Incidental Mutation 'R7563:Qrsl1'
ID 585270
Institutional Source Beutler Lab
Gene Symbol Qrsl1
Ensembl Gene ENSMUSG00000019863
Gene Name glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms 2700038P16Rik, GatA
MMRRC Submission 045655-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.958) question?
Stock # R7563 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 43750184-43777741 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 43752513 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 437 (R437C)
Ref Sequence ENSEMBL: ENSMUSP00000020012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020012]
AlphaFold Q9CZN8
Predicted Effect probably damaging
Transcript: ENSMUST00000020012
AA Change: R437C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000020012
Gene: ENSMUSG00000019863
AA Change: R437C

DomainStartEndE-ValueType
Pfam:Amidase 22 484 6e-129 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 A G 4: 144,184,464 (GRCm39) I98T probably damaging Het
Ahnak T C 19: 8,988,529 (GRCm39) I3271T probably damaging Het
Aox1 G A 1: 58,086,304 (GRCm39) V70I probably benign Het
Ap1g2 A G 14: 55,337,206 (GRCm39) S710P probably damaging Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Cacna1e T C 1: 154,347,162 (GRCm39) K1064E probably benign Het
Capn11 T A 17: 45,944,891 (GRCm39) I459F probably damaging Het
Ccnc A G 4: 21,732,220 (GRCm39) I48V probably damaging Het
Ces1d T A 8: 93,904,667 (GRCm39) I358F probably benign Het
Clgn A T 8: 84,147,185 (GRCm39) N379I probably damaging Het
Cym T C 3: 107,121,548 (GRCm39) Y248C probably damaging Het
Epha8 T C 4: 136,666,100 (GRCm39) D352G possibly damaging Het
Eya2 T C 2: 165,558,050 (GRCm39) probably null Het
Fam219a A C 4: 41,569,208 (GRCm39) V10G probably benign Het
Fbxl5 C T 5: 43,978,891 (GRCm39) V20I probably benign Het
Fbxl9 A G 8: 106,042,388 (GRCm39) C147R probably benign Het
Fscb T C 12: 64,520,059 (GRCm39) E469G possibly damaging Het
Glt8d2 A T 10: 82,496,659 (GRCm39) probably null Het
Grep1 A T 17: 23,936,302 (GRCm39) F8L probably benign Het
Helt T C 8: 46,746,630 (GRCm39) probably benign Het
Igkv8-27 G T 6: 70,148,887 (GRCm39) T89K probably benign Het
Ipo5 T A 14: 121,183,567 (GRCm39) H1048Q probably benign Het
Kalrn T C 16: 34,212,464 (GRCm39) D28G probably damaging Het
Kcnh4 G A 11: 100,632,680 (GRCm39) P936S probably benign Het
Klrd1 A G 6: 129,570,701 (GRCm39) I37M possibly damaging Het
Kmt2e T C 5: 23,705,271 (GRCm39) V1267A probably damaging Het
Marchf1 A T 8: 66,920,965 (GRCm39) Q214L probably damaging Het
Mlip G T 9: 77,020,279 (GRCm39) H52N probably damaging Het
Oas1e T C 5: 120,927,021 (GRCm39) R229G probably benign Het
Ogfr T A 2: 180,234,300 (GRCm39) probably null Het
Or4g16 T C 2: 111,137,134 (GRCm39) F195L probably benign Het
Or5m10 T A 2: 85,717,482 (GRCm39) Y113N probably damaging Het
Pde4d T C 13: 110,087,541 (GRCm39) I636T probably benign Het
Pex5l C T 3: 33,008,625 (GRCm39) V426I probably damaging Het
Pmfbp1 A G 8: 110,252,006 (GRCm39) K384E possibly damaging Het
Pramel22 A T 4: 143,380,675 (GRCm39) Y449* probably null Het
Prl6a1 T G 13: 27,498,221 (GRCm39) probably null Het
Prss23 A T 7: 89,159,038 (GRCm39) W344R probably damaging Het
Ptar1 T A 19: 23,697,680 (GRCm39) D397E probably benign Het
Rab6a G T 7: 100,257,404 (GRCm39) probably benign Het
Samd14 C A 11: 94,912,239 (GRCm39) S205R probably benign Het
Sel1l3 T C 5: 53,343,326 (GRCm39) Y322C probably damaging Het
Slc30a5 A T 13: 100,940,480 (GRCm39) L669I probably benign Het
Ssc4d A G 5: 135,991,887 (GRCm39) L419P probably damaging Het
Tbc1d2b A T 9: 90,101,063 (GRCm39) Y642* probably null Het
Tbc1d2b A C 9: 90,108,301 (GRCm39) F417V probably benign Het
Top2a T C 11: 98,907,005 (GRCm39) D212G probably damaging Het
Trim39 A T 17: 36,571,807 (GRCm39) V317E probably damaging Het
Uncx G A 5: 139,530,261 (GRCm39) R113H probably damaging Het
Usp4 A G 9: 108,256,543 (GRCm39) S655G probably benign Het
Vmn2r114 C T 17: 23,510,000 (GRCm39) V827I probably benign Het
Vmn2r28 T A 7: 5,491,200 (GRCm39) N349I probably benign Het
Vmn2r3 A G 3: 64,182,770 (GRCm39) W310R possibly damaging Het
Xirp2 T C 2: 67,340,245 (GRCm39) W829R probably damaging Het
Zfp574 C A 7: 24,780,777 (GRCm39) H600N possibly damaging Het
Other mutations in Qrsl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00477:Qrsl1 APN 10 43,752,488 (GRCm39) missense probably damaging 1.00
IGL01724:Qrsl1 APN 10 43,750,604 (GRCm39) missense probably benign 0.01
IGL01896:Qrsl1 APN 10 43,752,500 (GRCm39) missense probably benign 0.02
IGL02192:Qrsl1 APN 10 43,761,010 (GRCm39) missense probably damaging 1.00
IGL02239:Qrsl1 APN 10 43,770,596 (GRCm39) missense possibly damaging 0.96
IGL02478:Qrsl1 APN 10 43,758,158 (GRCm39) missense probably damaging 0.97
IGL02756:Qrsl1 APN 10 43,758,110 (GRCm39) missense probably benign 0.00
IGL03386:Qrsl1 APN 10 43,752,546 (GRCm39) missense possibly damaging 0.63
R0277:Qrsl1 UTSW 10 43,772,003 (GRCm39) critical splice donor site probably null
R0323:Qrsl1 UTSW 10 43,772,003 (GRCm39) critical splice donor site probably null
R0674:Qrsl1 UTSW 10 43,771,997 (GRCm39) splice site probably benign
R1054:Qrsl1 UTSW 10 43,758,077 (GRCm39) missense probably damaging 1.00
R1719:Qrsl1 UTSW 10 43,772,026 (GRCm39) missense probably damaging 0.97
R1743:Qrsl1 UTSW 10 43,757,511 (GRCm39) missense probably damaging 1.00
R1854:Qrsl1 UTSW 10 43,770,541 (GRCm39) missense probably damaging 1.00
R2233:Qrsl1 UTSW 10 43,772,092 (GRCm39) missense probably benign 0.00
R4176:Qrsl1 UTSW 10 43,760,828 (GRCm39) missense probably damaging 1.00
R4452:Qrsl1 UTSW 10 43,758,158 (GRCm39) missense probably damaging 1.00
R4732:Qrsl1 UTSW 10 43,752,659 (GRCm39) missense probably damaging 1.00
R4733:Qrsl1 UTSW 10 43,752,659 (GRCm39) missense probably damaging 1.00
R5626:Qrsl1 UTSW 10 43,757,516 (GRCm39) missense probably benign 0.00
R6159:Qrsl1 UTSW 10 43,758,189 (GRCm39) missense probably benign 0.00
R8050:Qrsl1 UTSW 10 43,750,631 (GRCm39) missense probably damaging 0.98
R8092:Qrsl1 UTSW 10 43,760,749 (GRCm39) missense probably damaging 1.00
R8221:Qrsl1 UTSW 10 43,758,080 (GRCm39) missense possibly damaging 0.81
R8331:Qrsl1 UTSW 10 43,752,521 (GRCm39) missense probably damaging 0.98
Z1176:Qrsl1 UTSW 10 43,760,944 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CTCTCAGGTGTCTTGAAGGG -3'
(R):5'- ATAACCTTAGTGTAAGAGACTTGCC -3'

Sequencing Primer
(F):5'- GGAGGGTGCTTTTAGGAAACAATC -3'
(R):5'- AAACAGAAACCAACAACATCTTTAAG -3'
Posted On 2019-10-17