Incidental Mutation 'R7546:Bid'
ID 585986
Institutional Source Beutler Lab
Gene Symbol Bid
Ensembl Gene ENSMUSG00000004446
Gene Name BH3 interacting domain death agonist
Synonyms 2700049M22Rik
MMRRC Submission 045617-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R7546 (G1)
Quality Score 200.009
Status Validated
Chromosome 6
Chromosomal Location 120870080-120894074 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to A at 120877112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000004560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004560] [ENSMUST00000145948] [ENSMUST00000160684]
AlphaFold P70444
PDB Structure STRUCTURE OF MOUSE BID, NMR, 20 STRUCTURES [SOLUTION NMR]
STRUCTURE OF MOUSE A1 BOUND TO THE BID BH3-DOMAIN [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000004560
SMART Domains Protein: ENSMUSP00000004560
Gene: ENSMUSG00000004446

DomainStartEndE-ValueType
Pfam:BID 3 192 2.8e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145948
SMART Domains Protein: ENSMUSP00000117529
Gene: ENSMUSG00000004446

DomainStartEndE-ValueType
Pfam:BID 1 52 1.7e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160684
SMART Domains Protein: ENSMUSP00000125731
Gene: ENSMUSG00000004446

DomainStartEndE-ValueType
Pfam:BID 1 195 3.8e-93 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas mice normally die from hepatocellular apoptosis and hemorragic necrosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik A G 17: 48,348,330 (GRCm39) S36P probably benign Het
A530084C06Rik G T 13: 31,742,978 (GRCm39) R92S unknown Het
Ampd1 A G 3: 103,003,028 (GRCm39) T582A probably benign Het
Ank1 A C 8: 23,555,011 (GRCm39) N57T probably damaging Het
Atxn3 A G 12: 101,914,261 (GRCm39) probably null Het
Bace2 G A 16: 97,200,882 (GRCm39) A117T probably benign Het
Bcl2l15 A G 3: 103,740,203 (GRCm39) N19S probably benign Het
Cadps2 A T 6: 23,626,607 (GRCm39) M227K probably benign Het
Clip4 G A 17: 72,135,697 (GRCm39) C483Y possibly damaging Het
Dennd4a A G 9: 64,780,326 (GRCm39) T621A probably damaging Het
E2f3 G A 13: 30,094,112 (GRCm39) S383L probably damaging Het
F2r C T 13: 95,754,858 (GRCm39) V9I probably benign Het
Gm14226 T C 2: 154,867,131 (GRCm39) S363P probably damaging Het
Gstm5 T C 3: 107,804,610 (GRCm39) Y65H probably damaging Het
H2bc13 A G 13: 21,900,040 (GRCm39) S92P probably benign Het
H60c A G 10: 3,209,907 (GRCm39) W127R probably damaging Het
Itgav G T 2: 83,606,894 (GRCm39) G448* probably null Het
Klrh1 T C 6: 129,749,343 (GRCm39) H84R probably benign Het
Lhx6 C T 2: 35,993,357 (GRCm39) probably null Het
Manba T A 3: 135,276,007 (GRCm39) V816D probably benign Het
Marchf10 G A 11: 105,280,906 (GRCm39) P460S not run Het
Mmp17 T A 5: 129,673,653 (GRCm39) V244E probably damaging Het
Mtrr C T 13: 68,730,268 (GRCm39) probably benign Het
Nup160 T C 2: 90,515,402 (GRCm39) I170T probably damaging Het
Or4c12b A G 2: 89,647,363 (GRCm39) N225S probably benign Het
Or4c12b A T 2: 89,647,538 (GRCm39) L283F probably damaging Het
Or51e1 T C 7: 102,358,996 (GRCm39) S177P probably damaging Het
Pappa G A 4: 65,074,352 (GRCm39) S302N possibly damaging Het
Plekhj1 G A 10: 80,633,748 (GRCm39) A53V possibly damaging Het
Pramel46 T A 5: 95,418,171 (GRCm39) H275L possibly damaging Het
Pramel48 C T 5: 95,630,539 (GRCm39) R139C probably benign Het
Prpf8 T C 11: 75,399,200 (GRCm39) V2157A probably damaging Het
Rps8 G A 4: 117,011,104 (GRCm39) R200W probably damaging Het
Sesn2 A G 4: 132,227,154 (GRCm39) F93L probably damaging Het
Skic3 C A 13: 76,282,954 (GRCm39) L759M probably damaging Het
Slf1 A G 13: 77,197,311 (GRCm39) S768P probably benign Het
Stat4 A G 1: 52,137,622 (GRCm39) N471S probably damaging Het
Trcg1 T C 9: 57,155,621 (GRCm39) L758P probably benign Het
Trim35 A G 14: 66,540,696 (GRCm39) T183A probably benign Het
Ttr C A 18: 20,803,102 (GRCm39) Y89* probably null Het
Zfp90 C A 8: 107,151,323 (GRCm39) H345Q probably benign Het
Zmym4 A G 4: 126,757,961 (GRCm39) V1531A probably damaging Het
Other mutations in Bid
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1331:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1332:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1333:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1335:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1760:Bid UTSW 6 120,877,209 (GRCm39) missense possibly damaging 0.65
R1930:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1932:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R2152:Bid UTSW 6 120,877,215 (GRCm39) missense probably damaging 1.00
R4937:Bid UTSW 6 120,872,707 (GRCm39) missense probably benign 0.31
R8272:Bid UTSW 6 120,877,176 (GRCm39) missense probably damaging 1.00
R8303:Bid UTSW 6 120,877,200 (GRCm39) missense probably benign 0.00
Z1177:Bid UTSW 6 120,877,219 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCATATGAACTGGACATTACTGGG -3'
(R):5'- ACCTTAGGTCAGCAACGGTTC -3'

Sequencing Primer
(F):5'- CATTACTGGGGGCAGTCACATG -3'
(R):5'- GGCCGAGCACATCACAG -3'
Posted On 2019-10-18