|Institutional Source||Beutler Lab|
|Gene Name||helicase with zinc finger 2, transcriptional coactivator|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7512 (G1)|
|Chromosomal Location||181227615-181242027 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 181235600 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000112917 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000094203] [ENSMUST00000108831] [ENSMUST00000121484]|
|AlphaFold||no structure available at present|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (59/59)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit slower weight gain, hyperleptinemia, increased oxygen consumption, decreased respiratory quotient, decreased liver triglyceride level and ameliorated hyperlipidemia and hepatosteatosis when fed a high-fat diet. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Helz2||
(F):5'- TCAGTCCCACCCTACATATATGTAC -3'
(R):5'- ATAACACCTGGCCTCACTGC -3'
(F):5'- TATGTACATCAAAGAAATGGGCTG -3'
(R):5'- CCGGGAGCAGAGACACATCTG -3'