Incidental Mutation 'R0620:Fam151a'
ID 58589
Institutional Source Beutler Lab
Gene Symbol Fam151a
Ensembl Gene ENSMUSG00000034871
Gene Name family with sequence simliarity 151, member A
Synonyms
MMRRC Submission 038809-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0620 (G1)
Quality Score 221
Status Validated
Chromosome 4
Chromosomal Location 106591112-106605489 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106605128 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 497 (M497V)
Ref Sequence ENSEMBL: ENSMUSP00000047860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047620] [ENSMUST00000065253] [ENSMUST00000102762] [ENSMUST00000140541]
AlphaFold Q8QZW3
Predicted Effect probably benign
Transcript: ENSMUST00000047620
AA Change: M497V

PolyPhen 2 Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000047860
Gene: ENSMUSG00000034871
AA Change: M497V

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:DUF2181 70 310 2.9e-107 PFAM
Pfam:DUF2181 342 579 8e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000065253
SMART Domains Protein: ENSMUSP00000069636
Gene: ENSMUSG00000034853

DomainStartEndE-ValueType
Pfam:4HBT 84 157 7e-10 PFAM
Pfam:4HBT 255 331 2.6e-13 PFAM
START 405 603 1.49e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102762
SMART Domains Protein: ENSMUSP00000099823
Gene: ENSMUSG00000034853

DomainStartEndE-ValueType
Pfam:4HBT 64 136 7.2e-10 PFAM
Pfam:4HBT 235 311 6.7e-13 PFAM
START 385 583 1.49e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140541
SMART Domains Protein: ENSMUSP00000124567
Gene: ENSMUSG00000034853

DomainStartEndE-ValueType
PDB:3B7K|C 32 71 3e-10 PDB
SCOP:d1lo7a_ 37 69 2e-3 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.1%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 T C 6: 92,835,094 (GRCm39) T679A possibly damaging Het
Ahr T C 12: 35,558,193 (GRCm39) T276A probably benign Het
Akap9 A T 5: 4,114,136 (GRCm39) Q3138H probably damaging Het
Armt1 T A 10: 4,382,689 (GRCm39) F7I probably benign Het
B3galt2 A G 1: 143,521,878 (GRCm39) R5G probably damaging Het
Bod1l T C 5: 41,958,576 (GRCm39) N2750S probably benign Het
Cadps2 T A 6: 23,583,395 (GRCm39) E365V probably damaging Het
Cd200r3 T A 16: 44,778,080 (GRCm39) probably null Het
Cemip2 T A 19: 21,795,335 (GRCm39) S743T probably benign Het
Cst7 T A 2: 150,417,806 (GRCm39) probably benign Het
Defb30 A T 14: 63,287,212 (GRCm39) probably benign Het
Dido1 C T 2: 180,301,644 (GRCm39) G2087S probably benign Het
Dio2 A G 12: 90,704,845 (GRCm39) Y72H probably benign Het
Dnah11 C T 12: 117,951,204 (GRCm39) E3035K probably damaging Het
Dnajb13 T C 7: 100,152,456 (GRCm39) K287E possibly damaging Het
Dnajc11 G A 4: 152,058,085 (GRCm39) V244I possibly damaging Het
Ect2 C T 3: 27,193,801 (GRCm39) A226T probably damaging Het
Ercc8 G A 13: 108,310,595 (GRCm39) probably null Het
Fam120b T A 17: 15,623,189 (GRCm39) M389K probably benign Het
Fam186b C A 15: 99,178,009 (GRCm39) G439V probably benign Het
Fank1 A G 7: 133,478,494 (GRCm39) Y185C probably damaging Het
Gart T C 16: 91,427,490 (GRCm39) probably benign Het
Glb1l T C 1: 75,176,364 (GRCm39) Y572C probably damaging Het
Gm11563 C T 11: 99,549,263 (GRCm39) A164T unknown Het
Gnb4 C T 3: 32,645,356 (GRCm39) V112I probably benign Het
Gsdmc3 T A 15: 63,731,542 (GRCm39) D330V probably damaging Het
H2-DMa C T 17: 34,356,934 (GRCm39) T144M probably damaging Het
Haus6 A T 4: 86,501,751 (GRCm39) F707I possibly damaging Het
Hmcn1 T A 1: 150,469,767 (GRCm39) T4971S probably benign Het
Ints6 A T 14: 62,934,208 (GRCm39) F766L probably benign Het
Kdm5d T A Y: 927,330 (GRCm39) M650K probably damaging Het
Kif21b T C 1: 136,087,166 (GRCm39) F881S possibly damaging Het
Klrk1 C A 6: 129,591,598 (GRCm39) Q176H possibly damaging Het
Ky T C 9: 102,414,820 (GRCm39) V244A probably benign Het
Mia2 T A 12: 59,201,205 (GRCm39) L191M possibly damaging Het
Miga2 T A 2: 30,271,756 (GRCm39) probably benign Het
Mtss2 C T 8: 111,464,580 (GRCm39) P322S probably damaging Het
Nalcn A G 14: 123,536,553 (GRCm39) probably benign Het
Ncbp3 T A 11: 72,940,671 (GRCm39) probably benign Het
Nprl3 G A 11: 32,184,876 (GRCm39) L378F probably damaging Het
Ntrk2 A T 13: 58,994,635 (GRCm39) M184L probably benign Het
Or11g1 G T 14: 50,651,154 (GRCm39) C51F probably benign Het
Or9e1 T G 11: 58,732,269 (GRCm39) C110G probably damaging Het
Osbpl9 T C 4: 108,940,325 (GRCm39) E287G probably damaging Het
Parva T C 7: 112,175,618 (GRCm39) F250L probably damaging Het
Pcdhb11 C T 18: 37,554,864 (GRCm39) Q65* probably null Het
Phtf1 A G 3: 103,901,081 (GRCm39) T377A probably damaging Het
Pkp4 G A 2: 59,152,987 (GRCm39) V612I possibly damaging Het
Plscr2 C A 9: 92,169,707 (GRCm39) S52R probably benign Het
Pnisr C T 4: 21,874,092 (GRCm39) probably benign Het
Pole2 A C 12: 69,256,653 (GRCm39) S291A probably damaging Het
Ppp2r5d A G 17: 46,994,944 (GRCm39) F586L probably benign Het
Prrx1 G A 1: 163,085,385 (GRCm39) R182C probably damaging Het
Ptprs A G 17: 56,736,103 (GRCm39) I110T possibly damaging Het
Rasgrf2 G A 13: 92,067,936 (GRCm39) probably benign Het
Resf1 A T 6: 149,229,873 (GRCm39) Q973L probably damaging Het
Riox2 T C 16: 59,312,255 (GRCm39) V464A probably benign Het
Robo2 A G 16: 73,764,690 (GRCm39) V646A possibly damaging Het
Ros1 T A 10: 51,994,444 (GRCm39) I1279F probably damaging Het
Siglec1 G A 2: 130,916,188 (GRCm39) T1254M probably benign Het
Snx7 T C 3: 117,640,324 (GRCm39) N62D probably damaging Het
Sp100 G A 1: 85,587,588 (GRCm39) probably null Het
Stil A T 4: 114,864,356 (GRCm39) I86L possibly damaging Het
Tbc1d16 T A 11: 119,099,864 (GRCm39) D170V probably benign Het
Trappc13 G A 13: 104,297,589 (GRCm39) T105M probably damaging Het
Trhr T A 15: 44,092,896 (GRCm39) S378T probably benign Het
Ttc7b T C 12: 100,466,332 (GRCm39) probably null Het
Vegfc A T 8: 54,610,174 (GRCm39) Y110F probably benign Het
Vmn1r184 C A 7: 25,966,602 (GRCm39) P116H possibly damaging Het
Vmn2r5 A T 3: 64,411,235 (GRCm39) C444* probably null Het
Zfp341 A G 2: 154,476,193 (GRCm39) E460G possibly damaging Het
Zfp819 T A 7: 43,265,868 (GRCm39) V41E probably benign Het
Other mutations in Fam151a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01303:Fam151a APN 4 106,604,790 (GRCm39) missense possibly damaging 0.56
IGL02095:Fam151a APN 4 106,605,072 (GRCm39) missense probably damaging 1.00
IGL02170:Fam151a APN 4 106,592,795 (GRCm39) critical splice donor site probably null
IGL02725:Fam151a APN 4 106,605,211 (GRCm39) missense probably damaging 0.99
R0025:Fam151a UTSW 4 106,605,371 (GRCm39) missense probably benign 0.16
R0114:Fam151a UTSW 4 106,591,201 (GRCm39) missense possibly damaging 0.63
R1345:Fam151a UTSW 4 106,599,491 (GRCm39) missense probably damaging 0.99
R1482:Fam151a UTSW 4 106,602,876 (GRCm39) missense probably damaging 1.00
R1965:Fam151a UTSW 4 106,591,112 (GRCm39) unclassified probably benign
R2086:Fam151a UTSW 4 106,592,760 (GRCm39) splice site probably null
R4078:Fam151a UTSW 4 106,604,954 (GRCm39) missense probably benign 0.31
R4677:Fam151a UTSW 4 106,605,456 (GRCm39) missense possibly damaging 0.72
R6110:Fam151a UTSW 4 106,605,395 (GRCm39) missense probably damaging 0.98
R6188:Fam151a UTSW 4 106,602,696 (GRCm39) missense possibly damaging 0.61
R6288:Fam151a UTSW 4 106,605,341 (GRCm39) missense probably damaging 0.99
R6526:Fam151a UTSW 4 106,591,201 (GRCm39) missense possibly damaging 0.63
R7298:Fam151a UTSW 4 106,592,725 (GRCm39) missense possibly damaging 0.80
R7341:Fam151a UTSW 4 106,592,707 (GRCm39) missense probably benign 0.00
R7363:Fam151a UTSW 4 106,602,681 (GRCm39) missense probably damaging 1.00
R7573:Fam151a UTSW 4 106,600,502 (GRCm39) missense probably damaging 1.00
R8368:Fam151a UTSW 4 106,604,190 (GRCm39) missense probably benign 0.03
R8464:Fam151a UTSW 4 106,605,102 (GRCm39) missense probably benign 0.04
R8503:Fam151a UTSW 4 106,603,377 (GRCm39) missense possibly damaging 0.78
R8822:Fam151a UTSW 4 106,602,842 (GRCm39) missense probably benign 0.12
R8840:Fam151a UTSW 4 106,602,819 (GRCm39) missense probably benign 0.06
R8927:Fam151a UTSW 4 106,603,242 (GRCm39) unclassified probably benign
R9062:Fam151a UTSW 4 106,605,306 (GRCm39) missense probably benign 0.01
R9076:Fam151a UTSW 4 106,603,254 (GRCm39) missense probably damaging 1.00
R9140:Fam151a UTSW 4 106,605,344 (GRCm39) nonsense probably null
R9663:Fam151a UTSW 4 106,604,894 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- GGCCACGTTAGCACACCTTTCTAC -3'
(R):5'- TGCTCACATCTGCCTGCAAGTC -3'

Sequencing Primer
(F):5'- AGCACACCTTTCTACCCTTGG -3'
(R):5'- TGCCTGCAAGTCTTTCCAG -3'
Posted On 2013-07-11