Incidental Mutation 'R7557:Txndc15'
ID 584851
Institutional Source Beutler Lab
Gene Symbol Txndc15
Ensembl Gene ENSMUSG00000021497
Gene Name thioredoxin domain containing 15
Synonyms 2310047H23Rik
MMRRC Submission 045652-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R7557 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 55862463-55874040 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 55865767 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 77 (M77K)
Ref Sequence ENSEMBL: ENSMUSP00000021959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021959]
AlphaFold Q6P6J9
Predicted Effect probably benign
Transcript: ENSMUST00000021959
AA Change: M77K

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000021959
Gene: ENSMUSG00000021497
AA Change: M77K

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:Thioredoxin 174 278 8.6e-11 PFAM
transmembrane domain 305 324 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,774,044 (GRCm39) Q1078* probably null Het
Aatk T C 11: 119,900,256 (GRCm39) K1310R possibly damaging Het
Acaa2 C T 18: 74,928,230 (GRCm39) T153M possibly damaging Het
Add3 A G 19: 53,227,868 (GRCm39) T518A probably damaging Het
Cacnb4 T C 2: 52,359,579 (GRCm39) E143G probably damaging Het
Cd209a T A 8: 3,795,541 (GRCm39) T177S probably benign Het
Chp1 T A 2: 119,391,238 (GRCm39) Y32N probably damaging Het
Clcn3 T C 8: 61,390,402 (GRCm39) T180A probably damaging Het
Dctn2 C A 10: 127,114,273 (GRCm39) T373N probably benign Het
Dipk2a T C 9: 94,402,591 (GRCm39) D357G probably damaging Het
Ecpas A G 4: 58,849,691 (GRCm39) Y483H possibly damaging Het
Emb T A 13: 117,386,252 (GRCm39) N136K probably benign Het
Enpp2 A T 15: 54,773,536 (GRCm39) C62S probably damaging Het
Fbxo28 G T 1: 182,169,000 (GRCm39) A52E unknown Het
Gask1b A T 3: 79,793,915 (GRCm39) K128* probably null Het
Gdi1 G A X: 73,350,461 (GRCm39) R55H probably benign Het
Ggta1 T C 2: 35,292,548 (GRCm39) D253G probably damaging Het
Gps1 C T 11: 120,677,193 (GRCm39) A164V probably benign Het
Gramd4 C T 15: 85,985,101 (GRCm39) Q146* probably null Het
Kcnh5 A T 12: 75,054,399 (GRCm39) M515K possibly damaging Het
Klrc3 T C 6: 129,616,107 (GRCm39) T203A probably damaging Het
Krt26 G T 11: 99,225,567 (GRCm39) R305S probably damaging Het
Lpin1 A G 12: 16,630,793 (GRCm39) V35A Het
Marf1 C T 16: 13,950,560 (GRCm39) R942H probably damaging Het
Mfhas1 T A 8: 36,056,758 (GRCm39) M411K possibly damaging Het
Mok A G 12: 110,774,833 (GRCm39) S330P probably benign Het
Msto1 A G 3: 88,817,435 (GRCm39) probably null Het
Omg T A 11: 79,393,679 (GRCm39) I60F possibly damaging Het
Or10w1 T A 19: 13,632,390 (GRCm39) I199N possibly damaging Het
Pcdhgb4 T A 18: 37,855,847 (GRCm39) C747* probably null Het
Pih1d1 A G 7: 44,806,183 (GRCm39) T40A probably benign Het
Pih1d2 A T 9: 50,536,216 (GRCm39) E290D probably damaging Het
Plce1 A G 19: 38,753,848 (GRCm39) K1849E probably benign Het
Plekha5 T C 6: 140,372,271 (GRCm39) Y74H probably damaging Het
Pole T G 5: 110,460,860 (GRCm39) I1183S probably damaging Het
Ptgs1 T C 2: 36,135,223 (GRCm39) S396P possibly damaging Het
Rasa2 T C 9: 96,439,478 (GRCm39) E575G probably damaging Het
Sec22b A G 3: 97,808,674 (GRCm39) T5A probably damaging Het
Slc18a1 T A 8: 69,518,213 (GRCm39) D267V probably damaging Het
Smad5 T C 13: 56,875,282 (GRCm39) F157L probably benign Het
Tcea1 T A 1: 4,965,213 (GRCm39) C294* probably null Het
Tut7 T C 13: 59,936,280 (GRCm39) I1274V possibly damaging Het
Urb1 CACTTAC CAC 16: 90,569,461 (GRCm39) probably benign Het
Vmn2r1 T A 3: 63,997,475 (GRCm39) V377D probably damaging Het
Vmn2r7 A G 3: 64,632,394 (GRCm39) Y23H probably benign Het
Vwa3a T A 7: 120,394,841 (GRCm39) M887K possibly damaging Het
Zbtb5 T C 4: 44,995,196 (GRCm39) N63D probably damaging Het
Other mutations in Txndc15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Txndc15 APN 13 55,873,488 (GRCm39) missense probably damaging 1.00
IGL01634:Txndc15 APN 13 55,869,438 (GRCm39) missense probably damaging 0.99
PIT4791001:Txndc15 UTSW 13 55,869,507 (GRCm39) missense probably benign 0.39
R0309:Txndc15 UTSW 13 55,872,395 (GRCm39) missense probably damaging 1.00
R0480:Txndc15 UTSW 13 55,872,436 (GRCm39) missense possibly damaging 0.91
R1473:Txndc15 UTSW 13 55,869,387 (GRCm39) splice site probably benign
R1856:Txndc15 UTSW 13 55,865,875 (GRCm39) missense possibly damaging 0.80
R4456:Txndc15 UTSW 13 55,865,977 (GRCm39) missense possibly damaging 0.82
R4945:Txndc15 UTSW 13 55,865,978 (GRCm39) missense probably benign 0.01
R5159:Txndc15 UTSW 13 55,865,734 (GRCm39) missense probably benign
R5376:Txndc15 UTSW 13 55,866,032 (GRCm39) missense probably damaging 1.00
R5776:Txndc15 UTSW 13 55,865,920 (GRCm39) missense probably benign 0.01
R7365:Txndc15 UTSW 13 55,862,601 (GRCm39) missense unknown
R7392:Txndc15 UTSW 13 55,869,399 (GRCm39) missense probably damaging 1.00
R7679:Txndc15 UTSW 13 55,873,621 (GRCm39) missense probably damaging 0.98
R9276:Txndc15 UTSW 13 55,865,914 (GRCm39) missense probably benign 0.01
R9369:Txndc15 UTSW 13 55,869,507 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- GCTTTAGTTGCAGAGGACAGTG -3'
(R):5'- ACTTGAGGCTGTCAGTGCTG -3'

Sequencing Primer
(F):5'- TTGCAGAGGACAGTGGTCACC -3'
(R):5'- TTGGCATCCTCGGTGGCTAC -3'
Posted On 2019-10-17