Incidental Mutation 'IGL00490:Mzt1'
ID5861
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mzt1
Ensembl Gene ENSMUSG00000033186
Gene Namemitotic spindle organizing protein 1
Synonyms2410129H14Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.878) question?
Stock #IGL00490
Quality Score
Status
Chromosome14
Chromosomal Location99034544-99046134 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 99040670 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154225 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042662] [ENSMUST00000227948]
Predicted Effect probably benign
Transcript: ENSMUST00000042662
SMART Domains Protein: ENSMUSP00000037557
Gene: ENSMUSG00000033186

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
Pfam:MOZART1 19 65 4.1e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227197
Predicted Effect probably benign
Transcript: ENSMUST00000227948
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228445
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 A G 4: 130,011,872 E837G possibly damaging Het
Atp13a3 A G 16: 30,352,354 M291T probably benign Het
Coq8b C A 7: 27,257,477 H518Q probably benign Het
Crebrf A G 17: 26,743,093 D388G probably damaging Het
Cyp2d10 A T 15: 82,403,314 S244T possibly damaging Het
Ddr2 A T 1: 170,005,194 L99H probably damaging Het
Dennd1a G T 2: 37,801,152 D251E probably damaging Het
Fam210a G T 18: 68,268,912 T210N probably damaging Het
Gigyf2 C A 1: 87,436,850 Q951K probably damaging Het
Gramd1b T A 9: 40,310,041 I280F probably damaging Het
Gsdmc3 T A 15: 63,859,677 K335N probably benign Het
Loxhd1 A T 18: 77,431,074 T993S possibly damaging Het
Mfsd6 A G 1: 52,708,254 L484P probably damaging Het
Myt1l T A 12: 29,827,424 V358E unknown Het
Nrxn2 C A 19: 6,473,593 H514Q possibly damaging Het
Nup214 G A 2: 32,033,979 E2K probably damaging Het
Pcdhb4 G T 18: 37,309,916 G760W possibly damaging Het
Ptger2 T C 14: 45,001,741 probably benign Het
Serpinb1c T C 13: 32,883,975 K213E probably damaging Het
Smcr8 T A 11: 60,778,632 probably null Het
Spef2 A T 15: 9,740,535 D46E probably damaging Het
Tbc1d32 G A 10: 56,155,765 P689L probably damaging Het
Tep1 C A 14: 50,833,473 W2123L probably damaging Het
Thg1l T C 11: 45,954,221 E8G probably benign Het
Tmem236 A G 2: 14,219,378 Y326C probably damaging Het
Trip4 C T 9: 65,833,410 G573R probably damaging Het
Trrap C T 5: 144,825,225 T2320I probably benign Het
Tsnaxip1 A G 8: 105,842,184 N435S probably damaging Het
Ube3a A G 7: 59,272,110 N77D probably damaging Het
Uvrag A T 7: 98,979,741 I373N probably damaging Het
Other mutations in Mzt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0542:Mzt1 UTSW 14 99040502 splice site probably benign
R1873:Mzt1 UTSW 14 99040661 critical splice acceptor site probably null
R4489:Mzt1 UTSW 14 99036490 makesense probably null
R4861:Mzt1 UTSW 14 99047474 splice site probably null
R7589:Mzt1 UTSW 14 99036512 critical splice acceptor site probably null
R7690:Mzt1 UTSW 14 99040588 missense probably damaging 1.00
R7771:Mzt1 UTSW 14 99040576 missense probably damaging 1.00
R7835:Mzt1 UTSW 14 99046003 missense probably benign 0.03
Posted On2012-04-20