Incidental Mutation 'R7538:Atp10b'
ID 583740
Institutional Source Beutler Lab
Gene Symbol Atp10b
Ensembl Gene ENSMUSG00000055415
Gene Name ATPase, class V, type 10B
Synonyms 9030605H24Rik, 5930426O13Rik
MMRRC Submission 045610-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R7538 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 43040704-43153112 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43116373 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 907 (I907V)
Ref Sequence ENSEMBL: ENSMUSP00000076844 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077659]
AlphaFold B1AWN4
Predicted Effect probably benign
Transcript: ENSMUST00000077659
AA Change: I907V

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000076844
Gene: ENSMUSG00000055415
AA Change: I907V

DomainStartEndE-ValueType
Pfam:PhoLip_ATPase_N 47 118 3.8e-26 PFAM
Pfam:E1-E2_ATPase 123 393 2.9e-7 PFAM
low complexity region 621 638 N/A INTRINSIC
Pfam:Cation_ATPase 692 799 7.1e-9 PFAM
Pfam:HAD 705 1062 6.7e-12 PFAM
Pfam:PhoLip_ATPase_C 1079 1324 1.9e-79 PFAM
low complexity region 1353 1366 N/A INTRINSIC
low complexity region 1457 1471 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 97% (77/79)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts8 C A 9: 30,864,766 (GRCm39) P419H probably damaging Het
Adgra3 C T 5: 50,118,792 (GRCm39) V919I probably benign Het
Akap12 G A 10: 4,303,213 (GRCm39) V113I probably damaging Het
Akr1d1 T A 6: 37,513,043 (GRCm39) I113K probably benign Het
Alx3 A T 3: 107,511,680 (GRCm39) I230F probably damaging Het
Apob A T 12: 8,052,219 (GRCm39) D1220V probably damaging Het
Ascc3 T C 10: 50,721,796 (GRCm39) L2083P probably damaging Het
B4galnt3 G T 6: 120,271,384 (GRCm39) S46* probably null Het
Bfsp1 A C 2: 143,673,755 (GRCm39) probably null Het
Cant1 G A 11: 118,302,291 (GRCm39) R9W possibly damaging Het
Ccdc88a A T 11: 29,413,370 (GRCm39) H636L probably benign Het
Cfi G A 3: 129,652,464 (GRCm39) R297H probably benign Het
Cherp T A 8: 73,216,263 (GRCm39) Q749L Het
Clec10a A G 11: 70,060,604 (GRCm39) D153G probably benign Het
Cnga1 T C 5: 72,769,723 (GRCm39) K99E probably benign Het
Cyp2r1 A T 7: 114,162,002 (GRCm39) V64D probably damaging Het
Dact3 T A 7: 16,609,443 (GRCm39) W32R probably damaging Het
Dennd4c T C 4: 86,692,753 (GRCm39) C88R probably damaging Het
Dock8 A T 19: 25,135,782 (GRCm39) D1200V probably damaging Het
Drosha C G 15: 12,926,329 (GRCm39) S1262W probably damaging Het
Dtnb T C 12: 3,823,611 (GRCm39) M592T possibly damaging Het
Eef2k T A 7: 120,491,215 (GRCm39) V567E probably benign Het
Fem1b A G 9: 62,718,449 (GRCm39) S47P probably damaging Het
Fryl T C 5: 73,180,019 (GRCm39) E2864G probably benign Het
Fscn2 A G 11: 120,258,152 (GRCm39) N358S possibly damaging Het
Fsip2 T C 2: 82,818,894 (GRCm39) S4876P possibly damaging Het
Ggh C G 4: 20,049,833 (GRCm39) S88C probably damaging Het
Grhl2 T C 15: 37,328,603 (GRCm39) Y410H probably damaging Het
Gucy2c C T 6: 136,686,742 (GRCm39) G831D probably damaging Het
Hars1 A T 18: 36,904,194 (GRCm39) D228E probably benign Het
Hdhd5 T C 6: 120,498,257 (GRCm39) D114G possibly damaging Het
Kcna2 A G 3: 107,011,884 (GRCm39) Y155C probably benign Het
Klc1 A G 12: 111,751,879 (GRCm39) K441R probably benign Het
Kmt2a A G 9: 44,759,041 (GRCm39) L936P probably damaging Het
Map3k6 T C 4: 132,979,238 (GRCm39) V1197A probably benign Het
Mthfsd C T 8: 121,825,525 (GRCm39) A349T probably benign Het
Mtmr7 G A 8: 41,050,427 (GRCm39) R123W probably damaging Het
Muc16 T A 9: 18,553,427 (GRCm39) I4289F probably benign Het
Muc16 G A 9: 18,566,747 (GRCm39) T1924I unknown Het
Mybpc3 A C 2: 90,950,832 (GRCm39) D220A probably damaging Het
Neb A T 2: 52,146,587 (GRCm39) probably null Het
Nectin2 A G 7: 19,464,544 (GRCm39) W287R probably damaging Het
Nipsnap1 A T 11: 4,834,089 (GRCm39) T114S probably damaging Het
Nol9 T C 4: 152,124,115 (GRCm39) S102P probably benign Het
Olfml2b A T 1: 170,477,402 (GRCm39) K179I possibly damaging Het
Or4a80 G T 2: 89,582,665 (GRCm39) P169H probably damaging Het
Pcnt T C 10: 76,235,773 (GRCm39) M1403V probably benign Het
Phf7 T C 14: 30,960,386 (GRCm39) D284G probably benign Het
Pias3 A G 3: 96,609,534 (GRCm39) T319A possibly damaging Het
Pik3ip1 A T 11: 3,283,558 (GRCm39) I189F probably damaging Het
Pik3r1 T A 13: 101,825,914 (GRCm39) T371S probably damaging Het
Prmt7 A G 8: 106,964,018 (GRCm39) D304G probably benign Het
Prpf6 T C 2: 181,294,248 (GRCm39) V818A probably benign Het
Pstpip2 A G 18: 77,959,305 (GRCm39) E185G probably damaging Het
Ptprz1 T G 6: 22,999,895 (GRCm39) F662V possibly damaging Het
Rasgrp3 T C 17: 75,803,411 (GRCm39) F70L probably benign Het
Rcor1 A T 12: 111,034,271 (GRCm39) probably null Het
Rnasel A G 1: 153,630,306 (GRCm39) K274R probably benign Het
Rsbn1l G A 5: 21,101,455 (GRCm39) T695I probably benign Het
Rsf1 GGCG GGCGACGGCCGCG 7: 97,229,113 (GRCm39) probably benign Het
Sema3a T C 5: 13,611,787 (GRCm39) V351A probably benign Het
Serpina12 A G 12: 104,004,587 (GRCm39) L15P unknown Het
Siah1a G A 8: 87,451,840 (GRCm39) R215C probably benign Het
Sin3a T A 9: 57,011,210 (GRCm39) V489D possibly damaging Het
Slc22a17 A G 14: 55,149,575 (GRCm39) I208T probably benign Het
Slc36a4 G A 9: 15,645,511 (GRCm39) V313M possibly damaging Het
Sod1 T A 16: 90,023,114 (GRCm39) L145* probably null Het
Svep1 T C 4: 58,053,260 (GRCm39) N3362D possibly damaging Het
Taf4b T C 18: 14,946,602 (GRCm39) L475P probably damaging Het
Telo2 G T 17: 25,329,795 (GRCm39) T239K probably benign Het
Trmt11 T G 10: 30,436,870 (GRCm39) D290A probably damaging Het
Trpc4 A T 3: 54,225,516 (GRCm39) D955V possibly damaging Het
Trpv6 T C 6: 41,603,101 (GRCm39) N257S probably benign Het
Usp12 T C 5: 146,731,430 (GRCm39) T15A probably benign Het
Vars2 G T 17: 35,971,672 (GRCm39) Q526K probably damaging Het
Vipas39 A G 12: 87,310,677 (GRCm39) probably null Het
Zfp689 A T 7: 127,044,010 (GRCm39) C207S probably damaging Het
Zfpl1 C A 19: 6,134,432 (GRCm39) E18* probably null Het
Other mutations in Atp10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Atp10b APN 11 43,092,988 (GRCm39) missense probably damaging 1.00
IGL01385:Atp10b APN 11 43,125,256 (GRCm39) missense probably damaging 1.00
IGL01524:Atp10b APN 11 43,150,672 (GRCm39) missense probably benign 0.18
IGL01575:Atp10b APN 11 43,063,548 (GRCm39) missense probably benign 0.00
IGL01588:Atp10b APN 11 43,063,548 (GRCm39) missense probably benign 0.00
IGL01590:Atp10b APN 11 43,063,548 (GRCm39) missense probably benign 0.00
IGL01832:Atp10b APN 11 43,125,262 (GRCm39) missense probably damaging 0.98
IGL01927:Atp10b APN 11 43,150,231 (GRCm39) splice site probably benign
IGL01933:Atp10b APN 11 43,085,457 (GRCm39) missense probably damaging 1.00
IGL02182:Atp10b APN 11 43,139,774 (GRCm39) missense probably damaging 1.00
IGL02215:Atp10b APN 11 43,085,492 (GRCm39) critical splice donor site probably null
IGL02216:Atp10b APN 11 43,150,616 (GRCm39) missense probably damaging 0.98
IGL02973:Atp10b APN 11 43,088,336 (GRCm39) missense probably damaging 1.00
IGL03012:Atp10b APN 11 43,085,482 (GRCm39) missense probably damaging 0.99
IGL03106:Atp10b APN 11 43,138,304 (GRCm39) missense probably benign 0.32
IGL03123:Atp10b APN 11 43,044,110 (GRCm39) missense probably benign 0.01
IGL03202:Atp10b APN 11 43,125,268 (GRCm39) critical splice donor site probably null
IGL03339:Atp10b APN 11 43,121,442 (GRCm39) missense probably null 0.71
R0053:Atp10b UTSW 11 43,107,391 (GRCm39) splice site probably benign
R0053:Atp10b UTSW 11 43,107,391 (GRCm39) splice site probably benign
R0098:Atp10b UTSW 11 43,080,431 (GRCm39) missense probably benign 0.00
R0098:Atp10b UTSW 11 43,080,431 (GRCm39) missense probably benign 0.00
R0281:Atp10b UTSW 11 43,044,131 (GRCm39) missense probably benign 0.00
R0379:Atp10b UTSW 11 43,145,141 (GRCm39) missense probably benign 0.05
R0380:Atp10b UTSW 11 43,116,424 (GRCm39) missense probably damaging 1.00
R0470:Atp10b UTSW 11 43,093,866 (GRCm39) missense possibly damaging 0.88
R1355:Atp10b UTSW 11 43,042,482 (GRCm39) nonsense probably null
R1368:Atp10b UTSW 11 43,092,981 (GRCm39) missense probably damaging 1.00
R1370:Atp10b UTSW 11 43,042,482 (GRCm39) nonsense probably null
R1413:Atp10b UTSW 11 43,121,391 (GRCm39) missense probably benign 0.00
R1502:Atp10b UTSW 11 43,121,174 (GRCm39) missense probably damaging 1.00
R1530:Atp10b UTSW 11 43,088,351 (GRCm39) missense probably benign 0.03
R1596:Atp10b UTSW 11 43,126,594 (GRCm39) missense probably damaging 1.00
R1675:Atp10b UTSW 11 43,116,475 (GRCm39) missense probably damaging 1.00
R1880:Atp10b UTSW 11 43,150,259 (GRCm39) missense probably damaging 1.00
R1938:Atp10b UTSW 11 43,121,245 (GRCm39) missense probably benign 0.00
R1986:Atp10b UTSW 11 43,063,595 (GRCm39) missense probably benign 0.12
R2081:Atp10b UTSW 11 43,092,955 (GRCm39) missense probably damaging 1.00
R2083:Atp10b UTSW 11 43,103,250 (GRCm39) missense probably benign 0.24
R2159:Atp10b UTSW 11 43,042,680 (GRCm39) missense possibly damaging 0.81
R2255:Atp10b UTSW 11 43,125,207 (GRCm39) missense probably damaging 1.00
R2259:Atp10b UTSW 11 43,080,440 (GRCm39) missense probably damaging 1.00
R2259:Atp10b UTSW 11 43,063,572 (GRCm39) missense probably damaging 1.00
R3741:Atp10b UTSW 11 43,126,489 (GRCm39) missense probably damaging 1.00
R3942:Atp10b UTSW 11 43,063,581 (GRCm39) missense probably damaging 1.00
R3971:Atp10b UTSW 11 43,107,339 (GRCm39) missense probably damaging 1.00
R4007:Atp10b UTSW 11 43,150,679 (GRCm39) missense probably benign 0.04
R4050:Atp10b UTSW 11 43,150,363 (GRCm39) missense probably benign 0.00
R4078:Atp10b UTSW 11 43,044,110 (GRCm39) missense probably benign 0.01
R4567:Atp10b UTSW 11 43,088,384 (GRCm39) missense probably benign 0.03
R4651:Atp10b UTSW 11 43,085,472 (GRCm39) missense probably damaging 1.00
R4652:Atp10b UTSW 11 43,085,472 (GRCm39) missense probably damaging 1.00
R4667:Atp10b UTSW 11 43,138,345 (GRCm39) missense probably damaging 1.00
R4720:Atp10b UTSW 11 43,093,949 (GRCm39) missense probably benign
R4987:Atp10b UTSW 11 43,042,440 (GRCm39) utr 5 prime probably benign
R5232:Atp10b UTSW 11 43,093,006 (GRCm39) missense probably damaging 1.00
R5233:Atp10b UTSW 11 43,121,387 (GRCm39) missense probably benign 0.06
R5281:Atp10b UTSW 11 43,145,163 (GRCm39) missense probably damaging 0.97
R5307:Atp10b UTSW 11 43,103,302 (GRCm39) missense probably damaging 1.00
R5460:Atp10b UTSW 11 43,121,282 (GRCm39) missense probably benign 0.00
R5518:Atp10b UTSW 11 43,042,463 (GRCm39) missense possibly damaging 0.84
R5659:Atp10b UTSW 11 43,136,252 (GRCm39) missense probably damaging 1.00
R5688:Atp10b UTSW 11 43,092,000 (GRCm39) missense probably benign 0.00
R5735:Atp10b UTSW 11 43,042,601 (GRCm39) missense probably benign 0.00
R6153:Atp10b UTSW 11 43,145,109 (GRCm39) missense probably damaging 1.00
R6251:Atp10b UTSW 11 43,126,573 (GRCm39) missense possibly damaging 0.95
R6259:Atp10b UTSW 11 43,092,065 (GRCm39) missense probably benign 0.24
R6394:Atp10b UTSW 11 43,116,464 (GRCm39) missense probably damaging 1.00
R6492:Atp10b UTSW 11 43,109,784 (GRCm39) missense probably damaging 1.00
R6769:Atp10b UTSW 11 43,094,079 (GRCm39) critical splice donor site probably null
R6771:Atp10b UTSW 11 43,094,079 (GRCm39) critical splice donor site probably null
R6775:Atp10b UTSW 11 43,113,040 (GRCm39) missense possibly damaging 0.80
R7134:Atp10b UTSW 11 43,136,291 (GRCm39) missense probably damaging 1.00
R7322:Atp10b UTSW 11 43,103,374 (GRCm39) missense probably damaging 1.00
R7367:Atp10b UTSW 11 43,138,328 (GRCm39) missense probably damaging 1.00
R7708:Atp10b UTSW 11 43,092,970 (GRCm39) missense probably damaging 1.00
R7787:Atp10b UTSW 11 43,150,700 (GRCm39) missense possibly damaging 0.91
R8145:Atp10b UTSW 11 43,092,949 (GRCm39) missense probably damaging 1.00
R8406:Atp10b UTSW 11 43,093,984 (GRCm39) missense probably benign 0.00
R8503:Atp10b UTSW 11 43,113,066 (GRCm39) missense possibly damaging 0.92
R8542:Atp10b UTSW 11 43,121,208 (GRCm39) missense probably benign 0.18
R8744:Atp10b UTSW 11 43,121,177 (GRCm39) missense probably damaging 1.00
R8815:Atp10b UTSW 11 43,093,978 (GRCm39) missense possibly damaging 0.63
R8833:Atp10b UTSW 11 43,112,986 (GRCm39) missense probably damaging 1.00
R8880:Atp10b UTSW 11 43,106,811 (GRCm39) missense probably benign
R8989:Atp10b UTSW 11 43,136,269 (GRCm39) nonsense probably null
R8998:Atp10b UTSW 11 43,150,726 (GRCm39) makesense probably null
R9255:Atp10b UTSW 11 43,107,148 (GRCm39) missense probably damaging 1.00
R9281:Atp10b UTSW 11 43,116,458 (GRCm39) missense probably benign 0.11
R9345:Atp10b UTSW 11 43,094,024 (GRCm39) missense probably damaging 0.99
R9357:Atp10b UTSW 11 43,150,711 (GRCm39) missense probably benign 0.18
R9393:Atp10b UTSW 11 43,063,608 (GRCm39) missense probably damaging 1.00
R9516:Atp10b UTSW 11 43,121,224 (GRCm39) missense probably benign 0.02
R9644:Atp10b UTSW 11 43,042,659 (GRCm39) missense probably damaging 1.00
R9747:Atp10b UTSW 11 43,088,339 (GRCm39) missense probably benign
Z1177:Atp10b UTSW 11 43,044,176 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TGTGTGCACAGACTAATACAGAGAG -3'
(R):5'- TGCTGGGCTGAATGACTTTC -3'

Sequencing Primer
(F):5'- CAGAGAGCATATTTGATTAACAGCTG -3'
(R):5'- ATCCAAGATCTCCAGAGTTGGCTG -3'
Posted On 2019-10-17