Incidental Mutation 'R7570:Cr2'
| ID |
585681 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cr2
|
| Ensembl Gene |
ENSMUSG00000026616 |
| Gene Name |
complement receptor 2 |
| Synonyms |
C3DR, CD21, Cr-2, Cr1, Cr-1, CD35 |
| MMRRC Submission |
045631-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R7570 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
194819119-194859024 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 194851648 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 115
(R115*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147804
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043104]
[ENSMUST00000082321]
[ENSMUST00000193801]
[ENSMUST00000195120]
[ENSMUST00000210219]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000043104
AA Change: R95*
|
| SMART Domains |
Protein: ENSMUSP00000044261
Gene: ENSMUSG00000026616
AA Change: R95*
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
2 |
58 |
5.04e-7 |
SMART |
|
CCP
|
63 |
120 |
3.58e-12 |
SMART |
|
CCP
|
125 |
191 |
1.2e-13 |
SMART |
|
CCP
|
197 |
252 |
2.73e-17 |
SMART |
|
CCP
|
256 |
311 |
1.01e-15 |
SMART |
|
Blast:CCP
|
316 |
347 |
2e-13 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082321
|
| SMART Domains |
Protein: ENSMUSP00000080938
Gene: ENSMUSG00000026616
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
1.01e-11 |
SMART |
|
CCP
|
91 |
147 |
9.1e-14 |
SMART |
|
CCP
|
155 |
211 |
1.9e-16 |
SMART |
|
CCP
|
216 |
272 |
1.6e-9 |
SMART |
|
CCP
|
277 |
343 |
1.01e-11 |
SMART |
|
CCP
|
352 |
407 |
1.2e-13 |
SMART |
|
CCP
|
411 |
467 |
2.34e-16 |
SMART |
|
CCP
|
472 |
523 |
1.24e0 |
SMART |
|
CCP
|
528 |
594 |
4.48e-13 |
SMART |
|
CCP
|
603 |
658 |
1.95e-13 |
SMART |
|
CCP
|
718 |
778 |
1.75e-15 |
SMART |
|
CCP
|
787 |
842 |
2.06e-12 |
SMART |
|
CCP
|
850 |
906 |
7.92e-14 |
SMART |
|
CCP
|
911 |
967 |
1.29e-13 |
SMART |
|
transmembrane domain
|
975 |
997 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193801
|
| SMART Domains |
Protein: ENSMUSP00000141276
Gene: ENSMUSG00000026616
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195120
|
| SMART Domains |
Protein: ENSMUSP00000141538
Gene: ENSMUSG00000026616
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
4.9e-14 |
SMART |
|
CCP
|
91 |
147 |
4.5e-16 |
SMART |
|
CCP
|
155 |
211 |
9.1e-19 |
SMART |
|
CCP
|
216 |
272 |
8e-12 |
SMART |
|
CCP
|
277 |
343 |
5e-14 |
SMART |
|
CCP
|
352 |
407 |
5.9e-16 |
SMART |
|
CCP
|
411 |
467 |
1.1e-18 |
SMART |
|
CCP
|
472 |
523 |
6.1e-3 |
SMART |
|
CCP
|
528 |
594 |
2.2e-15 |
SMART |
|
CCP
|
603 |
658 |
9.4e-16 |
SMART |
|
CCP
|
718 |
778 |
8.3e-18 |
SMART |
|
CCP
|
787 |
842 |
1e-14 |
SMART |
|
CCP
|
850 |
906 |
4e-16 |
SMART |
|
CCP
|
911 |
967 |
6.2e-16 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000210219
AA Change: R115*
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
98% (104/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930590J08Rik |
C |
T |
6: 91,911,591 (GRCm39) |
T613I |
probably benign |
Het |
| Ajuba |
T |
C |
14: 54,813,859 (GRCm39) |
E288G |
probably damaging |
Het |
| Ankrd12 |
C |
T |
17: 66,292,355 (GRCm39) |
R1026K |
probably benign |
Het |
| Apol7b |
T |
C |
15: 77,307,674 (GRCm39) |
T274A |
probably benign |
Het |
| Arid4a |
A |
T |
12: 71,109,916 (GRCm39) |
R86* |
probably null |
Het |
| Asnsd1 |
C |
T |
1: 53,387,417 (GRCm39) |
G70D |
probably damaging |
Het |
| Atg4c |
T |
A |
4: 99,116,797 (GRCm39) |
V313D |
possibly damaging |
Het |
| Atp13a5 |
A |
C |
16: 29,085,715 (GRCm39) |
C885G |
probably damaging |
Het |
| Bpifb9a |
A |
T |
2: 154,104,183 (GRCm39) |
I209F |
possibly damaging |
Het |
| Bsn |
T |
C |
9: 107,990,742 (GRCm39) |
D1670G |
probably damaging |
Het |
| Cct8 |
T |
A |
16: 87,288,210 (GRCm39) |
I121F |
probably benign |
Het |
| Cd209a |
T |
G |
8: 3,794,151 (GRCm39) |
D217A |
probably damaging |
Het |
| Cdk19 |
C |
T |
10: 40,353,954 (GRCm39) |
S456L |
possibly damaging |
Het |
| Chd9 |
C |
T |
8: 91,721,208 (GRCm39) |
H999Y |
unknown |
Het |
| Col5a1 |
G |
A |
2: 27,841,395 (GRCm39) |
V339M |
unknown |
Het |
| Cyb561 |
A |
T |
11: 105,828,470 (GRCm39) |
F62I |
probably damaging |
Het |
| Cyp2c38 |
A |
T |
19: 39,393,187 (GRCm39) |
N293K |
possibly damaging |
Het |
| Cyp2c69 |
A |
T |
19: 39,848,342 (GRCm39) |
D293E |
probably damaging |
Het |
| Dcbld2 |
T |
A |
16: 58,244,932 (GRCm39) |
C69S |
possibly damaging |
Het |
| Dcdc2a |
T |
C |
13: 25,303,356 (GRCm39) |
S296P |
probably benign |
Het |
| Dmxl1 |
T |
A |
18: 50,027,024 (GRCm39) |
I2044K |
possibly damaging |
Het |
| Dnah5 |
A |
G |
15: 28,347,098 (GRCm39) |
D2527G |
probably damaging |
Het |
| Dnah6 |
T |
C |
6: 73,126,413 (GRCm39) |
T1305A |
probably benign |
Het |
| Dnajc9 |
A |
G |
14: 20,438,712 (GRCm39) |
V47A |
probably benign |
Het |
| Dnmt3b |
A |
G |
2: 153,518,619 (GRCm39) |
Y594C |
probably damaging |
Het |
| Dph7 |
A |
G |
2: 24,855,642 (GRCm39) |
D147G |
probably damaging |
Het |
| Drap1 |
T |
C |
19: 5,473,380 (GRCm39) |
H164R |
possibly damaging |
Het |
| Dsg3 |
T |
A |
18: 20,660,837 (GRCm39) |
V392E |
possibly damaging |
Het |
| Dxo |
A |
G |
17: 35,056,616 (GRCm39) |
D81G |
probably benign |
Het |
| E230025N22Rik |
G |
T |
18: 36,828,645 (GRCm39) |
T11K |
probably benign |
Het |
| Esyt1 |
A |
G |
10: 128,354,801 (GRCm39) |
V533A |
possibly damaging |
Het |
| Etv3 |
T |
A |
3: 87,443,338 (GRCm39) |
C307* |
probably null |
Het |
| Fam114a1 |
T |
A |
5: 65,187,402 (GRCm39) |
|
probably null |
Het |
| Fam3c |
T |
A |
6: 22,326,404 (GRCm39) |
|
probably benign |
Het |
| Fbn1 |
G |
T |
2: 125,239,772 (GRCm39) |
T305K |
probably benign |
Het |
| Ggt1 |
A |
T |
10: 75,421,428 (GRCm39) |
I484F |
probably damaging |
Het |
| Gpatch1 |
T |
C |
7: 34,993,237 (GRCm39) |
D536G |
probably damaging |
Het |
| Gpx4 |
T |
C |
10: 79,890,875 (GRCm39) |
I189T |
probably damaging |
Het |
| Gsr |
T |
A |
8: 34,159,193 (GRCm39) |
C85S |
probably damaging |
Het |
| Gsta5 |
A |
T |
9: 78,211,751 (GRCm39) |
D171V |
possibly damaging |
Het |
| Havcr1 |
T |
A |
11: 46,661,369 (GRCm39) |
|
probably null |
Het |
| Heatr4 |
T |
C |
12: 84,026,418 (GRCm39) |
T280A |
probably benign |
Het |
| Hmcn2 |
A |
T |
2: 31,313,923 (GRCm39) |
E3532D |
probably benign |
Het |
| Hnrnpc |
T |
C |
14: 52,312,556 (GRCm39) |
N308S |
possibly damaging |
Het |
| Ighv8-9 |
A |
G |
12: 115,432,358 (GRCm39) |
V13A |
probably benign |
Het |
| Itgb2l |
A |
T |
16: 96,227,439 (GRCm39) |
F535I |
probably benign |
Het |
| Kdm5a |
T |
G |
6: 120,404,803 (GRCm39) |
D1348E |
probably damaging |
Het |
| Kndc1 |
CT |
C |
7: 139,503,691 (GRCm39) |
|
probably null |
Het |
| Ky |
A |
G |
9: 102,419,528 (GRCm39) |
I512V |
probably benign |
Het |
| Lamc1 |
A |
T |
1: 153,119,021 (GRCm39) |
F866Y |
possibly damaging |
Het |
| Lbx1 |
C |
A |
19: 45,223,687 (GRCm39) |
|
probably benign |
Het |
| Magel2 |
A |
G |
7: 62,028,658 (GRCm39) |
T521A |
possibly damaging |
Het |
| Mgam |
A |
T |
6: 40,723,367 (GRCm39) |
I491L |
probably benign |
Het |
| Mitd1 |
T |
C |
1: 37,929,273 (GRCm39) |
E40G |
probably damaging |
Het |
| Mpzl3 |
A |
G |
9: 44,981,985 (GRCm39) |
T218A |
probably benign |
Het |
| Mrpl42 |
A |
G |
10: 95,316,827 (GRCm39) |
S77P |
probably benign |
Het |
| Mup5 |
C |
T |
4: 61,752,911 (GRCm39) |
W37* |
probably null |
Het |
| Myh14 |
T |
C |
7: 44,281,850 (GRCm39) |
I803V |
probably benign |
Het |
| Ncor2 |
T |
A |
5: 125,107,153 (GRCm39) |
T744S |
|
Het |
| Ndufv3 |
A |
G |
17: 31,746,596 (GRCm39) |
D162G |
probably damaging |
Het |
| Nostrin |
A |
G |
2: 69,006,150 (GRCm39) |
E278G |
probably damaging |
Het |
| Nrxn1 |
T |
G |
17: 90,469,807 (GRCm39) |
E1288A |
probably benign |
Het |
| Or4c11c |
A |
G |
2: 88,661,472 (GRCm39) |
N4D |
possibly damaging |
Het |
| Or51b6b |
C |
A |
7: 103,310,088 (GRCm39) |
R123L |
probably damaging |
Het |
| Or52h1 |
T |
A |
7: 103,828,955 (GRCm39) |
Y220F |
probably damaging |
Het |
| Or8g55 |
A |
T |
9: 39,784,751 (GRCm39) |
Y60F |
possibly damaging |
Het |
| Patj |
T |
A |
4: 98,312,737 (GRCm39) |
|
probably null |
Het |
| Pcm1 |
T |
G |
8: 41,720,381 (GRCm39) |
I314R |
possibly damaging |
Het |
| Pcsk6 |
A |
G |
7: 65,683,646 (GRCm39) |
T754A |
probably benign |
Het |
| Pde2a |
A |
T |
7: 101,152,041 (GRCm39) |
N326I |
probably benign |
Het |
| Plekhg4 |
T |
C |
8: 106,105,316 (GRCm39) |
S594P |
possibly damaging |
Het |
| Plekhm3 |
T |
C |
1: 64,977,065 (GRCm39) |
D135G |
probably damaging |
Het |
| Plin4 |
A |
T |
17: 56,413,776 (GRCm39) |
M283K |
probably benign |
Het |
| Ppfia3 |
T |
C |
7: 44,990,172 (GRCm39) |
|
probably null |
Het |
| Prdm9 |
T |
C |
17: 15,775,914 (GRCm39) |
N179S |
probably benign |
Het |
| Prrt3 |
T |
C |
6: 113,471,449 (GRCm39) |
S908G |
probably damaging |
Het |
| Psg22 |
C |
A |
7: 18,456,660 (GRCm39) |
S181Y |
possibly damaging |
Het |
| Rcor3 |
C |
A |
1: 191,822,173 (GRCm39) |
G8V |
probably damaging |
Het |
| Rp1l1 |
T |
A |
14: 64,269,023 (GRCm39) |
C1536* |
probably null |
Het |
| Rpp25l |
T |
C |
4: 41,712,529 (GRCm39) |
H82R |
probably damaging |
Het |
| Rps3a1 |
T |
A |
3: 86,046,396 (GRCm39) |
M172L |
probably benign |
Het |
| Rtbdn |
T |
C |
8: 85,679,556 (GRCm39) |
L110P |
probably damaging |
Het |
| Ryr1 |
T |
A |
7: 28,778,010 (GRCm39) |
Q2169L |
probably damaging |
Het |
| Scn4a |
A |
T |
11: 106,211,299 (GRCm39) |
C1573S |
possibly damaging |
Het |
| Sec16b |
A |
T |
1: 157,358,965 (GRCm39) |
|
probably null |
Het |
| Serpina1a |
A |
T |
12: 103,820,096 (GRCm39) |
D383E |
possibly damaging |
Het |
| Sh3gl3 |
T |
C |
7: 81,934,285 (GRCm39) |
M262T |
probably benign |
Het |
| Sos2 |
G |
A |
12: 69,637,654 (GRCm39) |
T1052M |
probably damaging |
Het |
| Spag16 |
G |
A |
1: 70,036,000 (GRCm39) |
V343I |
probably benign |
Het |
| Spocd1 |
T |
G |
4: 129,823,957 (GRCm39) |
D251E |
|
Het |
| Stc2 |
G |
T |
11: 31,317,798 (GRCm39) |
N74K |
probably damaging |
Het |
| Tasor2 |
A |
G |
13: 3,623,621 (GRCm39) |
Y2110H |
probably damaging |
Het |
| Thbs3 |
C |
T |
3: 89,126,359 (GRCm39) |
Q227* |
probably null |
Het |
| Tmem92 |
A |
C |
11: 94,669,816 (GRCm39) |
I105R |
probably benign |
Het |
| Tmod1 |
T |
A |
4: 46,083,632 (GRCm39) |
N20K |
probably benign |
Het |
| Tns1 |
T |
C |
1: 73,992,638 (GRCm39) |
D53G |
probably damaging |
Het |
| Tspan33 |
T |
A |
6: 29,717,337 (GRCm39) |
L246Q |
probably damaging |
Het |
| Ttc16 |
A |
G |
2: 32,658,980 (GRCm39) |
L392P |
probably damaging |
Het |
| Uggt1 |
T |
A |
1: 36,224,919 (GRCm39) |
T572S |
probably benign |
Het |
| Usp17la |
A |
T |
7: 104,509,604 (GRCm39) |
T70S |
probably damaging |
Het |
| Usp31 |
C |
T |
7: 121,274,186 (GRCm39) |
R370H |
probably damaging |
Het |
| Wdr83 |
C |
T |
8: 85,806,463 (GRCm39) |
V112M |
probably damaging |
Het |
| Zbtb25 |
T |
A |
12: 76,416,366 (GRCm39) |
|
probably benign |
Het |
| Zfp110 |
T |
A |
7: 12,583,267 (GRCm39) |
N638K |
possibly damaging |
Het |
| Zfp747l1 |
T |
A |
7: 126,984,455 (GRCm39) |
S216C |
probably benign |
Het |
| Zfp820 |
T |
C |
17: 22,037,994 (GRCm39) |
T445A |
probably benign |
Het |
|
| Other mutations in Cr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00587:Cr2
|
APN |
1 |
194,836,559 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01326:Cr2
|
APN |
1 |
194,823,529 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01358:Cr2
|
APN |
1 |
194,842,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Cr2
|
APN |
1 |
194,845,542 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01468:Cr2
|
APN |
1 |
194,850,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01608:Cr2
|
APN |
1 |
194,837,528 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01810:Cr2
|
APN |
1 |
194,841,903 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01843:Cr2
|
APN |
1 |
194,833,222 (GRCm39) |
splice site |
probably benign |
|
|
IGL02332:Cr2
|
APN |
1 |
194,842,630 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02934:Cr2
|
APN |
1 |
194,836,633 (GRCm39) |
splice site |
probably benign |
|
|
IGL02938:Cr2
|
APN |
1 |
194,848,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03149:Cr2
|
APN |
1 |
194,848,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03346:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Pillar
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
PIT4354001:Cr2
|
UTSW |
1 |
194,848,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4418001:Cr2
|
UTSW |
1 |
194,839,760 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0128:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0130:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0380:Cr2
|
UTSW |
1 |
194,839,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Cr2
|
UTSW |
1 |
194,842,667 (GRCm39) |
splice site |
probably benign |
|
|
R0605:Cr2
|
UTSW |
1 |
194,845,904 (GRCm39) |
splice site |
probably benign |
|
|
R0626:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1135:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Cr2
|
UTSW |
1 |
194,851,561 (GRCm39) |
splice site |
probably null |
|
|
R1422:Cr2
|
UTSW |
1 |
194,853,433 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1511:Cr2
|
UTSW |
1 |
194,837,580 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1572:Cr2
|
UTSW |
1 |
194,845,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1714:Cr2
|
UTSW |
1 |
194,833,994 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1748:Cr2
|
UTSW |
1 |
194,838,213 (GRCm39) |
nonsense |
probably null |
|
|
R1761:Cr2
|
UTSW |
1 |
194,837,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1824:Cr2
|
UTSW |
1 |
194,839,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1893:Cr2
|
UTSW |
1 |
194,837,495 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1990:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1991:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1992:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2191:Cr2
|
UTSW |
1 |
194,845,689 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2276:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3548:Cr2
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
R3743:Cr2
|
UTSW |
1 |
194,832,274 (GRCm39) |
splice site |
probably benign |
|
|
R3941:Cr2
|
UTSW |
1 |
194,848,122 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3963:Cr2
|
UTSW |
1 |
194,842,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4211:Cr2
|
UTSW |
1 |
194,838,636 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4484:Cr2
|
UTSW |
1 |
194,836,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4546:Cr2
|
UTSW |
1 |
194,853,349 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4791:Cr2
|
UTSW |
1 |
194,838,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4874:Cr2
|
UTSW |
1 |
194,858,878 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4885:Cr2
|
UTSW |
1 |
194,841,039 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4889:Cr2
|
UTSW |
1 |
194,858,893 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5154:Cr2
|
UTSW |
1 |
194,841,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5574:Cr2
|
UTSW |
1 |
194,823,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5594:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5645:Cr2
|
UTSW |
1 |
194,836,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5700:Cr2
|
UTSW |
1 |
194,842,065 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5929:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6237:Cr2
|
UTSW |
1 |
194,839,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Cr2
|
UTSW |
1 |
194,850,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6368:Cr2
|
UTSW |
1 |
194,850,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Cr2
|
UTSW |
1 |
194,852,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Cr2
|
UTSW |
1 |
194,839,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6684:Cr2
|
UTSW |
1 |
194,853,329 (GRCm39) |
nonsense |
probably null |
|
|
R6720:Cr2
|
UTSW |
1 |
194,837,508 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6866:Cr2
|
UTSW |
1 |
194,833,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6915:Cr2
|
UTSW |
1 |
194,853,454 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7057:Cr2
|
UTSW |
1 |
194,833,918 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7117:Cr2
|
UTSW |
1 |
194,842,909 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7200:Cr2
|
UTSW |
1 |
194,845,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Cr2
|
UTSW |
1 |
194,851,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Cr2
|
UTSW |
1 |
194,837,594 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7414:Cr2
|
UTSW |
1 |
194,832,344 (GRCm39) |
missense |
probably benign |
|
|
R7453:Cr2
|
UTSW |
1 |
194,847,565 (GRCm39) |
splice site |
probably null |
|
|
R7479:Cr2
|
UTSW |
1 |
194,840,718 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7480:Cr2
|
UTSW |
1 |
194,836,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7666:Cr2
|
UTSW |
1 |
194,836,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7921:Cr2
|
UTSW |
1 |
194,833,975 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7923:Cr2
|
UTSW |
1 |
194,850,995 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8396:Cr2
|
UTSW |
1 |
194,840,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8503:Cr2
|
UTSW |
1 |
194,845,850 (GRCm39) |
missense |
probably benign |
|
|
R8517:Cr2
|
UTSW |
1 |
194,838,207 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8773:Cr2
|
UTSW |
1 |
194,840,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Cr2
|
UTSW |
1 |
194,839,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cr2
|
UTSW |
1 |
194,851,581 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8938:Cr2
|
UTSW |
1 |
194,853,424 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9027:Cr2
|
UTSW |
1 |
194,834,029 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9045:Cr2
|
UTSW |
1 |
194,837,680 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9116:Cr2
|
UTSW |
1 |
194,840,977 (GRCm39) |
nonsense |
probably null |
|
|
R9137:Cr2
|
UTSW |
1 |
194,850,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9476:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9497:Cr2
|
UTSW |
1 |
194,850,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9510:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9752:Cr2
|
UTSW |
1 |
194,823,575 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9799:Cr2
|
UTSW |
1 |
194,842,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
X0028:Cr2
|
UTSW |
1 |
194,832,290 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0066:Cr2
|
UTSW |
1 |
194,848,629 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Cr2
|
UTSW |
1 |
194,836,461 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGGTTCACAACAACTTAAGCC -3'
(R):5'- AAGTCTCCAGTGCTATTAACTAGG -3'
Sequencing Primer
(F):5'- CTTAAGCCTAGTAAAACTTCTCAAGC -3'
(R):5'- CCAGTGCTATTAACTAGGAAGTCAG -3'
|
| Posted On |
2019-10-17 |
Incidental Mutation