Mutagenetix > Incidental Mutations

Incidental Mutation 'R7552:Olfr791'

584490

Institutional Source

Beutler Lab

Gene Symbol

Olfr791

Ensembl Gene

ENSMUSG00000047626

Gene Name

olfactory receptor 791

Synonyms

GA_x6K02T2PULF-11205096-11206034, MOR114-1

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.130) question?

Stock #

R7552 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

129521792-129528353 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 129526560 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Tyrosine at position 111 (F111Y)

Ref Sequence

ENSEMBL: ENSMUSP00000150497 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057477] [ENSMUST00000217228]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000057477
AA Change: F111Y

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000052722
Gene: ENSMUSG00000047626
AA Change: F111Y

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	7.6e-45	PFAM
Pfam:7TM_GPCR_Srsx	33	303	4.3e-6	PFAM
Pfam:7tm_1	39	288	4.7e-24	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217228
AA Change: F111Y

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (89/89)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd17a	A	G	10: 80,583,903	Y290H	probably benign	Het
Aco2	T	C	15: 81,903,941	V257A	probably damaging	Het
Adam26a	C	A	8: 43,569,970	C161F	possibly damaging	Het
Adam9	G	A	8: 24,955,972	P820S	unknown	Het
Adcy4	G	A	14: 55,773,465	T665M	probably benign	Het
AF529169	T	A	9: 89,601,835	H503L	probably benign	Het
Ahnak	T	A	19: 9,006,824	M1824K	probably benign	Het
Alpi	T	C	1: 87,099,073	N428D	probably benign	Het
Ano5	C	T	7: 51,546,780	P153L	probably benign	Het
Atp1a1	A	T	3: 101,582,121	L725*	probably null	Het
Atp8b2	G	A	3: 89,946,764	T595I	probably damaging	Het
Ccdc66	T	C	14: 27,498,863	I35V	possibly damaging	Het
Cd163	A	G	6: 124,307,228	T120A	probably benign	Het
Cmah	A	T	13: 24,456,955	T396S	possibly damaging	Het
Cmya5	C	T	13: 93,069,312	V3350I	probably benign	Het
Commd9	A	C	2: 101,901,065	K198N	probably damaging	Het
Cxcr1	A	G	1: 74,192,614	V83A	probably benign	Het
D630045J12Rik	A	G	6: 38,148,448	S1544P	probably damaging	Het
Ddt	A	T	10: 75,773,214		probably null	Het
Depdc7	A	G	2: 104,727,240	S222P	possibly damaging	Het
Ehd2	A	G	7: 15,950,506	I456T	probably damaging	Het
Epas1	A	T	17: 86,829,043	M748L	probably benign	Het
Esr1	G	A	10: 4,856,903	R273H	probably damaging	Het
Fras1	G	A	5: 96,768,438	D3444N	probably damaging	Het
Gm7682	G	A	5: 94,448,535	C477Y	probably damaging	Het
Hand2	A	G	8: 57,322,237	R111G	probably damaging	Het
Hecw1	A	T	13: 14,316,250	V306E	probably damaging	Het
Ift140	T	C	17: 25,033,115	I312T	probably benign	Het
Ikbke	A	T	1: 131,272,150	L257*	probably null	Het
Kcnk5	G	A	14: 20,142,281	P271S	probably benign	Het
Lama1	T	C	17: 67,737,667	V187A		Het
Lemd2	A	T	17: 27,193,836		probably null	Het
Lig3	T	A	11: 82,788,891	D341E	probably benign	Het
Lpcat1	C	T	13: 73,494,895	S196L	probably damaging	Het
Lrp1b	A	T	2: 40,677,570	D4048E		Het
Lrrfip1	G	A	1: 91,105,283	E158K	probably damaging	Het
Mcm5	T	C	8: 75,121,592	S490P	probably damaging	Het
Mia3	A	C	1: 183,365,695	Y73*	probably null	Het
Msr1	A	T	8: 39,623,962	N202K	probably benign	Het
N4bp2l2	A	T	5: 150,661,821	Y231*	probably null	Het
Nbeal2	A	G	9: 110,653,917	W11R	probably benign	Het
Ncor1	T	C	11: 62,373,424	E384G	possibly damaging	Het
Neb	A	G	2: 52,247,190	V254A		Het
Nlrp9b	T	C	7: 20,045,766	S785P	probably benign	Het
Olfr1024	A	G	2: 85,904,103	V317A	probably benign	Het
Olfr1191-ps1	A	G	2: 88,643,408	I214V	probably benign	Het
Olfr1258	G	T	2: 89,930,720	D304Y	probably benign	Het
Olfr2	T	C	7: 107,001,327	T178A	probably benign	Het
Oprd1	T	G	4: 132,113,781	I289L	possibly damaging	Het
Orc1	A	G	4: 108,588,754	N23S	probably benign	Het
Paip1	A	T	13: 119,440,820	H149L	possibly damaging	Het
Pdhx	A	T	2: 103,046,754	D103E	probably benign	Het
Pi4ka	T	C	16: 17,291,216	Y1614C		Het
Pias3	ACC	AC	3: 96,701,385		probably null	Het
Pigb	A	G	9: 73,034,488	V163A	probably benign	Het
Pla2g4d	A	G	2: 120,284,139	I37T	possibly damaging	Het
Ppfia1	A	T	7: 144,506,245	V610D	probably damaging	Het
Prss1	T	C	6: 41,462,573	V80A	probably benign	Het
Psph	G	A	5: 129,770,736	R49W	probably benign	Het
Qrich2	T	C	11: 116,456,254	Y1248C	possibly damaging	Het
Rlbp1	T	A	7: 79,380,113	Y124F	probably damaging	Het
Scn4a	T	A	11: 106,349,169	E74V	probably benign	Het
Sdk2	A	T	11: 113,873,213	I249N	possibly damaging	Het
Sgsh	A	T	11: 119,346,552	L412Q	probably damaging	Het
Shank1	C	A	7: 44,353,028	D1390E	probably benign	Het
Slc12a6	A	G	2: 112,341,974	D421G	probably damaging	Het
Snx29	T	A	16: 11,420,785		probably null	Het
Spata31d1c	A	G	13: 65,036,123	Y493C	probably damaging	Het
Stmn4	G	A	14: 66,356,278	G40E	probably damaging	Het
Stox2	A	G	8: 47,203,119		probably null	Het
Strada	T	C	11: 106,187,004	S45G	unknown	Het
Taco1	G	A	11: 106,071,948	G154S	probably benign	Het
Tas2r121	T	C	6: 132,700,542	M156V	probably benign	Het
Tbc1d31	A	G	15: 57,940,740	S384G	probably benign	Het
Tbc1d9	A	T	8: 83,239,931	D387V	probably damaging	Het
Tet3	A	G	6: 83,368,307	L1716P	probably damaging	Het
Thbs1	A	G	2: 118,113,362	K154E	possibly damaging	Het
Ush2a	T	C	1: 188,267,044	Y184H	possibly damaging	Het
Vmn1r235	C	A	17: 21,261,451	Q13K	probably benign	Het
Vmn2r15	A	T	5: 109,292,908	Y361*	probably null	Het
Vmn2r88	A	T	14: 51,410,858		probably null	Het
Vps54	T	C	11: 21,298,831	V460A	probably benign	Het
Wdr64	A	G	1: 175,785,581	N674S	possibly damaging	Het
Zfp592	A	G	7: 81,023,642	D118G	probably benign	Het
Zfp763	A	G	17: 33,018,651	Y507H	probably benign	Het
Zfp934	T	C	13: 62,492,891	E16G	probably damaging	Het
Zfyve26	G	A	12: 79,290,957	L94F	probably damaging	Het

Other mutations in Olfr791

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01153:Olfr791	APN	10	129526995	missense	probably damaging	0.97
IGL03034:Olfr791	APN	10	129526658	missense	probably benign
IGL03281:Olfr791	APN	10	129526403	missense	probably benign	0.31
R0555:Olfr791	UTSW	10	129526896	missense	possibly damaging	0.90
R1474:Olfr791	UTSW	10	129526955	missense	probably benign	0.03
R1638:Olfr791	UTSW	10	129526619	missense	probably benign	0.00
R1917:Olfr791	UTSW	10	129527049	missense	probably damaging	0.99
R1918:Olfr791	UTSW	10	129527049	missense	probably damaging	0.99
R1919:Olfr791	UTSW	10	129527049	missense	probably damaging	0.99
R2303:Olfr791	UTSW	10	129527049	missense	probably benign	0.10
R3113:Olfr791	UTSW	10	129527143	missense	probably benign	0.08
R3929:Olfr791	UTSW	10	129526231	start codon destroyed	probably null	1.00
R4704:Olfr791	UTSW	10	129526302	missense	possibly damaging	0.90
R4831:Olfr791	UTSW	10	129526580	missense	probably damaging	1.00
R5207:Olfr791	UTSW	10	129526904	missense	probably benign	0.08
R5313:Olfr791	UTSW	10	129527081	missense	probably damaging	1.00
R5644:Olfr791	UTSW	10	129527103	missense	probably damaging	1.00
R5661:Olfr791	UTSW	10	129526749	missense	probably benign	0.45
R5894:Olfr791	UTSW	10	129526488	missense	probably damaging	0.98
R6988:Olfr791	UTSW	10	129526673	missense	probably benign	0.02
R6996:Olfr791	UTSW	10	129526863	missense	probably damaging	1.00
R7380:Olfr791	UTSW	10	129526661	missense	probably benign
R7539:Olfr791	UTSW	10	129527105	nonsense	probably null
R7635:Olfr791	UTSW	10	129526682	missense	probably benign	0.00
R8084:Olfr791	UTSW	10	129526940	missense	probably damaging	1.00
R8260:Olfr791	UTSW	10	129527088	missense	possibly damaging	0.55
X0066:Olfr791	UTSW	10	129526745	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCTTACGTTGGTGGATCCC -3'
(R):5'- TCACAGCTGAAATGATCAATGGC -3'

Sequencing Primer
(F):5'- GGTGGATCCCCATCTTAAAACAC -3'
(R):5'- TGATCAATGGCATTGGAGTCAC -3'

Posted On

2019-10-17