|Institutional Source||Beutler Lab|
|Gene Name||prostaglandin-endoperoxide synthase 1|
|Synonyms||Pghs1, Cox-3, COX1, Cox-1, cyclooxygenase 1|
|Is this an essential gene?||Possibly non essential (E-score: 0.351)|
|Stock #||R7557 (G1)|
|Chromosomal Location||36230426-36252272 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 36245211 bp|
|Amino Acid Change||Serine to Proline at position 396 (S396P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000059977 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000062069]|
|Predicted Effect||possibly damaging
AA Change: S396P
PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
AA Change: S396P
|Coding Region Coverage||
FUNCTION: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
PHENOTYPE: Null mutants show impaired platelet aggregation, reduced inflammatory responses, and diminished susceptibility to induced papillomas. Female mutants exhibit delayed parturition and their offspring die neonatally. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ptgs1||
(F):5'- TGCATTGAGCTCTGCTGAC -3'
(R):5'- TGGGGAGTTTGAACCAAGTCTG -3'
(F):5'- ATCTTCCCCTTGTAGGAGAAAC -3'
(R):5'- GAACCAAGTCTGTTGTATCCCAGAG -3'