Incidental Mutation 'R7557:Mok'
ID 584850
Institutional Source Beutler Lab
Gene Symbol Mok
Ensembl Gene ENSMUSG00000056458
Gene Name MOK protein kinase
Synonyms Rage, Stk30, MOK, MAPK/MAK/MRK/ overlapping kinase
MMRRC Submission 045652-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # R7557 (G1)
Quality Score 225.009
Status Not validated
Chromosome 12
Chromosomal Location 110774232-110807373 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 110774833 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 330 (S330P)
Ref Sequence ENSEMBL: ENSMUSP00000068904 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070565] [ENSMUST00000084974] [ENSMUST00000193053]
AlphaFold Q9WVS4
Predicted Effect probably benign
Transcript: ENSMUST00000070565
AA Change: S330P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000068904
Gene: ENSMUSG00000056458
AA Change: S330P

DomainStartEndE-ValueType
S_TKc 4 285 6.78e-85 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000084974
AA Change: S146P

PolyPhen 2 Score 0.868 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000082041
Gene: ENSMUSG00000056458
AA Change: S146P

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 1 138 8.4e-20 PFAM
Pfam:Pkinase 1 168 4.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193053
SMART Domains Protein: ENSMUSP00000141678
Gene: ENSMUSG00000037957

DomainStartEndE-ValueType
Blast:WD40 89 131 2e-16 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,774,044 (GRCm39) Q1078* probably null Het
Aatk T C 11: 119,900,256 (GRCm39) K1310R possibly damaging Het
Acaa2 C T 18: 74,928,230 (GRCm39) T153M possibly damaging Het
Add3 A G 19: 53,227,868 (GRCm39) T518A probably damaging Het
Cacnb4 T C 2: 52,359,579 (GRCm39) E143G probably damaging Het
Cd209a T A 8: 3,795,541 (GRCm39) T177S probably benign Het
Chp1 T A 2: 119,391,238 (GRCm39) Y32N probably damaging Het
Clcn3 T C 8: 61,390,402 (GRCm39) T180A probably damaging Het
Dctn2 C A 10: 127,114,273 (GRCm39) T373N probably benign Het
Dipk2a T C 9: 94,402,591 (GRCm39) D357G probably damaging Het
Ecpas A G 4: 58,849,691 (GRCm39) Y483H possibly damaging Het
Emb T A 13: 117,386,252 (GRCm39) N136K probably benign Het
Enpp2 A T 15: 54,773,536 (GRCm39) C62S probably damaging Het
Fbxo28 G T 1: 182,169,000 (GRCm39) A52E unknown Het
Gask1b A T 3: 79,793,915 (GRCm39) K128* probably null Het
Gdi1 G A X: 73,350,461 (GRCm39) R55H probably benign Het
Ggta1 T C 2: 35,292,548 (GRCm39) D253G probably damaging Het
Gps1 C T 11: 120,677,193 (GRCm39) A164V probably benign Het
Gramd4 C T 15: 85,985,101 (GRCm39) Q146* probably null Het
Kcnh5 A T 12: 75,054,399 (GRCm39) M515K possibly damaging Het
Klrc3 T C 6: 129,616,107 (GRCm39) T203A probably damaging Het
Krt26 G T 11: 99,225,567 (GRCm39) R305S probably damaging Het
Lpin1 A G 12: 16,630,793 (GRCm39) V35A Het
Marf1 C T 16: 13,950,560 (GRCm39) R942H probably damaging Het
Mfhas1 T A 8: 36,056,758 (GRCm39) M411K possibly damaging Het
Msto1 A G 3: 88,817,435 (GRCm39) probably null Het
Omg T A 11: 79,393,679 (GRCm39) I60F possibly damaging Het
Or10w1 T A 19: 13,632,390 (GRCm39) I199N possibly damaging Het
Pcdhgb4 T A 18: 37,855,847 (GRCm39) C747* probably null Het
Pih1d1 A G 7: 44,806,183 (GRCm39) T40A probably benign Het
Pih1d2 A T 9: 50,536,216 (GRCm39) E290D probably damaging Het
Plce1 A G 19: 38,753,848 (GRCm39) K1849E probably benign Het
Plekha5 T C 6: 140,372,271 (GRCm39) Y74H probably damaging Het
Pole T G 5: 110,460,860 (GRCm39) I1183S probably damaging Het
Ptgs1 T C 2: 36,135,223 (GRCm39) S396P possibly damaging Het
Rasa2 T C 9: 96,439,478 (GRCm39) E575G probably damaging Het
Sec22b A G 3: 97,808,674 (GRCm39) T5A probably damaging Het
Slc18a1 T A 8: 69,518,213 (GRCm39) D267V probably damaging Het
Smad5 T C 13: 56,875,282 (GRCm39) F157L probably benign Het
Tcea1 T A 1: 4,965,213 (GRCm39) C294* probably null Het
Tut7 T C 13: 59,936,280 (GRCm39) I1274V possibly damaging Het
Txndc15 T A 13: 55,865,767 (GRCm39) M77K probably benign Het
Urb1 CACTTAC CAC 16: 90,569,461 (GRCm39) probably benign Het
Vmn2r1 T A 3: 63,997,475 (GRCm39) V377D probably damaging Het
Vmn2r7 A G 3: 64,632,394 (GRCm39) Y23H probably benign Het
Vwa3a T A 7: 120,394,841 (GRCm39) M887K possibly damaging Het
Zbtb5 T C 4: 44,995,196 (GRCm39) N63D probably damaging Het
Other mutations in Mok
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Mok APN 12 110,774,631 (GRCm39) unclassified probably benign
IGL01925:Mok APN 12 110,774,646 (GRCm39) missense probably benign 0.15
IGL02660:Mok APN 12 110,794,499 (GRCm39) missense probably damaging 0.99
R0256:Mok UTSW 12 110,774,539 (GRCm39) missense probably damaging 1.00
R1797:Mok UTSW 12 110,774,479 (GRCm39) missense probably benign 0.28
R2022:Mok UTSW 12 110,778,257 (GRCm39) missense probably benign 0.00
R2175:Mok UTSW 12 110,781,634 (GRCm39) missense probably benign 0.01
R3840:Mok UTSW 12 110,781,591 (GRCm39) missense probably benign 0.04
R3841:Mok UTSW 12 110,781,591 (GRCm39) missense probably benign 0.04
R4645:Mok UTSW 12 110,774,873 (GRCm39) unclassified probably benign
R5711:Mok UTSW 12 110,774,503 (GRCm39) missense probably damaging 1.00
R6084:Mok UTSW 12 110,781,380 (GRCm39) missense probably benign 0.01
R6336:Mok UTSW 12 110,800,558 (GRCm39) critical splice donor site probably null
R6544:Mok UTSW 12 110,777,189 (GRCm39) missense probably damaging 1.00
R7403:Mok UTSW 12 110,781,563 (GRCm39) critical splice donor site probably null
R7789:Mok UTSW 12 110,778,261 (GRCm39) missense probably damaging 1.00
R8011:Mok UTSW 12 110,781,351 (GRCm39) utr 3 prime probably benign
R8169:Mok UTSW 12 110,774,799 (GRCm39) missense probably benign 0.00
R8487:Mok UTSW 12 110,776,341 (GRCm39) critical splice donor site probably null
R9437:Mok UTSW 12 110,774,659 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTTCACAGCAGCACACTTCAG -3'
(R):5'- TAAAGCTCCATTGAGGGCGTG -3'

Sequencing Primer
(F):5'- ACTTCAGGGGTCTCAGCACAG -3'
(R):5'- GGTCTGTACAATACAAGAGGCTTC -3'
Posted On 2019-10-17