Incidental Mutation 'R7526:Zpld2'
ID 585944
Institutional Source Beutler Lab
Gene Symbol Zpld2
Ensembl Gene ENSMUSG00000073747
Gene Name zona pellucida like domain containing 2
Synonyms Gm7534
MMRRC Submission 045598-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R7526 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 133918115-133930315 bp(-) (GRCm39)
Type of Mutation splice site (87 bp from exon)
DNA Base Change (assembly) T to C at 133927384 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000095461 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097849]
AlphaFold Q3UU21
Predicted Effect probably null
Transcript: ENSMUST00000097849
SMART Domains Protein: ENSMUSP00000095461
Gene: ENSMUSG00000073747

DomainStartEndE-ValueType
low complexity region 1 16 N/A INTRINSIC
internal_repeat_1 21 111 5.47e-40 PROSPERO
low complexity region 112 143 N/A INTRINSIC
low complexity region 158 177 N/A INTRINSIC
internal_repeat_1 181 271 5.47e-40 PROSPERO
low complexity region 322 334 N/A INTRINSIC
ZP 368 618 3.21e-13 SMART
low complexity region 650 668 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700086D15Rik A T 11: 65,043,807 (GRCm39) F85I unknown Het
Ankrd22 A T 19: 34,126,765 (GRCm39) W22R possibly damaging Het
Aqr A T 2: 113,938,590 (GRCm39) H1287Q probably damaging Het
Armh1 C A 4: 117,070,938 (GRCm39) A396S probably benign Het
Atp8b5 A G 4: 43,366,609 (GRCm39) E791G probably damaging Het
Bicd1 T G 6: 149,415,224 (GRCm39) S646A possibly damaging Het
Bmpr1b A T 3: 141,562,360 (GRCm39) Y276N probably damaging Het
Cadps2 T C 6: 23,496,850 (GRCm39) H465R probably damaging Het
Card11 A T 5: 140,899,184 (GRCm39) probably null Het
Ccdc9 A G 7: 16,016,325 (GRCm39) L139P probably damaging Het
Cdk5rap3 A T 11: 96,800,771 (GRCm39) M355K probably benign Het
Cnot2 A T 10: 116,342,985 (GRCm39) V116E probably benign Het
Defb48 A G 14: 63,215,280 (GRCm39) V32A possibly damaging Het
Dmkn A G 7: 30,477,076 (GRCm39) D460G possibly damaging Het
Dmxl2 A G 9: 54,308,241 (GRCm39) V2170A possibly damaging Het
Dnah1 A T 14: 31,009,833 (GRCm39) F1912I possibly damaging Het
Dok3 C T 13: 55,675,306 (GRCm39) V71I probably benign Het
Dzip3 A T 16: 48,795,837 (GRCm39) F178Y probably damaging Het
Enpp1 T C 10: 24,550,308 (GRCm39) probably null Het
Eogt A G 6: 97,090,913 (GRCm39) F409L probably damaging Het
Erich6 A T 3: 58,538,110 (GRCm39) L218H probably damaging Het
Fam186a G C 15: 99,839,796 (GRCm39) I2149M possibly damaging Het
Fat1 G A 8: 45,476,464 (GRCm39) V1837I probably damaging Het
Flrt3 T A 2: 140,502,126 (GRCm39) T501S probably damaging Het
Fmn1 A C 2: 113,518,479 (GRCm39) E1365D probably damaging Het
Fzd5 G T 1: 64,775,251 (GRCm39) P170Q probably benign Het
Gm14326 G A 2: 177,588,298 (GRCm39) H233Y probably damaging Het
Gm19410 G A 8: 36,257,766 (GRCm39) V735M probably damaging Het
Gm21886 ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG 18: 80,133,040 (GRCm39) probably benign Het
Gm2832 A T 14: 41,002,919 (GRCm39) I143L Het
Greb1 G A 12: 16,766,766 (GRCm39) T344I probably benign Het
Grik2 A T 10: 49,399,918 (GRCm39) Y271N possibly damaging Het
Grin3b A G 10: 79,808,885 (GRCm39) N212D probably benign Het
Hgsnat A G 8: 26,461,077 (GRCm39) L187P probably damaging Het
Hmcn1 A G 1: 150,532,324 (GRCm39) I3152T probably damaging Het
Hsp90aa1 A T 12: 110,661,728 (GRCm39) I96N unknown Het
Il18r1 T A 1: 40,510,932 (GRCm39) L6I probably damaging Het
Ing3 G A 6: 21,953,798 (GRCm39) V80I probably damaging Het
Kif18b T C 11: 102,805,493 (GRCm39) I255V probably damaging Het
Kif2c A T 4: 117,039,629 (GRCm39) N20K possibly damaging Het
Mfsd6l T C 11: 68,448,864 (GRCm39) W572R probably damaging Het
Mybphl A G 3: 108,281,496 (GRCm39) T71A probably benign Het
Myo7a G T 7: 97,734,655 (GRCm39) T613K possibly damaging Het
Nfatc3 T C 8: 106,805,715 (GRCm39) S195P probably damaging Het
Nrg1 T C 8: 32,308,351 (GRCm39) N603S probably benign Het
Or52ae9 T C 7: 103,389,607 (GRCm39) Y280C probably damaging Het
Or8k22 A T 2: 86,163,697 (GRCm39) M1K probably null Het
Or8k37 A G 2: 86,470,013 (GRCm39) I13T possibly damaging Het
Parp8 T C 13: 117,031,341 (GRCm39) E457G probably damaging Het
Pclo T C 5: 14,571,076 (GRCm39) F154L probably benign Het
Pear1 A G 3: 87,659,875 (GRCm39) S704P probably damaging Het
Pkib A G 10: 57,612,394 (GRCm39) T92A probably benign Het
Pnpla7 A G 2: 24,888,678 (GRCm39) R376G possibly damaging Het
Pramel28 A T 4: 143,692,387 (GRCm39) C205S probably benign Het
Ptprd T A 4: 75,984,564 (GRCm39) E527D probably benign Het
Pum1 T C 4: 130,474,337 (GRCm39) V469A probably damaging Het
Rnf148 G A 6: 23,654,283 (GRCm39) Q238* probably null Het
Scn9a A C 2: 66,313,990 (GRCm39) N1909K probably benign Het
Sema3c A T 5: 17,932,594 (GRCm39) H699L possibly damaging Het
Sema3f A T 9: 107,566,927 (GRCm39) C201S probably damaging Het
Serinc2 T A 4: 130,152,583 (GRCm39) D206V probably benign Het
Serping1 A T 2: 84,597,637 (GRCm39) S415T probably benign Het
Sirpb1b A T 3: 15,613,932 (GRCm39) L50Q probably damaging Het
Slc25a22 T C 7: 141,011,296 (GRCm39) E262G probably benign Het
Slc5a8 A G 10: 88,738,353 (GRCm39) I205M probably damaging Het
Sod2 G T 17: 13,226,918 (GRCm39) probably benign Het
Tec T C 5: 72,943,362 (GRCm39) I118V probably benign Het
Tenm3 A T 8: 48,740,847 (GRCm39) V1212E probably damaging Het
Tex44 G A 1: 86,354,237 (GRCm39) V49I probably benign Het
Tmem132d A T 5: 127,861,205 (GRCm39) L972* probably null Het
Tpte G A 8: 22,815,563 (GRCm39) probably null Het
Trim6 T A 7: 103,882,039 (GRCm39) I456N probably damaging Het
Ubr4 G C 4: 139,149,728 (GRCm39) V520L probably benign Het
Ubxn8 A T 8: 34,123,635 (GRCm39) N101K probably benign Het
Vmn2r60 AG A 7: 41,845,158 (GRCm39) probably null Het
Vmn2r83 A G 10: 79,327,392 (GRCm39) T667A probably damaging Het
Other mutations in Zpld2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02183:Zpld2 APN 4 133,929,291 (GRCm39) missense probably benign 0.27
IGL03170:Zpld2 APN 4 133,920,345 (GRCm39) missense possibly damaging 0.57
FR4342:Zpld2 UTSW 4 133,929,942 (GRCm39) small insertion probably benign
FR4976:Zpld2 UTSW 4 133,929,941 (GRCm39) small insertion probably benign
R0487:Zpld2 UTSW 4 133,930,089 (GRCm39) missense probably damaging 0.97
R0530:Zpld2 UTSW 4 133,930,221 (GRCm39) missense probably benign
R0553:Zpld2 UTSW 4 133,929,829 (GRCm39) missense possibly damaging 0.85
R1121:Zpld2 UTSW 4 133,930,248 (GRCm39) missense probably benign 0.00
R1458:Zpld2 UTSW 4 133,924,144 (GRCm39) missense probably benign 0.01
R1748:Zpld2 UTSW 4 133,929,430 (GRCm39) missense possibly damaging 0.57
R1748:Zpld2 UTSW 4 133,927,610 (GRCm39) missense probably damaging 1.00
R1913:Zpld2 UTSW 4 133,919,986 (GRCm39) critical splice donor site probably null
R2029:Zpld2 UTSW 4 133,929,669 (GRCm39) missense possibly damaging 0.87
R2069:Zpld2 UTSW 4 133,929,252 (GRCm39) missense possibly damaging 0.63
R2237:Zpld2 UTSW 4 133,929,516 (GRCm39) missense unknown
R2239:Zpld2 UTSW 4 133,929,516 (GRCm39) missense unknown
R3943:Zpld2 UTSW 4 133,927,656 (GRCm39) missense probably benign 0.15
R4646:Zpld2 UTSW 4 133,929,459 (GRCm39) missense probably benign 0.00
R4673:Zpld2 UTSW 4 133,927,658 (GRCm39) missense probably benign 0.01
R4838:Zpld2 UTSW 4 133,920,410 (GRCm39) missense probably benign 0.04
R5002:Zpld2 UTSW 4 133,924,231 (GRCm39) missense probably benign 0.09
R5593:Zpld2 UTSW 4 133,920,350 (GRCm39) missense probably damaging 0.99
R5606:Zpld2 UTSW 4 133,927,523 (GRCm39) missense probably benign 0.13
R6553:Zpld2 UTSW 4 133,929,367 (GRCm39) missense probably damaging 0.99
R6834:Zpld2 UTSW 4 133,920,476 (GRCm39) missense possibly damaging 0.95
R6931:Zpld2 UTSW 4 133,920,464 (GRCm39) missense probably benign 0.28
R7771:Zpld2 UTSW 4 133,922,754 (GRCm39) missense probably benign 0.01
R8271:Zpld2 UTSW 4 133,930,278 (GRCm39) missense unknown
R8725:Zpld2 UTSW 4 133,930,150 (GRCm39) missense probably benign 0.19
R8727:Zpld2 UTSW 4 133,930,150 (GRCm39) missense probably benign 0.19
R8757:Zpld2 UTSW 4 133,930,282 (GRCm39) missense unknown
R8966:Zpld2 UTSW 4 133,929,712 (GRCm39) missense probably damaging 0.98
R8992:Zpld2 UTSW 4 133,929,978 (GRCm39) missense probably damaging 0.99
R9039:Zpld2 UTSW 4 133,922,858 (GRCm39) missense probably damaging 0.98
R9275:Zpld2 UTSW 4 133,922,770 (GRCm39) missense probably damaging 1.00
R9278:Zpld2 UTSW 4 133,922,770 (GRCm39) missense probably damaging 1.00
R9434:Zpld2 UTSW 4 133,929,553 (GRCm39) missense probably benign 0.01
R9458:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9460:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9461:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9480:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9481:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9551:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9552:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9553:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
RF015:Zpld2 UTSW 4 133,920,338 (GRCm39) missense probably benign
T0975:Zpld2 UTSW 4 133,929,940 (GRCm39) small insertion probably benign
Z1176:Zpld2 UTSW 4 133,929,988 (GRCm39) missense probably benign
Z1176:Zpld2 UTSW 4 133,927,649 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- GTGTCTTGAAATTTGCAGGCAC -3'
(R):5'- TGCTTCCTGAAGACTCAACAC -3'

Sequencing Primer
(F):5'- CTTGAAATTTGCAGGCACAAAGAAC -3'
(R):5'- CGCGAAGTGTTCCAGTATCAGTAC -3'
Posted On 2019-10-18