Incidental Mutation 'R7549:Magi1'
| ID |
584382 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi1
|
| Ensembl Gene |
ENSMUSG00000045095 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
| MMRRC Submission |
045620-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.593)
|
| Stock # |
R7549 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 93685095 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Alanine
at position 761
(E761A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086730
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204532]
|
| AlphaFold |
Q6RHR9 |
| PDB Structure |
X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055224
AA Change: E748A
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000062085
Gene: ENSMUSG00000045095
AA Change: E748A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
348 |
380 |
2.88e-9 |
SMART |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
|
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
|
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
|
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
|
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
|
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000089317
AA Change: E761A
PolyPhen 2
Score 0.192 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000086730
Gene: ENSMUSG00000045095
AA Change: E761A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
|
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
|
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000093769
AA Change: E533A
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000091283
Gene: ENSMUSG00000045095
AA Change: E533A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
|
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
|
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
|
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203519
AA Change: E760A
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000145244
Gene: ENSMUSG00000045095
AA Change: E760A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
360 |
392 |
2.88e-9 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
|
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
|
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
|
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
|
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
|
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203688
AA Change: E534A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000145515
Gene: ENSMUSG00000045095
AA Change: E534A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
|
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
|
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
|
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204347
AA Change: E761A
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000144881
Gene: ENSMUSG00000045095
AA Change: E761A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
|
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
|
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
| SMART Domains |
Protein: ENSMUSP00000144769
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
|
WW
|
74 |
106 |
5.8e-13 |
SMART |
|
WW
|
133 |
165 |
1.7e-11 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
|
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530084C06Rik |
G |
T |
13: 31,742,978 (GRCm39) |
R92S |
unknown |
Het |
| Adam1b |
A |
G |
5: 121,639,981 (GRCm39) |
C355R |
probably damaging |
Het |
| Adamtsl3 |
T |
C |
7: 82,223,117 (GRCm39) |
L966P |
probably damaging |
Het |
| Aldh18a1 |
A |
G |
19: 40,553,291 (GRCm39) |
C486R |
probably damaging |
Het |
| Aqp11 |
C |
A |
7: 97,387,284 (GRCm39) |
|
probably benign |
Het |
| Arhgap28 |
A |
G |
17: 68,178,961 (GRCm39) |
L350P |
probably damaging |
Het |
| Art3 |
A |
G |
5: 92,551,514 (GRCm39) |
Q291R |
probably benign |
Het |
| Asb15 |
A |
G |
6: 24,559,029 (GRCm39) |
|
probably null |
Het |
| Bmp8b |
T |
C |
4: 122,999,448 (GRCm39) |
I102T |
possibly damaging |
Het |
| Bsn |
T |
C |
9: 107,992,014 (GRCm39) |
D1246G |
probably benign |
Het |
| Cass4 |
G |
A |
2: 172,268,718 (GRCm39) |
G267S |
probably benign |
Het |
| Cass4 |
G |
T |
2: 172,268,719 (GRCm39) |
G267V |
probably benign |
Het |
| Ccr7 |
T |
C |
11: 99,036,727 (GRCm39) |
Y65C |
probably damaging |
Het |
| Clstn2 |
A |
C |
9: 97,464,597 (GRCm39) |
I186S |
probably benign |
Het |
| Cyp2r1 |
A |
G |
7: 114,153,879 (GRCm39) |
I105T |
possibly damaging |
Het |
| Efr3a |
T |
A |
15: 65,687,262 (GRCm39) |
|
probably null |
Het |
| Erg |
A |
C |
16: 95,170,179 (GRCm39) |
|
probably null |
Het |
| Eya4 |
A |
T |
10: 22,987,557 (GRCm39) |
V524E |
probably damaging |
Het |
| Farp1 |
C |
A |
14: 121,472,589 (GRCm39) |
N241K |
possibly damaging |
Het |
| Fat1 |
A |
T |
8: 45,442,031 (GRCm39) |
Y1111F |
probably benign |
Het |
| Fbn1 |
T |
C |
2: 125,185,947 (GRCm39) |
E1607G |
probably damaging |
Het |
| Fbn2 |
A |
T |
18: 58,153,536 (GRCm39) |
C2575* |
probably null |
Het |
| Fsip2 |
A |
T |
2: 82,824,337 (GRCm39) |
D6690V |
probably damaging |
Het |
| Fzd4 |
T |
C |
7: 89,056,346 (GRCm39) |
V131A |
possibly damaging |
Het |
| Gfral |
T |
A |
9: 76,106,257 (GRCm39) |
N110I |
probably benign |
Het |
| Glce |
T |
C |
9: 61,968,275 (GRCm39) |
D292G |
probably damaging |
Het |
| Gm19410 |
T |
A |
8: 36,266,500 (GRCm39) |
I1051K |
probably benign |
Het |
| Gm5773 |
A |
T |
3: 93,680,323 (GRCm39) |
|
probably benign |
Het |
| Hcn3 |
A |
T |
3: 89,057,307 (GRCm39) |
H430Q |
probably null |
Het |
| Hspa8 |
T |
A |
9: 40,714,255 (GRCm39) |
|
probably null |
Het |
| Ifna7 |
A |
T |
4: 88,734,664 (GRCm39) |
D67V |
possibly damaging |
Het |
| Kif5c |
T |
A |
2: 49,591,105 (GRCm39) |
M319K |
probably benign |
Het |
| Klk7 |
G |
T |
7: 43,462,197 (GRCm39) |
|
probably null |
Het |
| Kmt2c |
T |
C |
5: 25,619,968 (GRCm39) |
K102E |
possibly damaging |
Het |
| Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,758,813 (GRCm39) |
|
probably benign |
Het |
| Lrp1b |
C |
T |
2: 40,765,134 (GRCm39) |
M2897I |
|
Het |
| Lysmd2 |
T |
C |
9: 75,544,519 (GRCm39) |
S211P |
probably damaging |
Het |
| Mbd5 |
T |
A |
2: 49,141,355 (GRCm39) |
I106N |
probably damaging |
Het |
| Mdc1 |
G |
A |
17: 36,159,749 (GRCm39) |
A669T |
probably null |
Het |
| Mmp1b |
A |
G |
9: 7,384,753 (GRCm39) |
I265T |
probably benign |
Het |
| Mmp2 |
T |
A |
8: 93,563,594 (GRCm39) |
L356Q |
probably null |
Het |
| Mroh8 |
A |
G |
2: 157,111,492 (GRCm39) |
L154P |
probably benign |
Het |
| Muc13 |
T |
C |
16: 33,619,806 (GRCm39) |
S185P |
unknown |
Het |
| Nuak1 |
T |
A |
10: 84,210,403 (GRCm39) |
I562F |
probably benign |
Het |
| Obscn |
C |
A |
11: 58,933,664 (GRCm39) |
|
probably null |
Het |
| Or51t4 |
T |
C |
7: 102,597,798 (GRCm39) |
I42T |
possibly damaging |
Het |
| Or5w14 |
A |
T |
2: 87,542,115 (GRCm39) |
M45K |
probably damaging |
Het |
| Or9k7 |
T |
C |
10: 130,046,853 (GRCm39) |
M49V |
probably benign |
Het |
| Pex3 |
T |
C |
10: 13,418,414 (GRCm39) |
M81V |
probably benign |
Het |
| Pex5l |
T |
A |
3: 33,136,184 (GRCm39) |
I12F |
probably benign |
Het |
| Phf3 |
G |
T |
1: 30,870,556 (GRCm39) |
T164N |
probably benign |
Het |
| Phpt1 |
G |
T |
2: 25,464,844 (GRCm39) |
A3E |
probably benign |
Het |
| Pja2 |
A |
T |
17: 64,616,410 (GRCm39) |
L162M |
probably damaging |
Het |
| Pkdrej |
T |
A |
15: 85,703,994 (GRCm39) |
K647N |
probably damaging |
Het |
| Ppp2r1a |
T |
C |
17: 21,182,944 (GRCm39) |
S543P |
possibly damaging |
Het |
| Prdm13 |
C |
A |
4: 21,679,072 (GRCm39) |
D473Y |
probably damaging |
Het |
| Prl6a1 |
A |
T |
13: 27,502,954 (GRCm39) |
E183D |
probably damaging |
Het |
| Psmd3 |
C |
T |
11: 98,581,787 (GRCm39) |
T304M |
probably benign |
Het |
| Ptpn5 |
C |
T |
7: 46,735,874 (GRCm39) |
|
probably null |
Het |
| Rassf6 |
T |
G |
5: 90,754,661 (GRCm39) |
I206L |
probably damaging |
Het |
| Rif1 |
A |
G |
2: 51,968,519 (GRCm39) |
H234R |
possibly damaging |
Het |
| Rint1 |
T |
C |
5: 24,020,702 (GRCm39) |
V575A |
probably benign |
Het |
| Ros1 |
G |
A |
10: 52,021,930 (GRCm39) |
T639I |
probably damaging |
Het |
| Ryr2 |
A |
G |
13: 11,752,871 (GRCm39) |
F1817L |
probably benign |
Het |
| Ska1 |
T |
C |
18: 74,333,088 (GRCm39) |
D110G |
probably benign |
Het |
| Slc25a41 |
G |
A |
17: 57,340,791 (GRCm39) |
T227I |
probably damaging |
Het |
| Slc6a15 |
T |
C |
10: 103,224,998 (GRCm39) |
S29P |
probably benign |
Het |
| Slc8a3 |
A |
T |
12: 81,361,544 (GRCm39) |
I425K |
probably benign |
Het |
| Sox8 |
T |
A |
17: 25,786,935 (GRCm39) |
Q256L |
probably damaging |
Het |
| Tars3 |
T |
C |
7: 65,297,341 (GRCm39) |
V152A |
probably damaging |
Het |
| Tbx10 |
A |
T |
19: 4,046,651 (GRCm39) |
T44S |
probably benign |
Het |
| Terb1 |
T |
A |
8: 105,224,716 (GRCm39) |
I52F |
possibly damaging |
Het |
| Tes |
AGCCGGCC |
AGCC |
6: 17,099,740 (GRCm39) |
|
probably null |
Het |
| Tgm1 |
A |
G |
14: 55,943,360 (GRCm39) |
V527A |
probably benign |
Het |
| Tmed10 |
G |
T |
12: 85,391,036 (GRCm39) |
Y167* |
probably null |
Het |
| Tmem165 |
T |
G |
5: 76,356,415 (GRCm39) |
S318R |
possibly damaging |
Het |
| Trim9 |
G |
T |
12: 70,393,715 (GRCm39) |
S76R |
probably damaging |
Het |
| Tti1 |
A |
G |
2: 157,849,088 (GRCm39) |
V717A |
probably damaging |
Het |
| Vmn2r86 |
T |
A |
10: 130,282,697 (GRCm39) |
I640F |
probably damaging |
Het |
| Vwf |
A |
G |
6: 125,603,230 (GRCm39) |
N860S |
|
Het |
| Xirp2 |
A |
G |
2: 67,339,241 (GRCm39) |
K494R |
possibly damaging |
Het |
| Zkscan4 |
G |
A |
13: 21,668,419 (GRCm39) |
S319N |
probably damaging |
Het |
|
| Other mutations in Magi1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1497:Magi1
|
UTSW |
6 |
93,724,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4670:Magi1
|
UTSW |
6 |
93,663,624 (GRCm39) |
splice site |
probably null |
|
|
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4839:Magi1
|
UTSW |
6 |
93,671,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7224:Magi1
|
UTSW |
6 |
93,660,070 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
|
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9300:Magi1
|
UTSW |
6 |
93,724,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9432:Magi1
|
UTSW |
6 |
93,660,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9567:Magi1
|
UTSW |
6 |
93,655,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTCTACCTGCTCCGAGGAG -3'
(R):5'- TGCGTGCAAAGTCAGGATGG -3'
Sequencing Primer
(F):5'- GACACCTAGGCCTTTTCGATTAAGAG -3'
(R):5'- GGGAGAGATGCCCACTGC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation