Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00507:Mroh2b'

5852

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mroh2b

Ensembl Gene

ENSMUSG00000022155

Gene Name

maestro heat-like repeat family member 2B

Synonyms

4930455B06Rik, Heatr7b2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

IGL00507

Quality Score

Status

Chromosome

Chromosomal Location

4898737-4962205 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 4962127 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 1569 (T1569I)

Ref Sequence

ENSEMBL: ENSMUSP00000036148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045736]

AlphaFold

Q7M6Y6

Predicted Effect

probably damaging
Transcript: ENSMUST00000045736
AA Change: T1569I

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000036148
Gene: ENSMUSG00000022155
AA Change: T1569I

Domain	Start	End	E-Value	Type
low complexity region	124	135	N/A	INTRINSIC
low complexity region	824	842	N/A	INTRINSIC
SCOP:d1gw5a_	937	1443	7e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226849

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228458

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsbg1	C	T	9: 54,622,428 (GRCm38)		probably benign	Het
Adgrb3	T	A	1: 25,074,715 (GRCm38)	R1450S	possibly damaging	Het
Apc	A	G	18: 34,316,926 (GRCm38)	I2258V	probably benign	Het
Atxn2l	C	A	7: 126,496,584 (GRCm38)	A374S	possibly damaging	Het
Cacna1a	T	A	8: 84,571,208 (GRCm38)	Y1182*	probably null	Het
Cc2d1b	G	T	4: 108,629,730 (GRCm38)	A647S	probably damaging	Het
Csn2	A	G	5: 87,694,773 (GRCm38)	S116P	probably benign	Het
Eya4	G	A	10: 23,157,536 (GRCm38)	Q163*	probably null	Het
Fam47c	A	T	X: 78,738,325 (GRCm38)	D171V	probably benign	Het
Fhdc1	A	T	3: 84,448,800 (GRCm38)	C446S	probably damaging	Het
Fkbp9	T	A	6: 56,850,701 (GRCm38)	V169E	probably damaging	Het
Fras1	A	T	5: 96,778,189 (GRCm38)	I3751F	probably damaging	Het
Gkn1	T	C	6: 87,346,339 (GRCm38)	Y164C	probably damaging	Het
Hs3st5	T	C	10: 36,832,922 (GRCm38)	I151T	probably benign	Het
Ighv8-6	A	T	12: 115,165,852 (GRCm38)	S95T	probably damaging	Het
Loxhd1	A	G	18: 77,332,567 (GRCm38)	I296V	probably benign	Het
Lrrc66	T	C	5: 73,607,114 (GRCm38)	E862G	probably benign	Het
Ltbp3	T	C	19: 5,756,016 (GRCm38)	V934A	probably damaging	Het
Mpp3	A	T	11: 102,002,103 (GRCm38)	I501K	possibly damaging	Het
Nup133	A	T	8: 123,918,967 (GRCm38)	Y626*	probably null	Het
Pak3	T	A	X: 143,789,333 (GRCm38)	N477K	probably damaging	Het
Plod3	A	G	5: 136,996,176 (GRCm38)	H714R	possibly damaging	Het
Ppil1	T	C	17: 29,251,701 (GRCm38)	N102S	probably damaging	Het
Rapgef6	A	T	11: 54,664,109 (GRCm38)	R996*	probably null	Het
Scd3	G	A	19: 44,235,834 (GRCm38)	D169N	probably damaging	Het
Sgo2a	T	A	1: 58,016,594 (GRCm38)	F646I	probably damaging	Het
Slc5a8	A	G	10: 88,908,040 (GRCm38)	Y346C	possibly damaging	Het
Slc7a15	A	T	12: 8,535,474 (GRCm38)	V49E	probably damaging	Het
Stard8	G	A	X: 99,069,335 (GRCm38)	E649K	probably damaging	Het

Other mutations in Mroh2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00503:Mroh2b	APN	15	4,899,197 (GRCm38)	missense	probably benign
IGL00548:Mroh2b	APN	15	4,931,316 (GRCm38)	missense	probably benign	0.35
IGL00902:Mroh2b	APN	15	4,915,222 (GRCm38)	missense	probably damaging	1.00
IGL00944:Mroh2b	APN	15	4,951,127 (GRCm38)	splice site	probably benign
IGL00954:Mroh2b	APN	15	4,903,054 (GRCm38)	missense	probably damaging	0.99
IGL01015:Mroh2b	APN	15	4,941,542 (GRCm38)	missense	probably damaging	1.00
IGL01134:Mroh2b	APN	15	4,915,152 (GRCm38)	missense	probably benign	0.00
IGL01337:Mroh2b	APN	15	4,905,024 (GRCm38)	missense	probably benign	0.38
IGL01780:Mroh2b	APN	15	4,912,000 (GRCm38)	missense	probably benign	0.01
IGL01919:Mroh2b	APN	15	4,923,688 (GRCm38)	missense	probably benign	0.10
IGL02069:Mroh2b	APN	15	4,904,324 (GRCm38)	splice site	probably benign
IGL02146:Mroh2b	APN	15	4,951,294 (GRCm38)	splice site	probably null
IGL02221:Mroh2b	APN	15	4,923,641 (GRCm38)	missense	probably damaging	1.00
IGL02281:Mroh2b	APN	15	4,952,263 (GRCm38)	missense	probably benign	0.04
IGL02350:Mroh2b	APN	15	4,912,000 (GRCm38)	missense	probably benign	0.01
IGL02357:Mroh2b	APN	15	4,912,000 (GRCm38)	missense	probably benign	0.01
IGL02401:Mroh2b	APN	15	4,900,501 (GRCm38)	missense	possibly damaging	0.71
IGL02427:Mroh2b	APN	15	4,951,560 (GRCm38)	splice site	probably benign
IGL02432:Mroh2b	APN	15	4,914,186 (GRCm38)	missense	probably benign
IGL02582:Mroh2b	APN	15	4,908,515 (GRCm38)	missense	probably damaging	0.98
IGL02632:Mroh2b	APN	15	4,931,101 (GRCm38)	missense	probably damaging	0.99
IGL02741:Mroh2b	APN	15	4,905,632 (GRCm38)	missense	probably benign
IGL02811:Mroh2b	APN	15	4,915,236 (GRCm38)	missense	possibly damaging	0.55
IGL02826:Mroh2b	APN	15	4,962,148 (GRCm38)	missense	probably damaging	0.99
IGL03412:Mroh2b	APN	15	4,944,372 (GRCm38)	missense	probably benign	0.14
PIT4468001:Mroh2b	UTSW	15	4,912,812 (GRCm38)	missense	probably damaging	1.00
R0024:Mroh2b	UTSW	15	4,925,627 (GRCm38)	missense	probably damaging	1.00
R0333:Mroh2b	UTSW	15	4,931,118 (GRCm38)	missense	probably damaging	1.00
R0433:Mroh2b	UTSW	15	4,941,634 (GRCm38)	missense	probably benign	0.01
R0530:Mroh2b	UTSW	15	4,934,395 (GRCm38)	missense	probably damaging	0.97
R1411:Mroh2b	UTSW	15	4,918,317 (GRCm38)	missense	probably damaging	1.00
R1457:Mroh2b	UTSW	15	4,925,684 (GRCm38)	missense	probably damaging	1.00
R1466:Mroh2b	UTSW	15	4,925,684 (GRCm38)	missense	probably damaging	1.00
R1466:Mroh2b	UTSW	15	4,925,684 (GRCm38)	missense	probably damaging	1.00
R1472:Mroh2b	UTSW	15	4,948,655 (GRCm38)	missense	probably benign	0.00
R1525:Mroh2b	UTSW	15	4,951,130 (GRCm38)	splice site	probably null
R1584:Mroh2b	UTSW	15	4,925,684 (GRCm38)	missense	probably damaging	1.00
R1605:Mroh2b	UTSW	15	4,945,090 (GRCm38)	missense	probably benign	0.08
R1657:Mroh2b	UTSW	15	4,931,043 (GRCm38)	nonsense	probably null
R1671:Mroh2b	UTSW	15	4,951,294 (GRCm38)	splice site	probably null
R1698:Mroh2b	UTSW	15	4,914,140 (GRCm38)	missense	probably benign	0.02
R2002:Mroh2b	UTSW	15	4,925,684 (GRCm38)	missense	probably damaging	1.00
R2005:Mroh2b	UTSW	15	4,917,158 (GRCm38)	missense	probably damaging	1.00
R2077:Mroh2b	UTSW	15	4,944,966 (GRCm38)	missense	probably damaging	1.00
R2179:Mroh2b	UTSW	15	4,921,446 (GRCm38)	critical splice donor site	probably null
R2183:Mroh2b	UTSW	15	4,918,225 (GRCm38)	splice site	probably null
R3713:Mroh2b	UTSW	15	4,943,649 (GRCm38)	missense	probably benign	0.01
R3714:Mroh2b	UTSW	15	4,943,649 (GRCm38)	missense	probably benign	0.01
R3747:Mroh2b	UTSW	15	4,952,246 (GRCm38)	nonsense	probably null
R3748:Mroh2b	UTSW	15	4,952,246 (GRCm38)	nonsense	probably null
R3749:Mroh2b	UTSW	15	4,952,246 (GRCm38)	nonsense	probably null
R3750:Mroh2b	UTSW	15	4,952,246 (GRCm38)	nonsense	probably null
R3792:Mroh2b	UTSW	15	4,923,620 (GRCm38)	missense	probably damaging	1.00
R3872:Mroh2b	UTSW	15	4,925,061 (GRCm38)	nonsense	probably null
R4021:Mroh2b	UTSW	15	4,925,100 (GRCm38)	missense	possibly damaging	0.75
R4329:Mroh2b	UTSW	15	4,931,379 (GRCm38)	missense	probably damaging	0.99
R4456:Mroh2b	UTSW	15	4,947,925 (GRCm38)	missense	probably benign	0.21
R4592:Mroh2b	UTSW	15	4,918,290 (GRCm38)	missense	probably damaging	1.00
R4836:Mroh2b	UTSW	15	4,904,270 (GRCm38)	missense	probably damaging	1.00
R5050:Mroh2b	UTSW	15	4,900,450 (GRCm38)	missense	possibly damaging	0.82
R5230:Mroh2b	UTSW	15	4,941,522 (GRCm38)	missense	probably benign	0.07
R5342:Mroh2b	UTSW	15	4,914,133 (GRCm38)	nonsense	probably null
R5353:Mroh2b	UTSW	15	4,917,178 (GRCm38)	missense	probably damaging	1.00
R5368:Mroh2b	UTSW	15	4,905,572 (GRCm38)	missense	probably damaging	1.00
R5424:Mroh2b	UTSW	15	4,941,612 (GRCm38)	missense	probably damaging	0.98
R5484:Mroh2b	UTSW	15	4,908,981 (GRCm38)	missense	possibly damaging	0.92
R5999:Mroh2b	UTSW	15	4,912,884 (GRCm38)	splice site	probably null
R6046:Mroh2b	UTSW	15	4,951,281 (GRCm38)	missense	probably benign	0.01
R6081:Mroh2b	UTSW	15	4,944,377 (GRCm38)	missense	probably damaging	1.00
R6162:Mroh2b	UTSW	15	4,915,225 (GRCm38)	missense	probably damaging	1.00
R6165:Mroh2b	UTSW	15	4,918,350 (GRCm38)	missense	probably benign	0.23
R6240:Mroh2b	UTSW	15	4,934,644 (GRCm38)	missense	probably benign	0.38
R6487:Mroh2b	UTSW	15	4,947,239 (GRCm38)	missense	probably damaging	1.00
R6539:Mroh2b	UTSW	15	4,905,574 (GRCm38)	missense	probably damaging	1.00
R6616:Mroh2b	UTSW	15	4,953,282 (GRCm38)	missense	probably benign	0.36
R6663:Mroh2b	UTSW	15	4,947,935 (GRCm38)	missense	probably benign	0.21
R6820:Mroh2b	UTSW	15	4,953,274 (GRCm38)	missense	probably damaging	1.00
R6900:Mroh2b	UTSW	15	4,908,987 (GRCm38)	missense	probably benign	0.00
R6990:Mroh2b	UTSW	15	4,912,802 (GRCm38)	missense	possibly damaging	0.55
R7067:Mroh2b	UTSW	15	4,900,504 (GRCm38)	missense	probably benign	0.35
R7092:Mroh2b	UTSW	15	4,934,678 (GRCm38)	missense	possibly damaging	0.92
R7102:Mroh2b	UTSW	15	4,948,003 (GRCm38)	missense	probably benign	0.06
R7264:Mroh2b	UTSW	15	4,921,362 (GRCm38)	missense	possibly damaging	0.81
R7436:Mroh2b	UTSW	15	4,941,554 (GRCm38)	missense	probably benign	0.21
R7462:Mroh2b	UTSW	15	4,908,627 (GRCm38)	missense	probably damaging	1.00
R7529:Mroh2b	UTSW	15	4,949,009 (GRCm38)	missense	probably damaging	1.00
R7575:Mroh2b	UTSW	15	4,934,605 (GRCm38)	missense	probably damaging	1.00
R7579:Mroh2b	UTSW	15	4,931,061 (GRCm38)	missense	probably benign	0.09
R7605:Mroh2b	UTSW	15	4,945,023 (GRCm38)	missense	probably damaging	1.00
R7624:Mroh2b	UTSW	15	4,917,131 (GRCm38)	missense	probably damaging	1.00
R7797:Mroh2b	UTSW	15	4,949,105 (GRCm38)	missense	probably benign	0.36
R7848:Mroh2b	UTSW	15	4,938,379 (GRCm38)	nonsense	probably null
R7952:Mroh2b	UTSW	15	4,951,211 (GRCm38)	missense	probably damaging	1.00
R7995:Mroh2b	UTSW	15	4,921,357 (GRCm38)	nonsense	probably null
R8088:Mroh2b	UTSW	15	4,900,503 (GRCm38)	missense	possibly damaging	0.57
R8207:Mroh2b	UTSW	15	4,938,410 (GRCm38)	missense	possibly damaging	0.95
R8242:Mroh2b	UTSW	15	4,909,040 (GRCm38)	missense	probably benign	0.04
R8248:Mroh2b	UTSW	15	4,931,104 (GRCm38)	missense	probably benign	0.40
R8258:Mroh2b	UTSW	15	4,911,909 (GRCm38)	missense	probably benign	0.01
R8259:Mroh2b	UTSW	15	4,911,909 (GRCm38)	missense	probably benign	0.01
R8304:Mroh2b	UTSW	15	4,925,637 (GRCm38)	missense	probably damaging	0.99
R8316:Mroh2b	UTSW	15	4,951,264 (GRCm38)	nonsense	probably null
R8345:Mroh2b	UTSW	15	4,944,326 (GRCm38)	missense	probably benign	0.09
R8507:Mroh2b	UTSW	15	4,949,090 (GRCm38)	missense	probably damaging	1.00
R8728:Mroh2b	UTSW	15	4,905,640 (GRCm38)	missense	probably damaging	1.00
R8747:Mroh2b	UTSW	15	4,935,300 (GRCm38)	missense	probably damaging	0.99
R8798:Mroh2b	UTSW	15	4,948,709 (GRCm38)	missense	probably damaging	1.00
R8814:Mroh2b	UTSW	15	4,941,625 (GRCm38)	missense	possibly damaging	0.61
R8856:Mroh2b	UTSW	15	4,931,028 (GRCm38)	nonsense	probably null
R8910:Mroh2b	UTSW	15	4,931,373 (GRCm38)	missense	probably benign	0.01
R8913:Mroh2b	UTSW	15	4,917,528 (GRCm38)	intron	probably benign
R8941:Mroh2b	UTSW	15	4,962,124 (GRCm38)	missense	possibly damaging	0.86
R9014:Mroh2b	UTSW	15	4,899,188 (GRCm38)	start codon destroyed	probably null	0.95
R9086:Mroh2b	UTSW	15	4,953,272 (GRCm38)	critical splice acceptor site	probably null
R9101:Mroh2b	UTSW	15	4,900,453 (GRCm38)	missense	probably benign	0.20
R9118:Mroh2b	UTSW	15	4,962,091 (GRCm38)	missense	possibly damaging	0.86
R9393:Mroh2b	UTSW	15	4,951,184 (GRCm38)	missense	probably benign
R9429:Mroh2b	UTSW	15	4,934,425 (GRCm38)	missense	probably damaging	1.00
R9431:Mroh2b	UTSW	15	4,934,470 (GRCm38)	missense	probably damaging	1.00
R9443:Mroh2b	UTSW	15	4,944,339 (GRCm38)	missense	probably damaging	1.00
R9447:Mroh2b	UTSW	15	4,931,341 (GRCm38)	missense	probably damaging	1.00
R9497:Mroh2b	UTSW	15	4,921,363 (GRCm38)	missense	probably damaging	0.98
R9588:Mroh2b	UTSW	15	4,948,648 (GRCm38)	missense	probably benign	0.00
R9631:Mroh2b	UTSW	15	4,917,074 (GRCm38)	missense	probably damaging	0.97
R9686:Mroh2b	UTSW	15	4,945,123 (GRCm38)	missense	probably benign	0.34
R9774:Mroh2b	UTSW	15	4,914,131 (GRCm38)	missense	probably benign	0.08
X0067:Mroh2b	UTSW	15	4,951,591 (GRCm38)	missense	possibly damaging	0.90
Z1177:Mroh2b	UTSW	15	4,905,005 (GRCm38)	missense	probably damaging	1.00

Posted On

2012-04-20