Incidental Mutation 'R7568:Slc39a10'
ID 585566
Institutional Source Beutler Lab
Gene Symbol Slc39a10
Ensembl Gene ENSMUSG00000025986
Gene Name solute carrier family 39 (zinc transporter), member 10
Synonyms 2900042E17Rik, Zip10
MMRRC Submission 045630-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.622) question?
Stock # R7568 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 46846704-46932012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 46874290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 337 (H337Q)
Ref Sequence ENSEMBL: ENSMUSP00000027131 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027131] [ENSMUST00000185520] [ENSMUST00000186852]
AlphaFold Q6P5F6
Predicted Effect probably benign
Transcript: ENSMUST00000027131
AA Change: H337Q

PolyPhen 2 Score 0.145 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000027131
Gene: ENSMUSG00000025986
AA Change: H337Q

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 122 134 N/A INTRINSIC
low complexity region 170 195 N/A INTRINSIC
low complexity region 224 244 N/A INTRINSIC
Pfam:Zip 406 607 9.9e-44 PFAM
Pfam:Zip 588 821 2.5e-69 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185520
SMART Domains Protein: ENSMUSP00000140570
Gene: ENSMUSG00000025986

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
low complexity region 132 144 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186852
SMART Domains Protein: ENSMUSP00000140176
Gene: ENSMUSG00000025986

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 122 134 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice with conditional loss of function display defects in cellular proliferation and differentiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 T A 13: 111,391,956 (GRCm39) V97E possibly damaging Het
Actl7a A T 4: 56,744,498 (GRCm39) T342S probably damaging Het
Alcam A G 16: 52,088,749 (GRCm39) S554P probably damaging Het
Ano3 T C 2: 110,780,638 (GRCm39) probably benign Het
Atad2b T A 12: 5,060,390 (GRCm39) probably null Het
Baz2a T C 10: 127,961,139 (GRCm39) S1621P possibly damaging Het
BC028528 CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT 3: 95,795,448 (GRCm39) probably benign Het
BC028528 GGTTCTGTGGTCACT GGTTCTGTGGTCACTAGTTCTGTGGTCACT 3: 95,795,484 (GRCm39) probably benign Het
BC028528 GTCACTGGTTCTGTGGTCACTGGTTCTGTG GTCACTGGTTCTGTGATCACTGGTTCTGTGGTCACTGGTTCTGTG 3: 95,795,463 (GRCm39) probably benign Het
Best1 T A 19: 9,966,639 (GRCm39) probably null Het
Catip G T 1: 74,408,089 (GRCm39) E474* probably null Het
Comp A G 8: 70,826,509 (GRCm39) D28G probably benign Het
Crebbp G A 16: 3,944,353 (GRCm39) R600W probably benign Het
Cyfip1 A G 7: 55,521,997 (GRCm39) probably null Het
Ddr1 A G 17: 35,995,174 (GRCm39) S675P probably damaging Het
Dhtkd1 A T 2: 5,926,898 (GRCm39) probably null Het
F2rl1 G A 13: 95,650,522 (GRCm39) A120V probably damaging Het
Fam136a A G 6: 86,342,784 (GRCm39) N24D probably benign Het
Fbxw10 C A 11: 62,765,994 (GRCm39) Q755K probably benign Het
Fbxw16 C A 9: 109,268,657 (GRCm39) Q244H possibly damaging Het
Gabrg2 T C 11: 41,807,119 (GRCm39) K373E probably benign Het
Herc3 G A 6: 58,820,795 (GRCm39) V60I probably benign Het
Igkv19-93 T A 6: 68,713,477 (GRCm39) K51* probably null Het
Krt23 T A 11: 99,383,626 (GRCm39) K89* probably null Het
Mavs A G 2: 131,087,395 (GRCm39) T298A probably benign Het
Mlec T C 5: 115,288,181 (GRCm39) Y198C probably damaging Het
Ncam2 C A 16: 81,386,689 (GRCm39) N689K probably benign Het
Nfkbia A G 12: 55,538,546 (GRCm39) I82T probably damaging Het
Or12d14-ps1 A G 17: 37,673,496 (GRCm39) I163V probably benign Het
Or12j2 A G 7: 139,915,895 (GRCm39) N40S probably damaging Het
Or7a35 A T 10: 78,853,341 (GRCm39) I62F probably benign Het
Or8b43 A G 9: 38,360,942 (GRCm39) Y258C probably damaging Het
Pom121l2 A T 13: 22,166,796 (GRCm39) I356F probably benign Het
Ppip5k1 A T 2: 121,168,096 (GRCm39) L719Q probably damaging Het
Satb1 A T 17: 52,089,752 (GRCm39) V365D possibly damaging Het
Scrn2 T C 11: 96,921,712 (GRCm39) Y61H probably damaging Het
Siglec1 C T 2: 130,914,602 (GRCm39) V1505M probably damaging Het
Slc2a10 A G 2: 165,356,802 (GRCm39) N154S probably damaging Het
Slc39a12 T A 2: 14,404,939 (GRCm39) probably null Het
Slc6a6 T G 6: 91,701,832 (GRCm39) L80R probably damaging Het
Slit1 T C 19: 41,590,074 (GRCm39) Y1404C probably damaging Het
Sowahc A G 10: 59,059,121 (GRCm39) E419G probably damaging Het
Ssh1 T C 5: 114,095,441 (GRCm39) probably null Het
Stab1 C A 14: 30,874,552 (GRCm39) C952F probably damaging Het
Stat5a T C 11: 100,765,850 (GRCm39) M312T possibly damaging Het
Tex2 A G 11: 106,439,562 (GRCm39) I606T unknown Het
Tex55 T C 16: 38,648,809 (GRCm39) E100G possibly damaging Het
Vmn1r19 A G 6: 57,381,813 (GRCm39) H122R possibly damaging Het
Zfp959 A G 17: 56,204,886 (GRCm39) I308V probably benign Het
Other mutations in Slc39a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00543:Slc39a10 APN 1 46,858,217 (GRCm39) splice site probably benign
IGL01628:Slc39a10 APN 1 46,874,683 (GRCm39) missense probably benign 0.23
IGL01939:Slc39a10 APN 1 46,871,895 (GRCm39) missense probably benign 0.07
IGL02068:Slc39a10 APN 1 46,858,599 (GRCm39) splice site probably benign
IGL02093:Slc39a10 APN 1 46,874,369 (GRCm39) missense probably damaging 1.00
IGL02101:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02122:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02125:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02171:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02175:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02186:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02699:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02700:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
R0217:Slc39a10 UTSW 1 46,874,700 (GRCm39) missense probably benign
R0704:Slc39a10 UTSW 1 46,875,021 (GRCm39) missense possibly damaging 0.76
R0782:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R1527:Slc39a10 UTSW 1 46,858,422 (GRCm39) missense probably benign
R1566:Slc39a10 UTSW 1 46,875,245 (GRCm39) missense possibly damaging 0.90
R1568:Slc39a10 UTSW 1 46,865,375 (GRCm39) missense probably benign 0.00
R1664:Slc39a10 UTSW 1 46,865,269 (GRCm39) missense probably damaging 1.00
R1830:Slc39a10 UTSW 1 46,875,230 (GRCm39) missense probably damaging 1.00
R1954:Slc39a10 UTSW 1 46,874,334 (GRCm39) missense possibly damaging 0.50
R2327:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R3434:Slc39a10 UTSW 1 46,874,877 (GRCm39) missense probably benign
R3761:Slc39a10 UTSW 1 46,851,285 (GRCm39) missense possibly damaging 0.88
R4035:Slc39a10 UTSW 1 46,851,234 (GRCm39) missense probably damaging 1.00
R4419:Slc39a10 UTSW 1 46,849,226 (GRCm39) missense probably benign 0.42
R4675:Slc39a10 UTSW 1 46,857,144 (GRCm39) intron probably benign
R4689:Slc39a10 UTSW 1 46,875,173 (GRCm39) missense probably benign 0.00
R5310:Slc39a10 UTSW 1 46,875,285 (GRCm39) missense probably damaging 1.00
R6073:Slc39a10 UTSW 1 46,871,772 (GRCm39) missense possibly damaging 0.68
R6161:Slc39a10 UTSW 1 46,866,567 (GRCm39) missense probably damaging 1.00
R6199:Slc39a10 UTSW 1 46,874,993 (GRCm39) missense probably damaging 1.00
R6562:Slc39a10 UTSW 1 46,874,724 (GRCm39) missense probably benign 0.02
R7087:Slc39a10 UTSW 1 46,874,880 (GRCm39) missense probably damaging 1.00
R7222:Slc39a10 UTSW 1 46,858,452 (GRCm39) missense possibly damaging 0.82
R7286:Slc39a10 UTSW 1 46,849,230 (GRCm39) missense probably damaging 0.97
R7891:Slc39a10 UTSW 1 46,851,328 (GRCm39) missense probably damaging 1.00
R7918:Slc39a10 UTSW 1 46,874,912 (GRCm39) missense possibly damaging 0.88
R9725:Slc39a10 UTSW 1 46,849,223 (GRCm39) missense probably damaging 1.00
RF020:Slc39a10 UTSW 1 46,849,175 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGGCTTGAGGAACCCAAATTTGAG -3'
(R):5'- CATCTTCCTGAGCACAGTGGTC -3'

Sequencing Primer
(F):5'- CCCTGATTAAAATTTTCCAACCTTG -3'
(R):5'- TCATGAGCTTGGCCATGGAC -3'
Posted On 2019-10-17