Incidental Mutation 'R7566:Or6c206'
ID 585463
Institutional Source Beutler Lab
Gene Symbol Or6c206
Ensembl Gene ENSMUSG00000095483
Gene Name olfactory receptor family 6 subfamily C member 206
Synonyms GA_x6K02T2PULF-10947193-10948131, MOR111-12, Olfr776
MMRRC Submission 045628-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R7566 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129096832-129097770 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129097469 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 213 (I213T)
Ref Sequence ENSEMBL: ENSMUSP00000150656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073704] [ENSMUST00000204573] [ENSMUST00000213512]
AlphaFold Q7TRI3
Predicted Effect probably damaging
Transcript: ENSMUST00000073704
AA Change: I213T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000073383
Gene: ENSMUSG00000095483
AA Change: I213T

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 8.3e-50 PFAM
Pfam:7tm_1 39 288 3.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204573
SMART Domains Protein: ENSMUSP00000145475
Gene: ENSMUSG00000062914

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213512
AA Change: I213T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.3502 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik T G 1: 12,021,252 (GRCm39) S420R probably damaging Het
Acat2 C T 17: 13,166,346 (GRCm39) D219N probably damaging Het
Anapc10 G A 8: 80,446,308 (GRCm39) R46Q possibly damaging Het
Ankub1 G A 3: 57,573,039 (GRCm39) R228* probably null Het
Arhgap21 T C 2: 20,917,102 (GRCm39) N91S probably benign Het
Arhgap32 T A 9: 32,162,018 (GRCm39) V323D probably benign Het
Bcas1 C T 2: 170,212,369 (GRCm39) probably null Het
Cd109 C T 9: 78,588,119 (GRCm39) P716S probably damaging Het
Chd4 C T 6: 125,078,866 (GRCm39) P267L possibly damaging Het
Cpne7 G T 8: 123,860,552 (GRCm39) V502F probably damaging Het
Cracd G A 5: 77,014,122 (GRCm39) probably null Het
Dlgap4 C T 2: 156,604,657 (GRCm39) A921V probably benign Het
Faap24 G T 7: 35,092,465 (GRCm39) R151S probably benign Het
Fam98a A G 17: 75,854,657 (GRCm39) S51P probably damaging Het
Fbxl8 A G 8: 105,994,938 (GRCm39) D150G possibly damaging Het
Fut10 A G 8: 31,749,950 (GRCm39) K412R probably benign Het
G0s2 T C 1: 192,955,076 (GRCm39) S3G probably benign Het
Gm1527 T C 3: 28,974,767 (GRCm39) Y527H probably benign Het
Gsdmc3 T C 15: 63,733,510 (GRCm39) K227R possibly damaging Het
Gtf2ird2 A G 5: 134,242,848 (GRCm39) Y354C probably damaging Het
Hmcn2 T A 2: 31,344,869 (GRCm39) N4685K probably damaging Het
Itgad A T 7: 127,791,279 (GRCm39) Y717F probably benign Het
Kcnh5 C T 12: 75,161,166 (GRCm39) W247* probably null Het
Kcnt1 C A 2: 25,806,048 (GRCm39) S1212R probably benign Het
Kirrel1 A G 3: 86,995,791 (GRCm39) V381A probably damaging Het
Loxl1 T A 9: 58,219,481 (GRCm39) Q230L probably damaging Het
Magi1 T C 6: 93,655,308 (GRCm39) E1446G probably benign Het
Man1a A G 10: 53,795,330 (GRCm39) V550A possibly damaging Het
Mgat4d T C 8: 84,084,652 (GRCm39) S132P probably damaging Het
Muc16 T A 9: 18,549,925 (GRCm39) H5456L probably benign Het
Nhsl1 A G 10: 18,391,867 (GRCm39) K207R probably damaging Het
Nlrp4a A C 7: 26,148,670 (GRCm39) probably null Het
Nr6a1 T C 2: 38,621,085 (GRCm39) M407V possibly damaging Het
Or13c7b A G 4: 43,820,711 (GRCm39) S217P probably damaging Het
Or2b2b T G 13: 21,858,737 (GRCm39) I126L possibly damaging Het
Or2z2 G T 11: 58,346,489 (GRCm39) F95L probably benign Het
Ovgp1 A G 3: 105,881,626 (GRCm39) probably benign Het
Ovol3 G T 7: 29,933,791 (GRCm39) F110L probably damaging Het
Pcsk5 T C 19: 17,549,821 (GRCm39) T724A probably benign Het
Phtf2 G T 5: 20,970,799 (GRCm39) T653N probably damaging Het
Plch1 A T 3: 63,688,663 (GRCm39) probably null Het
Prkce A T 17: 86,800,757 (GRCm39) E391V probably benign Het
Prob1 A G 18: 35,788,038 (GRCm39) V72A probably benign Het
Prrc2b C A 2: 32,084,402 (GRCm39) P289Q probably benign Het
Ptbp3 A T 4: 59,514,280 (GRCm39) N114K probably benign Het
Rho T A 6: 115,909,135 (GRCm39) L57H probably damaging Het
Slc44a5 A C 3: 153,975,626 (GRCm39) D679A probably damaging Het
Slit2 A T 5: 48,407,239 (GRCm39) D898V probably damaging Het
Spag16 C T 1: 69,909,487 (GRCm39) R195C probably damaging Het
Tmprss11a T G 5: 86,591,993 (GRCm39) D60A possibly damaging Het
Ttn T A 2: 76,565,293 (GRCm39) R28311S probably damaging Het
Wfikkn1 T C 17: 26,097,352 (GRCm39) D324G probably damaging Het
Zan A C 5: 137,410,845 (GRCm39) probably null Het
Zfp945 A T 17: 23,070,727 (GRCm39) C412S possibly damaging Het
Other mutations in Or6c206
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Or6c206 APN 10 129,097,204 (GRCm39) missense probably damaging 1.00
IGL01956:Or6c206 APN 10 129,096,911 (GRCm39) missense possibly damaging 0.88
IGL03299:Or6c206 APN 10 129,097,196 (GRCm39) missense probably benign 0.26
IGL03388:Or6c206 APN 10 129,097,312 (GRCm39) missense probably benign 0.00
IGL02802:Or6c206 UTSW 10 129,097,136 (GRCm39) splice site probably null
R1538:Or6c206 UTSW 10 129,097,082 (GRCm39) missense probably damaging 0.99
R3711:Or6c206 UTSW 10 129,097,093 (GRCm39) nonsense probably null
R3712:Or6c206 UTSW 10 129,097,093 (GRCm39) nonsense probably null
R4201:Or6c206 UTSW 10 129,097,646 (GRCm39) missense probably benign 0.19
R4202:Or6c206 UTSW 10 129,097,646 (GRCm39) missense probably benign 0.19
R4726:Or6c206 UTSW 10 129,097,045 (GRCm39) missense possibly damaging 0.84
R5029:Or6c206 UTSW 10 129,097,707 (GRCm39) missense probably benign 0.15
R5623:Or6c206 UTSW 10 129,096,901 (GRCm39) missense probably benign 0.17
R7678:Or6c206 UTSW 10 129,096,937 (GRCm39) missense probably damaging 0.98
R9149:Or6c206 UTSW 10 129,097,184 (GRCm39) missense probably damaging 1.00
R9291:Or6c206 UTSW 10 129,097,202 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCATGGCTGGCAGGATTTC -3'
(R):5'- ATTGAAGTATTGAGAACAGCCACC -3'

Sequencing Primer
(F):5'- GGCAGGATTTCTGAGCATCTTCC -3'
(R):5'- GTATTGAGAACAGCCACCCCTTTG -3'
Posted On 2019-10-17