Incidental Mutation 'R7571:Vmn2r116'
ID 586027
Institutional Source Beutler Lab
Gene Symbol Vmn2r116
Ensembl Gene ENSMUSG00000090966
Gene Name vomeronasal 2, receptor 116
Synonyms V2Rp5, EG619697
MMRRC Submission 045711-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R7571 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 23603777-23620838 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 23603830 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000128106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164856]
AlphaFold E9Q6I0
Predicted Effect probably null
Transcript: ENSMUST00000164856
SMART Domains Protein: ENSMUSP00000128106
Gene: ENSMUSG00000090966

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 4.4e-30 PFAM
Pfam:NCD3G 511 564 1.2e-22 PFAM
low complexity region 589 594 N/A INTRINSIC
Pfam:7tm_3 595 832 8.7e-57 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele stimulated with male pheromone (Gm6084) fail to exhibit an increase in lordosis behavior and successful intromission. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 112 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A T 7: 120,119,211 (GRCm39) N985I probably benign Het
Abi3bp T A 16: 56,451,345 (GRCm39) probably null Het
Acad12 A T 5: 121,745,257 (GRCm39) Y309* probably null Het
Acadsb G T 7: 131,045,283 (GRCm39) R405L probably damaging Het
Acan G A 7: 78,736,015 (GRCm39) V154M probably damaging Het
Adam22 G A 5: 8,132,160 (GRCm39) R894* probably null Het
Ahnak A T 19: 8,978,150 (GRCm39) K90* probably null Het
Ak4 T C 4: 101,317,739 (GRCm39) I103T probably benign Het
Ap4e1 C T 2: 126,861,256 (GRCm39) L132F probably damaging Het
Apol7b C T 15: 77,307,677 (GRCm39) V273I probably benign Het
Arhgef37 T A 18: 61,637,403 (GRCm39) I420F probably damaging Het
Atg13 C T 2: 91,510,687 (GRCm39) probably null Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Cabin1 A T 10: 75,482,500 (GRCm39) S2148T probably damaging Het
Cacna1i T C 15: 80,259,537 (GRCm39) V1269A probably damaging Het
Cdipt T C 7: 126,578,794 (GRCm39) I195T probably benign Het
Ces2b A T 8: 105,561,641 (GRCm39) H245L probably damaging Het
Cimip2c A T 5: 30,639,502 (GRCm39) E143V possibly damaging Het
Clstn1 T G 4: 149,730,744 (GRCm39) M825R probably benign Het
Cntn3 G A 6: 102,255,364 (GRCm39) T178I probably damaging Het
Col7a1 A G 9: 108,811,775 (GRCm39) M2789V probably null Het
Col9a2 A T 4: 120,896,981 (GRCm39) I24F unknown Het
Cpne2 T C 8: 95,278,408 (GRCm39) M134T probably benign Het
Cpt1b A G 15: 89,305,546 (GRCm39) probably null Het
Crocc T C 4: 140,773,360 (GRCm39) probably null Het
Cts8 T C 13: 61,395,981 (GRCm39) Y330C probably damaging Het
Cwc22 T C 2: 77,747,411 (GRCm39) D434G probably benign Het
Cyp3a13 T C 5: 137,897,125 (GRCm39) I396M possibly damaging Het
Ddr2 A T 1: 169,829,420 (GRCm39) I278N probably benign Het
Dnaaf5 A G 5: 139,155,963 (GRCm39) E548G possibly damaging Het
Dync2h1 A G 9: 7,002,623 (GRCm39) L3808P probably damaging Het
Faf2 T A 13: 54,798,027 (GRCm39) W209R probably damaging Het
Fbln2 A T 6: 91,245,557 (GRCm39) E992D probably damaging Het
Fdxacb1 T A 9: 50,683,093 (GRCm39) V352D probably damaging Het
Flg2 G T 3: 93,127,303 (GRCm39) G2072* probably null Het
Flii A T 11: 60,611,962 (GRCm39) L347Q probably damaging Het
Fndc3a A T 14: 72,827,336 (GRCm39) H116Q probably damaging Het
Fnta A T 8: 26,505,493 (GRCm39) M39K probably benign Het
Gabra4 A G 5: 71,729,335 (GRCm39) S482P probably benign Het
Gapdhs G A 7: 30,437,383 (GRCm39) P61S unknown Het
Gm10153 A T 7: 141,743,401 (GRCm39) C242* probably null Het
Gp1ba A G 11: 70,530,920 (GRCm39) I229V unknown Het
Grap2 T A 15: 80,527,905 (GRCm39) L117Q probably damaging Het
Grik5 A G 7: 24,713,310 (GRCm39) I766T possibly damaging Het
Hrh3 A T 2: 179,743,079 (GRCm39) I183N probably damaging Het
Htr5a C A 5: 28,047,893 (GRCm39) Y149* probably null Het
Ibtk T C 9: 85,604,353 (GRCm39) I527V probably benign Het
Il33 T A 19: 29,934,341 (GRCm39) S184R probably damaging Het
Kansl3 T A 1: 36,404,668 (GRCm39) Q94L possibly damaging Het
Katnip C T 7: 125,307,193 (GRCm39) probably benign Het
Kcnh6 A G 11: 105,908,242 (GRCm39) D286G probably benign Het
Kmt2e T A 5: 23,683,585 (GRCm39) M281K probably damaging Het
Lrp2 T A 2: 69,346,747 (GRCm39) H833L probably damaging Het
Meis1 A T 11: 18,891,702 (GRCm39) V282E probably damaging Het
Mfsd8 T G 3: 40,785,097 (GRCm39) D240A probably damaging Het
Muc5b A G 7: 141,400,986 (GRCm39) T534A unknown Het
Myo18b G A 5: 112,978,194 (GRCm39) L1243F probably damaging Het
Nefl A G 14: 68,322,123 (GRCm39) I238V probably benign Het
Nexn T A 3: 151,959,284 (GRCm39) I62F possibly damaging Het
Niban1 T C 1: 151,594,048 (GRCm39) V911A probably benign Het
Notch4 T C 17: 34,802,548 (GRCm39) L1323P probably damaging Het
Or51h1 T C 7: 102,308,258 (GRCm39) S77P probably damaging Het
Or5p68 A T 7: 107,945,689 (GRCm39) F166L probably benign Het
Or8b1 T C 9: 38,399,952 (GRCm39) V209A probably benign Het
Patj C A 4: 98,457,217 (GRCm39) H1244N probably damaging Het
Peg10 T A 6: 4,756,082 (GRCm39) D219E unknown Het
Pi4kb G T 3: 94,906,425 (GRCm39) probably null Het
Piezo1 A G 8: 123,225,157 (GRCm39) F614S Het
Pisd T A 5: 32,894,681 (GRCm39) N372Y probably damaging Het
Piwil4 T C 9: 14,645,893 (GRCm39) D178G probably benign Het
Plekho1 G T 3: 95,896,566 (GRCm39) P301Q probably damaging Het
Pop1 T A 15: 34,529,093 (GRCm39) W738R probably null Het
Ppp4r1 C T 17: 66,117,611 (GRCm39) P125L possibly damaging Het
Pramel48 A T 5: 95,630,819 (GRCm39) N232I probably damaging Het
Prdm9 T A 17: 15,783,526 (GRCm39) N13I probably damaging Het
Psd4 T G 2: 24,297,023 (GRCm39) V932G probably damaging Het
Ptger3 T C 3: 157,347,412 (GRCm39) S355P probably benign Het
Ptprb T C 10: 116,175,335 (GRCm39) V823A probably damaging Het
Ptprj C T 2: 90,285,530 (GRCm39) V841I probably benign Het
Ranbp3 T C 17: 57,014,923 (GRCm39) S281P probably benign Het
Rasal3 T A 17: 32,614,835 (GRCm39) M541L possibly damaging Het
Rassf1 A G 9: 107,428,982 (GRCm39) T63A possibly damaging Het
Rcor3 C A 1: 191,822,173 (GRCm39) G8V probably damaging Het
Rgs4 G A 1: 169,571,927 (GRCm39) T124I probably damaging Het
Rspo2 T A 15: 43,033,372 (GRCm39) probably benign Het
Scgn T C 13: 24,137,897 (GRCm39) D258G probably damaging Het
Shkbp1 A G 7: 27,046,556 (GRCm39) S403P possibly damaging Het
Slc25a13 A G 6: 6,052,785 (GRCm39) L525P probably damaging Het
Snd1 G T 6: 28,526,202 (GRCm39) K193N possibly damaging Het
Sntg2 C T 12: 30,225,201 (GRCm39) A516T probably damaging Het
Stard13 A G 5: 150,982,967 (GRCm39) I699T probably damaging Het
Svil T A 18: 5,114,636 (GRCm39) V1984D probably damaging Het
Swt1 A G 1: 151,270,470 (GRCm39) S582P probably benign Het
Sypl2 A G 3: 108,121,854 (GRCm39) *265Q probably null Het
Taar8a T A 10: 23,953,306 (GRCm39) Y303* probably null Het
Tasor2 T C 13: 3,625,292 (GRCm39) T1553A probably benign Het
Tlr2 T A 3: 83,743,849 (GRCm39) I745F probably damaging Het
Tnrc6b A G 15: 80,813,594 (GRCm39) T1784A probably benign Het
Tpo C A 12: 30,169,431 (GRCm39) M101I probably benign Het
Trpm2 G T 10: 77,773,784 (GRCm39) R544S probably benign Het
Ttc14 A G 3: 33,863,400 (GRCm39) R603G unknown Het
Tubgcp6 A C 15: 88,984,925 (GRCm39) V1694G probably damaging Het
Uba6 C A 5: 86,294,970 (GRCm39) K356N probably benign Het
Usp16 T C 16: 87,261,723 (GRCm39) V113A possibly damaging Het
Vcam1 G A 3: 115,908,032 (GRCm39) Q677* probably null Het
Vmn1r238 T A 18: 3,122,721 (GRCm39) E231V probably damaging Het
Vmn1r70 T C 7: 10,367,871 (GRCm39) F120L probably benign Het
Vmn2r5 A T 3: 64,411,825 (GRCm39) C248S probably damaging Het
Vmn2r87 A T 10: 130,314,940 (GRCm39) D215E probably damaging Het
Xkr4 T G 1: 3,740,911 (GRCm39) I221L probably benign Het
Zfp366 T C 13: 99,382,895 (GRCm39) I686T probably benign Het
Zfp398 T A 6: 47,843,666 (GRCm39) C573S probably damaging Het
Other mutations in Vmn2r116
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00898:Vmn2r116 APN 17 23,604,969 (GRCm39) missense possibly damaging 0.94
IGL00985:Vmn2r116 APN 17 23,620,489 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r116 APN 17 23,606,210 (GRCm39) missense probably benign 0.12
IGL00990:Vmn2r116 APN 17 23,616,701 (GRCm39) missense probably damaging 1.00
IGL01383:Vmn2r116 APN 17 23,620,575 (GRCm39) missense probably damaging 1.00
IGL01459:Vmn2r116 APN 17 23,603,903 (GRCm39) missense probably damaging 1.00
IGL01725:Vmn2r116 APN 17 23,605,619 (GRCm39) missense probably damaging 1.00
IGL02125:Vmn2r116 APN 17 23,616,601 (GRCm39) splice site probably benign
IGL02170:Vmn2r116 APN 17 23,603,907 (GRCm39) missense probably benign
IGL02209:Vmn2r116 APN 17 23,607,761 (GRCm39) missense probably damaging 1.00
IGL02226:Vmn2r116 APN 17 23,603,808 (GRCm39) missense probably null
IGL02272:Vmn2r116 APN 17 23,604,978 (GRCm39) missense probably damaging 1.00
IGL02272:Vmn2r116 APN 17 23,604,973 (GRCm39) missense probably benign 0.06
IGL02403:Vmn2r116 APN 17 23,606,338 (GRCm39) missense probably damaging 1.00
IGL02686:Vmn2r116 APN 17 23,607,767 (GRCm39) missense probably damaging 0.99
IGL02750:Vmn2r116 APN 17 23,616,608 (GRCm39) splice site probably benign
IGL02977:Vmn2r116 APN 17 23,607,748 (GRCm39) missense possibly damaging 0.90
PIT4449001:Vmn2r116 UTSW 17 23,607,921 (GRCm39) missense probably benign 0.41
R0015:Vmn2r116 UTSW 17 23,620,823 (GRCm39) missense probably benign 0.03
R0219:Vmn2r116 UTSW 17 23,605,072 (GRCm39) nonsense probably null
R0281:Vmn2r116 UTSW 17 23,620,387 (GRCm39) missense possibly damaging 0.90
R0415:Vmn2r116 UTSW 17 23,606,253 (GRCm39) missense possibly damaging 0.55
R0592:Vmn2r116 UTSW 17 23,605,889 (GRCm39) missense probably damaging 0.99
R0610:Vmn2r116 UTSW 17 23,606,286 (GRCm39) missense probably damaging 1.00
R0635:Vmn2r116 UTSW 17 23,605,861 (GRCm39) missense possibly damaging 0.95
R0843:Vmn2r116 UTSW 17 23,619,934 (GRCm39) missense probably benign 0.01
R1329:Vmn2r116 UTSW 17 23,606,162 (GRCm39) missense possibly damaging 0.89
R1396:Vmn2r116 UTSW 17 23,605,115 (GRCm39) missense probably benign
R1401:Vmn2r116 UTSW 17 23,605,570 (GRCm39) splice site probably benign
R1574:Vmn2r116 UTSW 17 23,606,063 (GRCm39) missense probably damaging 0.99
R1574:Vmn2r116 UTSW 17 23,606,063 (GRCm39) missense probably damaging 0.99
R1766:Vmn2r116 UTSW 17 23,620,740 (GRCm39) missense probably damaging 0.98
R2157:Vmn2r116 UTSW 17 23,620,443 (GRCm39) missense probably damaging 1.00
R3622:Vmn2r116 UTSW 17 23,605,025 (GRCm39) missense probably benign 0.11
R3690:Vmn2r116 UTSW 17 23,603,798 (GRCm39) missense unknown
R4298:Vmn2r116 UTSW 17 23,620,801 (GRCm39) missense possibly damaging 0.69
R4373:Vmn2r116 UTSW 17 23,620,395 (GRCm39) missense probably benign 0.01
R4860:Vmn2r116 UTSW 17 23,620,777 (GRCm39) missense probably benign
R4941:Vmn2r116 UTSW 17 23,620,116 (GRCm39) missense probably damaging 1.00
R5119:Vmn2r116 UTSW 17 23,606,138 (GRCm39) missense probably benign 0.01
R5503:Vmn2r116 UTSW 17 23,605,778 (GRCm39) missense probably benign 0.07
R5510:Vmn2r116 UTSW 17 23,605,095 (GRCm39) missense probably damaging 1.00
R5538:Vmn2r116 UTSW 17 23,620,041 (GRCm39) missense probably benign 0.00
R5689:Vmn2r116 UTSW 17 23,616,693 (GRCm39) missense probably benign 0.30
R5765:Vmn2r116 UTSW 17 23,620,378 (GRCm39) missense probably damaging 0.99
R5794:Vmn2r116 UTSW 17 23,604,942 (GRCm39) missense probably damaging 0.99
R5807:Vmn2r116 UTSW 17 23,606,281 (GRCm39) missense probably damaging 1.00
R5837:Vmn2r116 UTSW 17 23,606,054 (GRCm39) missense probably damaging 1.00
R6262:Vmn2r116 UTSW 17 23,606,351 (GRCm39) missense probably benign 0.03
R6298:Vmn2r116 UTSW 17 23,605,736 (GRCm39) missense probably damaging 1.00
R6651:Vmn2r116 UTSW 17 23,607,805 (GRCm39) nonsense probably null
R6667:Vmn2r116 UTSW 17 23,620,066 (GRCm39) missense probably damaging 1.00
R7393:Vmn2r116 UTSW 17 23,605,099 (GRCm39) missense probably benign 0.14
R7940:Vmn2r116 UTSW 17 23,605,946 (GRCm39) missense probably damaging 0.99
R8510:Vmn2r116 UTSW 17 23,604,905 (GRCm39) nonsense probably null
R8950:Vmn2r116 UTSW 17 23,620,467 (GRCm39) missense probably damaging 1.00
R8956:Vmn2r116 UTSW 17 23,605,736 (GRCm39) missense probably damaging 1.00
R8977:Vmn2r116 UTSW 17 23,605,916 (GRCm39) missense possibly damaging 0.56
R9030:Vmn2r116 UTSW 17 23,603,864 (GRCm39) missense possibly damaging 0.82
R9077:Vmn2r116 UTSW 17 23,604,956 (GRCm39) missense probably benign 0.14
R9223:Vmn2r116 UTSW 17 23,620,141 (GRCm39) missense probably damaging 1.00
R9401:Vmn2r116 UTSW 17 23,620,566 (GRCm39) missense probably damaging 1.00
R9449:Vmn2r116 UTSW 17 23,605,919 (GRCm39) missense probably benign 0.01
R9746:Vmn2r116 UTSW 17 23,620,797 (GRCm39) missense probably benign 0.08
R9755:Vmn2r116 UTSW 17 23,620,065 (GRCm39) missense probably damaging 1.00
R9759:Vmn2r116 UTSW 17 23,620,360 (GRCm39) missense possibly damaging 0.90
R9800:Vmn2r116 UTSW 17 23,620,399 (GRCm39) missense probably damaging 0.97
S24628:Vmn2r116 UTSW 17 23,606,253 (GRCm39) missense possibly damaging 0.55
Z1176:Vmn2r116 UTSW 17 23,620,402 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r116 UTSW 17 23,607,866 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCATGTGTAGCATCTCCC -3'
(R):5'- CCGTGCAAAAGCCTCATAGC -3'

Sequencing Primer
(F):5'- CTCCCTGGGACACAGTGTTAATAG -3'
(R):5'- CATCCTCAGTAGTCTTGGGAAAC -3'
Posted On 2019-10-18