Incidental Mutation 'R7556:Vmn2r102'
| ID |
584805 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r102
|
| Ensembl Gene |
ENSMUSG00000095961 |
| Gene Name |
vomeronasal 2, receptor 102 |
| Synonyms |
EG224572 |
| MMRRC Submission |
045624-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7556 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19880661-19915010 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 19898093 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 369
(N369K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
| AlphaFold |
L7N279 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171741
AA Change: N369K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: N369K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931429L15Rik |
C |
T |
9: 46,221,611 (GRCm39) |
W11* |
probably null |
Het |
| A2ml1 |
A |
G |
6: 128,546,927 (GRCm39) |
S401P |
probably damaging |
Het |
| Adamtsl1 |
T |
A |
4: 86,195,358 (GRCm39) |
Y592N |
probably benign |
Het |
| Adh6b |
C |
T |
3: 138,058,546 (GRCm39) |
T76I |
probably damaging |
Het |
| Aebp2 |
C |
A |
6: 140,623,137 (GRCm39) |
P503Q |
probably benign |
Het |
| Ankrd2 |
A |
G |
19: 42,028,839 (GRCm39) |
D134G |
|
Het |
| Atf7ip |
T |
C |
6: 136,538,239 (GRCm39) |
S491P |
probably damaging |
Het |
| Atp1a3 |
T |
C |
7: 24,680,991 (GRCm39) |
D832G |
probably benign |
Het |
| Atrnl1 |
G |
A |
19: 57,643,278 (GRCm39) |
V389I |
probably benign |
Het |
| Bahcc1 |
T |
C |
11: 120,178,589 (GRCm39) |
S2383P |
probably damaging |
Het |
| Brd9 |
A |
G |
13: 74,092,886 (GRCm39) |
D292G |
possibly damaging |
Het |
| Cacna1e |
G |
T |
1: 154,348,419 (GRCm39) |
Q781K |
probably benign |
Het |
| Ccdc9 |
T |
C |
7: 16,018,491 (GRCm39) |
|
probably benign |
Het |
| Cdc42ep4 |
C |
G |
11: 113,619,366 (GRCm39) |
E342Q |
probably damaging |
Het |
| Celf3 |
C |
T |
3: 94,387,590 (GRCm39) |
T54M |
probably damaging |
Het |
| Cenpn |
T |
C |
8: 117,664,008 (GRCm39) |
Y267H |
probably damaging |
Het |
| Chrnb4 |
T |
C |
9: 54,942,339 (GRCm39) |
T312A |
probably benign |
Het |
| Clcn3 |
T |
A |
8: 61,382,521 (GRCm39) |
T383S |
probably damaging |
Het |
| Cln3 |
T |
C |
7: 126,174,242 (GRCm39) |
Q327R |
probably damaging |
Het |
| Cnep1r1 |
T |
C |
8: 88,851,761 (GRCm39) |
L50P |
probably damaging |
Het |
| Cnot6 |
T |
C |
11: 49,566,144 (GRCm39) |
N512S |
probably benign |
Het |
| Col7a1 |
T |
A |
9: 108,811,533 (GRCm39) |
|
probably null |
Het |
| Cryba4 |
C |
T |
5: 112,398,969 (GRCm39) |
R25Q |
probably damaging |
Het |
| Dnah5 |
A |
G |
15: 28,290,389 (GRCm39) |
I1260V |
probably null |
Het |
| Dock2 |
G |
T |
11: 34,611,778 (GRCm39) |
T195K |
probably benign |
Het |
| Dpp9 |
A |
T |
17: 56,497,012 (GRCm39) |
I740N |
possibly damaging |
Het |
| Fbxl21 |
A |
T |
13: 56,674,741 (GRCm39) |
N31Y |
probably benign |
Het |
| Frat1 |
G |
A |
19: 41,818,959 (GRCm39) |
R118Q |
possibly damaging |
Het |
| Gna11 |
A |
G |
10: 81,367,208 (GRCm39) |
F228S |
|
Het |
| Golgb1 |
A |
T |
16: 36,736,155 (GRCm39) |
M1842L |
probably benign |
Het |
| Got1 |
A |
T |
19: 43,491,469 (GRCm39) |
M327K |
probably damaging |
Het |
| H4c9 |
A |
G |
13: 22,225,414 (GRCm39) |
I27T |
probably damaging |
Het |
| Hexa |
T |
A |
9: 59,470,582 (GRCm39) |
L468Q |
probably damaging |
Het |
| Ift57 |
G |
A |
16: 49,526,491 (GRCm39) |
V178I |
probably benign |
Het |
| Kbtbd13 |
T |
C |
9: 65,298,757 (GRCm39) |
T60A |
probably benign |
Het |
| Klk1b5 |
A |
G |
7: 43,496,649 (GRCm39) |
T194A |
probably damaging |
Het |
| Krtap16-3 |
C |
A |
16: 88,759,666 (GRCm39) |
G16C |
unknown |
Het |
| Lamb3 |
T |
C |
1: 193,014,757 (GRCm39) |
S639P |
probably benign |
Het |
| Mapt |
C |
A |
11: 104,189,528 (GRCm39) |
P182Q |
probably benign |
Het |
| Mcf2l |
A |
G |
8: 13,023,071 (GRCm39) |
T86A |
probably damaging |
Het |
| Mecom |
G |
T |
3: 30,041,220 (GRCm39) |
H125N |
probably benign |
Het |
| Med18 |
T |
C |
4: 132,187,247 (GRCm39) |
H84R |
probably benign |
Het |
| Muc2 |
A |
G |
7: 141,307,439 (GRCm39) |
Y798C |
|
Het |
| Mycbp |
T |
C |
4: 123,799,060 (GRCm39) |
Y17H |
probably damaging |
Het |
| Nacad |
C |
T |
11: 6,551,272 (GRCm39) |
V640M |
possibly damaging |
Het |
| Ncoa1 |
C |
T |
12: 4,320,794 (GRCm39) |
V1092I |
probably damaging |
Het |
| Nomo1 |
A |
G |
7: 45,715,642 (GRCm39) |
E696G |
probably damaging |
Het |
| Notch4 |
G |
A |
17: 34,794,444 (GRCm39) |
C741Y |
probably damaging |
Het |
| Or10g7 |
A |
G |
9: 39,905,978 (GRCm39) |
N291D |
probably damaging |
Het |
| Or6d12 |
C |
T |
6: 116,493,697 (GRCm39) |
Q320* |
probably null |
Het |
| Osbpl10 |
C |
A |
9: 115,036,692 (GRCm39) |
H229Q |
probably damaging |
Het |
| Pif1 |
A |
T |
9: 65,496,993 (GRCm39) |
|
probably null |
Het |
| Plk2 |
T |
G |
13: 110,533,122 (GRCm39) |
|
probably null |
Het |
| Ppp1r42 |
T |
C |
1: 10,065,408 (GRCm39) |
H172R |
probably benign |
Het |
| Ring1 |
A |
G |
17: 34,240,688 (GRCm39) |
I363T |
possibly damaging |
Het |
| Rnf168 |
T |
G |
16: 32,117,863 (GRCm39) |
Y475D |
probably damaging |
Het |
| Sbf2 |
T |
A |
7: 109,913,260 (GRCm39) |
K1671N |
probably benign |
Het |
| Sema6d |
A |
G |
2: 124,496,109 (GRCm39) |
N51S |
probably damaging |
Het |
| Setx |
C |
A |
2: 29,036,505 (GRCm39) |
Q997K |
possibly damaging |
Het |
| Skint5 |
T |
G |
4: 113,425,162 (GRCm39) |
Q1088P |
unknown |
Het |
| Slc22a27 |
T |
C |
19: 7,843,119 (GRCm39) |
D528G |
probably damaging |
Het |
| Slc6a7 |
T |
A |
18: 61,140,514 (GRCm39) |
K173* |
probably null |
Het |
| Smc2 |
T |
C |
4: 52,457,379 (GRCm39) |
F380L |
probably benign |
Het |
| Spata31d1a |
T |
C |
13: 59,849,798 (GRCm39) |
M777V |
probably benign |
Het |
| Stkld1 |
A |
T |
2: 26,837,307 (GRCm39) |
N319I |
possibly damaging |
Het |
| Tanc2 |
T |
C |
11: 105,799,857 (GRCm39) |
V93A |
|
Het |
| Tbx20 |
T |
C |
9: 24,661,573 (GRCm39) |
|
probably null |
Het |
| Trbv20 |
G |
A |
6: 41,165,715 (GRCm39) |
V47I |
probably benign |
Het |
| Trip4 |
A |
T |
9: 65,782,155 (GRCm39) |
C192* |
probably null |
Het |
| Tsbp1 |
A |
T |
17: 34,656,691 (GRCm39) |
I103F |
unknown |
Het |
| Tulp2 |
A |
G |
7: 45,168,005 (GRCm39) |
|
probably null |
Het |
| Ush2a |
C |
A |
1: 188,689,690 (GRCm39) |
P5084Q |
probably benign |
Het |
| Virma |
T |
C |
4: 11,518,927 (GRCm39) |
Y675H |
probably damaging |
Het |
| Vmn2r59 |
A |
T |
7: 41,695,233 (GRCm39) |
M393K |
probably damaging |
Het |
| Vmn2r69 |
GAAAA |
GAAAAA |
7: 85,060,768 (GRCm39) |
|
probably null |
Het |
| Xpot |
A |
G |
10: 121,449,411 (GRCm39) |
S30P |
probably benign |
Het |
| Zfp947 |
T |
C |
17: 22,364,597 (GRCm39) |
Y359C |
probably benign |
Het |
|
| Other mutations in Vmn2r102 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Vmn2r102
|
APN |
17 |
19,899,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Vmn2r102
|
APN |
17 |
19,897,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00978:Vmn2r102
|
APN |
17 |
19,899,185 (GRCm39) |
splice site |
probably null |
|
|
IGL01589:Vmn2r102
|
APN |
17 |
19,899,066 (GRCm39) |
missense |
probably benign |
|
|
IGL01738:Vmn2r102
|
APN |
17 |
19,898,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01994:Vmn2r102
|
APN |
17 |
19,880,731 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r102
|
APN |
17 |
19,914,191 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02525:Vmn2r102
|
APN |
17 |
19,901,447 (GRCm39) |
missense |
probably benign |
|
|
IGL02589:Vmn2r102
|
APN |
17 |
19,901,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Vmn2r102
|
APN |
17 |
19,898,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Vmn2r102
|
APN |
17 |
19,914,328 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03162:Vmn2r102
|
APN |
17 |
19,914,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,896,958 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0042:Vmn2r102
|
UTSW |
17 |
19,880,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0132:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0268:Vmn2r102
|
UTSW |
17 |
19,898,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0441:Vmn2r102
|
UTSW |
17 |
19,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0583:Vmn2r102
|
UTSW |
17 |
19,897,043 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Vmn2r102
|
UTSW |
17 |
19,898,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Vmn2r102
|
UTSW |
17 |
19,899,106 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0709:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0879:Vmn2r102
|
UTSW |
17 |
19,914,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r102
|
UTSW |
17 |
19,880,887 (GRCm39) |
splice site |
probably benign |
|
|
R1473:Vmn2r102
|
UTSW |
17 |
19,914,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1630:Vmn2r102
|
UTSW |
17 |
19,899,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1727:Vmn2r102
|
UTSW |
17 |
19,897,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1759:Vmn2r102
|
UTSW |
17 |
19,914,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2013:Vmn2r102
|
UTSW |
17 |
19,897,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2086:Vmn2r102
|
UTSW |
17 |
19,896,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2241:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Vmn2r102
|
UTSW |
17 |
19,914,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3814:Vmn2r102
|
UTSW |
17 |
19,899,093 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3827:Vmn2r102
|
UTSW |
17 |
19,914,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4159:Vmn2r102
|
UTSW |
17 |
19,898,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Vmn2r102
|
UTSW |
17 |
19,880,845 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4517:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4535:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4662:Vmn2r102
|
UTSW |
17 |
19,901,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r102
|
UTSW |
17 |
19,914,576 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r102
|
UTSW |
17 |
19,897,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Vmn2r102
|
UTSW |
17 |
19,898,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4927:Vmn2r102
|
UTSW |
17 |
19,880,661 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R5077:Vmn2r102
|
UTSW |
17 |
19,897,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5181:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5277:Vmn2r102
|
UTSW |
17 |
19,914,393 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5418:Vmn2r102
|
UTSW |
17 |
19,914,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Vmn2r102
|
UTSW |
17 |
19,897,804 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5864:Vmn2r102
|
UTSW |
17 |
19,914,943 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6168:Vmn2r102
|
UTSW |
17 |
19,914,402 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6266:Vmn2r102
|
UTSW |
17 |
19,899,007 (GRCm39) |
missense |
probably benign |
|
|
R6432:Vmn2r102
|
UTSW |
17 |
19,901,483 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6487:Vmn2r102
|
UTSW |
17 |
19,898,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Vmn2r102
|
UTSW |
17 |
19,914,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6797:Vmn2r102
|
UTSW |
17 |
19,880,694 (GRCm39) |
nonsense |
probably null |
|
|
R7009:Vmn2r102
|
UTSW |
17 |
19,914,456 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7098:Vmn2r102
|
UTSW |
17 |
19,914,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Vmn2r102
|
UTSW |
17 |
19,897,749 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7463:Vmn2r102
|
UTSW |
17 |
19,896,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7511:Vmn2r102
|
UTSW |
17 |
19,901,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7512:Vmn2r102
|
UTSW |
17 |
19,914,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8126:Vmn2r102
|
UTSW |
17 |
19,880,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8385:Vmn2r102
|
UTSW |
17 |
19,914,088 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8410:Vmn2r102
|
UTSW |
17 |
19,898,196 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9045:Vmn2r102
|
UTSW |
17 |
19,880,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Vmn2r102
|
UTSW |
17 |
19,896,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Vmn2r102
|
UTSW |
17 |
19,897,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9363:Vmn2r102
|
UTSW |
17 |
19,897,614 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9524:Vmn2r102
|
UTSW |
17 |
19,897,564 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9747:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r102
|
UTSW |
17 |
19,914,305 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACATCATGTTATTGACAGAGCTGAC -3'
(R):5'- CTGCCATGGAAAGAACACTATC -3'
Sequencing Primer
(F):5'- GAGCTGACTATTTCATGTTAGACAC -3'
(R):5'- TGGAAAGAACACTATCCCTTTGC -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation