39) unclassified probably benign
R1964:Kmt2a UTSW 9 44,731,941 (GRCm39) missense probably benign 0.23
R1965:Kmt2a UTSW 9 44,732,757 (GRCm39) unclassified probably benign
R2029:Kmt2a UTSW 9 44,729,747 (GRCm39) missense probably benign 0.23
R2054:Kmt2a UTSW 9 44,734,671 (GRCm39) utr 3 prime probably benign
R2259:Kmt2a UTSW 9 44,792,440 (GRCm39) unclassified probably benign
R2382:Kmt2a UTSW 9 44,732,207 (GRCm39) unclassified probably benign
R2483:Kmt2a UTSW 9 44,760,263 (GRCm39) missense probably damaging 0.99
R3033:Kmt2a UTSW 9 44,733,160 (GRCm39) unclassified probably benign
R3423:Kmt2a UTSW 9 44,731,394 (GRCm39) unclassified probably benign
R3428:Kmt2a UTSW 9 44,759,416 (GRCm39) missense probably benign 0.06
R3605:Kmt2a UTSW 9 44,760,493 (GRCm39) missense probably damaging 1.00
R3607:Kmt2a UTSW 9 44,760,493 (GRCm39) missense probably damaging 1.00
R3611:Kmt2a UTSW 9 44,733,763 (GRCm39) unclassified probably benign
R3623:Kmt2a UTSW 9 44,760,263 (GRCm39) missense probably damaging 0.99
R3745:Kmt2a UTSW 9 44,742,637 (GRCm39) utr 3 prime probably benign
R3806:Kmt2a UTSW 9 44,731,653 (GRCm39) unclassified probably benign
R3841:Kmt2a UTSW 9 44,742,588 (GRCm39) utr 3 prime probably benign
R3855:Kmt2a UTSW 9 44,741,796 (GRCm39) utr 3 prime probably benign
R4027:Kmt2a UTSW 9 44,747,990 (GRCm39) utr 3 prime probably benign
R4124:Kmt2a UTSW 9 44,731,093 (GRCm39) unclassified probably benign
R4177:Kmt2a UTSW 9 44,732,280 (GRCm39) unclassified probably benign
R4296:Kmt2a UTSW 9 44,732,472 (GRCm39) unclassified probably benign
R4414:Kmt2a UTSW 9 44,721,077 (GRCm39) unclassified probably benign
R4461:Kmt2a UTSW 9 44,760,263 (GRCm39) missense probably damaging 0.99
R4668:Kmt2a UTSW 9 44,735,869 (GRCm39) utr 3 prime probably benign
R4761:Kmt2a UTSW 9 44,760,421 (GRCm39) missense probably damaging 1.00
R4812:Kmt2a UTSW 9 44,742,651 (GRCm39) utr 3 prime probably benign
R4815:Kmt2a UTSW 9 44,732,553 (GRCm39) unclassified probably benign
R4817:Kmt2a UTSW 9 44,732,763 (GRCm39) unclassified probably benign
R4888:Kmt2a UTSW 9 44,732,977 (GRCm39) unclassified probably benign
R4958:Kmt2a UTSW 9 44,759,764 (GRCm39) missense probably damaging 1.00
R5055:Kmt2a UTSW 9 44,729,649 (GRCm39) unclassified probably benign
R5065:Kmt2a UTSW 9 44,753,997 (GRCm39) unclassified probably benign
R5185:Kmt2a UTSW 9 44,731,543 (GRCm39) unclassified probably benign
R5358:Kmt2a UTSW 9 44,730,571 (GRCm39) unclassified probably benign
R5411:Kmt2a UTSW 9 44,759,782 (GRCm39) missense probably damaging 1.00
R5420:Kmt2a UTSW 9 44,759,633 (GRCm39) missense probably damaging 1.00
R5483:Kmt2a UTSW 9 44,735,921 (GRCm39) utr 3 prime probably benign
R5487:Kmt2a UTSW 9 44,733,272 (GRCm39) unclassified probably benign
R5488:Kmt2a UTSW 9 44,752,335 (GRCm39) utr 3 prime probably benign
R5489:Kmt2a UTSW 9 44,752,335 (GRCm39) utr 3 prime probably benign
R5538:Kmt2a UTSW 9 44,731,639 (GRCm39) unclassified probably benign
R5576:Kmt2a UTSW 9 44,753,931 (GRCm39) missense possibly damaging 0.94
R5631:Kmt2a UTSW 9 44,731,985 (GRCm39) unclassified probably benign
R5781:Kmt2a UTSW 9 44,759,139 (GRCm39) nonsense probably null
R5789:Kmt2a UTSW 9 44,731,201 (GRCm39) unclassified probably benign
R5932:Kmt2a UTSW 9 44,731,944 (GRCm39) unclassified probably benign
R6027:Kmt2a UTSW 9 44,730,587 (GRCm39) unclassified probably benign
R6191:Kmt2a UTSW 9 44,738,125 (GRCm39) utr 3 prime probably benign
R6239:Kmt2a UTSW 9 44,731,093 (GRCm39) unclassified probably benign
R6291:Kmt2a UTSW 9 44,744,171 (GRCm39) utr 3 prime probably benign
R6344:Kmt2a UTSW 9 44,733,156 (GRCm39) unclassified probably benign
R6611:Kmt2a UTSW 9 44,760,569 (GRCm39) missense probably damaging 0.98
R6641:Kmt2a UTSW 9 44,731,132 (GRCm39) unclassified probably benign
R6651:Kmt2a UTSW 9 44,740,108 (GRCm39) nonsense probably null
R6825:Kmt2a UTSW 9 44,729,704 (GRCm39) unclassified probably benign
R6853:Kmt2a UTSW 9 44,729,704 (GRCm39) unclassified probably benign
R6897:Kmt2a UTSW 9 44,758,942 (GRCm39) missense probably benign 0.03
R6930:Kmt2a UTSW 9 44,753,962 (GRCm39) unclassified probably benign
R6932:Kmt2a UTSW 9 44,740,558 (GRCm39) utr 3 prime probably benign
R6957:Kmt2a UTSW 9 44,731,319 (GRCm39) unclassified probably benign
R7170:Kmt2a UTSW 9 44,722,018 (GRCm39) missense unknown
R7202:Kmt2a UTSW 9 44,759,012 (GRCm39) missense probably benign 0.03
R7481:Kmt2a UTSW 9 44,720,368 (GRCm39) missense unknown
R7597:Kmt2a UTSW 9 44,742,650 (GRCm39) missense unknown
R7741:Kmt2a UTSW 9 44,719,359 (GRCm39) missense unknown
R7767:Kmt2a UTSW 9 44,730,295 (GRCm39) missense unknown
R7768:Kmt2a UTSW 9 44,731,900 (GRCm39) missense unknown
R7861:Kmt2a UTSW 9 44,730,031 (GRCm39) missense unknown
R7894:Kmt2a UTSW 9 44,761,154 (GRCm39) nonsense probably null
R7922:Kmt2a UTSW 9 44,754,157 (GRCm39) missense unknown
R7943:Kmt2a UTSW 9 44,760,437 (GRCm39) missense probably damaging 0.97
R7997:Kmt2a UTSW 9 44,745,220 (GRCm39) missense unknown
R8033:Kmt2a UTSW 9 44,756,767 (GRCm39) missense probably damaging 1.00
R8055:Kmt2a UTSW 9 44,732,378 (GRCm39) missense unknown
R8139:Kmt2a UTSW 9 44,730,587 (GRCm39) unclassified probably benign
R8156:Kmt2a UTSW 9 44,733,686 (GRCm39) missense unknown
R8224:Kmt2a UTSW 9 44,719,326 (GRCm39) missense unknown
R8427:Kmt2a UTSW 9 44,756,720 (GRCm39) missense probably damaging 1.00
R8535:Kmt2a UTSW 9 44,730,812 (GRCm39) missense possibly damaging 0.91
R8693:Kmt2a UTSW 9 44,721,981 (GRCm39) missense unknown
R8757:Kmt2a UTSW 9 44,754,210 (GRCm39) missense unknown
R8840:Kmt2a UTSW 9 44,721,016 (GRCm39) missense unknown
R8933:Kmt2a UTSW 9 44,733,802 (GRCm39) unclassified probably benign
R8998:Kmt2a UTSW 9 44,733,174 (GRCm39) missense unknown
R9013:Kmt2a UTSW 9 44,761,208 (GRCm39) missense probably damaging 0.97
R9053:Kmt2a UTSW 9 44,732,716 (GRCm39) missense unknown
R9084:Kmt2a UTSW 9 44,740,130 (GRCm39) missense unknown
R9146:Kmt2a UTSW 9 44,725,938 (GRCm39) nonsense probably null
R9162:Kmt2a UTSW 9 44,759,363 (GRCm39) missense probably benign 0.32
R9231:Kmt2a UTSW 9 44,759,912 (GRCm39) missense probably damaging 0.99
R9250:Kmt2a UTSW 9 44,759,683 (GRCm39) missense possibly damaging 0.82
R9262:Kmt2a UTSW 9 44,731,222 (GRCm39) missense probably benign 0.23
R9323:Kmt2a UTSW 9 44,731,261 (GRCm39) unclassified probably benign
R9472:Kmt2a UTSW 9 44,733,453 (GRCm39) missense unknown
R9510:Kmt2a UTSW 9 44,734,531 (GRCm39) missense unknown
R9524:Kmt2a UTSW 9 44,730,294 (GRCm39) missense unknown
R9662:Kmt2a UTSW 9 44,731,428 (GRCm39) missense unknown
R9664:Kmt2a UTSW 9 44,760,102 (GRCm39) nonsense probably null
R9691:Kmt2a UTSW 9 44,731,557 (GRCm39) missense unknown
R9750:Kmt2a UTSW 9 44,747,499 (GRCm39) missense unknown
X0021:Kmt2a UTSW 9 44,742,532 (GRCm39) utr 3 prime probably benign
X0025:Kmt2a UTSW 9 44,736,689 (GRCm39) nonsense probably null
X0026:Kmt2a UTSW 9 44,732,203 (GRCm39) unclassified probably benign
X0027:Kmt2a UTSW 9 44,792,194 (GRCm39) missense possibly damaging 0.85
Z1176:Kmt2a UTSW 9 44,759,276 (GRCm39) missense probably damaging 1.00
Z1177:Kmt2a UTSW 9 44,730,418 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTTAACAGTGCTAGATGAAGGAGC -3'
(R):5'- CCAAAGATCGCGATGCTGAC -3'

Sequencing Primer
(F):5'- CGGAAAGGCAGGGGGTTCTC -3'
(R):5'- TCGCGATGCTGACAAGAGC -3'
Posted On 2019-10-17