Incidental Mutation 'R0619:Trappc14'
ID 58526
Institutional Source Beutler Lab
Gene Symbol Trappc14
Ensembl Gene ENSMUSG00000036948
Gene Name trafficking protein particle complex 14
Synonyms Map11, BC037034
MMRRC Submission 038808-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R0619 (G1)
Quality Score 220
Status Not validated
Chromosome 5
Chromosomal Location 138257918-138262295 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 138262088 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125084 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048421] [ENSMUST00000062067] [ENSMUST00000100530] [ENSMUST00000159123] [ENSMUST00000161647] [ENSMUST00000159067] [ENSMUST00000159146] [ENSMUST00000159649] [ENSMUST00000161279]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000048421
AA Change: S3P
SMART Domains Protein: ENSMUSP00000046898
Gene: ENSMUSG00000036948
AA Change: S3P

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
low complexity region 215 225 N/A INTRINSIC
low complexity region 488 502 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000062067
Predicted Effect probably benign
Transcript: ENSMUST00000100530
SMART Domains Protein: ENSMUSP00000098099
Gene: ENSMUSG00000075593

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 2 231 1.1e-57 PFAM
Pfam:Gal-3-0_sulfotr 270 463 1e-54 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124298
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125662
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138911
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159534
Predicted Effect unknown
Transcript: ENSMUST00000159123
AA Change: S3P
SMART Domains Protein: ENSMUSP00000137679
Gene: ENSMUSG00000036948
AA Change: S3P

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159872
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144460
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160157
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141454
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162557
Predicted Effect probably benign
Transcript: ENSMUST00000161647
SMART Domains Protein: ENSMUSP00000125084
Gene: ENSMUSG00000075593

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 4 226 5.3e-58 PFAM
Pfam:Gal-3-0_sulfotr 265 458 3.8e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159067
SMART Domains Protein: ENSMUSP00000125178
Gene: ENSMUSG00000106247

DomainStartEndE-ValueType
Pfam:Glypican 7 250 1e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159146
Predicted Effect probably benign
Transcript: ENSMUST00000159649
SMART Domains Protein: ENSMUSP00000125208
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 219 233 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161279
SMART Domains Protein: ENSMUSP00000124841
Gene: ENSMUSG00000075593

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 2 231 1.1e-57 PFAM
Pfam:Gal-3-0_sulfotr 270 463 1e-54 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000164203
AA Change: S3P
SMART Domains Protein: ENSMUSP00000127440
Gene: ENSMUSG00000091964
AA Change: S3P

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
Pfam:DUF4707 139 579 4.7e-252 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170479
AA Change: S70P
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162632
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad2 G A 8: 120,339,739 (GRCm39) D74N probably benign Het
Adgre4 T A 17: 56,127,679 (GRCm39) V573D possibly damaging Het
Ak7 A G 12: 105,699,770 (GRCm39) K230E probably damaging Het
Amdhd2 T C 17: 24,375,562 (GRCm39) D375G possibly damaging Het
Anpep T C 7: 79,490,757 (GRCm39) E253G probably benign Het
Bbs7 A G 3: 36,661,725 (GRCm39) L158S probably benign Het
Bdp1 T C 13: 100,174,366 (GRCm39) T2057A probably benign Het
C2 G T 17: 35,091,479 (GRCm39) H61Q probably damaging Het
Ccdc18 A G 5: 108,328,282 (GRCm39) K661E probably benign Het
Cdh23 C T 10: 60,269,556 (GRCm39) V655I probably damaging Het
Cep78 T C 19: 15,956,226 (GRCm39) T238A probably damaging Het
Ces2a T A 8: 105,462,742 (GRCm39) N110K probably benign Het
Crat T C 2: 30,299,996 (GRCm39) D128G probably benign Het
Dclre1a A T 19: 56,533,841 (GRCm39) M233K probably benign Het
Dsg4 T C 18: 20,594,416 (GRCm39) V515A probably benign Het
Fer1l6 T C 15: 58,534,784 (GRCm39) probably null Het
Fryl T C 5: 73,226,074 (GRCm39) D1863G probably benign Het
Fsip2 T A 2: 82,774,484 (GRCm39) L57Q probably damaging Het
Gnb4 C T 3: 32,645,356 (GRCm39) V112I probably benign Het
Iqsec1 T C 6: 90,647,388 (GRCm39) probably null Het
Kcnn3 A C 3: 89,559,337 (GRCm39) T536P probably damaging Het
Kctd3 T C 1: 188,710,840 (GRCm39) D441G probably damaging Het
Kifc3 G A 8: 95,829,293 (GRCm39) T528M probably benign Het
Kmt2c G A 5: 25,503,914 (GRCm39) T3798I probably benign Het
Map1a T A 2: 121,135,736 (GRCm39) M1946K probably damaging Het
Mfhas1 T A 8: 36,057,829 (GRCm39) V768E probably benign Het
Mroh8 C A 2: 157,107,001 (GRCm39) V223F possibly damaging Het
Mss51 A T 14: 20,537,641 (GRCm39) V30E probably benign Het
Mtmr10 G A 7: 63,970,961 (GRCm39) R392H probably benign Het
Mup3 T C 4: 62,004,198 (GRCm39) N105S probably benign Het
Myh7b T C 2: 155,453,642 (GRCm39) M22T probably benign Het
Or1o2 T A 17: 37,543,046 (GRCm39) I72F possibly damaging Het
Or2aj5 T A 16: 19,425,022 (GRCm39) Y132F probably damaging Het
Or5m9 T A 2: 85,877,655 (GRCm39) Y276* probably null Het
Os9 A G 10: 126,956,860 (GRCm39) I43T probably damaging Het
Pkhd1l1 T C 15: 44,347,234 (GRCm39) L200P probably damaging Het
Ptpru C T 4: 131,548,198 (GRCm39) V100M possibly damaging Het
Rnf6 G A 5: 146,147,531 (GRCm39) R496C possibly damaging Het
Rsad1 C T 11: 94,433,465 (GRCm39) R407Q probably damaging Het
Rspo3 T C 10: 29,380,633 (GRCm39) D127G probably damaging Het
Sbf2 T A 7: 109,909,469 (GRCm39) T1760S possibly damaging Het
Sh2d3c T A 2: 32,643,037 (GRCm39) V588E probably damaging Het
Siglech A T 7: 55,418,910 (GRCm39) T238S probably benign Het
Slc15a2 T A 16: 36,579,669 (GRCm39) N328I probably damaging Het
Slc16a11 G T 11: 70,105,858 (GRCm39) G94C probably damaging Het
Stub1 T C 17: 26,050,296 (GRCm39) probably null Het
Tacc2 T A 7: 130,318,483 (GRCm39) V40D probably damaging Het
Tagln3 C A 16: 45,544,635 (GRCm39) R12L probably damaging Het
Tsen54 A G 11: 115,705,890 (GRCm39) E69G probably damaging Het
Tsks A G 7: 44,600,258 (GRCm39) E150G probably damaging Het
Ubap2l A C 3: 89,924,527 (GRCm39) V680G probably benign Het
Usp16 A T 16: 87,269,052 (GRCm39) H315L probably benign Het
Vav2 A G 2: 27,186,133 (GRCm39) probably null Het
Zfc3h1 T C 10: 115,256,715 (GRCm39) F1562L possibly damaging Het
Zfp764 C A 7: 127,005,713 (GRCm39) V22L probably benign Het
Other mutations in Trappc14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Trappc14 APN 5 138,259,967 (GRCm39) missense possibly damaging 0.46
IGL01617:Trappc14 APN 5 138,260,478 (GRCm39) missense probably damaging 1.00
IGL02256:Trappc14 APN 5 138,258,577 (GRCm39) missense probably damaging 0.99
IGL02493:Trappc14 APN 5 138,261,432 (GRCm39) splice site probably null
IGL02904:Trappc14 APN 5 138,258,864 (GRCm39) missense probably benign 0.04
IGL03151:Trappc14 APN 5 138,260,934 (GRCm39) missense possibly damaging 0.95
R0005:Trappc14 UTSW 5 138,260,916 (GRCm39) splice site probably null
R0010:Trappc14 UTSW 5 138,258,555 (GRCm39) splice site probably null
R0010:Trappc14 UTSW 5 138,258,555 (GRCm39) splice site probably null
R0630:Trappc14 UTSW 5 138,260,551 (GRCm39) missense probably damaging 0.98
R1579:Trappc14 UTSW 5 138,260,128 (GRCm39) missense probably benign 0.00
R1778:Trappc14 UTSW 5 138,260,739 (GRCm39) splice site probably null
R1816:Trappc14 UTSW 5 138,258,603 (GRCm39) missense possibly damaging 0.91
R2009:Trappc14 UTSW 5 138,259,191 (GRCm39) missense probably damaging 1.00
R4711:Trappc14 UTSW 5 138,261,167 (GRCm39) unclassified probably benign
R4923:Trappc14 UTSW 5 138,260,641 (GRCm39) unclassified probably benign
R4999:Trappc14 UTSW 5 138,259,884 (GRCm39) missense probably damaging 1.00
R5103:Trappc14 UTSW 5 138,260,562 (GRCm39) missense probably benign 0.15
R5221:Trappc14 UTSW 5 138,260,502 (GRCm39) missense probably benign 0.14
R5444:Trappc14 UTSW 5 138,259,260 (GRCm39) splice site probably null
R5720:Trappc14 UTSW 5 138,261,964 (GRCm39) missense probably benign 0.00
R6519:Trappc14 UTSW 5 138,260,110 (GRCm39) missense probably damaging 0.99
R6599:Trappc14 UTSW 5 138,261,720 (GRCm39) splice site probably null
R6918:Trappc14 UTSW 5 138,258,926 (GRCm39) missense probably benign 0.03
R7275:Trappc14 UTSW 5 138,261,839 (GRCm39) missense probably benign 0.18
R7460:Trappc14 UTSW 5 138,260,991 (GRCm39) missense probably benign 0.32
R7564:Trappc14 UTSW 5 138,261,104 (GRCm39) splice site probably null
R8745:Trappc14 UTSW 5 138,261,327 (GRCm39) critical splice donor site probably null
R9043:Trappc14 UTSW 5 138,259,889 (GRCm39) missense possibly damaging 0.84
R9057:Trappc14 UTSW 5 138,260,949 (GRCm39) missense probably damaging 1.00
R9540:Trappc14 UTSW 5 138,260,127 (GRCm39) missense probably benign 0.28
R9607:Trappc14 UTSW 5 138,259,862 (GRCm39) missense probably damaging 1.00
R9798:Trappc14 UTSW 5 138,259,940 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- TGTCACCCAGAGATCCTCACCG -3'
(R):5'- CCTTAAAGGTTCCTCAGCAGCCC -3'

Sequencing Primer
(F):5'- GGGCTGCAACCTCGAAAC -3'
(R):5'- TCAGCCAAGAAGCCTCGG -3'
Posted On 2013-07-11